Click here to switch to the map view.

The map label for this gene is panE [H]

Identifier: 77460643

GI number: 77460643

Start: 4978927

End: 4979844

Strand: Direct

Name: panE [H]

Synonym: Pfl01_4422

Alternate gene names: 77460643

Gene position: 4978927-4979844 (Clockwise)

Preceding gene: 77460640

Following gene: 77460644

Centisome position: 77.33

GC content: 66.12

Gene sequence:

>918_bases
ATGTCCACCCCCTGGCATGTCCTCGGCGCCGGAAGTCTCGGCACGCTCTGGGCCACGCGCCTGGCCCGGGCCGGCCTGCC
GGTTCGGTTGATCCTGCGCGACATTGACCGCTTGCACGACTATGCAACGGCGGGCGGCCTGACCCTCGTCGAACAAGGCG
TGGCCAGCAGTTACGCCATCCCCGGCGAAACCCCGGACAGCCCCGAACCGATCCGCCGCCTGCTCGTGGCGTGTAAGGCC
TACGACGCCGAAGCGGCTGTGGCCGGACTTGCCCATCGCCTGGCACCGGACGCCGAGCTGATCCTCTTGCAGAACGGCCT
CGGCAGCCAGGAAGCGGTCGCCGCGCGAGTCCCGCAGGCCCGCTGCATCAGCGCCTCCAGCACCGAAGGCGCCTTTCGCG
ACGGCGACTGGCGCGTGGTGTTCGCCGGCCACGGTTACACCTGGCTGGGGGACGCCGGTCATCCGGTAGCGCCGATCTGG
CTGGACGATCTCGAGGCGGCGAAAATCCCCCATGAATGGAGCGCCGATATCCTCACTCGTCTGTGGCGCAAACTGGCACT
CAACTGTGCAATCAATCCGCTGACGGTGCTGCACGACTGCCGCAACGGTGGCTTGCAGCAACATCACTGCGAAGTCGCCA
CGCTGTGCGGCGAACTGACCGAGCTGCTCGAACGCTGCGGGCAACCGGCGGCGGCGGACAACCTGCAACAGGAAGTGGAG
CGGGTGATCCAGGCCACGGCGGCGAATTTCTCGTCCATGTATCAGGACGTGGCCAGCCAGCGCCGCACCGAGATCAGCTA
TTTGCTTGGGCATGCCTGCAAGGTTGCAGAGCGTCATCAGTTGAACCTGCCGCATCTCAAGCAGTTGCAGCAGCGCCTGA
CTGCCCATCTGCACAGTCTCGGATTGCCCGTCGACTGA

Upstream 100 bases:

>100_bases
GCGCGCTTGGCTTGCGGTTAAAATCGGGCTCATTATAACGGGTCTTTTCCCACCGACACGGCGAGCCTTGCATGCCTGTA
CCTTACCGAGTGAAAAACTG

Downstream 100 bases:

>100_bases
GCAGCGGCTACGCTGGCCACTTGTTCCTTTGCTGCGATAAACCTGATGCCATTGCGCCAGCGTCTTGAAAACCTGCCGGT
CGGCCAGAAACTGCTGGCCG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSTPWHVLGAGSLGTLWATRLARAGLPVRLILRDIDRLHDYATAGGLTLVEQGVASSYAIPGETPDSPEPIRRLLVACKA
YDAEAAVAGLAHRLAPDAELILLQNGLGSQEAVAARVPQARCISASSTEGAFRDGDWRVVFAGHGYTWLGDAGHPVAPIW
LDDLEAAKIPHEWSADILTRLWRKLALNCAINPLTVLHDCRNGGLQQHHCEVATLCGELTELLERCGQPAAADNLQQEVE
RVIQATAANFSSMYQDVASQRRTEISYLLGHACKVAERHQLNLPHLKQLQQRLTAHLHSLGLPVD

Sequences:

>Translated_305_residues
MSTPWHVLGAGSLGTLWATRLARAGLPVRLILRDIDRLHDYATAGGLTLVEQGVASSYAIPGETPDSPEPIRRLLVACKA
YDAEAAVAGLAHRLAPDAELILLQNGLGSQEAVAARVPQARCISASSTEGAFRDGDWRVVFAGHGYTWLGDAGHPVAPIW
LDDLEAAKIPHEWSADILTRLWRKLALNCAINPLTVLHDCRNGGLQQHHCEVATLCGELTELLERCGQPAAADNLQQEVE
RVIQATAANFSSMYQDVASQRRTEISYLLGHACKVAERHQLNLPHLKQLQQRLTAHLHSLGLPVD
>Mature_304_residues
STPWHVLGAGSLGTLWATRLARAGLPVRLILRDIDRLHDYATAGGLTLVEQGVASSYAIPGETPDSPEPIRRLLVACKAY
DAEAAVAGLAHRLAPDAELILLQNGLGSQEAVAARVPQARCISASSTEGAFRDGDWRVVFAGHGYTWLGDAGHPVAPIWL
DDLEAAKIPHEWSADILTRLWRKLALNCAINPLTVLHDCRNGGLQQHHCEVATLCGELTELLERCGQPAAADNLQQEVER
VIQATAANFSSMYQDVASQRRTEISYLLGHACKVAERHQLNLPHLKQLQQRLTAHLHSLGLPVD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=286, Percent_Identity=34.6153846153846, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33141; Mature: 33010

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPWHVLGAGSLGTLWATRLARAGLPVRLILRDIDRLHDYATAGGLTLVEQGVASSYAI
CCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PGETPDSPEPIRRLLVACKAYDAEAAVAGLAHRLAPDAELILLQNGLGSQEAVAARVPQA
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHH
RCISASSTEGAFRDGDWRVVFAGHGYTWLGDAGHPVAPIWLDDLEAAKIPHEWSADILTR
HHCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCEECCCHHHHCCCCCCCHHHHHH
LWRKLALNCAINPLTVLHDCRNGGLQQHHCEVATLCGELTELLERCGQPAAADNLQQEVE
HHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RVIQATAANFSSMYQDVASQRRTEISYLLGHACKVAERHQLNLPHLKQLQQRLTAHLHSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GLPVD
CCCCC
>Mature Secondary Structure 
STPWHVLGAGSLGTLWATRLARAGLPVRLILRDIDRLHDYATAGGLTLVEQGVASSYAI
CCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PGETPDSPEPIRRLLVACKAYDAEAAVAGLAHRLAPDAELILLQNGLGSQEAVAARVPQA
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHH
RCISASSTEGAFRDGDWRVVFAGHGYTWLGDAGHPVAPIWLDDLEAAKIPHEWSADILTR
HHCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCEECCCHHHHCCCCCCCHHHHHH
LWRKLALNCAINPLTVLHDCRNGGLQQHHCEVATLCGELTELLERCGQPAAADNLQQEVE
HHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RVIQATAANFSSMYQDVASQRRTEISYLLGHACKVAERHQLNLPHLKQLQQRLTAHLHSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GLPVD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]