Click here to switch to the map view.

The map label for this gene is edd [H]

Identifier: 77460596

GI number: 77460596

Start: 4929232

End: 4931058

Strand: Reverse

Name: edd [H]

Synonym: Pfl01_4375

Alternate gene names: 77460596

Gene position: 4931058-4929232 (Counterclockwise)

Preceding gene: 77460605

Following gene: 77460595

Centisome position: 76.59

GC content: 63.38

Gene sequence:

>1827_bases
ATGCATCCCCGCGTTCTTGAGGTCACCGAACGGCTTATCGCCCGCAGCCGCGCCACGCGTCAGGCTTACCTTGCGCTGAT
TCGCGGCGCTGCAACTGACGGGCCGATGCGCGGCAAACTGCAATGCGCCAACTTCGCCCACGGCGTGGCCGGGTGTGGCA
GCGAAGACAAGCACAGCCTGCGGATGATGAACTCGGCCAACATCGCGATTGTTTCGTCATATAACGACATGCTCTCGGCG
CACCAGCCGTACGAAGTCTTCCCGGAACAGATCAAGAACGCCCTGCGCGAAATCGGTTCGGTCGGCCAGTTCGCCGGCGG
CACGCCTGCCATGTGCGACGGCGTGACCCAGGGCGAGCCGGGCATGGAGCTAAGCCTGCCGAGCCGCGAAGTGATCGCAA
TGTCGACGGCGGTGGCGCTGTCCCACAACATGTTCGACGGCGCGCTGATGCTCGGCATCTGCGACAAGATCGTGCCGGGC
CTGATGATGGGCTCTCTGCGTTTTGGTCACTTGCCGACGATTTTCGTCCCGGGCGGGCCGATGGTCTCGGGGATTTCCAA
CAAGGAAAAAGCCGACGTGCGGCAGAAGTACGCCGAAGGCAAGGCAACCCGCGAAGAGCTGCTGGAATCGGAAATGAAGT
CCTACCACAGCCCCGGCACCTGCACCTTCTACGGCACCGCCAACACCAACCAGTTGCTGATGGAAGTCATGGGCCTGCAC
TTGCCGGGCGCATCGTTCGTCAACCCGAACACGCCGCTGCGTGAGGCCCTGACTCGCGAAGCCGCGCATCAGGTCACGCG
CCTGACCAAACAGAATGGCAACTTCCTGCCGATCGGCGAAATCGTCGACGAGAAGGCGCTGGTCAACTCGATCGTCGCGC
TGCACGCCACCGGCGGCTCGACCAACCACACCCTGCATATGCCGGCCATCGCCATGGCGGCAGGCATTCAACTGACCTGG
CAGGACATGGCCGACCTCTCCGAAGTCGTGCCGACCCTGAGCCACGTATATCCGAACGGCAAGGCTGACATCAACCACTT
CCAGGCGGCGGGCGGCATGTCGTTCCTGATCCGCGAACTGCTCGAAGCCGGCCTGTTGCACGAAGACGTCAACACCGTGC
TCGGCCACGGCCTGAGCCAGTACACCAAGGAGCCGTTCCTCGATAACGGCAAACTGGTGTGGCGCGAAGGCCCGACCGAA
AGCCTCGACGAAAACATCCTGCGTCCGGTGGCCCGTGCGTTCTCGGCAGAGGGCGGCTTGCGCGTGATGGAGGGCAACCT
CGGTCGCGGCGTGATGAAAGTGTCCGCCGTGGCGCTGGAAAACCAGATCGTCGAAGCACCGGCCATGGTGTTCCAGGATC
AGCAGGATCTGGCCGACGCTTTCAAGGCCGGTCTGCTGGAGAAGGATTTCGTCGCGGTGATGCGCTTCCAGGGCCCGCGC
TCCAACGGCATGCCGGAGCTGCACAAGATGACGCCGTTCCTCGGCGTGCTGCAGGATCGCGGCTTCAAGGTGGCGCTGGT
GACGGACGGGCGCATGTCCGGCGCATCCGGGAAAATTCCGGCGGCCATTCACGTCAGCCCCGAGGCTTATGTCGGCGGCG
CTTTGGCGCGCGTGCAAGAGGGCGATATCATCCGCGTCGATGGCGTCAAAGGCACTTTGGAACTCAAGGTGGACGCCGCC
GAATTCGCAGCGCGCGAACCCGCCAAAGGCCTGTTGGGCAACAACATCGGCAGCGGTCGCGAACTGTTTGGCTTCATGCG
TTTGGCCTTCAGCTCGGCGGAGCAGGGCGCCAGCGCCTTCACTTCTGCCCTGGAGACGCTTAATTGA

Upstream 100 bases:

>100_bases
GTCCGAATGATCAACAAAACCGTTCGTCATCCCACGCGAACGGGCTTTTGATCAGCATAGACAATCAGGTCGCCACATCC
GTTAGCCTGGAGTTCTACAC

Downstream 100 bases:

>100_bases
AACTGGCTTTGGTCGGTGACATCGGAGGCACCAACGCGCGGTTCGCGTTGTGGAAAGATCAGCAGCTCGAATCGGTTCAG
GTGCTGGCCACGGCCGACCA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHPRVLEVTERLIARSRATRQAYLALIRGAATDGPMRGKLQCANFAHGVAGCGSEDKHSLRMMNSANIAIVSSYNDMLSA
HQPYEVFPEQIKNALREIGSVGQFAGGTPAMCDGVTQGEPGMELSLPSREVIAMSTAVALSHNMFDGALMLGICDKIVPG
LMMGSLRFGHLPTIFVPGGPMVSGISNKEKADVRQKYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLH
LPGASFVNPNTPLREALTREAAHQVTRLTKQNGNFLPIGEIVDEKALVNSIVALHATGGSTNHTLHMPAIAMAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLEAGLLHEDVNTVLGHGLSQYTKEPFLDNGKLVWREGPTE
SLDENILRPVARAFSAEGGLRVMEGNLGRGVMKVSAVALENQIVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPR
SNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQEGDIIRVDGVKGTLELKVDAA
EFAAREPAKGLLGNNIGSGRELFGFMRLAFSSAEQGASAFTSALETLN

Sequences:

>Translated_608_residues
MHPRVLEVTERLIARSRATRQAYLALIRGAATDGPMRGKLQCANFAHGVAGCGSEDKHSLRMMNSANIAIVSSYNDMLSA
HQPYEVFPEQIKNALREIGSVGQFAGGTPAMCDGVTQGEPGMELSLPSREVIAMSTAVALSHNMFDGALMLGICDKIVPG
LMMGSLRFGHLPTIFVPGGPMVSGISNKEKADVRQKYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLH
LPGASFVNPNTPLREALTREAAHQVTRLTKQNGNFLPIGEIVDEKALVNSIVALHATGGSTNHTLHMPAIAMAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLEAGLLHEDVNTVLGHGLSQYTKEPFLDNGKLVWREGPTE
SLDENILRPVARAFSAEGGLRVMEGNLGRGVMKVSAVALENQIVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPR
SNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQEGDIIRVDGVKGTLELKVDAA
EFAAREPAKGLLGNNIGSGRELFGFMRLAFSSAEQGASAFTSALETLN
>Mature_608_residues
MHPRVLEVTERLIARSRATRQAYLALIRGAATDGPMRGKLQCANFAHGVAGCGSEDKHSLRMMNSANIAIVSSYNDMLSA
HQPYEVFPEQIKNALREIGSVGQFAGGTPAMCDGVTQGEPGMELSLPSREVIAMSTAVALSHNMFDGALMLGICDKIVPG
LMMGSLRFGHLPTIFVPGGPMVSGISNKEKADVRQKYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLH
LPGASFVNPNTPLREALTREAAHQVTRLTKQNGNFLPIGEIVDEKALVNSIVALHATGGSTNHTLHMPAIAMAAGIQLTW
QDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIRELLEAGLLHEDVNTVLGHGLSQYTKEPFLDNGKLVWREGPTE
SLDENILRPVARAFSAEGGLRVMEGNLGRGVMKVSAVALENQIVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPR
SNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQEGDIIRVDGVKGTLELKVDAA
EFAAREPAKGLLGNNIGSGRELFGFMRLAFSSAEQGASAFTSALETLN

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=64.2857142857143, Blast_Score=803, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=32.0512820512821, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI2367371, Length=483, Percent_Identity=30.0207039337474, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1786464, Length=481, Percent_Identity=29.7297297297297, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322476, Length=479, Percent_Identity=30.6889352818372, Blast_Score=180, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65130; Mature: 65130

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00845 CAP_GLY_1 ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPRVLEVTERLIARSRATRQAYLALIRGAATDGPMRGKLQCANFAHGVAGCGSEDKHSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCCCHHHH
RMMNSANIAIVSSYNDMLSAHQPYEVFPEQIKNALREIGSVGQFAGGTPAMCDGVTQGEP
HEECCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCC
GMELSLPSREVIAMSTAVALSHNMFDGALMLGICDKIVPGLMMGSLRFGHLPTIFVPGGP
CCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
MVSGISNKEKADVRQKYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLH
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCC
LPGASFVNPNTPLREALTREAAHQVTRLTKQNGNFLPIGEIVDEKALVNSIVALHATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEEECCCC
TNHTLHMPAIAMAAGIQLTWQDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIREL
CCCEEECCHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LEAGLLHEDVNTVLGHGLSQYTKEPFLDNGKLVWREGPTESLDENILRPVARAFSAEGGL
HHHCCHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RVMEGNLGRGVMKVSAVALENQIVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPR
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCC
SNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQE
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCHHHHHCCC
GDIIRVDGVKGTLELKVDAAEFAAREPAKGLLGNNIGSGRELFGFMRLAFSSAEQGASAF
CCEEEECCCCEEEEEEEEHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TSALETLN
HHHHHHCC
>Mature Secondary Structure
MHPRVLEVTERLIARSRATRQAYLALIRGAATDGPMRGKLQCANFAHGVAGCGSEDKHSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCCCHHHH
RMMNSANIAIVSSYNDMLSAHQPYEVFPEQIKNALREIGSVGQFAGGTPAMCDGVTQGEP
HEECCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCC
GMELSLPSREVIAMSTAVALSHNMFDGALMLGICDKIVPGLMMGSLRFGHLPTIFVPGGP
CCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
MVSGISNKEKADVRQKYAEGKATREELLESEMKSYHSPGTCTFYGTANTNQLLMEVMGLH
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCC
LPGASFVNPNTPLREALTREAAHQVTRLTKQNGNFLPIGEIVDEKALVNSIVALHATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHEEEECCCC
TNHTLHMPAIAMAAGIQLTWQDMADLSEVVPTLSHVYPNGKADINHFQAAGGMSFLIREL
CCCEEECCHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LEAGLLHEDVNTVLGHGLSQYTKEPFLDNGKLVWREGPTESLDENILRPVARAFSAEGGL
HHHCCHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
RVMEGNLGRGVMKVSAVALENQIVEAPAMVFQDQQDLADAFKAGLLEKDFVAVMRFQGPR
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCC
SNGMPELHKMTPFLGVLQDRGFKVALVTDGRMSGASGKIPAAIHVSPEAYVGGALARVQE
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCHHHHHCCC
GDIIRVDGVKGTLELKVDAAEFAAREPAKGLLGNNIGSGRELFGFMRLAFSSAEQGASAF
CCEEEECCCCEEEEEEEEHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TSALETLN
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]