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The map label for this gene is ftsI [H]

Identifier: 77460900

GI number: 77460900

Start: 5282689

End: 5284431

Strand: Reverse

Name: ftsI [H]

Synonym: Pfl01_4679

Alternate gene names: 77460900

Gene position: 5284431-5282689 (Counterclockwise)

Preceding gene: 77460901

Following gene: 77460899

Centisome position: 82.08

GC content: 62.25

Gene sequence:

>1743_bases
ATGATGAAACTCGAAGGGGCTCTCTTCCCGTGGCGCTTCCGTCTGATGGTGGCACTGCTCGGCGTGATGGTCGCGGCCAT
CTGCTGGCGCATCATCGACCTGCAAGTGGTTGACCGAGACTTCCTCAAAGGCCAGGGCGACGCGCGCAGTCTTCGGCACA
TTCCGATTCCGGCTCACCGTGGTCTGATCACCGACCGTAACGGCGAGCCGCTGGCCGTGAGTACCCCGGTGACCACGCTC
TGGGCGAACGCCAAGGAAATGCAGACCGCCAAAGAGAAGTGGCCGGCACTGGCCGCCGCGCTGGGGCAGGATCCGAAAGC
CCTGGCCGAACGTCTCGAAGCCCAGGCCAACAAAGAATTCATTTATCTGGTGCGCGGGTTGACCCCCGAGCAGGGCCAGG
CCGTGCTCGACCTCAAAGTCCCGGGTGTCTACGGCATCGAAGAATTCCGCCGGTTCTACCCGGCCGGTGAAGTGACGGCG
CACATGGTCGGGTTCACCGATATCGATGACCACGGTCGTGAAGGTGTCGAACTGGCCTACGACGAATGGCTGGCCGGCGT
GCCCGGCAAGCGGCAAGTCATCAAAGATCGGCGCGGTCGGCTGATCAAGGATGTCCAGGTCACCAAAAACGCCAAGGCCG
GCAAGCCCTTGGCGTTGTCGATTGACCTGCGCCTGCAATACCTGGCCAACCGCGAACTGCGCAACGCGATCATCGAGAAC
GGCGCCAAGGCCGGCAGTCTGGTGATCATGGACGTGAAGACCGGCGAGATTCTCGCCATGGTCAACCAGCCGACCTACAA
CCCGAACAACCGTCGCAACCTGCAACCGGCGATGATGCGTAACCGCGCGATGATCGACGTGTTCGAACCCGGTTCGACCA
TGAAAGCGATCTCGATGAGCGCCGCGATCGAAACCGGCCGCTGGAAACCGAGCGACACCGTCGAGGTGTATCCGGGCTCC
CTGCAGATCGGTAAATACACGATCAAGGACGTATCGAAGACCGAAGGTCCGGTACTCGATCTGACCGGCATTCTGATCAA
TTCCAGTAACGTCGGCATGAGCAAGGTCGCGTTCGACATCGGCGGCGAAACCATTTTCCGCCTCGCACAGAAAGTCGGCC
TCGGTCAGGACACCGGCCTCGGCTTCCCGGGCGAGCGTGTCGGCAACTTGCCGAACTACCGCGAGTGGCGCAAGGCCGAG
ACCGCAACGCTGTCGTACGGCTACGGTATTTCGGTGACTGCGATCCAGCTGGTGCATGCATTCTCGGCGCTGGCCAACAA
CGGTCGTCTCGCACCGCTGACCCTGATCAAAACCGACAAGGCACCGCAGACCACCCAGGTGCTGCCGGAGGCCGTCGCGA
AAACCATGCAAGGCATGCTGCAACAAGTGATCGAAGCCCCGCGCGGCGTGTTCCGTGCGCAGGTGCCGGCGTATCACGTG
GGCGGCAAGTCCGGTACCGCGCGTAAAACGTCGGTCGGCACCAAGGGCTACGCCGAAAACTCTTACCGCTCGCTGTTCGC
CGGTTTCGGCCCGATGAGCGATCCACGTTATGCAATCGTCGTGGTGATCGATGAACCGACCAAGGCCGGTTACTTCGGTG
GTCTGGTTTCGGCGCCGGTGTTCAGCCGTGTGATGTCGGGCACCCTGCGCCTGATGAACGTCACCCCGGACAACCTGCCG
ACCACACAACAGGCCAACGCCACCCCGGCCGTTCCGCTGAAAGCCAATGGAGGGCGCGGCTGA

Upstream 100 bases:

>100_bases
AGCAAAGCACCTGGACCGCCCACAGCCGGATCGAAGTGCTGGCCACCGAACAACTGAAGATGCACATCCCCGGCGCAGCT
GACGTGAAGATGGTGGCGCC

Downstream 100 bases:

>100_bases
TGTCTCTGAGTCTGAACAAGATTTTCCCCCACGCCGGCCACGATCTGTTGATCCGTGAACTGGCGCTCGACAGCCGCAAC
GTGCGCGCGGGTGACCTGTT

Product: peptidoglycan synthetase FtsI

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MMKLEGALFPWRFRLMVALLGVMVAAICWRIIDLQVVDRDFLKGQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANAKEMQTAKEKWPALAAALGQDPKALAERLEAQANKEFIYLVRGLTPEQGQAVLDLKVPGVYGIEEFRRFYPAGEVTA
HMVGFTDIDDHGREGVELAYDEWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKPLALSIDLRLQYLANRELRNAIIEN
GAKAGSLVIMDVKTGEILAMVNQPTYNPNNRRNLQPAMMRNRAMIDVFEPGSTMKAISMSAAIETGRWKPSDTVEVYPGS
LQIGKYTIKDVSKTEGPVLDLTGILINSSNVGMSKVAFDIGGETIFRLAQKVGLGQDTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGISVTAIQLVHAFSALANNGRLAPLTLIKTDKAPQTTQVLPEAVAKTMQGMLQQVIEAPRGVFRAQVPAYHV
GGKSGTARKTSVGTKGYAENSYRSLFAGFGPMSDPRYAIVVVIDEPTKAGYFGGLVSAPVFSRVMSGTLRLMNVTPDNLP
TTQQANATPAVPLKANGGRG

Sequences:

>Translated_580_residues
MMKLEGALFPWRFRLMVALLGVMVAAICWRIIDLQVVDRDFLKGQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANAKEMQTAKEKWPALAAALGQDPKALAERLEAQANKEFIYLVRGLTPEQGQAVLDLKVPGVYGIEEFRRFYPAGEVTA
HMVGFTDIDDHGREGVELAYDEWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKPLALSIDLRLQYLANRELRNAIIEN
GAKAGSLVIMDVKTGEILAMVNQPTYNPNNRRNLQPAMMRNRAMIDVFEPGSTMKAISMSAAIETGRWKPSDTVEVYPGS
LQIGKYTIKDVSKTEGPVLDLTGILINSSNVGMSKVAFDIGGETIFRLAQKVGLGQDTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGISVTAIQLVHAFSALANNGRLAPLTLIKTDKAPQTTQVLPEAVAKTMQGMLQQVIEAPRGVFRAQVPAYHV
GGKSGTARKTSVGTKGYAENSYRSLFAGFGPMSDPRYAIVVVIDEPTKAGYFGGLVSAPVFSRVMSGTLRLMNVTPDNLP
TTQQANATPAVPLKANGGRG
>Mature_580_residues
MMKLEGALFPWRFRLMVALLGVMVAAICWRIIDLQVVDRDFLKGQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANAKEMQTAKEKWPALAAALGQDPKALAERLEAQANKEFIYLVRGLTPEQGQAVLDLKVPGVYGIEEFRRFYPAGEVTA
HMVGFTDIDDHGREGVELAYDEWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKPLALSIDLRLQYLANRELRNAIIEN
GAKAGSLVIMDVKTGEILAMVNQPTYNPNNRRNLQPAMMRNRAMIDVFEPGSTMKAISMSAAIETGRWKPSDTVEVYPGS
LQIGKYTIKDVSKTEGPVLDLTGILINSSNVGMSKVAFDIGGETIFRLAQKVGLGQDTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGISVTAIQLVHAFSALANNGRLAPLTLIKTDKAPQTTQVLPEAVAKTMQGMLQQVIEAPRGVFRAQVPAYHV
GGKSGTARKTSVGTKGYAENSYRSLFAGFGPMSDPRYAIVVVIDEPTKAGYFGGLVSAPVFSRVMSGTLRLMNVTPDNLP
TTQQANATPAVPLKANGGRG

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=559, Percent_Identity=42.9338103756708, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1786854, Length=616, Percent_Identity=25.6493506493506, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63053; Mature: 63053

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLEGALFPWRFRLMVALLGVMVAAICWRIIDLQVVDRDFLKGQGDARSLRHIPIPAHR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCCCCCEEECCCCCCC
GLITDRNGEPLAVSTPVTTLWANAKEMQTAKEKWPALAAALGQDPKALAERLEAQANKEF
CEEECCCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCE
IYLVRGLTPEQGQAVLDLKVPGVYGIEEFRRFYPAGEVTAHMVGFTDIDDHGREGVELAY
EEEEECCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEH
DEWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKPLALSIDLRLQYLANRELRNAIIEN
HHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEEHHHHCHHHHHHHHHC
GAKAGSLVIMDVKTGEILAMVNQPTYNPNNRRNLQPAMMRNRAMIDVFEPGSTMKAISMS
CCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHH
AAIETGRWKPSDTVEVYPGSLQIGKYTIKDVSKTEGPVLDLTGILINSSNVGMSKVAFDI
HHHHCCCCCCCCCEEEECCEEEECCEEECCCCCCCCCEEEEEEEEEECCCCCHHHEEEEC
GGETIFRLAQKVGLGQDTGLGFPGERVGNLPNYREWRKAETATLSYGYGISVTAIQLVHA
CHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHEEEEECCCCHHHHHHHHHH
FSALANNGRLAPLTLIKTDKAPQTTQVLPEAVAKTMQGMLQQVIEAPRGVFRAQVPAYHV
HHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCEEEE
GGKSGTARKTSVGTKGYAENSYRSLFAGFGPMSDPRYAIVVVIDEPTKAGYFGGLVSAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHH
FSRVMSGTLRLMNVTPDNLPTTQQANATPAVPLKANGGRG
HHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MMKLEGALFPWRFRLMVALLGVMVAAICWRIIDLQVVDRDFLKGQGDARSLRHIPIPAHR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCCCCCCCCEEECCCCCCC
GLITDRNGEPLAVSTPVTTLWANAKEMQTAKEKWPALAAALGQDPKALAERLEAQANKEF
CEEECCCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCE
IYLVRGLTPEQGQAVLDLKVPGVYGIEEFRRFYPAGEVTAHMVGFTDIDDHGREGVELAY
EEEEECCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEH
DEWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKPLALSIDLRLQYLANRELRNAIIEN
HHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEEHHHHCHHHHHHHHHC
GAKAGSLVIMDVKTGEILAMVNQPTYNPNNRRNLQPAMMRNRAMIDVFEPGSTMKAISMS
CCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHH
AAIETGRWKPSDTVEVYPGSLQIGKYTIKDVSKTEGPVLDLTGILINSSNVGMSKVAFDI
HHHHCCCCCCCCCEEEECCEEEECCEEECCCCCCCCCEEEEEEEEEECCCCCHHHEEEEC
GGETIFRLAQKVGLGQDTGLGFPGERVGNLPNYREWRKAETATLSYGYGISVTAIQLVHA
CHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHEEEEECCCCHHHHHHHHHH
FSALANNGRLAPLTLIKTDKAPQTTQVLPEAVAKTMQGMLQQVIEAPRGVFRAQVPAYHV
HHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCEEEE
GGKSGTARKTSVGTKGYAENSYRSLFAGFGPMSDPRYAIVVVIDEPTKAGYFGGLVSAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHH
FSRVMSGTLRLMNVTPDNLPTTQQANATPAVPLKANGGRG
HHHHHHCCEEEEECCCCCCCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]