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The map label for this gene is murC [H]

Identifier: 77460893

GI number: 77460893

Start: 5273705

End: 5275165

Strand: Reverse

Name: murC [H]

Synonym: Pfl01_4672

Alternate gene names: 77460893

Gene position: 5275165-5273705 (Counterclockwise)

Preceding gene: 77460894

Following gene: 77460892

Centisome position: 81.93

GC content: 63.45

Gene sequence:

>1461_bases
ATGGTTGAGAATCAGAAAGCCATGCCGCAACCGGAAATGCGCCGCATCCGTCGCATCCACTTCGTCGGGATCGGCGGCGT
GGGCATGTGCGGCATCGCCGAAGTGCTGCTGAACCTGGGCTATGAAGTGTCCGGTTCGGACCTGAAAGCTTCGCCGGTGA
CCGAGCGCCTGGAATCCTTCGGTGCGCAGATCTTCATCGGCCACCGTGCCGAGAACGCCGCTGCCGCCGATGTGCTGGTG
GTGTCGAGCGCCGTCAACACCTCCAACCCGGAAGTGGCGACCGCACTGGAACGCCGCATCCCGGTGGTGCCGCGTGCCGA
AATGCTCGCCGAACTGATGCGCTACCGCCACGGCATCGCCGTCGCCGGTACCCATGGCAAAACCACCACCACCAGCCTGA
TCGCTTCGGTGTTCGCGGCGGGTGGCCTGGATCCGACCTTCGTCATCGGTGGCCGTTTGAATGCTGCGGGCACCAATGCC
CAGCTCGGCACCAGCCGTTATCTGATTGCCGAAGCCGATGAAAGCGACGCAAGCTTCCTGCATCTGCAGCCGCTGGTGGC
TGTGGTCACCAATATCGACGCCGACCACATGGCGACCTACGACGGTGACTTCAACAAACTGAAGAAAACCTTCGTCGAGT
TCCTGCACAACCTGCCGTTCTACGGTCTGGCGGTGATGTGCCTGGACGATCCGGTGGTGCGTGAAATCCTGCCGCTGGTC
AAGCGTCCGACCGTGACCTATGGCTTCAGCGAAGACGCCGACGTGCGCGCGATCAATGTTCGTCAGCAGGGCATGCAGAC
CTTCTTTACCGTGCTGCGCCCTGATCGCGAGCCTCTTGATGTGTCCGTGAACATGCCGGGCAATCACAACGTGCTCAATT
CCCTGGCGACCATCTGCATCGCCACCGACGAAGGCGTCAGCGACGAGGCCATCGTCCAGGGCCTGTCCGGCTTCCAGGGT
GTCGGCCGACGCTTCCAGGTCTACGGCGAACTGCCGGTGGACGGCGGCAATGTGATGCTGGTCGACGACTACGGTCACCA
CCCGACCGAAGTCGCAGCCGTGATCAAAGCCGTGCGCGGTGGCTGGCCGGAGCGCCGTCTGGTGATGGTCTACCAGCCGC
ACCGTTACAGCCGCACCCGCGACCTGTACGACGATTTCGTCAATGTCCTGGCCGACGCCAACGTGCTGCTGCTGATGGAA
GTCTACCCGGCCGGCGAAGAGCCGATCCCGGGCGCCGACAGCCGCAAGCTGTGCAACAGCATCCGCCAGCGCGGTCAGCT
CGACCCGATCTACATCGAGCGCGGCGTCGATCTGGCGCCACTGGTCAAGCCGCTGCTGCGTGCCGGCGACATTCTGCTGT
GCCAGGGCGCCGGTGACATCGGCGGTCTCGCACCGAAACTGTTGAAAAGCGAGTTGTTCGCCGGTGCCGTGGCGGCATCG
GTCGAGGGGAAGTTGAAATGA

Upstream 100 bases:

>100_bases
ATGCAACCGCAACGACTCGAACAAATGGCCCAAGCGGCCCGCCGTCTGGCGAAACCCGAAGCCACCCGTAGCGTGGTCGA
TACCTGTCTGGAGGTGGCCC

Downstream 100 bases:

>100_bases
CTGCTGCCTACGCCAATCTGTTCTCCACCATCGCCCCGAAGGATTTCGGCCGTGTGGCCGTGTTGTTCGGTGGCCTGAGT
GCCGAGCGTGAAGTCTCGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MVENQKAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKASPVTERLESFGAQIFIGHRAENAAAADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYDGDFNKLKKTFVEFLHNLPFYGLAVMCLDDPVVREILPLV
KRPTVTYGFSEDADVRAINVRQQGMQTFFTVLRPDREPLDVSVNMPGNHNVLNSLATICIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGNVMLVDDYGHHPTEVAAVIKAVRGGWPERRLVMVYQPHRYSRTRDLYDDFVNVLADANVLLLME
VYPAGEEPIPGADSRKLCNSIRQRGQLDPIYIERGVDLAPLVKPLLRAGDILLCQGAGDIGGLAPKLLKSELFAGAVAAS
VEGKLK

Sequences:

>Translated_486_residues
MVENQKAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKASPVTERLESFGAQIFIGHRAENAAAADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYDGDFNKLKKTFVEFLHNLPFYGLAVMCLDDPVVREILPLV
KRPTVTYGFSEDADVRAINVRQQGMQTFFTVLRPDREPLDVSVNMPGNHNVLNSLATICIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGNVMLVDDYGHHPTEVAAVIKAVRGGWPERRLVMVYQPHRYSRTRDLYDDFVNVLADANVLLLME
VYPAGEEPIPGADSRKLCNSIRQRGQLDPIYIERGVDLAPLVKPLLRAGDILLCQGAGDIGGLAPKLLKSELFAGAVAAS
VEGKLK
>Mature_486_residues
MVENQKAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKASPVTERLESFGAQIFIGHRAENAAAADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYDGDFNKLKKTFVEFLHNLPFYGLAVMCLDDPVVREILPLV
KRPTVTYGFSEDADVRAINVRQQGMQTFFTVLRPDREPLDVSVNMPGNHNVLNSLATICIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGNVMLVDDYGHHPTEVAAVIKAVRGGWPERRLVMVYQPHRYSRTRDLYDDFVNVLADANVLLLME
VYPAGEEPIPGADSRKLCNSIRQRGQLDPIYIERGVDLAPLVKPLLRAGDILLCQGAGDIGGLAPKLLKSELFAGAVAAS
VEGKLK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=467, Percent_Identity=62.3126338329765, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1790680, Length=469, Percent_Identity=28.5714285714286, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52538; Mature: 52538

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVENQKAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKASPVTERLESF
CCCCCCCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
GAQIFIGHRAENAAAADVLVVSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIA
CCEEEEEECCCCCHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGTSRYLIAEADESDASFL
EEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPLVAVVTNIDADHMATYDGDFNKLKKTFVEFLHNLPFYGLAVMCLDDPVVREILPLV
EHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHH
KRPTVTYGFSEDADVRAINVRQQGMQTFFTVLRPDREPLDVSVNMPGNHNVLNSLATICI
CCCCEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHEEEE
ATDEGVSDEAIVQGLSGFQGVGRRFQVYGELPVDGGNVMLVDDYGHHPTEVAAVIKAVRG
ECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GWPERRLVMVYQPHRYSRTRDLYDDFVNVLADANVLLLMEVYPAGEEPIPGADSRKLCNS
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHH
IRQRGQLDPIYIERGVDLAPLVKPLLRAGDILLCQGAGDIGGLAPKLLKSELFAGAVAAS
HHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
VEGKLK
CCCCCC
>Mature Secondary Structure
MVENQKAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKASPVTERLESF
CCCCCCCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHC
GAQIFIGHRAENAAAADVLVVSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIA
CCEEEEEECCCCCHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGTSRYLIAEADESDASFL
EEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPLVAVVTNIDADHMATYDGDFNKLKKTFVEFLHNLPFYGLAVMCLDDPVVREILPLV
EHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHH
KRPTVTYGFSEDADVRAINVRQQGMQTFFTVLRPDREPLDVSVNMPGNHNVLNSLATICI
CCCCEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHEEEE
ATDEGVSDEAIVQGLSGFQGVGRRFQVYGELPVDGGNVMLVDDYGHHPTEVAAVIKAVRG
ECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHC
GWPERRLVMVYQPHRYSRTRDLYDDFVNVLADANVLLLMEVYPAGEEPIPGADSRKLCNS
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHH
IRQRGQLDPIYIERGVDLAPLVKPLLRAGDILLCQGAGDIGGLAPKLLKSELFAGAVAAS
HHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
VEGKLK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA