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The map label for this gene is czcR [H]

Identifier: 77460884

GI number: 77460884

Start: 5262736

End: 5263413

Strand: Direct

Name: czcR [H]

Synonym: Pfl01_4663

Alternate gene names: 77460884

Gene position: 5262736-5263413 (Clockwise)

Preceding gene: 77460883

Following gene: 77460885

Centisome position: 81.74

GC content: 64.01

Gene sequence:

>678_bases
ATGCGCGTTCTGATTATCGAAGACGAAGAGAAAACCGCGGACTACCTGCACCGCGGCCTGACGGAACAGGGTTACACCGT
GGATCGGGCCCGCGACGGCGTCGAGGGCCTGCACCTGGCGCTGGAAAGCGACTACGCGGTGATCGTCCTCGACGTGATGC
TGCCGGGCCTCGACGGCTTCGGCGTACTGCGCGCATTGCGTGCGCGCAAGCAGACGCCGGTGATCATGCTCACCGCCCGC
GAACGGGTCGAAGACCGGATCCGAGGCCTGCGCGATGGCGCCGACGATTACCTCGGCAAACCGTTCTCCTTCCTCGAACT
CGTGGCGCGCCTGCAAGCGCTGACCCGGCGCAGTGGCGGCCACGAACCGGTACAAGTGAGCATCGCCGACCTGTGGATCG
ATCTGATCAGCCGCAAGGCCACCCGCGCCGGCACCCGCCTGGATCTGACCGCGAAGGAGTTTTCACTGCTCAGCGTGCTG
GCCCGGCGTCAGGGCGAAATCCTCTCGAAAACCGCGATTGCCGAGATGGTCTGGGACATCAATTTCGACAGCGACGCCAA
TGTGGTCGAAGTCGCGATCAAGCGCCTGCGAGCCAAGCTCGACGGGCCGTTCGACGAGAAACTGCTGCACACCATCCGTG
GCATGGGTTATGTGCTGGAGAGCCGTGGTGTCCAGTAA

Upstream 100 bases:

>100_bases
TGTTCACCACGCCGGTCATATACTTGTGGCTTGAGCGGCTGTTCCACAAGCCCAAACCTGCGCCCGTCGCGGCGCTGGCA
ACGACAGACTGAGGCGGGTC

Downstream 100 bases:

>100_bases
TTCCATTGCGCTGCGCTTGAGCGGGATGTTCACGCTGGTGGCGCTGCTGGTGTTCCTGTTGATCGGCGGCGCGCTGTATC
AACAAGTGGACAAAGGCCTC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRVLIIEDEEKTADYLHRGLTEQGYTVDRARDGVEGLHLALESDYAVIVLDVMLPGLDGFGVLRALRARKQTPVIMLTAR
ERVEDRIRGLRDGADDYLGKPFSFLELVARLQALTRRSGGHEPVQVSIADLWIDLISRKATRAGTRLDLTAKEFSLLSVL
ARRQGEILSKTAIAEMVWDINFDSDANVVEVAIKRLRAKLDGPFDEKLLHTIRGMGYVLESRGVQ

Sequences:

>Translated_225_residues
MRVLIIEDEEKTADYLHRGLTEQGYTVDRARDGVEGLHLALESDYAVIVLDVMLPGLDGFGVLRALRARKQTPVIMLTAR
ERVEDRIRGLRDGADDYLGKPFSFLELVARLQALTRRSGGHEPVQVSIADLWIDLISRKATRAGTRLDLTAKEFSLLSVL
ARRQGEILSKTAIAEMVWDINFDSDANVVEVAIKRLRAKLDGPFDEKLLHTIRGMGYVLESRGVQ
>Mature_225_residues
MRVLIIEDEEKTADYLHRGLTEQGYTVDRARDGVEGLHLALESDYAVIVLDVMLPGLDGFGVLRALRARKQTPVIMLTAR
ERVEDRIRGLRDGADDYLGKPFSFLELVARLQALTRRSGGHEPVQVSIADLWIDLISRKATRAGTRLDLTAKEFSLLSVL
ARRQGEILSKTAIAEMVWDINFDSDANVVEVAIKRLRAKLDGPFDEKLLHTIRGMGYVLESRGVQ

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=52.7027027027027, Blast_Score=243, Evalue=6e-66,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=53.9170506912442, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.7777777777778, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=31.6017316017316, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=35.2678571428571, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.219730941704, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=35.8078602620087, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.1838565022422, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=36.697247706422, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=32.8888888888889, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=30.2222222222222, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=34.7826086956522, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=28.6764705882353, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25225; Mature: 25225

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIIEDEEKTADYLHRGLTEQGYTVDRARDGVEGLHLALESDYAVIVLDVMLPGLDGF
CEEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCHHHHHEEECCCCEEEEEEHHHCCCCHH
GVLRALRARKQTPVIMLTARERVEDRIRGLRDGADDYLGKPFSFLELVARLQALTRRSGG
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCC
HEPVQVSIADLWIDLISRKATRAGTRLDLTAKEFSLLSVLARRQGEILSKTAIAEMVWDI
CCCEEEHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDANVVEVAIKRLRAKLDGPFDEKLLHTIRGMGYVLESRGVQ
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRVLIIEDEEKTADYLHRGLTEQGYTVDRARDGVEGLHLALESDYAVIVLDVMLPGLDGF
CEEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCHHHHHEEECCCCEEEEEEHHHCCCCHH
GVLRALRARKQTPVIMLTARERVEDRIRGLRDGADDYLGKPFSFLELVARLQALTRRSGG
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCC
HEPVQVSIADLWIDLISRKATRAGTRLDLTAKEFSLLSVLARRQGEILSKTAIAEMVWDI
CCCEEEHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NFDSDANVVEVAIKRLRAKLDGPFDEKLLHTIRGMGYVLESRGVQ
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]