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The map label for this gene is fabB [H]

Identifier: 77460434

GI number: 77460434

Start: 4755213

End: 4756433

Strand: Direct

Name: fabB [H]

Synonym: Pfl01_4213

Alternate gene names: 77460434

Gene position: 4755213-4756433 (Clockwise)

Preceding gene: 77460433

Following gene: 77460435

Centisome position: 73.86

GC content: 62.41

Gene sequence:

>1221_bases
ATGCGCCGCGTCGTTATCACTGGTCTGGGCATCGTTTCGTGCCTGGGCAATGACAAAGAGACCGTCTCCGCTAACCTGCG
TGCAAGCCGCCCTGGCATCCGGTTCAACCCGGAATACGCCGAAATGGGTCTGCGTAGCCAGGTTTCCGGCTCCATCGACC
TCAACCTTGAAGAGCTGATCGATCGCAAGATCTATCGCTTCGTCGGCCACGCAGCGGCTTACGCCTACCTGGCCATGAAA
GACGCCATCGCCGACTCCGGTCTGACCGAAGAGCAAGTGTCCAACCCGCGTACCGGCCTGATCGCAGGTTCCGGCGGCGC
GTCGACCCTGAACCAGATGGAAGCGCTGGACATCCTGCGCGAGAAAGGCGTCAAGCGCGTCGGCCCATACCGTGTAACGC
GGACCATGAGCAGCACCGTTTCGGCTTGCCTGGCCACGCCGTTCAAGATCAAGGGCCTGAACTACTCCATCGCTTCTGCC
TGCGCCACCAGTGCTCACTGCATCGGTACCGCCATGGAACAGATCCAGATGGGCAAGCAGGACATCGTGTTCGCCGGCGG
CGGTGAAGAGGAGCACTGGAGCCAGTCGTTCCTGTTCGACGCAATGGGCGCTCTGTCCAGCAAGCGTAACGACACCCCGG
AACAAGCCTCCCGCGCCTACGACGCCGACCGTGACGGTTTCGTCATCGCTGGCGGTGGCGGCATGGTCGTGGTCGAGGAG
CTGGAACACGCTCTGGCCCGTGGCGCGAAAATCTACGCGGAAATCGTTGGCTACGGCGCAACGTCCGACGGCTACGACAT
GGTGGCCCCGAGCGGCGAAGGCGCGATCCGCTGCATGCAGCAGGCGCTGTCCACCGTCGATACCCCGATCGACTACCTGA
ACACCCACGGCACTTCGACTCCGGTCGGCGACGTCGCGGAAATGAAAGGTGTGCGTGAAGTATTCGGCGACAAGGCCCCG
GCCATCAGCTCCACCAAGAGCCTGTCGGGTCACTCCCTGGGCGCCGCCGGCGTTCACGAAGCGATCTACTGCATGCTGAT
GATGGAAGGCAACTTCATCGCCGGTTCGGCCAACATCGACGAACTGGACCCTGAAGTGGCCGATCTGCCGGTGCTGACCA
AGACCCGCGAGAACGCCACCATCAACACCGTGATGAGCAACAGCTTCGGCTTCGGTGGCACCAACGCCACCCTCGTGCTG
AAGCGCTGGGAAGGCAAGTAA

Upstream 100 bases:

>100_bases
CCGACGGTTCGGTGACTGTCGACGGTCGCGAAATCTACACCGCCGAAGGCCTTCGCGTCGGCGTGTTCACCTCCACTGAC
AACTTCTAAGGGTTATTCGC

Downstream 100 bases:

>100_bases
TTCCCTCCCGCTGAGCCGCACATGAAAACGCCCCGACCGGTTCGGGGCGTTTTTTTTCGCTTGGAGAAAGGCATTTTCAG
CGGCGCCAAGATGAAACGTT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRVVITGLGIVSCLGNDKETVSANLRASRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIYRFVGHAAAYAYLAMK
DAIADSGLTEEQVSNPRTGLIAGSGGASTLNQMEALDILREKGVKRVGPYRVTRTMSSTVSACLATPFKIKGLNYSIASA
CATSAHCIGTAMEQIQMGKQDIVFAGGGEEEHWSQSFLFDAMGALSSKRNDTPEQASRAYDADRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMQQALSTVDTPIDYLNTHGTSTPVGDVAEMKGVREVFGDKAP
AISSTKSLSGHSLGAAGVHEAIYCMLMMEGNFIAGSANIDELDPEVADLPVLTKTRENATINTVMSNSFGFGGTNATLVL
KRWEGK

Sequences:

>Translated_406_residues
MRRVVITGLGIVSCLGNDKETVSANLRASRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIYRFVGHAAAYAYLAMK
DAIADSGLTEEQVSNPRTGLIAGSGGASTLNQMEALDILREKGVKRVGPYRVTRTMSSTVSACLATPFKIKGLNYSIASA
CATSAHCIGTAMEQIQMGKQDIVFAGGGEEEHWSQSFLFDAMGALSSKRNDTPEQASRAYDADRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMQQALSTVDTPIDYLNTHGTSTPVGDVAEMKGVREVFGDKAP
AISSTKSLSGHSLGAAGVHEAIYCMLMMEGNFIAGSANIDELDPEVADLPVLTKTRENATINTVMSNSFGFGGTNATLVL
KRWEGK
>Mature_406_residues
MRRVVITGLGIVSCLGNDKETVSANLRASRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIYRFVGHAAAYAYLAMK
DAIADSGLTEEQVSNPRTGLIAGSGGASTLNQMEALDILREKGVKRVGPYRVTRTMSSTVSACLATPFKIKGLNYSIASA
CATSAHCIGTAMEQIQMGKQDIVFAGGGEEEHWSQSFLFDAMGALSSKRNDTPEQASRAYDADRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMQQALSTVDTPIDYLNTHGTSTPVGDVAEMKGVREVFGDKAP
AISSTKSLSGHSLGAAGVHEAIYCMLMMEGNFIAGSANIDELDPEVADLPVLTKTRENATINTVMSNSFGFGGTNATLVL
KRWEGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=34.7721822541966, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=44.2028985507246, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI41872631, Length=340, Percent_Identity=27.3529411764706, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=66.7487684729064, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=38.9294403892944, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=34.7721822541966, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=41.2213740458015, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=25.4901960784314, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=386, Percent_Identity=23.8341968911917, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=31.4606741573034, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=36.21103117506, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI19920632, Length=335, Percent_Identity=28.0597014925373, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221330659, Length=335, Percent_Identity=28.0597014925373, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=340, Percent_Identity=23.2352941176471, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43049; Mature: 43049

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGLGIVSCLGNDKETVSANLRASRPGIRFNPEYAEMGLRSQVSGSIDLNLEELI
CCEEEEECCHHHHHCCCCHHHEEECCCCCCCCCEECCHHHHHCCHHHCCCCCCCCHHHHH
DRKIYRFVGHAAAYAYLAMKDAIADSGLTEEQVSNPRTGLIAGSGGASTLNQMEALDILR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHH
EKGVKRVGPYRVTRTMSSTVSACLATPFKIKGLNYSIASACATSAHCIGTAMEQIQMGKQ
HCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEEEHWSQSFLFDAMGALSSKRNDTPEQASRAYDADRDGFVIAGGGGMVVVEE
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMQQALSTVDTPIDYLNTHGTST
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCC
PVGDVAEMKGVREVFGDKAPAISSTKSLSGHSLGAAGVHEAIYCMLMMEGNFIAGSANID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCEEECCCCCC
ELDPEVADLPVLTKTRENATINTVMSNSFGFGGTNATLVLKRWEGK
CCCCCHHCCCCEEECCCCCEEEEEECCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRRVVITGLGIVSCLGNDKETVSANLRASRPGIRFNPEYAEMGLRSQVSGSIDLNLEELI
CCEEEEECCHHHHHCCCCHHHEEECCCCCCCCCEECCHHHHHCCHHHCCCCCCCCHHHHH
DRKIYRFVGHAAAYAYLAMKDAIADSGLTEEQVSNPRTGLIAGSGGASTLNQMEALDILR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHH
EKGVKRVGPYRVTRTMSSTVSACLATPFKIKGLNYSIASACATSAHCIGTAMEQIQMGKQ
HCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEEEHWSQSFLFDAMGALSSKRNDTPEQASRAYDADRDGFVIAGGGGMVVVEE
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMQQALSTVDTPIDYLNTHGTST
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCC
PVGDVAEMKGVREVFGDKAPAISSTKSLSGHSLGAAGVHEAIYCMLMMEGNFIAGSANID
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCEEECCCCCC
ELDPEVADLPVLTKTRENATINTVMSNSFGFGGTNATLVLKRWEGK
CCCCCHHCCCCEEECCCCCEEEEEECCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]