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The map label for this gene is tsaA [H]

Identifier: 77460742

GI number: 77460742

Start: 5095730

End: 5096332

Strand: Reverse

Name: tsaA [H]

Synonym: Pfl01_4521

Alternate gene names: 77460742

Gene position: 5096332-5095730 (Counterclockwise)

Preceding gene: 77460745

Following gene: 77460739

Centisome position: 79.16

GC content: 58.37

Gene sequence:

>603_bases
ATGAGCGTACTCGTAGGCAAACAAGCCCCTGACTTCACCGTCCCGGCCGTACTCGGCAATGGCGAGATCGTTGACAGCTT
CACCCTGTCCTCGGCCATCAAAGGCAAATACGGCCTGGTGTTCTTCTACCCGCTGGACTTCACCTTTGTCTGCCCGTCCG
AGCTGATCGCTCTGGACAACCGCATGGCCGACTTCAAGGCACGCAACGTTGAAGTAGTCGCCGTTTCGATCGACTCGCAC
TTCACCCACAACGCCTGGCGCAACACACCGGTCAACAATGGCGGCATCGGCCAGGTGAAATACACCATGGCTGCCGACAT
GAAGCACGAAATCGCCAAGGCCTACGACGTTGAGTCCGAAGGCGGCGTGGCTTTCCGTGGCGCGTTCCTGATCGATGACA
AAGGCGTTGTCCGCTCGCAGATCATCAACGACCTGCCGCTGGGCCGTAACATGGAAGAGCTGATCCGTCTGGTCGACGCT
CTGCAATTCCACGAAGAGCACGGCGAAGTCTGCCCTGCCAACTGGAAAAAAGGCGACAAAGGCATGAACGCTTCGCCAGA
AGGCGTTGCGGCTTACCTGACCGAGAACGCTGCTGCCCTGTAA

Upstream 100 bases:

>100_bases
GTCGGCCCTTGCGAAGGGGGTTCGTGTCACAGGGCTGTCGCCTGAGGGTGGCAGGCTGGCCCGAACCCTGAACTTCAAGT
TTCTACACCAGGAGATATCA

Downstream 100 bases:

>100_bases
GGCGCAACGTCGAGGTACAAAAAAACCGGCTCTTGAGCCGGTTTTTTCATGCGCGGGATTTAACCCGACGACCCTCAGTC
GTCGAAGTCTTCCCAGCCGC

Product: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSVLVGKQAPDFTVPAVLGNGEIVDSFTLSSAIKGKYGLVFFYPLDFTFVCPSELIALDNRMADFKARNVEVVAVSIDSH
FTHNAWRNTPVNNGGIGQVKYTMAADMKHEIAKAYDVESEGGVAFRGAFLIDDKGVVRSQIINDLPLGRNMEELIRLVDA
LQFHEEHGEVCPANWKKGDKGMNASPEGVAAYLTENAAAL

Sequences:

>Translated_200_residues
MSVLVGKQAPDFTVPAVLGNGEIVDSFTLSSAIKGKYGLVFFYPLDFTFVCPSELIALDNRMADFKARNVEVVAVSIDSH
FTHNAWRNTPVNNGGIGQVKYTMAADMKHEIAKAYDVESEGGVAFRGAFLIDDKGVVRSQIINDLPLGRNMEELIRLVDA
LQFHEEHGEVCPANWKKGDKGMNASPEGVAAYLTENAAAL
>Mature_199_residues
SVLVGKQAPDFTVPAVLGNGEIVDSFTLSSAIKGKYGLVFFYPLDFTFVCPSELIALDNRMADFKARNVEVVAVSIDSHF
THNAWRNTPVNNGGIGQVKYTMAADMKHEIAKAYDVESEGGVAFRGAFLIDDKGVVRSQIINDLPLGRNMEELIRLVDAL
QFHEEHGEVCPANWKKGDKGMNASPEGVAAYLTENAAAL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=193, Percent_Identity=46.1139896373057, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI32455266, Length=193, Percent_Identity=46.1139896373057, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI32455264, Length=193, Percent_Identity=46.1139896373057, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=47.9166666666667, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI32483377, Length=189, Percent_Identity=48.6772486772487, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=46.1139896373057, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI5453549, Length=161, Percent_Identity=50.3105590062112, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=53.6585365853659, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786822, Length=168, Percent_Identity=34.5238095238095, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI193204376, Length=176, Percent_Identity=51.1363636363636, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32565831, Length=176, Percent_Identity=51.1363636363636, Blast_Score=178, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17554494, Length=169, Percent_Identity=47.9289940828402, Blast_Score=171, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=187, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323613, Length=194, Percent_Identity=40.7216494845361, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=40.7821229050279, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319407, Length=184, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=49.4845360824742, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=49.4845360824742, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17157991, Length=188, Percent_Identity=48.936170212766, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641739, Length=188, Percent_Identity=48.936170212766, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17738015, Length=187, Percent_Identity=45.4545454545455, Blast_Score=179, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=43.1578947368421, Blast_Score=170, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=29.7297297297297, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17975518, Length=157, Percent_Identity=29.2993630573248, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652436, Length=157, Percent_Identity=29.2993630573248, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652434, Length=157, Percent_Identity=29.2993630573248, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21765; Mature: 21634

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVGKQAPDFTVPAVLGNGEIVDSFTLSSAIKGKYGLVFFYPLDFTFVCPSELIALDN
CCEEECCCCCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEEEEECCEEEECCHHHHHHCC
RMADFKARNVEVVAVSIDSHFTHNAWRNTPVNNGGIGQVKYTMAADMKHEIAKAYDVESE
HHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
GGVAFRGAFLIDDKGVVRSQIINDLPLGRNMEELIRLVDALQFHEEHGEVCPANWKKGDK
CCEEEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMNASPEGVAAYLTENAAAL
CCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SVLVGKQAPDFTVPAVLGNGEIVDSFTLSSAIKGKYGLVFFYPLDFTFVCPSELIALDN
CEEECCCCCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEEEEECCEEEECCHHHHHHCC
RMADFKARNVEVVAVSIDSHFTHNAWRNTPVNNGGIGQVKYTMAADMKHEIAKAYDVESE
HHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCC
GGVAFRGAFLIDDKGVVRSQIINDLPLGRNMEELIRLVDALQFHEEHGEVCPANWKKGDK
CCEEEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMNASPEGVAAYLTENAAAL
CCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]