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The map label for this gene is zraS [H]

Identifier: 77460846

GI number: 77460846

Start: 5224756

End: 5227026

Strand: Direct

Name: zraS [H]

Synonym: Pfl01_4625

Alternate gene names: 77460846

Gene position: 5224756-5227026 (Clockwise)

Preceding gene: 77460845

Following gene: 77460847

Centisome position: 81.15

GC content: 42.05

Gene sequence:

>2271_bases
ATGAAAGAATTGTTAGATGAGCTGCCTTTTGAGATCGCTGCTCGCTTACCTATTCAGCTCGGACGGCAAAGCATATCGAG
CTCTATGGTTGCTATTTCTGAGCTTATTAAAAACTCCTACGATGCCGATTCTAAAAAGGTAAAACTTACATTCACAAACT
CTAAAGACAACCTTCCATCTTTAATAATCGAGGATGATGGGGAAGGCATGTCTTACGAGGATGTAAAAGAAAACTGGCTA
ATTATTGGAACAAGTCACAAGACACATCAGGACATCTCGGAAAAGTACAGAGTTTATACCGGCGCAAAAGGGCTTGGCCG
ACTTGGAGCAGATAGGCTCTGTAAAACTTTGGTTCTGCAGACCAAGCAAGAAAGTGACCAAGCCGCACTGGAGCTTCAAA
TAGAATGGGAGGCATATGAAAATGCAGAAAAGCCTCTTTCACAAATAAAGCACAAACTCTATAAACATACCAGCCAAATA
CAAGACAGACATGGAAAATTTCCGGACAATGAAAAAAACTCCGGTACGCGAGTCATACTCCAAGGATTAAAAGACGATTG
GAACTTGAATCTTTTAACAGACCTAAAAAAAGAGCTGTCACTTTTAATCTCTCCATTCGACGAAACTAACGACTTCTCAA
TTTCAATTCAATCGGATTTTCCTGAAGTAAATGGCAACGTCTCAAGCTCGTCTGCGGTTGAATACGCACGCTGGGTAGTT
GATGCCGAGCTTGATGGCGAAATCATTAATGCCAACTTTAGATATTCTGACGGCCGAGAGTTTAAAATCAATTCAGAAGA
GTGGAAGAACTGGATTAAGGATCGGCCGCCGGTGCCTAGCTCTGGCCCTCTAAAACTCAAAATGTATTTTATTCCTTGGG
ATGCACCTGGTCTAAAGAACGTAGACTTTACTAAGCGTAATTGGCGGGAGTTCATGAATGCGAACCAAGGAATACGCATT
TATCGAGATAGGTTCAGAGTGCGTCCTTATGGCGAGCCCACCGGTAAAGGTGATTGGCTAGACCTTGGTATCCGTCGCGC
ACGTAGTCCTGGCGGGGTCAAACAAGGGGGCTGGAAAGTCGGGCCGCACCAAGTTATTGGCGCAGTATTCATTGGTAGAA
AGACCAATCCTCTCCTGGAAGATCAAACAAATCGTGAGGGTATCGTTGAGTCAGAAGCATTTTATGACATGCGTGCTTTT
TGCGTAAAAATCATCGATCGATTTGAGTTGTACGCTCATCAAATAGCCCGAGAAGAGGATGACGGGTCTGATACAGAAGA
AAAAAAACTGCTTGCTAAAAAAGCTATCGCCGACACAACAAAGGAAGTTGAAAAACTTAAAGAATCAATCTCTAAGAATT
TGCAAGAAACCGTTGATACTGGTGAGCAGAAAGATATCAGCGCTAACGAACCTGAAACTCTAATGGTCAGAATTGCGGAG
GTGGAATCCAGATTAGCAGAGGCTGCTGCCCGATCAAGCGAGCTGGAAATCCACTTAGAGAAAAAGGCTGAAGAGTTAGA
GCATGAAAAGGACACGTTAGCTAACCTAGCGTCGCTAGGTATTCTGACAGTATGTTTCGGACATGAAGCAAAAGAATTTA
CAAATCTTTCATTAGTTAATGCAAAAAACCTTAAGGACAGTTTCGAAAAAGGCATTTTCATGCTGACGCCTCCTTATGAC
GAGGAGTTCTCAAACTGCCTAAAAACGATAATTTCAAGCACAGGCTTCGTAAGAAACTTTGCATCTTTTGCCTTAGGAAA
CATTAAACCGGACAAAAGAAAGCGCAGAGCCGTTGATATTGGTGACGTCGCATCAGGCGTATTCAAAGCCTTAAGCGCGT
CATTAGAAAGACAAAATATTGAAACAAGCGTTACTTGCGAAACCAAAAGAAAAATTATTGCCTTTGAAATAGATCTAGAA
AGCATATTTGTCAACCTCATATCGAACTCTATATGGGCACTCAAAAAAACCGCCGTAGGCGAACGTTTCATATCCGTTAA
CATTCACGAAAAAAACGATCACATAACTGTTAGTTTTGCTGATAGCGGTTTCGGATTAGAATCAGGAACAGAAGAGCAAA
TTTTTCAACCAATGTATAGTACTCGACTAGATAGAAAGGGCTCAGTTGAAGGCACAGGCATGGGGCTTTCCATTGTGAAA
AGTTTTGTTGACAACCATACAGGTGGGAATATTTCCGCAATATCAAAAGGAAGACTTGGCGGCGCAGAGTTTTTAATCAA
TATACCATTGAACACAAACAACAAGGCCTGA

Upstream 100 bases:

>100_bases
AATTACTCAAAGAAAACCATATCAATGAGTTTCTGAACAATAGGATTCGATGCCGCCACTTAACAGTATCGGCAATATCA
GAAATACCATGGAGGTTTGA

Downstream 100 bases:

>100_bases
CTTCATGGAAAAGAATGTTGTGCTATACATTGACGAGGAGCAAATCGCTCTAGACTCTTACGGCCGAGAACTAAGAAAAA
ATTTACCTCCAGAATTAGAG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MKELLDELPFEIAARLPIQLGRQSISSSMVAISELIKNSYDADSKKVKLTFTNSKDNLPSLIIEDDGEGMSYEDVKENWL
IIGTSHKTHQDISEKYRVYTGAKGLGRLGADRLCKTLVLQTKQESDQAALELQIEWEAYENAEKPLSQIKHKLYKHTSQI
QDRHGKFPDNEKNSGTRVILQGLKDDWNLNLLTDLKKELSLLISPFDETNDFSISIQSDFPEVNGNVSSSSAVEYARWVV
DAELDGEIINANFRYSDGREFKINSEEWKNWIKDRPPVPSSGPLKLKMYFIPWDAPGLKNVDFTKRNWREFMNANQGIRI
YRDRFRVRPYGEPTGKGDWLDLGIRRARSPGGVKQGGWKVGPHQVIGAVFIGRKTNPLLEDQTNREGIVESEAFYDMRAF
CVKIIDRFELYAHQIAREEDDGSDTEEKKLLAKKAIADTTKEVEKLKESISKNLQETVDTGEQKDISANEPETLMVRIAE
VESRLAEAAARSSELEIHLEKKAEELEHEKDTLANLASLGILTVCFGHEAKEFTNLSLVNAKNLKDSFEKGIFMLTPPYD
EEFSNCLKTIISSTGFVRNFASFALGNIKPDKRKRRAVDIGDVASGVFKALSASLERQNIETSVTCETKRKIIAFEIDLE
SIFVNLISNSIWALKKTAVGERFISVNIHEKNDHITVSFADSGFGLESGTEEQIFQPMYSTRLDRKGSVEGTGMGLSIVK
SFVDNHTGGNISAISKGRLGGAEFLINIPLNTNNKA

Sequences:

>Translated_756_residues
MKELLDELPFEIAARLPIQLGRQSISSSMVAISELIKNSYDADSKKVKLTFTNSKDNLPSLIIEDDGEGMSYEDVKENWL
IIGTSHKTHQDISEKYRVYTGAKGLGRLGADRLCKTLVLQTKQESDQAALELQIEWEAYENAEKPLSQIKHKLYKHTSQI
QDRHGKFPDNEKNSGTRVILQGLKDDWNLNLLTDLKKELSLLISPFDETNDFSISIQSDFPEVNGNVSSSSAVEYARWVV
DAELDGEIINANFRYSDGREFKINSEEWKNWIKDRPPVPSSGPLKLKMYFIPWDAPGLKNVDFTKRNWREFMNANQGIRI
YRDRFRVRPYGEPTGKGDWLDLGIRRARSPGGVKQGGWKVGPHQVIGAVFIGRKTNPLLEDQTNREGIVESEAFYDMRAF
CVKIIDRFELYAHQIAREEDDGSDTEEKKLLAKKAIADTTKEVEKLKESISKNLQETVDTGEQKDISANEPETLMVRIAE
VESRLAEAAARSSELEIHLEKKAEELEHEKDTLANLASLGILTVCFGHEAKEFTNLSLVNAKNLKDSFEKGIFMLTPPYD
EEFSNCLKTIISSTGFVRNFASFALGNIKPDKRKRRAVDIGDVASGVFKALSASLERQNIETSVTCETKRKIIAFEIDLE
SIFVNLISNSIWALKKTAVGERFISVNIHEKNDHITVSFADSGFGLESGTEEQIFQPMYSTRLDRKGSVEGTGMGLSIVK
SFVDNHTGGNISAISKGRLGGAEFLINIPLNTNNKA
>Mature_756_residues
MKELLDELPFEIAARLPIQLGRQSISSSMVAISELIKNSYDADSKKVKLTFTNSKDNLPSLIIEDDGEGMSYEDVKENWL
IIGTSHKTHQDISEKYRVYTGAKGLGRLGADRLCKTLVLQTKQESDQAALELQIEWEAYENAEKPLSQIKHKLYKHTSQI
QDRHGKFPDNEKNSGTRVILQGLKDDWNLNLLTDLKKELSLLISPFDETNDFSISIQSDFPEVNGNVSSSSAVEYARWVV
DAELDGEIINANFRYSDGREFKINSEEWKNWIKDRPPVPSSGPLKLKMYFIPWDAPGLKNVDFTKRNWREFMNANQGIRI
YRDRFRVRPYGEPTGKGDWLDLGIRRARSPGGVKQGGWKVGPHQVIGAVFIGRKTNPLLEDQTNREGIVESEAFYDMRAF
CVKIIDRFELYAHQIAREEDDGSDTEEKKLLAKKAIADTTKEVEKLKESISKNLQETVDTGEQKDISANEPETLMVRIAE
VESRLAEAAARSSELEIHLEKKAEELEHEKDTLANLASLGILTVCFGHEAKEFTNLSLVNAKNLKDSFEKGIFMLTPPYD
EEFSNCLKTIISSTGFVRNFASFALGNIKPDKRKRRAVDIGDVASGVFKALSASLERQNIETSVTCETKRKIIAFEIDLE
SIFVNLISNSIWALKKTAVGERFISVNIHEKNDHITVSFADSGFGLESGTEEQIFQPMYSTRLDRKGSVEGTGMGLSIVK
SFVDNHTGGNISAISKGRLGGAEFLINIPLNTNNKA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=198, Percent_Identity=23.7373737373737, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84982; Mature: 84982

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELLDELPFEIAARLPIQLGRQSISSSMVAISELIKNSYDADSKKVKLTFTNSKDNLPS
CHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCE
LIIEDDGEGMSYEDVKENWLIIGTSHKTHQDISEKYRVYTGAKGLGRLGADRLCKTLVLQ
EEEECCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHEEEECCCHHHHCCHHHHHHHHHHH
TKQESDQAALELQIEWEAYENAEKPLSQIKHKLYKHTSQIQDRHGKFPDNEKNSGTRVIL
CCCCCCCEEEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
QGLKDDWNLNLLTDLKKELSLLISPFDETNDFSISIQSDFPEVNGNVSSSSAVEYARWVV
ECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEE
DAELDGEIINANFRYSDGREFKINSEEWKNWIKDRPPVPSSGPLKLKMYFIPWDAPGLKN
ECCCCCEEEECEEEECCCCEEEECHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCC
VDFTKRNWREFMNANQGIRIYRDRFRVRPYGEPTGKGDWLDLGIRRARSPGGVKQGGWKV
CCCCHHHHHHHHCCCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
GPHQVIGAVFIGRKTNPLLEDQTNREGIVESEAFYDMRAFCVKIIDRFELYAHQIAREED
CHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGSDTEEKKLLAKKAIADTTKEVEKLKESISKNLQETVDTGEQKDISANEPETLMVRIAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
VESRLAEAAARSSELEIHLEKKAEELEHEKDTLANLASLGILTVCFGHEAKEFTNLSLVN
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEE
AKNLKDSFEKGIFMLTPPYDEEFSNCLKTIISSTGFVRNFASFALGNIKPDKRKRRAVDI
HHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHCCCH
GDVASGVFKALSASLERQNIETSVTCETKRKIIAFEIDLESIFVNLISNSIWALKKTAVG
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHHHHHHHHHCHHHHHHHHHCC
ERFISVNIHEKNDHITVSFADSGFGLESGTEEQIFQPMYSTRLDRKGSVEGTGMGLSIVK
CEEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SFVDNHTGGNISAISKGRLGGAEFLINIPLNTNNKA
HHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKELLDELPFEIAARLPIQLGRQSISSSMVAISELIKNSYDADSKKVKLTFTNSKDNLPS
CHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCE
LIIEDDGEGMSYEDVKENWLIIGTSHKTHQDISEKYRVYTGAKGLGRLGADRLCKTLVLQ
EEEECCCCCCCHHHCCCCEEEEECCCCHHHHHHHHHEEEECCCHHHHCCHHHHHHHHHHH
TKQESDQAALELQIEWEAYENAEKPLSQIKHKLYKHTSQIQDRHGKFPDNEKNSGTRVIL
CCCCCCCEEEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHE
QGLKDDWNLNLLTDLKKELSLLISPFDETNDFSISIQSDFPEVNGNVSSSSAVEYARWVV
ECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHEE
DAELDGEIINANFRYSDGREFKINSEEWKNWIKDRPPVPSSGPLKLKMYFIPWDAPGLKN
ECCCCCEEEECEEEECCCCEEEECHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCC
VDFTKRNWREFMNANQGIRIYRDRFRVRPYGEPTGKGDWLDLGIRRARSPGGVKQGGWKV
CCCCHHHHHHHHCCCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
GPHQVIGAVFIGRKTNPLLEDQTNREGIVESEAFYDMRAFCVKIIDRFELYAHQIAREED
CHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGSDTEEKKLLAKKAIADTTKEVEKLKESISKNLQETVDTGEQKDISANEPETLMVRIAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
VESRLAEAAARSSELEIHLEKKAEELEHEKDTLANLASLGILTVCFGHEAKEFTNLSLVN
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEE
AKNLKDSFEKGIFMLTPPYDEEFSNCLKTIISSTGFVRNFASFALGNIKPDKRKRRAVDI
HHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHCCCH
GDVASGVFKALSASLERQNIETSVTCETKRKIIAFEIDLESIFVNLISNSIWALKKTAVG
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECHHHHHHHHHHCHHHHHHHHHCC
ERFISVNIHEKNDHITVSFADSGFGLESGTEEQIFQPMYSTRLDRKGSVEGTGMGLSIVK
CEEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SFVDNHTGGNISAISKGRLGGAEFLINIPLNTNNKA
HHHHCCCCCCEEEECCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]