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The map label for this gene is hemT

Identifier: 77465041

GI number: 77465041

Start: 60315

End: 61538

Strand: Direct

Name: hemT

Synonym: RSP_3028

Alternate gene names: 77465041

Gene position: 60315-61538 (Clockwise)

Preceding gene: 77465037

Following gene: 77465043

Centisome position: 6.4

GC content: 66.01

Gene sequence:

>1224_bases
ATGGAGTTCTCTCAGCACTTCCAGAAGCTCATTGACGACATGCGACTGGACGGGCGGTACAGGACGTTCGCGGAACTCGA
GCGCATCGCCGGGGAGTTTCCGACCGCGCTCTGGCATGGTCCGGACGGGCAGGCCAGACGCGTGACGGTCTGGTGCAGCA
ACGACTATCTGGGCATGGGCCAGAACGCCGAAGTGCTGGCCGCGATGCACCGGTCGATCGATCTGTCGGGCGCCGGCACC
GGAGGCACCCGCAACATCTCGGGGACCAACCGGCAGCACGTCGCCCTCGAGGCGGAACTTGCGGACCTGCACGGCAAGGA
ATCCGCGCTCATCTTCACCTCCGGGTGGATCTCCAACCTCGCGGCTCTGGGCACGCTGGGCAAGATTCTGCCCGAATGCG
CGATCTTCTCGGATGCGCTGAACCACAATTCGATGATCGAGGGCATCCGCCGGTCCGGCGCCGAGCGCTTCATCTTCCAC
CACAACGATCCCGTCCATCTGGACCGGTTGCTTTCGTCCGTCGATCCGGCGCGCCCGAAGATCGTGGCCTTCGAAAGCGT
CTACAGCATGGACGGCGACATCGCCCCCATCGCCGAAATCTGCGACGTGGCCGAGCGGCATGGTGCGCTGACCTATCTCG
ACGAGGTTCATGCGGTCGGACTTTACGGCCCGCGCGGCGGCGGCATCAGCGACCGCGACGGGTTGGCGGATCGGGTGACG
ATCATCGAGGGCACGCTCGCCAAGGCTTTCGGCGTGATGGGCGGCTATGTCAGCGGCCCGTCCCTGCTGATGGATGTGAT
CCGCAGCATGTCCGACAGTTTCATCTTCACCACCTCGATCTGCCCGCACCTCGCGGCGGGGGCCCTCGCGGCGGTCCGGC
ATGTGAAGGCTCATCCCGACGAGCGCCGCCGGCAGGCGGAGAATGCGGTGCGCCTCAAGGTCCTGCTGCAGAAGGCCGGT
CTCCCGGTTCTCGACACGCCCAGTCACATCCTTCCCGTGATGGTGGGCGAGGCGCATCTCTGCCGCAGCATCAGCGAGGC
GTTGCTCGCCCGCCACGCCATCTACGTCCAGCCGATCAACTATCCGACCGTGGCTCGGGGGCAGGAGCGGTTTCGGCTGA
CGCCGACGCCCTTCCATACGACGTCTCACATGGAGGCACTGGTCGAGGCGCTCCTCGCCGTTGGCCGGGATCTCGGATGG
GCCATGTCGAGGCGGGCTGCCTAG

Upstream 100 bases:

>100_bases
TGTCCGTTGATTCATCCAGATTGTAAGCCATACAAATGGCCGATAGGCGGCTCGGCAATGCCTGCCGCGATGCGTGTCGC
TCCAACAGAAGGTGATCCCC

Downstream 100 bases:

>100_bases
GCAGGAGCCACCACCGGCTCTCGGTCCCGTGGCCGGCGCCTGCGCGGGATCGAAGCGCTCTCGCCCGCCGGCCATGCGCA
ACGGACCCGGGTGCCGGAAG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MEFSQHFQKLIDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMGQNAEVLAAMHRSIDLSGAGT
GGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNLAALGTLGKILPECAIFSDALNHNSMIEGIRRSGAERFIFH
HNDPVHLDRLLSSVDPARPKIVAFESVYSMDGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVT
IIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPDERRRQAENAVRLKVLLQKAG
LPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPINYPTVARGQERFRLTPTPFHTTSHMEALVEALLAVGRDLGW
AMSRRAA

Sequences:

>Translated_407_residues
MEFSQHFQKLIDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMGQNAEVLAAMHRSIDLSGAGT
GGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNLAALGTLGKILPECAIFSDALNHNSMIEGIRRSGAERFIFH
HNDPVHLDRLLSSVDPARPKIVAFESVYSMDGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVT
IIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPDERRRQAENAVRLKVLLQKAG
LPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPINYPTVARGQERFRLTPTPFHTTSHMEALVEALLAVGRDLGW
AMSRRAA
>Mature_407_residues
MEFSQHFQKLIDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMGQNAEVLAAMHRSIDLSGAGT
GGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNLAALGTLGKILPECAIFSDALNHNSMIEGIRRSGAERFIFH
HNDPVHLDRLLSSVDPARPKIVAFESVYSMDGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVT
IIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPDERRRQAENAVRLKVLLQKAG
LPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPINYPTVARGQERFRLTPTPFHTTSHMEALVEALLAVGRDLGW
AMSRRAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=50.3722084367246, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI83977440, Length=395, Percent_Identity=50.8860759493671, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI83977444, Length=395, Percent_Identity=50.8860759493671, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI4502025, Length=405, Percent_Identity=49.3827160493827, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI40316939, Length=405, Percent_Identity=49.3827160493827, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=35.1123595505618, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=35.4466858789625, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=27.8378378378378, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=27.8378378378378, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI5454084, Length=246, Percent_Identity=27.6422764227642, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1790046, Length=401, Percent_Identity=32.9177057356608, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=32.183908045977, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=361, Percent_Identity=32.409972299169, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=29.8630136986301, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=374, Percent_Identity=26.7379679144385, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=374, Percent_Identity=26.4705882352941, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=26.5384615384615, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=260, Percent_Identity=26.5384615384615, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=418, Percent_Identity=46.88995215311, Blast_Score=378, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320267, Length=367, Percent_Identity=25.8855585831063, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=263, Percent_Identity=23.9543726235741, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137420, Length=404, Percent_Identity=48.7623762376238, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24662918, Length=357, Percent_Identity=33.8935574229692, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17136286, Length=387, Percent_Identity=29.7157622739018, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24653280, Length=263, Percent_Identity=25.0950570342205, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653276, Length=263, Percent_Identity=25.0950570342205, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653278, Length=263, Percent_Identity=25.0950570342205, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM0_RHOS4 (Q06965)

Other databases:

- EMBL:   L07489
- EMBL:   CP000144
- PIR:   A49845
- RefSeq:   YP_354544.1
- ProteinModelPortal:   Q06965
- SMR:   Q06965
- STRING:   Q06965
- GeneID:   3721613
- GenomeReviews:   CP000144_GR
- KEGG:   rsp:RSP_3028
- NMPDR:   fig|272943.3.peg.3643
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   ERARHQE
- PhylomeDB:   Q06965
- ProtClustDB:   PRK13393
- BioCyc:   MetaCyc:MONOMER-13234
- BioCyc:   RSPH272943:RSP_3028-MONOMER
- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01821

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.37

Molecular weight: Translated: 44333; Mature: 44333

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSQHFQKLIDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEECCCCCCEEEEEEECCCCCCCC
QNAEVLAAMHRSIDLSGAGTGGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNL
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCEEEEECHHHHHH
AALGTLGKILPECAIFSDALNHNSMIEGIRRSGAERFIFHHNDPVHLDRLLSSVDPARPK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCC
IVAFESVYSMDGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVT
EEEEHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHEEEEECCCCCCCCCCCCCHHHHH
IIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCH
ERRRQAENAVRLKVLLQKAGLPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCC
YPTVARGQERFRLTPTPFHTTSHMEALVEALLAVGRDLGWAMSRRAA
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MEFSQHFQKLIDDMRLDGRYRTFAELERIAGEFPTALWHGPDGQARRVTVWCSNDYLGMG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEECCCCCCEEEEEEECCCCCCCC
QNAEVLAAMHRSIDLSGAGTGGTRNISGTNRQHVALEAELADLHGKESALIFTSGWISNL
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCEEEEECHHHHHH
AALGTLGKILPECAIFSDALNHNSMIEGIRRSGAERFIFHHNDPVHLDRLLSSVDPARPK
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCC
IVAFESVYSMDGDIAPIAEICDVAERHGALTYLDEVHAVGLYGPRGGGISDRDGLADRVT
EEEEHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHEEEEECCCCCCCCCCCCCHHHHH
IIEGTLAKAFGVMGGYVSGPSLLMDVIRSMSDSFIFTTSICPHLAAGALAAVRHVKAHPD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCH
ERRRQAENAVRLKVLLQKAGLPVLDTPSHILPVMVGEAHLCRSISEALLARHAIYVQPIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCC
YPTVARGQERFRLTPTPFHTTSHMEALVEALLAVGRDLGWAMSRRAA
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468290