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The map label for this gene is proA

Identifier: 77461195

GI number: 77461195

Start: 5601733

End: 5603004

Strand: Reverse

Name: proA

Synonym: Pfl01_4974

Alternate gene names: 77461195

Gene position: 5603004-5601733 (Counterclockwise)

Preceding gene: 77461200

Following gene: 77461194

Centisome position: 87.02

GC content: 64.47

Gene sequence:

>1272_bases
ATGACTGAGTCCGTTCTTGACTACATGACCCGATTGGGTCGCGCCGCCCGCGAAGCCTCCCGCGTCATCGGCCGTGCCAG
CACCGCGCAGAAAAACCGCGCCCTGCTGGCTGCCGCCAATGCCCTGGACGCCGCTCGCGCCGAGCTTGCGGCAGCCAATG
AACAGGATCTGGCCACCGGTCGCGCCAACGGCCTGGAGCCGGCCCTGCTGGAACGTCTGGAACTGACCCCGGCGCGCATC
GACGGCATGATCGTCGGCCTGCGTCAGGTCGCAGCGCTGCCGGATCCGGTCGGCGCTATCCGTGATATGAGCTTCCGTCC
GTCGGGCATTCAGGTCGGCAAGATGCGCGTGCCGCTGGGCGTGATCGGGATCATCTACGAATCCCGTCCCAACGTGACCA
TCGATGCCGCCAGCCTGTGCCTGAAGTCCGGTAACGCGACCATCCTGCGCGGCGGTTCCGAGGCGATTCATTCCAACCGT
GCGATCGCTGCCTGCATCCAGCGCGGTCTGGCCGCAGCCGAACTGCCGGCTGCCGTTGTGCAAGTGGTGGAAACCACCGA
CCGCGCCGCCGTTGGCGCGCTGATCACCATGCCCGAGTACGTCGATGTGATCGTCCCGCGCGGTGGGCGTGGCCTGATCG
AGCGCATCAGTCGTGACGCCCGGGTGCCGGTGATCAAGCACCTGGACGGCATCTGCCACGTCTATGTCAGCGAACACGCC
GACCTGCCGAAAGCCCAGCGCATTGCCTTCAATGCCAAGACCTATCGCTATGGCATCTGCGGTGCGATGGAGACCTTGCT
GGTCGATCAACGTGTGGCGAAGGATTTCCTGCCGTCGATGGCCAAACAGTTCCGCGAAAAGGGCGTCGAGCTGCGGGGGT
GTGAACGCACCCGGGCGATCATCGAGGCCGTAGCCGCGACCGAAGAAGACTGGAGCACCGAGTACCTGGCGCCGATTCTG
TCGATCCGCGTGGTGGATGGCCTGGATCAGGCCATCGAGCACATCAACCATTTCGGCTCCCATCACACCGACTCGATCGT
CAGCGAAAACCTCGCCGACACCCGCCAGTTCGTGGCTCAGGTCGACTCGGCGTCGGTGATGATCAACACCCCGACCTGCT
TCGCCGACGGATTCGAATACGGATTGGGTGCCGAGATCGGCATTTCTACTGATAAGCTGCACGCCCGTGGCCCGGTGGGC
CTCGAAGGGCTGACCTGCGAGAAGTACATCGTGGTCGGTGATGGTCAGTTGCGCGGCCAGGCGACGGTCTGA

Upstream 100 bases:

>100_bases
ATCGTGGTCCATTTCGACCATCCGCCCGTCACCGCTGTTAGTCCCGGGACGCGACAGCTATAATCTGCCGCTTTCCTCTT
TGCCAAGACCCCAGCAGACC

Downstream 100 bases:

>100_bases
CTTGTCCGACCTCGACCTGAAAACGCCGAAAACCGGCAAGAAACCTCGTCCCCGGCGCATTGGCGTACTGGGCGGGACGT
TCGATCCGGTGCATGTCGGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALLAAANALDAARAELAAANEQDLATGRANGLEPALLERLELTPARI
DGMIVGLRQVAALPDPVGAIRDMSFRPSGIQVGKMRVPLGVIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNR
AIAACIQRGLAAAELPAAVVQVVETTDRAAVGALITMPEYVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSEHA
DLPKAQRIAFNAKTYRYGICGAMETLLVDQRVAKDFLPSMAKQFREKGVELRGCERTRAIIEAVAATEEDWSTEYLAPIL
SIRVVDGLDQAIEHINHFGSHHTDSIVSENLADTRQFVAQVDSASVMINTPTCFADGFEYGLGAEIGISTDKLHARGPVG
LEGLTCEKYIVVGDGQLRGQATV

Sequences:

>Translated_423_residues
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALLAAANALDAARAELAAANEQDLATGRANGLEPALLERLELTPARI
DGMIVGLRQVAALPDPVGAIRDMSFRPSGIQVGKMRVPLGVIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNR
AIAACIQRGLAAAELPAAVVQVVETTDRAAVGALITMPEYVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSEHA
DLPKAQRIAFNAKTYRYGICGAMETLLVDQRVAKDFLPSMAKQFREKGVELRGCERTRAIIEAVAATEEDWSTEYLAPIL
SIRVVDGLDQAIEHINHFGSHHTDSIVSENLADTRQFVAQVDSASVMINTPTCFADGFEYGLGAEIGISTDKLHARGPVG
LEGLTCEKYIVVGDGQLRGQATV
>Mature_422_residues
TESVLDYMTRLGRAAREASRVIGRASTAQKNRALLAAANALDAARAELAAANEQDLATGRANGLEPALLERLELTPARID
GMIVGLRQVAALPDPVGAIRDMSFRPSGIQVGKMRVPLGVIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRA
IAACIQRGLAAAELPAAVVQVVETTDRAAVGALITMPEYVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSEHAD
LPKAQRIAFNAKTYRYGICGAMETLLVDQRVAKDFLPSMAKQFREKGVELRGCERTRAIIEAVAATEEDWSTEYLAPILS
IRVVDGLDQAIEHINHFGSHHTDSIVSENLADTRQFVAQVDSASVMINTPTCFADGFEYGLGAEIGISTDKLHARGPVGL
EGLTCEKYIVVGDGQLRGQATV

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=406, Percent_Identity=35.9605911330049, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI21361368, Length=406, Percent_Identity=35.9605911330049, Blast_Score=241, Evalue=7e-64,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=44.3373493975904, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569967, Length=406, Percent_Identity=35.2216748768473, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569969, Length=406, Percent_Identity=35.2216748768473, Blast_Score=249, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=37.2960372960373, Blast_Score=290, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=37.7777777777778, Blast_Score=261, Evalue=8e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PSEPF (Q3K693)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_350702.1
- ProteinModelPortal:   Q3K693
- SMR:   Q3K693
- STRING:   Q3K693
- GeneID:   3715893
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4974
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- ProtClustDB:   PRK00197
- BioCyc:   PFLU205922:PFL_4974-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45308; Mature: 45176

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALLAAANALDAARAELAAANEQDLATG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
RANGLEPALLERLELTPARIDGMIVGLRQVAALPDPVGAIRDMSFRPSGIQVGKMRVPLG
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEECEEECCEE
VIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIAACIQRGLAAAELPAAVV
EEEEEEECCCCEEEEHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHCCHHHHHHHHHH
QVVETTDRAAVGALITMPEYVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSEHA
HHHHHCCHHHHHHHHCCCCHHEEEECCCCHHHHHHHCCCCCCCHHHHCCCCEEEEECCCC
DLPKAQRIAFNAKTYRYGICGAMETLLVDQRVAKDFLPSMAKQFREKGVELRGCERTRAI
CCCHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
IEAVAATEEDWSTEYLAPILSIRVVDGLDQAIEHINHFGSHHTDSIVSENLADTRQFVAQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VDSASVMINTPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYIVVGDGQLRGQ
HCCCEEEEECCCHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCEECEEEEEECCCCCCC
ATV
CCC
>Mature Secondary Structure 
TESVLDYMTRLGRAAREASRVIGRASTAQKNRALLAAANALDAARAELAAANEQDLATG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHCCC
RANGLEPALLERLELTPARIDGMIVGLRQVAALPDPVGAIRDMSFRPSGIQVGKMRVPLG
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEECEEECCEE
VIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIAACIQRGLAAAELPAAVV
EEEEEEECCCCEEEEHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHCCHHHHHHHHHH
QVVETTDRAAVGALITMPEYVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVSEHA
HHHHHCCHHHHHHHHCCCCHHEEEECCCCHHHHHHHCCCCCCCHHHHCCCCEEEEECCCC
DLPKAQRIAFNAKTYRYGICGAMETLLVDQRVAKDFLPSMAKQFREKGVELRGCERTRAI
CCCHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHH
IEAVAATEEDWSTEYLAPILSIRVVDGLDQAIEHINHFGSHHTDSIVSENLADTRQFVAQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VDSASVMINTPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYIVVGDGQLRGQ
HCCCEEEEECCCHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCEECEEEEEECCCCCCC
ATV
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA