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The map label for this gene is vllY [H]

Identifier: 77461126

GI number: 77461126

Start: 5527541

End: 5529442

Strand: Reverse

Name: vllY [H]

Synonym: Pfl01_4905

Alternate gene names: 77461126

Gene position: 5529442-5527541 (Counterclockwise)

Preceding gene: 77461127

Following gene: 77461125

Centisome position: 85.88

GC content: 62.2

Gene sequence:

>1902_bases
ATGCAGCGATCCATTGCCACCGTCTCCTTGAGCGGAACCCTGCCGGAAAAACTCGAAGCCATTGCCGCCGCCGGGTTCGA
CGGAGTGGAGATTTTCGAGAACGATCTTCTTTATTACGACGGCAGCCCCCGGGAAATCCGGCAGATGTGCGCCGACCTCG
GGATTGCCATCACGCTGTTTCAACCGTTCCGCGATTTCGAAGGCTGCCGCCGCGATCGCCTGGAGCGCAACCTGGAGCGG
GCCGAGCGCAAGTTCGACCTGATGCAGGAGCTGGGCACCGACCTGGTGCTGGTCTGCAGCAATGCCTCCCCCGACAGTCT
CGGCGAGCAACAGATCCTCATCGACGACCTGCGCCTGCTGGCCGAACACGCGGGTGCCCGTGGCTTGCGCATCGGTTATG
AAGCGCTGGCCTGGGGCCGTCACGTCAATACTTATCAACAGGTCTGGGACATCGTGCGTCAGGCCGATCACCCGGCCCTC
GGCGTGTTGCTCGACAGCTTCCACACCTTGTCGCTCAAGGGCGATCCACGGGCGATCGCCGAGATTCCCGGTGACAAGAT
TTTCTTCGTGCAGATGGCCGATGCGCCGATCCTGGCGATGGACGTGCTGGAGTGGAGCCGGCATTTCCGCTGCTTCCCGG
GGCAGGGCGAATTCGATCTGCCGGGCTTCCTCGCACCAATTATTCAGAGCGGCTACACCGGGCCGCTGTCGCTGGAAATC
TTCAACGACGGCTTCCGCGCCGCACCGCCTCGCGCCAATGCGGCCGACGGTCTGCGTTCGCTGCTGTACCTGGAGGAGAA
AACCCGCCAGCGTCTGGAGCAGGAAATCCGGCCTGTGGATAACCGCGACATCCTCTTCGAAACGCCGAAGGCCAGCGAAT
ACAACGGCATCGAGTTTCTTGAGTTCGCCGTGGATGAAAGCCTCGGGGCCAAGCTGTCGAACTGGCTGGAACGGCTGGGT
TTCGTCAAGGCTGGCCAGCATCGCTCCAAGAGCGTCAGCCTGTTGCGTCAGGGCGATATCAATCTGATCCTCAACTCTGA
ACCCTATTCGTTCGGTCACAGTTTTTTCGAGGCCCACGGCCCGTCGCTGTGCGCCACCGCCGTGCGGGTCAAGGACAGCG
CCAGTGCGCTGGCCCGCGCCGTCGCCTATAAAGGTCAGCCGTATCGCGGACTGGTCGGCCCCAACGAACTGGAGCTGGCG
GCGGTGCGTGCACCGGACGGCAGCCTGATTTATCTGGTGGATCAGGAGGCGGATGTCTACGGCACCGACTTCAATCTGCT
GCCGGATGCGGTAGCGCGTGGCGGCCTCAAGCGCATCGATCACATGGCCATGGCGCTGCCGGCGGACAGCCTCGACAGTT
GGGTGCTGTTCTACAAGAGCCTGCTGGATTTCGAGGCCGACGATGAAGTGGTGCTGCCCGACCCGTACGGTCTGGTGAAA
AGCCGTGCCCTGCGTAGCCGCGACAGTTCGATCCGTCTGCCGCTGAACATTTCCGAGAACCGCAACACCGCGATCTCACA
CGCGCTGTCGAGTTATCGCGGCTCCGGGGTGCATCACATTGCCTTCGATTGCGACGATATCTTCGCCGAAGTCAGTCGCG
CGAAGGAGGCGGGCGTACCGCTGCTGGATATCCCGCTGAACTATTACGACGATCTGGCGGCGCGTTTCGATTTCGATGAC
GAGTTCCTCAGCGAGCTGGCGTACTACAACGTGCTGTACGACCGCGATGCGCAGGGCGGCGAGTTGTTCCACGTCTACAC
CGAGCCGTTCGAAGGGCGTTTCTTCTTCGAGATCATCCAGCGCAAGAACGGTTACGCCGGTTATGGCGCGGCCAACGTCG
CGGTGCGGCTGGCGGCGATGGCCAAGTCACGCAGTGGTGCGGTTCGCCAGGCGAAGTTGTAG

Upstream 100 bases:

>100_bases
ACAGTTTAAATTGCTCAATGAAAAACCGGGACCAATAATTCGCTCACCCTATAAAAGCGGCGCAATTTTCGTAGCCGACG
TCTCCACCGGGAGTTGAAAC

Downstream 100 bases:

>100_bases
GAAATTCGTAAACGCGGGATTAAACACCGGCCGCGCGGCTTCCTTCACTGGGGCGCGCGGCCCATAATCGCCAGCCTGTG
CAGTGATGGCCGTGAGCCCG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREIRQMCADLGIAITLFQPFRDFEGCRRDRLERNLER
AERKFDLMQELGTDLVLVCSNASPDSLGEQQILIDDLRLLAEHAGARGLRIGYEALAWGRHVNTYQQVWDIVRQADHPAL
GVLLDSFHTLSLKGDPRAIAEIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLPGFLAPIIQSGYTGPLSLEI
FNDGFRAAPPRANAADGLRSLLYLEEKTRQRLEQEIRPVDNRDILFETPKASEYNGIEFLEFAVDESLGAKLSNWLERLG
FVKAGQHRSKSVSLLRQGDINLILNSEPYSFGHSFFEAHGPSLCATAVRVKDSASALARAVAYKGQPYRGLVGPNELELA
AVRAPDGSLIYLVDQEADVYGTDFNLLPDAVARGGLKRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
SRALRSRDSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCDDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDFDD
EFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQRKNGYAGYGAANVAVRLAAMAKSRSGAVRQAKL

Sequences:

>Translated_633_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREIRQMCADLGIAITLFQPFRDFEGCRRDRLERNLER
AERKFDLMQELGTDLVLVCSNASPDSLGEQQILIDDLRLLAEHAGARGLRIGYEALAWGRHVNTYQQVWDIVRQADHPAL
GVLLDSFHTLSLKGDPRAIAEIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLPGFLAPIIQSGYTGPLSLEI
FNDGFRAAPPRANAADGLRSLLYLEEKTRQRLEQEIRPVDNRDILFETPKASEYNGIEFLEFAVDESLGAKLSNWLERLG
FVKAGQHRSKSVSLLRQGDINLILNSEPYSFGHSFFEAHGPSLCATAVRVKDSASALARAVAYKGQPYRGLVGPNELELA
AVRAPDGSLIYLVDQEADVYGTDFNLLPDAVARGGLKRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
SRALRSRDSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCDDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDFDD
EFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQRKNGYAGYGAANVAVRLAAMAKSRSGAVRQAKL
>Mature_633_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREIRQMCADLGIAITLFQPFRDFEGCRRDRLERNLER
AERKFDLMQELGTDLVLVCSNASPDSLGEQQILIDDLRLLAEHAGARGLRIGYEALAWGRHVNTYQQVWDIVRQADHPAL
GVLLDSFHTLSLKGDPRAIAEIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLPGFLAPIIQSGYTGPLSLEI
FNDGFRAAPPRANAADGLRSLLYLEEKTRQRLEQEIRPVDNRDILFETPKASEYNGIEFLEFAVDESLGAKLSNWLERLG
FVKAGQHRSKSVSLLRQGDINLILNSEPYSFGHSFFEAHGPSLCATAVRVKDSASALARAVAYKGQPYRGLVGPNELELA
AVRAPDGSLIYLVDQEADVYGTDFNLLPDAVARGGLKRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
SRALRSRDSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCDDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDFDD
EFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQRKNGYAGYGAANVAVRLAAMAKSRSGAVRQAKL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=198, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4504477, Length=198, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555220, Length=205, Percent_Identity=30.7317073170732, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550752, Length=198, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24667510, Length=365, Percent_Identity=24.6575342465753, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356105, Length=286, Percent_Identity=24.8251748251748, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 70467; Mature: 70467

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREIRQMCADLGIAITLF
CCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHCCEEEEEE
QPFRDFEGCRRDRLERNLERAERKFDLMQELGTDLVLVCSNASPDSLGEQQILIDDLRLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AEHAGARGLRIGYEALAWGRHVNTYQQVWDIVRQADHPALGVLLDSFHTLSLKGDPRAIA
HHHCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCHHH
EIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLPGFLAPIIQSGYTGPLSLEI
HCCCCEEEEEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEE
FNDGFRAAPPRANAADGLRSLLYLEEKTRQRLEQEIRPVDNRDILFETPKASEYNGIEFL
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHH
EFAVDESLGAKLSNWLERLGFVKAGQHRSKSVSLLRQGDINLILNSEPYSFGHSFFEAHG
HHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC
PSLCATAVRVKDSASALARAVAYKGQPYRGLVGPNELELAAVRAPDGSLIYLVDQEADVY
CHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCEE
GTDFNLLPDAVARGGLKRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
CCCCCCCHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHH
SRALRSRDSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCDDIFAEVSRAKEAGVP
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCC
LLDIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQ
EEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCHHHHHHHH
RKNGYAGYGAANVAVRLAAMAKSRSGAVRQAKL
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPREIRQMCADLGIAITLF
CCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHCCEEEEEE
QPFRDFEGCRRDRLERNLERAERKFDLMQELGTDLVLVCSNASPDSLGEQQILIDDLRLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
AEHAGARGLRIGYEALAWGRHVNTYQQVWDIVRQADHPALGVLLDSFHTLSLKGDPRAIA
HHHCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCHHH
EIPGDKIFFVQMADAPILAMDVLEWSRHFRCFPGQGEFDLPGFLAPIIQSGYTGPLSLEI
HCCCCEEEEEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEE
FNDGFRAAPPRANAADGLRSLLYLEEKTRQRLEQEIRPVDNRDILFETPKASEYNGIEFL
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHH
EFAVDESLGAKLSNWLERLGFVKAGQHRSKSVSLLRQGDINLILNSEPYSFGHSFFEAHG
HHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC
PSLCATAVRVKDSASALARAVAYKGQPYRGLVGPNELELAAVRAPDGSLIYLVDQEADVY
CHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCEE
GTDFNLLPDAVARGGLKRIDHMAMALPADSLDSWVLFYKSLLDFEADDEVVLPDPYGLVK
CCCCCCCHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHH
SRALRSRDSSIRLPLNISENRNTAISHALSSYRGSGVHHIAFDCDDIFAEVSRAKEAGVP
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCC
LLDIPLNYYDDLAARFDFDDEFLSELAYYNVLYDRDAQGGELFHVYTEPFEGRFFFEIIQ
EEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCHHHHHHHH
RKNGYAGYGAANVAVRLAAMAKSRSGAVRQAKL
HCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA