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The map label for this gene is acsA [H]

Identifier: 77460514

GI number: 77460514

Start: 4849381

End: 4851336

Strand: Reverse

Name: acsA [H]

Synonym: Pfl01_4293

Alternate gene names: 77460514

Gene position: 4851336-4849381 (Counterclockwise)

Preceding gene: 77460520

Following gene: 77460513

Centisome position: 75.35

GC content: 62.17

Gene sequence:

>1956_bases
ATGAGTGCGGCTTCCCTGTATCCCGTTCGTCCCGAGGTTCTGGCCAATACGCTGACCGATGAGGCGACCTACAAAGCCAT
GTACCAACAGTCGGTCGTCAACCCTGACGGCTTCTGGCGCGAACAAGCCAAGCGCCTCGACTGGATCAAGCCTTTCACCA
CGGTGAAACAGACTTCGTTCGACGATCACCATGTCGACATCAAGTGGTTTGCAGACGGCACCCTGAACGTTTCCTACAAC
TGCCTCGACCGCCATCTGGCCGAGCGCGGCGATCAGGTCGCCATCATCTGGGAAGGCGACGACCCTTCCGAAAGCCGCAA
CATCACCTACCGCGAGCTGCACGAACAAGTGTGCAAGCTCGCCAACGCCCTGCGTGGCCAGGACGTACACCGCGGCGACG
TGGTGACCATTTATATGCCGATGATCCCCGAAGCCGTGGTCGCCATGCTGGCCTGCACCCGGATCGGCGCGATTCACTCG
GTGGTGTTCGGCGGCTTCTCGCCGGAAGCCCTGGCCGGTCGCATCATCGACTGCCGCTCGAAAGTGGTGATCACCGCTGA
CGAAGGCATCCGTGCCGGCAAGAAGATTTCCCTCAAGGCCAACGTCGACGACGCCCTGACCAACCCGGAAACCAGCAGCA
TCCAGAAAGTCATCGTGTGCAAGCGCACCGGCGGCGACATCAAGTGGAACCAGCATCGTGACATCTGGTACGAAGACCTG
ATGAAAGTGGCGGGCACCGTTTGCGCGCCGAAAGAGATGGGCGCCGAAGAAGCACTGTTCATCCTTTATACCTCCGGCTC
CACCGGCAAGCCGAAGGGCGTGCAGCACACCACCGGCGGCTATCTGTTGTACGCGGCCATGACTCACGAGCGCGTGTTCG
ACTACCGTCCGGGTGAAATCTACTGGTGCACCGCCGACGTCGGCTGGGTCACCGGTCACTCCTACATCGTCTACGGCCCG
CTGGCCAACGGCGCGACCACGCTGCTCTTCGAAGGCGTGCCGAACTATCCGGACATCACCCGGGTGGCGAAGATCGTCGA
CAAGCACAAGGTCAACATCCTCTACACCGCGCCGACCGCGATCCGCGCGATGATGGCTTCCGGCACCGCCGCTGTTGAAG
GCGCGGACGGCAGCAGCCTGCGTCTGCTCGGTTCGGTGGGCGAGCCGATCAACCCGGAAGCCTGGGACTGGTACTACAAG
AATGTCGGCAAGTCCCGTTGCCCGATCGTCGATACCTGGTGGCAGACCGAAACCGGCGGCAACATGATGAGCCCGCTGCC
GGGCGCTCACGCGCTGAAGCCGGGTTCGGCCGCACGTCCGTTCTTCGGTGTGGTGCCGGCGCTGGTGGACAACCTCGGCA
ACATCATCGAGGGCGAGGCCGAAGGCAATCTGGTGATTCTCGATTCGTGGCCGGGTCAGGCGCGCACCCTGTACGGCGAC
CACGACCGTTTCGTCGACACCTACTTCAAGACCTTCCGTGGCATGTACTTCACCGGTGACGGCGCCCGTCGCGATGCCGA
CGGTTACTACTGGATCACCGGTCGCGTGGACGACGTGCTCAACGTTTCCGGCCACCGCATGGGTACTGCCGAGATCGAAA
GCGCGATGGTCGCTCACCCGAAAGTCGCCGAAGCGGCGGTGGTCGGTGTGCCGCACGACATCAAGGGGCAGGGCATTTAT
GTCTATGTCACCCTGAAAAATGGCGAAGAGCCGAGCGAGCAACTGCGCCTGGAACTGAAAAACTGGGTGCGCAAGGAGAT
CGGGCCGATCGCTTCGCCGGACGTGATCCAGTGGGCGCCGGGGCTGCCGAAGACTCGTTCGGGCAAGATCATGCGCCGCA
TCCTGCGCAAGATCGCTACCGCCGAATACGAAGGGTTGGGCGACATCTCCACCCTGGCGGATCCGGGTGTGGTGCAGCAT
CTGATCGATACGCACAAGACCATGAACGTCGCGTAA

Upstream 100 bases:

>100_bases
TTTGTAGGGGCTTGTTACTACCATCGTCGAATGGTTCTATACGGGCGCCCCGGCTACAACAGGGTCATACAAAAACAACT
ATTACACCGAGGTAGGAAAG

Downstream 100 bases:

>100_bases
GCGACGGGTCTGAAGGCTGAAAAGCCCCGCCCGGCATTGCGCCGGGCGGGGCTTTTTGTTTTCCAATAATTATCGGTTTC
GTCCGTCAGGCAATTCCCAC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSAASLYPVRPEVLANTLTDEATYKAMYQQSVVNPDGFWREQAKRLDWIKPFTTVKQTSFDDHHVDIKWFADGTLNVSYN
CLDRHLAERGDQVAIIWEGDDPSESRNITYRELHEQVCKLANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHS
VVFGGFSPEALAGRIIDCRSKVVITADEGIRAGKKISLKANVDDALTNPETSSIQKVIVCKRTGGDIKWNQHRDIWYEDL
MKVAGTVCAPKEMGAEEALFILYTSGSTGKPKGVQHTTGGYLLYAAMTHERVFDYRPGEIYWCTADVGWVTGHSYIVYGP
LANGATTLLFEGVPNYPDITRVAKIVDKHKVNILYTAPTAIRAMMASGTAAVEGADGSSLRLLGSVGEPINPEAWDWYYK
NVGKSRCPIVDTWWQTETGGNMMSPLPGAHALKPGSAARPFFGVVPALVDNLGNIIEGEAEGNLVILDSWPGQARTLYGD
HDRFVDTYFKTFRGMYFTGDGARRDADGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDIKGQGIY
VYVTLKNGEEPSEQLRLELKNWVRKEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIATAEYEGLGDISTLADPGVVQH
LIDTHKTMNVA

Sequences:

>Translated_651_residues
MSAASLYPVRPEVLANTLTDEATYKAMYQQSVVNPDGFWREQAKRLDWIKPFTTVKQTSFDDHHVDIKWFADGTLNVSYN
CLDRHLAERGDQVAIIWEGDDPSESRNITYRELHEQVCKLANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHS
VVFGGFSPEALAGRIIDCRSKVVITADEGIRAGKKISLKANVDDALTNPETSSIQKVIVCKRTGGDIKWNQHRDIWYEDL
MKVAGTVCAPKEMGAEEALFILYTSGSTGKPKGVQHTTGGYLLYAAMTHERVFDYRPGEIYWCTADVGWVTGHSYIVYGP
LANGATTLLFEGVPNYPDITRVAKIVDKHKVNILYTAPTAIRAMMASGTAAVEGADGSSLRLLGSVGEPINPEAWDWYYK
NVGKSRCPIVDTWWQTETGGNMMSPLPGAHALKPGSAARPFFGVVPALVDNLGNIIEGEAEGNLVILDSWPGQARTLYGD
HDRFVDTYFKTFRGMYFTGDGARRDADGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDIKGQGIY
VYVTLKNGEEPSEQLRLELKNWVRKEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIATAEYEGLGDISTLADPGVVQH
LIDTHKTMNVA
>Mature_650_residues
SAASLYPVRPEVLANTLTDEATYKAMYQQSVVNPDGFWREQAKRLDWIKPFTTVKQTSFDDHHVDIKWFADGTLNVSYNC
LDRHLAERGDQVAIIWEGDDPSESRNITYRELHEQVCKLANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHSV
VFGGFSPEALAGRIIDCRSKVVITADEGIRAGKKISLKANVDDALTNPETSSIQKVIVCKRTGGDIKWNQHRDIWYEDLM
KVAGTVCAPKEMGAEEALFILYTSGSTGKPKGVQHTTGGYLLYAAMTHERVFDYRPGEIYWCTADVGWVTGHSYIVYGPL
ANGATTLLFEGVPNYPDITRVAKIVDKHKVNILYTAPTAIRAMMASGTAAVEGADGSSLRLLGSVGEPINPEAWDWYYKN
VGKSRCPIVDTWWQTETGGNMMSPLPGAHALKPGSAARPFFGVVPALVDNLGNIIEGEAEGNLVILDSWPGQARTLYGDH
DRFVDTYFKTFRGMYFTGDGARRDADGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHPKVAEAAVVGVPHDIKGQGIYV
YVTLKNGEEPSEQLRLELKNWVRKEIGPIASPDVIQWAPGLPKTRSGKIMRRILRKIATAEYEGLGDISTLADPGVVQHL
IDTHKTMNVA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=656, Percent_Identity=53.6585365853659, Blast_Score=690, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=669, Percent_Identity=52.6158445440957, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=52.3052464228935, Blast_Score=657, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.6377952755906, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=547, Percent_Identity=28.3363802559415, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI122937307, Length=555, Percent_Identity=27.5675675675676, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI38505220, Length=520, Percent_Identity=28.8461538461538, Blast_Score=180, Evalue=5e-45,
Organism=Homo sapiens, GI58082049, Length=512, Percent_Identity=27.34375, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI115511026, Length=552, Percent_Identity=25.5434782608696, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI157311624, Length=512, Percent_Identity=26.7578125, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI157311622, Length=512, Percent_Identity=26.7578125, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI31982927, Length=619, Percent_Identity=23.9095315024233, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI195947378, Length=436, Percent_Identity=25.2293577981651, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI187761345, Length=577, Percent_Identity=24.0901213171577, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI187761343, Length=577, Percent_Identity=24.0901213171577, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI42544134, Length=364, Percent_Identity=24.1758241758242, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI156151445, Length=395, Percent_Identity=24.3037974683544, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1790505, Length=648, Percent_Identity=67.7469135802469, Blast_Score=943, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=37.7777777777778, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=563, Percent_Identity=23.9786856127886, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693145, Length=532, Percent_Identity=24.0601503759398, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786810, Length=575, Percent_Identity=21.9130434782609, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI221142682, Length=531, Percent_Identity=21.4689265536723, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=635, Percent_Identity=51.3385826771654, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=635, Percent_Identity=51.3385826771654, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=638, Percent_Identity=22.4137931034483, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=566, Percent_Identity=22.791519434629, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=22.2648752399232, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=126, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=554, Percent_Identity=25.6317689530686, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=21.9047619047619, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=126, Percent_Identity=31.7460317460317, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=49.2979719188768, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=47.7449455676516, Blast_Score=590, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=548, Percent_Identity=23.9051094890511, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24667955, Length=658, Percent_Identity=53.0395136778115, Blast_Score=697, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=56.8872987477639, Blast_Score=646, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=57.6402321083172, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI21355225, Length=615, Percent_Identity=36.9105691056911, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24581924, Length=539, Percent_Identity=23.5621521335807, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656500, Length=532, Percent_Identity=23.1203007518797, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355181, Length=522, Percent_Identity=21.6475095785441, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859661, Length=121, Percent_Identity=33.0578512396694, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71733; Mature: 71602

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00018 EF_HAND_1 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASLYPVRPEVLANTLTDEATYKAMYQQSVVNPDGFWREQAKRLDWIKPFTTVKQTSF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCC
DDHHVDIKWFADGTLNVSYNCLDRHLAERGDQVAIIWEGDDPSESRNITYRELHEQVCKL
CCCEEEEEEEECCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHSVVFGGFSPEALAGRIIDCRS
HHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEECCC
KVVITADEGIRAGKKISLKANVDDALTNPETSSIQKVIVCKRTGGDIKWNQHRDIWYEDL
CEEEEECCCCCCCCEEEEEECCCHHHCCCCHHCCEEEEEEEECCCCCEECCCCCHHHHHH
MKVAGTVCAPKEMGAEEALFILYTSGSTGKPKGVQHTTGGYLLYAAMTHERVFDYRPGEI
HHHHCCCCCHHHCCCCCEEEEEEECCCCCCCCCCEECCCCEEEEEEEHHHHHHCCCCCEE
YWCTADVGWVTGHSYIVYGPLANGATTLLFEGVPNYPDITRVAKIVDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRAMMASGTAAVEGADGSSLRLLGSVGEPINPEAWDWYYKNVGKSRCPIVDTWWQTETGG
HHHHHHCCCEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCC
NMMSPLPGAHALKPGSAARPFFGVVPALVDNLGNIIEGEAEGNLVILDSWPGQARTLYGD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCEEEECC
HDRFVDTYFKTFRGMYFTGDGARRDADGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHP
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KVAEAAVVGVPHDIKGQGIYVYVTLKNGEEPSEQLRLELKNWVRKEIGPIASPDVIQWAP
CHHCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIATAEYEGLGDISTLADPGVVQHLIDTHKTMNVA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAASLYPVRPEVLANTLTDEATYKAMYQQSVVNPDGFWREQAKRLDWIKPFTTVKQTSF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHCCC
DDHHVDIKWFADGTLNVSYNCLDRHLAERGDQVAIIWEGDDPSESRNITYRELHEQVCKL
CCCEEEEEEEECCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
ANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHSVVFGGFSPEALAGRIIDCRS
HHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEECCC
KVVITADEGIRAGKKISLKANVDDALTNPETSSIQKVIVCKRTGGDIKWNQHRDIWYEDL
CEEEEECCCCCCCCEEEEEECCCHHHCCCCHHCCEEEEEEEECCCCCEECCCCCHHHHHH
MKVAGTVCAPKEMGAEEALFILYTSGSTGKPKGVQHTTGGYLLYAAMTHERVFDYRPGEI
HHHHCCCCCHHHCCCCCEEEEEEECCCCCCCCCCEECCCCEEEEEEEHHHHHHCCCCCEE
YWCTADVGWVTGHSYIVYGPLANGATTLLFEGVPNYPDITRVAKIVDKHKVNILYTAPTA
EEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRAMMASGTAAVEGADGSSLRLLGSVGEPINPEAWDWYYKNVGKSRCPIVDTWWQTETGG
HHHHHHCCCEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCC
NMMSPLPGAHALKPGSAARPFFGVVPALVDNLGNIIEGEAEGNLVILDSWPGQARTLYGD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCEEEECC
HDRFVDTYFKTFRGMYFTGDGARRDADGYYWITGRVDDVLNVSGHRMGTAEIESAMVAHP
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCC
KVAEAAVVGVPHDIKGQGIYVYVTLKNGEEPSEQLRLELKNWVRKEIGPIASPDVIQWAP
CHHCEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIATAEYEGLGDISTLADPGVVQHLIDTHKTMNVA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]