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The map label for this gene is metR [H]

Identifier: 77460767

GI number: 77460767

Start: 5126952

End: 5127869

Strand: Direct

Name: metR [H]

Synonym: Pfl01_4546

Alternate gene names: 77460767

Gene position: 5126952-5127869 (Clockwise)

Preceding gene: 77460765

Following gene: 77460772

Centisome position: 79.63

GC content: 64.05

Gene sequence:

>918_bases
GTGCTTGAGATCCGTCACCTGAAAACCCTGCATGCCCTGCGTGAAGCCGACAGCCTGGTCGATGCAGCCGACCGCCTGCA
CCTGACCCAGTCGGCGCTGTCCCACCAGTTCAAGGAGCTGGAAGAGCGCATGGGCATGCCGTTGTTCGTGCGCAAGACCA
AACCGGTGCGCTTCACCAGCGCCGGCCTGCGCCTGTTGCAACTGGCCGACGCGACCCTGCCGCTGCTGCGTGCCGCCGAA
CGTGACATTGGGCGTCTGGCCGGTGGCACTGCCGGACGTCTGCACATGGCCATCGAATGCCACAGCTGCTTCCAGTGGCT
GATGCCGACCATCGATCAGTTCCGCGATGCCTGGCCGGAAGTCGAACTCGACCTCGCTTCGGGTTTCTCGTTTGCACCGC
TGCCGGCGCTGGCCCGGGGCGATCTGGATCTGGTGGTGACGTCCGACCCGCTGGAAATCGCCGGCATCACCTACGTGCCG
CTGTTCACCTACGAAGCCATGCTCGCGGTCGCCAATCAGCACGTGCTGGCAAGCAAACCGTACATCGTTCCCGAAGACCT
GCTGACCGAAACCCTGATCACCTACCCGGTCGAACGCGATCGCCTGGACATCTTCACCCGTTTCCTCGAACCGGCCGACA
TCGAACCGGCGCAGGTACGCACCTCGGAGCTGACGGTGATGATGATGCAGCTGGTGGCCAGCGGCCGTGGCGTGTGCGGC
ATGCCGCACTGGGCGCTGCATGAATACAGCTCGCGGGGTTACGTGAAGGGCAAGCGGCTGGGCGAGAAAGGTCTGTTTGC
CACGCTGTACGCAGCGATCCGCGCCGACATGCTGGATGCGCCGTACATGCGCGACTTCCTGCTGACGGCCAAGGACACTT
CGTTCTCGACCCTGGATGGGGTCAGCGCGGTTCGTTGA

Upstream 100 bases:

>100_bases
TCCATTGCGTAAAAGATGGCGCCATTGTCGACAGCCAGGGCAACATGAGACAAACTCAACCTTTTCGTGTTGATCACAAA
TTTTCCTCATGGAGCCTGCA

Downstream 100 bases:

>100_bases
GGCTGGCGGTTGGCACGAAAGGCGCGCACCACATGTGGATCTTGTCGAAGTAGTCCTCGCCGACCCGCACCGCCATCGGT
TCGAGGCCGAACTGGATGAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADATLPLLRAAE
RDIGRLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLASGFSFAPLPALARGDLDLVVTSDPLEIAGITYVP
LFTYEAMLAVANQHVLASKPYIVPEDLLTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKGKRLGEKGLFATLYAAIRADMLDAPYMRDFLLTAKDTSFSTLDGVSAVR

Sequences:

>Translated_305_residues
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADATLPLLRAAE
RDIGRLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLASGFSFAPLPALARGDLDLVVTSDPLEIAGITYVP
LFTYEAMLAVANQHVLASKPYIVPEDLLTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKGKRLGEKGLFATLYAAIRADMLDAPYMRDFLLTAKDTSFSTLDGVSAVR
>Mature_305_residues
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADATLPLLRAAE
RDIGRLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLASGFSFAPLPALARGDLDLVVTSDPLEIAGITYVP
LFTYEAMLAVANQHVLASKPYIVPEDLLTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKGKRLGEKGLFATLYAAIRADMLDAPYMRDFLLTAKDTSFSTLDGVSAVR

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=303, Percent_Identity=46.2046204620462, Blast_Score=277, Evalue=6e-76,
Organism=Escherichia coli, GI157672245, Length=228, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=25.938566552901, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790208, Length=170, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790399, Length=249, Percent_Identity=28.5140562248996, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786401, Length=252, Percent_Identity=25.7936507936508, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787806, Length=274, Percent_Identity=21.1678832116788, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789173, Length=242, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=24.6073298429319, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI2367136, Length=246, Percent_Identity=25.609756097561, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=23.0452674897119, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788296, Length=254, Percent_Identity=28.740157480315, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=181, Percent_Identity=24.8618784530387, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87081904, Length=198, Percent_Identity=27.7777777777778, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34031; Mature: 34031

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHH
AGLRLLQLADATLPLLRAAERDIGRLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
VELDLASGFSFAPLPALARGDLDLVVTSDPLEIAGITYVPLFTYEAMLAVANQHVLASKP
EEEECCCCCCCCCCCHHHCCCEEEEEECCCCEECCEEEHHHHHHHHHHHHHHCHHCCCCC
YIVPEDLLTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
MPHWALHEYSSRGYVKGKRLGEKGLFATLYAAIRADMLDAPYMRDFLLTAKDTSFSTLDG
CCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCHHCC
VSAVR
HHHCC
>Mature Secondary Structure
MLEIRHLKTLHALREADSLVDAADRLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHH
AGLRLLQLADATLPLLRAAERDIGRLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
VELDLASGFSFAPLPALARGDLDLVVTSDPLEIAGITYVPLFTYEAMLAVANQHVLASKP
EEEECCCCCCCCCCCHHHCCCEEEEEECCCCEECCEEEHHHHHHHHHHHHHHCHHCCCCC
YIVPEDLLTETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
MPHWALHEYSSRGYVKGKRLGEKGLFATLYAAIRADMLDAPYMRDFLLTAKDTSFSTLDG
CCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCHHCC
VSAVR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]