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The map label for this gene is pth [H]

Identifier: 77460976

GI number: 77460976

Start: 5358897

End: 5359481

Strand: Direct

Name: pth [H]

Synonym: Pfl01_4755

Alternate gene names: 77460976

Gene position: 5358897-5359481 (Clockwise)

Preceding gene: 77460975

Following gene: 77460977

Centisome position: 83.23

GC content: 59.83

Gene sequence:

>585_bases
GTGACTGCCATCAAACTGATCGTTGGCCTGGGAAATCCAGGCGCTGAATACGAGCAGACCCGGCATAACGCAGGGGCCCT
TTTTGTTGAGCGCATCGCCCACGCACAGAATGTGAATCTCGTGGCCGATCGCAAGTATTTCGGCCTGACCGGGCGTTTTT
CGCATCAGGGTCAGGATGTTCGTCTGCTGATTCCCACCACCTACATGAACCGCAGCGGCCAGGCCGTGGCGGCACTCGCC
GGTTTCTTCCGCATCAAGCCTGAAGAGATCCTGGTGGCACACGACGAACTCGATCTGCCTCCGGGCGTCGCCAAACTCAA
AGTCGGCGGCGGCCATGGCGGTCACAACGGGTTGCGCGACATCATTGCGCAATTGGGCAATCAGAATACGTTCCACCGCC
TGCGGCTTGGCATCGGCCACCCGGGCGTCGCCAGTATGGTTTCAAATTTCGTCCTGGGTCGTGCGCCACGCGCCGAACAG
GAAAAACTCGATGCCAGCATCGACTTTGCCCTCGGCGTGCTGCCGGATATCCTCGCCGGTGAATGGAACCGCGCGATGAA
AAACCTGCACAGCCAGAAGGCCTGA

Upstream 100 bases:

>100_bases
CGGAGTTTACATCCATGGTAAATGAGCATTTTTCGTCCACTTTCGCCGCCTTCCCTGATCGCGGCGATGTTATCCACCAC
TCAAAGGAAGGGCCCCTATC

Downstream 100 bases:

>100_bases
CTCTAATCCGAGGGGAAACACCATGGGATTCAATTGCGGCATCGTCGGCCTGCCTAACGTCGGCAAGTCCACCCTGTTCA
ACGCCCTGACCAAGTCCGGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTAIKLIVGLGNPGAEYEQTRHNAGALFVERIAHAQNVNLVADRKYFGLTGRFSHQGQDVRLLIPTTYMNRSGQAVAALA
GFFRIKPEEILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGVASMVSNFVLGRAPRAEQ
EKLDASIDFALGVLPDILAGEWNRAMKNLHSQKA

Sequences:

>Translated_194_residues
MTAIKLIVGLGNPGAEYEQTRHNAGALFVERIAHAQNVNLVADRKYFGLTGRFSHQGQDVRLLIPTTYMNRSGQAVAALA
GFFRIKPEEILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGVASMVSNFVLGRAPRAEQ
EKLDASIDFALGVLPDILAGEWNRAMKNLHSQKA
>Mature_193_residues
TAIKLIVGLGNPGAEYEQTRHNAGALFVERIAHAQNVNLVADRKYFGLTGRFSHQGQDVRLLIPTTYMNRSGQAVAALAG
FFRIKPEEILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGVASMVSNFVLGRAPRAEQE
KLDASIDFALGVLPDILAGEWNRAMKNLHSQKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=173, Percent_Identity=37.5722543352601, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=59.375, Blast_Score=204, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321983, Length=167, Percent_Identity=32.3353293413174, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20982; Mature: 20851

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIKLIVGLGNPGAEYEQTRHNAGALFVERIAHAQNVNLVADRKYFGLTGRFSHQGQDV
CCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCE
RLLIPTTYMNRSGQAVAALAGFFRIKPEEILVAHDELDLPPGVAKLKVGGGHGGHNGLRD
EEEEEEHHCCCCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
IIAQLGNQNTFHRLRLGIGHPGVASMVSNFVLGRAPRAEQEKLDASIDFALGVLPDILAG
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHC
EWNRAMKNLHSQKA
CHHHHHHHHHHCCC
>Mature Secondary Structure 
TAIKLIVGLGNPGAEYEQTRHNAGALFVERIAHAQNVNLVADRKYFGLTGRFSHQGQDV
CEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEEECCEEECCCCCCCCCCCCE
RLLIPTTYMNRSGQAVAALAGFFRIKPEEILVAHDELDLPPGVAKLKVGGGHGGHNGLRD
EEEEEEHHCCCCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
IIAQLGNQNTFHRLRLGIGHPGVASMVSNFVLGRAPRAEQEKLDASIDFALGVLPDILAG
HHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHC
EWNRAMKNLHSQKA
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA