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The map label for this gene is dacC [H]

Identifier: 77461187

GI number: 77461187

Start: 5593582

End: 5594739

Strand: Reverse

Name: dacC [H]

Synonym: Pfl01_4966

Alternate gene names: 77461187

Gene position: 5594739-5593582 (Counterclockwise)

Preceding gene: 77461188

Following gene: 77461186

Centisome position: 86.9

GC content: 60.79

Gene sequence:

>1158_bases
ATGAACATCACCACCTTTGCCAAACGCCTGTGTCTGCTAGTCCCGCTGCTCCTCTCGCCAGCCGCCTTCGCGGCCGAGAT
GATGCCGTCGCCACCACAACTGGCCGCCAAATCCTACGTGCTCATGGATGCCAACAGCGGCAACGTGCTGGTGGAGAACA
ACGGTGACCAGCGTCTGCCGCCGGCCAGCCTGACCAAACTGATGACCGCGTACATCGCCACGCTGGAAATCCGTCGCGGC
CAGATCGGTGAAAACGACCCGGTGACCGTCAGCGAGAACGCCTGGCGCACCGGCGGTTCGCGGATGTTCATCAAGGTCGG
CTCGCAGGTCACTGTCAGCGATCTGCTGCACGGCATCATCATCCAGTCCGGCAACGACGCCAGCGTCGCGGTGGCTGAAC
ACATCGCCGGCAGCGAAGACGCCTTCGCCGACCTGATGAACAAGACCGTCGCCGATCTGGGCATGACCAATACCCACTTC
ATGAACCCGACCGGTCTGCCGAACCCCGAGCACTACTCGTCGGCTCACGACATGGCGATTCTGGCGCGCGCGATCATCCA
CGAAGACCCGGCTCACTATGCGATCTACTCGCAGAAAGAGTTCTTCTGGAACGGCATCAAACAGCCTAACCGCAACCTGC
TGCTGTGGCGCGACAAGACCGTCGACGGTCTGAAAACCGGCCACACCGACGAAGCCGGCTACTGCATGGTGTCCTCGGCC
GTACGTGACGGCATGCGCCTGATTGCCGTGGTGTTCGGTACCAACAGCGAAGTGGCCCGCGCCGCCGAGACCCAGAAGTT
GCTGACCTACGGTTTCCGCTTCTTCGAAACCCAGACCTTTTACCAGAAGGGCACCGAACTGGCTCAGGCTCCGGTGTGGA
AAGGCACTACCAGTCAAGTCAAGGCCGGCCTGGCACAAGACCTGACCATGACCCTGCCGAAAGGCCAGCTGAAGAAGCTC
GCTGCCAGCATGACCATGAACCCGCAACTGACCGCGCCAATCGCCAAGGGCGACGTGATCGGTAAAGTCGAAGTGAAACT
AGACGACAAGGTGGTGCACAGCGCCGACCTGATCGCCCTGGACGCTGTCGAGGAGGGTGGTATCTTCCGCCGCATGTGGG
ATAGCATCCGTCTATTCTTCTACGGCTTGTTCAACTGA

Upstream 100 bases:

>100_bases
GTGACTGGAGTGAGCAACTGAACACGCGATGGCCCGTTAGAAAGCCATCTGATTAATTTTGTCCGCAAGGGCAGTTTCCA
TTAGCGATTTCGAGAGACGG

Downstream 100 bases:

>100_bases
TTCGAGTTGACCTGCATGGCCCCGTTCCGATCCGGAGCGGGGCCTTGTTCGTTACCGGGCTTACGCTTACGAGGCCGTTA
CGCCATGACCGATACCGAAG

Product: penicillin-binding protein 6

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNITTFAKRLCLLVPLLLSPAAFAAEMMPSPPQLAAKSYVLMDANSGNVLVENNGDQRLPPASLTKLMTAYIATLEIRRG
QIGENDPVTVSENAWRTGGSRMFIKVGSQVTVSDLLHGIIIQSGNDASVAVAEHIAGSEDAFADLMNKTVADLGMTNTHF
MNPTGLPNPEHYSSAHDMAILARAIIHEDPAHYAIYSQKEFFWNGIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCMVSSA
VRDGMRLIAVVFGTNSEVARAAETQKLLTYGFRFFETQTFYQKGTELAQAPVWKGTTSQVKAGLAQDLTMTLPKGQLKKL
AASMTMNPQLTAPIAKGDVIGKVEVKLDDKVVHSADLIALDAVEEGGIFRRMWDSIRLFFYGLFN

Sequences:

>Translated_385_residues
MNITTFAKRLCLLVPLLLSPAAFAAEMMPSPPQLAAKSYVLMDANSGNVLVENNGDQRLPPASLTKLMTAYIATLEIRRG
QIGENDPVTVSENAWRTGGSRMFIKVGSQVTVSDLLHGIIIQSGNDASVAVAEHIAGSEDAFADLMNKTVADLGMTNTHF
MNPTGLPNPEHYSSAHDMAILARAIIHEDPAHYAIYSQKEFFWNGIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCMVSSA
VRDGMRLIAVVFGTNSEVARAAETQKLLTYGFRFFETQTFYQKGTELAQAPVWKGTTSQVKAGLAQDLTMTLPKGQLKKL
AASMTMNPQLTAPIAKGDVIGKVEVKLDDKVVHSADLIALDAVEEGGIFRRMWDSIRLFFYGLFN
>Mature_385_residues
MNITTFAKRLCLLVPLLLSPAAFAAEMMPSPPQLAAKSYVLMDANSGNVLVENNGDQRLPPASLTKLMTAYIATLEIRRG
QIGENDPVTVSENAWRTGGSRMFIKVGSQVTVSDLLHGIIIQSGNDASVAVAEHIAGSEDAFADLMNKTVADLGMTNTHF
MNPTGLPNPEHYSSAHDMAILARAIIHEDPAHYAIYSQKEFFWNGIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCMVSSA
VRDGMRLIAVVFGTNSEVARAAETQKLLTYGFRFFETQTFYQKGTELAQAPVWKGTTSQVKAGLAQDLTMTLPKGQLKKL
AASMTMNPQLTAPIAKGDVIGKVEVKLDDKVVHSADLIALDAVEEGGIFRRMWDSIRLFFYGLFN

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=377, Percent_Identity=46.684350132626, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI1786851, Length=392, Percent_Identity=45.9183673469388, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI87082022, Length=381, Percent_Identity=41.994750656168, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082054, Length=254, Percent_Identity=29.9212598425197, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42112; Mature: 42112

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITTFAKRLCLLVPLLLSPAAFAAEMMPSPPQLAAKSYVLMDANSGNVLVENNGDQRLP
CCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCEEEEEECCCCCEEEECCCCCCCC
PASLTKLMTAYIATLEIRRGQIGENDPVTVSENAWRTGGSRMFIKVGSQVTVSDLLHGII
HHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCEEHHHHHHHHE
IQSGNDASVAVAEHIAGSEDAFADLMNKTVADLGMTNTHFMNPTGLPNPEHYSSAHDMAI
EECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHCCHHHHHH
LARAIIHEDPAHYAIYSQKEFFWNGIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCMVSSA
HHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEHHH
VRDGMRLIAVVFGTNSEVARAAETQKLLTYGFRFFETQTFYQKGTELAQAPVWKGTTSQV
HHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHH
KAGLAQDLTMTLPKGQLKKLAASMTMNPQLTAPIAKGDVIGKVEVKLDDKVVHSADLIAL
HHHHHHCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCEEEE
DAVEEGGIFRRMWDSIRLFFYGLFN
ECHHCCCHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MNITTFAKRLCLLVPLLLSPAAFAAEMMPSPPQLAAKSYVLMDANSGNVLVENNGDQRLP
CCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCEEEEEECCCCCEEEECCCCCCCC
PASLTKLMTAYIATLEIRRGQIGENDPVTVSENAWRTGGSRMFIKVGSQVTVSDLLHGII
HHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCEEHHHHHHHHE
IQSGNDASVAVAEHIAGSEDAFADLMNKTVADLGMTNTHFMNPTGLPNPEHYSSAHDMAI
EECCCCCEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHCCHHHHHH
LARAIIHEDPAHYAIYSQKEFFWNGIKQPNRNLLLWRDKTVDGLKTGHTDEAGYCMVSSA
HHHHHHHCCCCCEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEHHH
VRDGMRLIAVVFGTNSEVARAAETQKLLTYGFRFFETQTFYQKGTELAQAPVWKGTTSQV
HHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHH
KAGLAQDLTMTLPKGQLKKLAASMTMNPQLTAPIAKGDVIGKVEVKLDDKVVHSADLIAL
HHHHHHCCEEECCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCHHHCCCCEEEE
DAVEEGGIFRRMWDSIRLFFYGLFN
ECHHCCCHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]