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The map label for this gene is adhB [H]

Identifier: 77465414

GI number: 77465414

Start: 478244

End: 479422

Strand: Direct

Name: adhB [H]

Synonym: RSP_3412

Alternate gene names: 77465414

Gene position: 478244-479422 (Clockwise)

Preceding gene: 77465407

Following gene: 77465419

Centisome position: 50.71

GC content: 72.18

Gene sequence:

>1179_bases
ATGCCCCCGATCCGGGGCCTGCTCCCCGACCGAAACGAACAGACGCGGAGTGCTGCGATGGCGGACGACCTCACCCGACC
GATTACCCTTCTTCGGCCTGCCGCCGTGCATTTCGGCGAAGGCAGCCTTGCCCGCCTGCCAGAGTGGGTGGCCGCGCGCG
GCTTCCGCGCGCCCTTCGTCATCGCCGATGCGGTGAATGCGCAGCGGCTGGACCGGCTGGGGCTCGGATCGGTCGGCTGC
TTCGGGACCGTCGTGCCCGAGCCCGACACCGCCAATCTGCAGGCCGCCGTCGCCGCGGCCGAAGGGGCCGACCTGATCGT
GGGATTCGGCGGCGGCTCGGCCATGGACCTGGCCAAGCTCGTGGCGGTGCTCGTGGGAACCGGCCTCGCGCTTTCGGACA
TCTCCGGTCCCGGCCGGGCGCCGGCCCGGCGCGTGGGCCTCGTGCAGGTGCCGACCACCGCCGGGACCGGCTCGGAAGTG
GGCACGCGCGCCCTCGTGACGGATCCCGCGAGCCTTGCCAAGATCGCGACCGAAAGCGCCGAGATGCTTGCCGACATGGC
GATCGTGGACCCTGCGCTCACGCTCAGCGTGCCGCCCGCGGTCACGGCCGCAACCGGGGTCGACGCCATGGCCCATTGCG
CCGAGGCCCTGACCTCGAAACGGGCGCATCCGCTGGTCGATGCCTATGCGCTGGAGGGGATCGCGCTCGTCGGCCGCTTC
CTGCGTCGCGCGGTCGAGGACGGGCAGGATGTCGAAGCCCGGGCAGGCCTGTCGCTCGCGGCCTTCTACGGCGGCATCTG
CCTCGGCCCCGTGAACACGACGGCGGGCCATGCGCTCTCCTATCCGCTCGGCACGCGCCACAAGCTGCCGCACGGGATCG
CGAATGCGCTGATCTTCCCGCATGTGCTGGCGGCCAACGCCTCGGCCGCGCCGGAGAAGACGGCCCGGATCTGCGAGGCT
CTGGGCTTTGCCGCGGGCGCCGAGGAGACGGTGCGGGCCGGTGCGCTCGCCTTCTGCGCCGGGCTCGGGCTCGACATGCG
GCTGCGGGCACATGGCGTGCCGTCCGAGGATCTGCCGGTCATGGCAACGGAGGCGCATGGCATCCGCCGCCTGCTCGACT
GGAACCCGCGCGATCTGAGCGTGGCCGAGATCGAGGCGATCTACCGCCGCGCCTACTGA

Upstream 100 bases:

>100_bases
TTTCGCATTGTTTTGGAATGATAATCACTCTGCAGCGCCAGACCGCCCTGCCCACAGGCCGGAACTATACAGGTTGACAA
GTTGACGATCCCTCCCTTGA

Downstream 100 bases:

>100_bases
TCGGAGACCCCTCCGGTGCCCTGCGACGGGCGGATGCGCCGCTCCGCTCAGCCGCCGGCGCGGTGGCGGCCGATCGGCAG
CATCATGGGCCGGCCGCTCA

Product: Iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MPPIRGLLPDRNEQTRSAAMADDLTRPITLLRPAAVHFGEGSLARLPEWVAARGFRAPFVIADAVNAQRLDRLGLGSVGC
FGTVVPEPDTANLQAAVAAAEGADLIVGFGGGSAMDLAKLVAVLVGTGLALSDISGPGRAPARRVGLVQVPTTAGTGSEV
GTRALVTDPASLAKIATESAEMLADMAIVDPALTLSVPPAVTAATGVDAMAHCAEALTSKRAHPLVDAYALEGIALVGRF
LRRAVEDGQDVEARAGLSLAAFYGGICLGPVNTTAGHALSYPLGTRHKLPHGIANALIFPHVLAANASAAPEKTARICEA
LGFAAGAEETVRAGALAFCAGLGLDMRLRAHGVPSEDLPVMATEAHGIRRLLDWNPRDLSVAEIEAIYRRAY

Sequences:

>Translated_392_residues
MPPIRGLLPDRNEQTRSAAMADDLTRPITLLRPAAVHFGEGSLARLPEWVAARGFRAPFVIADAVNAQRLDRLGLGSVGC
FGTVVPEPDTANLQAAVAAAEGADLIVGFGGGSAMDLAKLVAVLVGTGLALSDISGPGRAPARRVGLVQVPTTAGTGSEV
GTRALVTDPASLAKIATESAEMLADMAIVDPALTLSVPPAVTAATGVDAMAHCAEALTSKRAHPLVDAYALEGIALVGRF
LRRAVEDGQDVEARAGLSLAAFYGGICLGPVNTTAGHALSYPLGTRHKLPHGIANALIFPHVLAANASAAPEKTARICEA
LGFAAGAEETVRAGALAFCAGLGLDMRLRAHGVPSEDLPVMATEAHGIRRLLDWNPRDLSVAEIEAIYRRAY
>Mature_391_residues
PPIRGLLPDRNEQTRSAAMADDLTRPITLLRPAAVHFGEGSLARLPEWVAARGFRAPFVIADAVNAQRLDRLGLGSVGCF
GTVVPEPDTANLQAAVAAAEGADLIVGFGGGSAMDLAKLVAVLVGTGLALSDISGPGRAPARRVGLVQVPTTAGTGSEVG
TRALVTDPASLAKIATESAEMLADMAIVDPALTLSVPPAVTAATGVDAMAHCAEALTSKRAHPLVDAYALEGIALVGRFL
RRAVEDGQDVEARAGLSLAAFYGGICLGPVNTTAGHALSYPLGTRHKLPHGIANALIFPHVLAANASAAPEKTARICEAL
GFAAGAEETVRAGALAFCAGLGLDMRLRAHGVPSEDLPVMATEAHGIRRLLDWNPRDLSVAEIEAIYRRAY

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=355, Percent_Identity=27.3239436619718, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI48994951, Length=382, Percent_Identity=30.3664921465969, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=32.5396825396825, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789163, Length=380, Percent_Identity=28.9473684210526, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1787493, Length=369, Percent_Identity=28.4552845528455, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789386, Length=371, Percent_Identity=24.7978436657682, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17537053, Length=309, Percent_Identity=25.8899676375405, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=30.9333333333333, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24657991, Length=351, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40365; Mature: 40234

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPIRGLLPDRNEQTRSAAMADDLTRPITLLRPAAVHFGEGSLARLPEWVAARGFRAPFV
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCCEE
IADAVNAQRLDRLGLGSVGCFGTVVPEPDTANLQAAVAAAEGADLIVGFGGGSAMDLAKL
EEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCCEEEEECCCCCHHHHHHH
VAVLVGTGLALSDISGPGRAPARRVGLVQVPTTAGTGSEVGTRALVTDPASLAKIATESA
HHHHHCCCCEEECCCCCCCCCHHHCCEEEECCCCCCCCHHCCEEEEECCHHHHHHHHHHH
EMLADMAIVDPALTLSVPPAVTAATGVDAMAHCAEALTSKRAHPLVDAYALEGIALVGRF
HHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LRRAVEDGQDVEARAGLSLAAFYGGICLGPVNTTAGHALSYPLGTRHKLPHGIANALIFP
HHHHHHCCCCCHHHCCCCHHHHHCCEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
HVLAANASAAPEKTARICEALGFAAGAEETVRAGALAFCAGLGLDMRLRAHGVPSEDLPV
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
MATEAHGIRRLLDWNPRDLSVAEIEAIYRRAY
EEECHHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PPIRGLLPDRNEQTRSAAMADDLTRPITLLRPAAVHFGEGSLARLPEWVAARGFRAPFV
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCCEE
IADAVNAQRLDRLGLGSVGCFGTVVPEPDTANLQAAVAAAEGADLIVGFGGGSAMDLAKL
EEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCCEEEEECCCCCHHHHHHH
VAVLVGTGLALSDISGPGRAPARRVGLVQVPTTAGTGSEVGTRALVTDPASLAKIATESA
HHHHHCCCCEEECCCCCCCCCHHHCCEEEECCCCCCCCHHCCEEEEECCHHHHHHHHHHH
EMLADMAIVDPALTLSVPPAVTAATGVDAMAHCAEALTSKRAHPLVDAYALEGIALVGRF
HHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LRRAVEDGQDVEARAGLSLAAFYGGICLGPVNTTAGHALSYPLGTRHKLPHGIANALIFP
HHHHHHCCCCCHHHCCCCHHHHHCCEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
HVLAANASAAPEKTARICEALGFAAGAEETVRAGALAFCAGLGLDMRLRAHGVPSEDLPV
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
MATEAHGIRRLLDWNPRDLSVAEIEAIYRRAY
EEECHHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]