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The map label for this gene is moeB [H]

Identifier: 77460967

GI number: 77460967

Start: 5349552

End: 5350307

Strand: Reverse

Name: moeB [H]

Synonym: Pfl01_4746

Alternate gene names: 77460967

Gene position: 5350307-5349552 (Counterclockwise)

Preceding gene: 77460968

Following gene: 77460966

Centisome position: 83.1

GC content: 63.23

Gene sequence:

>756_bases
GTGCTGAATGATCAGGAATTGTTGCGCTACAGTCGGCAGATCCTGCTGCAACACATCGACATCGATGGCCAGTTGAAGCT
CAAGGACAGTCGGGTATTGATCGTCGGTCTCGGTGGTCTCGGTGCGCCGGTGGCCTTGTATCTGGCGGCGGCGGGTGTCG
GTGAATTGCACCTGGCGGATTTCGACACGGTCGACCTGACCAACCTGCAACGCCAGATCATCCACGACACCGATAGCGTC
GGCATGACCAAGGTCGACTCGGCGCTCAAGCGCCTGAGCGCGATCAACCCTGAAATCCGACTGGTGCCCCATCGTCAGGC
GCTGGACGAGGATTCCCTCGCCGCAGCCGTGGCGGCGGTAGATGTGGTACTCGACTGCTCGGACAATTTCTCCACCCGCG
AAGCGGTCAACGCCGCGTGCGTGGCGGCGCGCAAGCCCTTGGTCAGCGGCGCCGCGATCCGCCTTGAAGGACAGCTTTCG
GTGTTCGACCCGCGTCGCGCCGAAAGCCCGTGCTACCACTGCCTGTACGGTCACGGCAGCGAAGCCGAACTGACTTGCAG
CGAAGCCGGCGTGGTCGGGCCGCTGGTCGGTCTGGTCGGCAGCTTGCAAGCGCTGGAAGCCTTGAAGTTGCTGGCAGGTT
TTGGCGAGCCACTGGTGGGTCGTCTGCTGTTGATCGATGCACTGGGCTCGCGTTTCCGTGAGCTGCGGGTCAAGCGCGAC
CCCGGTTGCAGCGTCTGTGGTTCGCAGCATGCGTGA

Upstream 100 bases:

>100_bases
CCGAAGCCGTGCGCGATCTGCTGCTGACGCAAGGTTTCGACGAAGTCCACAGCCGCACCGATCTGGGCGGCCATCAACGG
ATCAGCCTGGGGCGCCTGCC

Downstream 100 bases:

>100_bases
AGCGCCGATTGCCGTCTTCGATTCCGGCGTCGGCGGTCTGTCGGTGCTGGCGGAAATCCAACAACTGCTGCCGAATGAAT
CGCTGCTGTACCTCGGCGAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLNDQELLRYSRQILLQHIDIDGQLKLKDSRVLIVGLGGLGAPVALYLAAAGVGELHLADFDTVDLTNLQRQIIHDTDSV
GMTKVDSALKRLSAINPEIRLVPHRQALDEDSLAAAVAAVDVVLDCSDNFSTREAVNAACVAARKPLVSGAAIRLEGQLS
VFDPRRAESPCYHCLYGHGSEAELTCSEAGVVGPLVGLVGSLQALEALKLLAGFGEPLVGRLLLIDALGSRFRELRVKRD
PGCSVCGSQHA

Sequences:

>Translated_251_residues
MLNDQELLRYSRQILLQHIDIDGQLKLKDSRVLIVGLGGLGAPVALYLAAAGVGELHLADFDTVDLTNLQRQIIHDTDSV
GMTKVDSALKRLSAINPEIRLVPHRQALDEDSLAAAVAAVDVVLDCSDNFSTREAVNAACVAARKPLVSGAAIRLEGQLS
VFDPRRAESPCYHCLYGHGSEAELTCSEAGVVGPLVGLVGSLQALEALKLLAGFGEPLVGRLLLIDALGSRFRELRVKRD
PGCSVCGSQHA
>Mature_251_residues
MLNDQELLRYSRQILLQHIDIDGQLKLKDSRVLIVGLGGLGAPVALYLAAAGVGELHLADFDTVDLTNLQRQIIHDTDSV
GMTKVDSALKRLSAINPEIRLVPHRQALDEDSLAAAVAAVDVVLDCSDNFSTREAVNAACVAARKPLVSGAAIRLEGQLS
VFDPRRAESPCYHCLYGHGSEAELTCSEAGVVGPLVGLVGSLQALEALKLLAGFGEPLVGRLLLIDALGSRFRELRVKRD
PGCSVCGSQHA

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=233, Percent_Identity=47.2103004291845, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4885649, Length=145, Percent_Identity=29.6551724137931, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI13376212, Length=256, Percent_Identity=28.90625, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI23510338, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI23510340, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI38327032, Length=221, Percent_Identity=27.6018099547511, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=56.5040650406504, Blast_Score=284, Evalue=4e-78,
Organism=Escherichia coli, GI87082356, Length=250, Percent_Identity=52, Blast_Score=227, Evalue=5e-61,
Organism=Escherichia coli, GI1789177, Length=124, Percent_Identity=33.0645161290323, Blast_Score=67, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=244, Percent_Identity=41.8032786885246, Blast_Score=199, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=31.7880794701987, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508819, Length=256, Percent_Identity=28.125, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=254, Percent_Identity=35.4330708661417, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320598, Length=168, Percent_Identity=26.7857142857143, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322639, Length=175, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24582879, Length=251, Percent_Identity=44.6215139442231, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24641311, Length=256, Percent_Identity=31.640625, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24660640, Length=149, Percent_Identity=31.5436241610738, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26721; Mature: 26721

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDQELLRYSRQILLQHIDIDGQLKLKDSRVLIVGLGGLGAPVALYLAAAGVGELHLAD
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHCCCCCEEECC
FDTVDLTNLQRQIIHDTDSVGMTKVDSALKRLSAINPEIRLVPHRQALDEDSLAAAVAAV
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHHHHHHHH
DVVLDCSDNFSTREAVNAACVAARKPLVSGAAIRLEGQLSVFDPRRAESPCYHCLYGHGS
HHEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCCCCCEEEECCCCC
EAELTCSEAGVVGPLVGLVGSLQALEALKLLAGFGEPLVGRLLLIDALGSRFRELRVKRD
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
PGCSVCGSQHA
CCCCCCCCCCC
>Mature Secondary Structure
MLNDQELLRYSRQILLQHIDIDGQLKLKDSRVLIVGLGGLGAPVALYLAAAGVGELHLAD
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHCCCCCEEECC
FDTVDLTNLQRQIIHDTDSVGMTKVDSALKRLSAINPEIRLVPHRQALDEDSLAAAVAAV
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHHHHHHHH
DVVLDCSDNFSTREAVNAACVAARKPLVSGAAIRLEGQLSVFDPRRAESPCYHCLYGHGS
HHEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCCCCCCCEEEECCCCC
EAELTCSEAGVVGPLVGLVGSLQALEALKLLAGFGEPLVGRLLLIDALGSRFRELRVKRD
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
PGCSVCGSQHA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]