Click here to switch to the map view.

The map label for this gene is dctB [H]

Identifier: 77460678

GI number: 77460678

Start: 5028055

End: 5029815

Strand: Direct

Name: dctB [H]

Synonym: Pfl01_4457

Alternate gene names: 77460678

Gene position: 5028055-5029815 (Clockwise)

Preceding gene: 77460677

Following gene: 77460679

Centisome position: 78.09

GC content: 64.45

Gene sequence:

>1761_bases
ATGCTGCCGACTTCCCGTACCTTGCGTCTGTCGTTGTATACCCTGCTGATCATCGCTGGCGCCGCCCTCGCCGCGACGCT
TGCGATCCGCCACGCCGAGCGCCAGGCGCTGGAAGAAGACGCCGCGCGGGCCAATCAACAGCTGGCGCTGTATGCCAACT
CGCTGCACACCCTGATCGACCGCTATCGCGCCTTGCCCGCCGTGCTCGCACTGGACCCGCAATTACGCGCGGCGCTGGCC
GGTCCTGTGAGTACCGAACAGCAAACGGCGCTCAATCTGAAACTGGAAAAGATCAACGGCGCTGCACAATCCTCGACCCT
TGAACTGCTCGACCGCACCGGCCTGGCGGTGGCGGCCAGCAACTGGCGTCTGCCCAGCAGTTACGTCGGTCACAACTACG
GCTTTCGCCCCTATTTCAGTCAGACCCGCACTCAGGGCACCGGGCGTTTCTACGCAGTCGGTGTGACCAGCGGGATTCCC
GGTTACTTCCTGTCCAGCGCCGTGCTCGGCGACAACGGCGAGTTCCTCGGGGCGATGGTGGTCAAGCTCGAATTCCCCGA
ACTCGAACGCGAATGGAGCCAGGGCAGCGACACCCTGCTGGTCAGCGATGCGCGCGGGATCATCTTCATCGCCAACCAGC
CCGGCTGGCGCTATCGCCTGCTGCACCCGCTGAGCCCGGCCGATTACCGCGAGATCAAGGCCACCCGCCAATACGACAAA
CAGTCGCTGGTGCCGCTGACGCATCTGGCGCTGCGCAGCTTCGACGACAACAGTGATCTGCGCCGCGTCGAAGGCCCGCA
AGGCACGGCGGATTACCTGTGGGAATCGCTGCCGCTGACCGCCGAAGGCTGGACCCTGCATCTGCTGCGCCGTCCGCAAC
TGTCCTTCGAGGATCAGCGCAATGCCGGGCTCGCCGCTGCCGGGGTATGGCTGGCGCTGGTGTTCCTGTTGCTGTTCCTC
AACCAGCGCTGGCGTCTGGCGAAGATGCGCCAGCGCAGCCGCGAAGAGCTTGAGCAACTGGTCGAGGAACGCACCCGCGA
CTTGCGCACCGCCCAGGACGGTCTGGTGCAATCAGCGAAACTGGCGGCACTGGGGCAGATGTCCGCCGCGCTGGCCCACG
AAATCAATCAGCCGTTGACCGCCCAGCGCATGCAACTGGCGACCCTGCGCCTGCTGCTCGATCATGGCCGGGTCGATGAC
GCCTACAAGGCACTCAAACCGGTGGATGACATGCTCACGCGCATGGCCGCCCTTACCGGCCACCTGAAAACCTTTGCCCG
CAAGAGCCCCAGCGGCCTGCGCGAACGGCTGGATCTGGCGACGGTGGTCGATCAGGCCCTGCAATTGCTCGATGCGCGCC
TGCGCGATGAACAGGTCAGTCTGGTGCTGCACCTGACCCGTCCGGCCTGGGTGCGTGGCGATGCGATCCGCCTGGAGCAG
GTGCTGATCAACCTGCTGCGCAATGCCCTCGATGCCATGCAGGGCAAGCCGTGCAAGCGTCTGGAAATCCGTCTGGACGC
CGACGAGCAACTGTGGCGCCTGAGCGTCATCGACAACGGCGGCGGCATCGCCGACGAACATCTGGGTCAAGTGTTCGATC
CGTTCTTCACCACCAAACCTGTGGGTGACGGGTTGGGTCTGGGGCTGGCGGTATCCTTCGCCATCGTCCATGAATCCGGC
GGGCGTCTGTGCGTCGAAAATGGTGACAATGGCGCAGTGTTCAGCCTGACCTTGCCGATCGATCTGGAGGCGCACATCTG
A

Upstream 100 bases:

>100_bases
AGGATGAGCGAAACGTACGTCTGAGTCGCTTCGACAATACGCCGTACCGAGCGGGCACATGCTATCGTGCCCGCCCGTCC
TGCCACCCCTTTGACCCAGC

Downstream 100 bases:

>100_bases
TGCTCAATTCCGTGATGGTGGTGGATGACGAAAGCAGCATTCGCAGTGCCGTCGAGCAATGGCTGAGCCTGTCCGGGTTC
GAGGTGCAGCTGTTCAGCCG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MLPTSRTLRLSLYTLLIIAGAALAATLAIRHAERQALEEDAARANQQLALYANSLHTLIDRYRALPAVLALDPQLRAALA
GPVSTEQQTALNLKLEKINGAAQSSTLELLDRTGLAVAASNWRLPSSYVGHNYGFRPYFSQTRTQGTGRFYAVGVTSGIP
GYFLSSAVLGDNGEFLGAMVVKLEFPELEREWSQGSDTLLVSDARGIIFIANQPGWRYRLLHPLSPADYREIKATRQYDK
QSLVPLTHLALRSFDDNSDLRRVEGPQGTADYLWESLPLTAEGWTLHLLRRPQLSFEDQRNAGLAAAGVWLALVFLLLFL
NQRWRLAKMRQRSREELEQLVEERTRDLRTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDD
AYKALKPVDDMLTRMAALTGHLKTFARKSPSGLRERLDLATVVDQALQLLDARLRDEQVSLVLHLTRPAWVRGDAIRLEQ
VLINLLRNALDAMQGKPCKRLEIRLDADEQLWRLSVIDNGGGIADEHLGQVFDPFFTTKPVGDGLGLGLAVSFAIVHESG
GRLCVENGDNGAVFSLTLPIDLEAHI

Sequences:

>Translated_586_residues
MLPTSRTLRLSLYTLLIIAGAALAATLAIRHAERQALEEDAARANQQLALYANSLHTLIDRYRALPAVLALDPQLRAALA
GPVSTEQQTALNLKLEKINGAAQSSTLELLDRTGLAVAASNWRLPSSYVGHNYGFRPYFSQTRTQGTGRFYAVGVTSGIP
GYFLSSAVLGDNGEFLGAMVVKLEFPELEREWSQGSDTLLVSDARGIIFIANQPGWRYRLLHPLSPADYREIKATRQYDK
QSLVPLTHLALRSFDDNSDLRRVEGPQGTADYLWESLPLTAEGWTLHLLRRPQLSFEDQRNAGLAAAGVWLALVFLLLFL
NQRWRLAKMRQRSREELEQLVEERTRDLRTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDD
AYKALKPVDDMLTRMAALTGHLKTFARKSPSGLRERLDLATVVDQALQLLDARLRDEQVSLVLHLTRPAWVRGDAIRLEQ
VLINLLRNALDAMQGKPCKRLEIRLDADEQLWRLSVIDNGGGIADEHLGQVFDPFFTTKPVGDGLGLGLAVSFAIVHESG
GRLCVENGDNGAVFSLTLPIDLEAHI
>Mature_586_residues
MLPTSRTLRLSLYTLLIIAGAALAATLAIRHAERQALEEDAARANQQLALYANSLHTLIDRYRALPAVLALDPQLRAALA
GPVSTEQQTALNLKLEKINGAAQSSTLELLDRTGLAVAASNWRLPSSYVGHNYGFRPYFSQTRTQGTGRFYAVGVTSGIP
GYFLSSAVLGDNGEFLGAMVVKLEFPELEREWSQGSDTLLVSDARGIIFIANQPGWRYRLLHPLSPADYREIKATRQYDK
QSLVPLTHLALRSFDDNSDLRRVEGPQGTADYLWESLPLTAEGWTLHLLRRPQLSFEDQRNAGLAAAGVWLALVFLLLFL
NQRWRLAKMRQRSREELEQLVEERTRDLRTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDD
AYKALKPVDDMLTRMAALTGHLKTFARKSPSGLRERLDLATVVDQALQLLDARLRDEQVSLVLHLTRPAWVRGDAIRLEQ
VLINLLRNALDAMQGKPCKRLEIRLDADEQLWRLSVIDNGGGIADEHLGQVFDPFFTTKPVGDGLGLGLAVSFAIVHESG
GRLCVENGDNGAVFSLTLPIDLEAHI

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=32.3770491803279, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=31.4893617021277, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=257, Percent_Identity=29.5719844357977, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=266, Percent_Identity=27.4436090225564, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64897; Mature: 64897

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPTSRTLRLSLYTLLIIAGAALAATLAIRHAERQALEEDAARANQQLALYANSLHTLID
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHH
RYRALPAVLALDPQLRAALAGPVSTEQQTALNLKLEKINGAAQSSTLELLDRTGLAVAAS
HHHHHHHHEECCHHHHHHHCCCCCCCCHHHHEEEEEECCCCHHHHHHHHHHHCCCEEEEC
NWRLPSSYVGHNYGFRPYFSQTRTQGTGRFYAVGVTSGIPGYFLSSAVLGDNGEFLGAMV
CCCCCHHHCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEE
VKLEFPELEREWSQGSDTLLVSDARGIIFIANQPGWRYRLLHPLSPADYREIKATRQYDK
EEEECCHHHHHHCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCH
QSLVPLTHLALRSFDDNSDLRRVEGPQGTADYLWESLPLTAEGWTLHLLRRPQLSFEDQR
HCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
NAGLAAAGVWLALVFLLLFLNQRWRLAKMRQRSREELEQLVEERTRDLRTAQDGLVQSAK
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDDAYKALKPVDDMLTRMAALTG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHH
HLKTFARKSPSGLRERLDLATVVDQALQLLDARLRDEQVSLVLHLTRPAWVRGDAIRLEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHHHHH
VLINLLRNALDAMQGKPCKRLEIRLDADEQLWRLSVIDNGGGIADEHLGQVFDPFFTTKP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCC
VGDGLGLGLAVSFAIVHESGGRLCVENGDNGAVFSLTLPIDLEAHI
CCCCCCHHHHEEEEEEECCCCEEEEEECCCCEEEEEEEEEEEECCC
>Mature Secondary Structure
MLPTSRTLRLSLYTLLIIAGAALAATLAIRHAERQALEEDAARANQQLALYANSLHTLID
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHH
RYRALPAVLALDPQLRAALAGPVSTEQQTALNLKLEKINGAAQSSTLELLDRTGLAVAAS
HHHHHHHHEECCHHHHHHHCCCCCCCCHHHHEEEEEECCCCHHHHHHHHHHHCCCEEEEC
NWRLPSSYVGHNYGFRPYFSQTRTQGTGRFYAVGVTSGIPGYFLSSAVLGDNGEFLGAMV
CCCCCHHHCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCEEEEEE
VKLEFPELEREWSQGSDTLLVSDARGIIFIANQPGWRYRLLHPLSPADYREIKATRQYDK
EEEECCHHHHHHCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCH
QSLVPLTHLALRSFDDNSDLRRVEGPQGTADYLWESLPLTAEGWTLHLLRRPQLSFEDQR
HCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCC
NAGLAAAGVWLALVFLLLFLNQRWRLAKMRQRSREELEQLVEERTRDLRTAQDGLVQSAK
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALGQMSAALAHEINQPLTAQRMQLATLRLLLDHGRVDDAYKALKPVDDMLTRMAALTG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHH
HLKTFARKSPSGLRERLDLATVVDQALQLLDARLRDEQVSLVLHLTRPAWVRGDAIRLEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEECCCHHHHHH
VLINLLRNALDAMQGKPCKRLEIRLDADEQLWRLSVIDNGGGIADEHLGQVFDPFFTTKP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCC
VGDGLGLGLAVSFAIVHESGGRLCVENGDNGAVFSLTLPIDLEAHI
CCCCCCHHHHEEEEEEECCCCEEEEEECCCCEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]