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The map label for this gene is fabG2 [H]

Identifier: 77465196

GI number: 77465196

Start: 235092

End: 235853

Strand: Reverse

Name: fabG2 [H]

Synonym: RSP_3183

Alternate gene names: 77465196

Gene position: 235853-235092 (Counterclockwise)

Preceding gene: 77465197

Following gene: 77465195

Centisome position: 25.01

GC content: 75.07

Gene sequence:

>762_bases
ATGGACCTTCGGGATCAGGCGGCGCTCGTCACCGGCGCGGGATCGGGCTTGGGCGAGGCCACGGCGCGGGCGCTGGCGGC
GGCGGGGGCGCGGGTGGCGCTCCTCGATTTCAACCTGCCCGCGGCCGAGGCGGTCGCGGCCGAGATCGGCGGGCTCGCCA
TCGGCTGCGACGTGGCCTCGGCCGAGGGCGCCGAAGCGGCGGTGGCGCGGGCCGCGGCCGAGCAGGGCGTGGCGCGCATC
CTCGTCAATTGCGCGGGGGTGGCGCCGGCGAAGAAGATGCTCGGGCGCGCGGGCGTCATGCCGCTCGAGGAGTTCCGCCG
CACGGTCGAGGTGAACCTCGTGGGCAGCTTCAACCTTCTGCGCCTCTTCGCGGCGGGGGCGGCGGAACTCGCGCCGCTCG
AGACCGGCGAGCGGGGGGTGGCGATCCACACCGCCTCGGTGGCGGCCTGGGAGGGGCAGATCGGCCAGACCGCCTATGCC
GCCTCGAAGGGGGGCATCGTGGGCCTCACCCTGCCCGCCGCGCGCGAACTCGCCCCGCTCGGCATCCGGGTCTGCGCCAT
CGCCCCCGGCATCTTCGAGACCGCGATGCTGAAGGGCCTGCCCGAGGCCGCGCAGGAGAGCCTCGGCGCGGCGGTGCCCT
TCCCCTCGCGGCTCGGCCGGCCGGCCGAATTCGCGGCCCTTGCGCTCCACATCCTGTCGAACCCCATGTTGAACGGCGAG
ACGATCCGGCTCGACGGCGCGCTGCGGATGGCACCGAAATGA

Upstream 100 bases:

>100_bases
CTTTGATCGAGGCGCTGCGGGCGCGGGGATTGAGACGCGGCGTGGCCTCGCTCTGCATCGGCGGCGGCGAGGCGACGGCG
CTGGCGGTGGAGGTGATCTG

Downstream 100 bases:

>100_bases
GCGTCCTGACCGACGAGCAGCGCCTCGTGCAGGAGATGGCGCGCACCTTCGCCCGCGAGGTGCTGGCACCCGGCGCCGCG
GCCCGCGCGAAGGCCAAGGC

Product: 3-hydroxyacyl-CoA dehydrogenase type II

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDLRDQAALVTGAGSGLGEATARALAAAGARVALLDFNLPAAEAVAAEIGGLAIGCDVASAEGAEAAVARAAAEQGVARI
LVNCAGVAPAKKMLGRAGVMPLEEFRRTVEVNLVGSFNLLRLFAAGAAELAPLETGERGVAIHTASVAAWEGQIGQTAYA
ASKGGIVGLTLPAARELAPLGIRVCAIAPGIFETAMLKGLPEAAQESLGAAVPFPSRLGRPAEFAALALHILSNPMLNGE
TIRLDGALRMAPK

Sequences:

>Translated_253_residues
MDLRDQAALVTGAGSGLGEATARALAAAGARVALLDFNLPAAEAVAAEIGGLAIGCDVASAEGAEAAVARAAAEQGVARI
LVNCAGVAPAKKMLGRAGVMPLEEFRRTVEVNLVGSFNLLRLFAAGAAELAPLETGERGVAIHTASVAAWEGQIGQTAYA
ASKGGIVGLTLPAARELAPLGIRVCAIAPGIFETAMLKGLPEAAQESLGAAVPFPSRLGRPAEFAALALHILSNPMLNGE
TIRLDGALRMAPK
>Mature_253_residues
MDLRDQAALVTGAGSGLGEATARALAAAGARVALLDFNLPAAEAVAAEIGGLAIGCDVASAEGAEAAVARAAAEQGVARI
LVNCAGVAPAKKMLGRAGVMPLEEFRRTVEVNLVGSFNLLRLFAAGAAELAPLETGERGVAIHTASVAAWEGQIGQTAYA
ASKGGIVGLTLPAARELAPLGIRVCAIAPGIFETAMLKGLPEAAQESLGAAVPFPSRLGRPAEFAALALHILSNPMLNGE
TIRLDGALRMAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=249, Percent_Identity=51.4056224899598, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI83715985, Length=249, Percent_Identity=48.5943775100402, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=31.4741035856574, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=33.8403041825095, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31542939, Length=260, Percent_Identity=31.5384615384615, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=31.6, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI10190704, Length=240, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=32.8358208955224, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI224922801, Length=181, Percent_Identity=34.2541436464088, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=29.2490118577075, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI59889578, Length=218, Percent_Identity=28.8990825688073, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=30.1204819277108, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=33.0708661417323, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=32.8125, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787905, Length=238, Percent_Identity=36.1344537815126, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=31.0077519379845, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=29.3436293436293, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=31.0756972111554, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=30.1587301587302, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789057, Length=212, Percent_Identity=32.5471698113208, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=28.9156626506024, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=245, Percent_Identity=50.2040816326531, Blast_Score=224, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=31.0756972111554, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=32.6771653543307, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193203115, Length=206, Percent_Identity=31.0679611650485, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=202, Percent_Identity=30.6930693069307, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=222, Percent_Identity=29.2792792792793, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=203, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=29.811320754717, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=25.6505576208178, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=28.125, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=33.8235294117647, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320089, Length=222, Percent_Identity=26.1261261261261, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=47.244094488189, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=34.6613545816733, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357041, Length=234, Percent_Identity=29.0598290598291, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.718875502008, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI23397609, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571526, Length=234, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=237, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221331218, Length=221, Percent_Identity=27.1493212669683, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25418; Mature: 25418

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDQAALVTGAGSGLGEATARALAAAGARVALLDFNLPAAEAVAAEIGGLAIGCDVAS
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEEECCCC
AEGAEAAVARAAAEQGVARILVNCAGVAPAKKMLGRAGVMPLEEFRRTVEVNLVGSFNLL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHEEEEEEECCHHHH
RLFAAGAAELAPLETGERGVAIHTASVAAWEGQIGQTAYAASKGGIVGLTLPAARELAPL
HHHHCCCHHCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHCCCCCEEEEECCCHHHHCCC
GIRVCAIAPGIFETAMLKGLPEAAQESLGAAVPFPSRLGRPAEFAALALHILSNPMLNGE
CEEEEEECCCHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCC
TIRLDGALRMAPK
EEEECCEEECCCC
>Mature Secondary Structure
MDLRDQAALVTGAGSGLGEATARALAAAGARVALLDFNLPAAEAVAAEIGGLAIGCDVAS
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEEECCCC
AEGAEAAVARAAAEQGVARILVNCAGVAPAKKMLGRAGVMPLEEFRRTVEVNLVGSFNLL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHEEEEEEECCHHHH
RLFAAGAAELAPLETGERGVAIHTASVAAWEGQIGQTAYAASKGGIVGLTLPAARELAPL
HHHHCCCHHCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHCCCCCEEEEECCCHHHHCCC
GIRVCAIAPGIFETAMLKGLPEAAQESLGAAVPFPSRLGRPAEFAALALHILSNPMLNGE
CEEEEEECCCHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCC
TIRLDGALRMAPK
EEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]