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The map label for this gene is nhaA [H]

Identifier: 77460384

GI number: 77460384

Start: 4698470

End: 4699459

Strand: Reverse

Name: nhaA [H]

Synonym: Pfl01_4163

Alternate gene names: 77460384

Gene position: 4699459-4698470 (Counterclockwise)

Preceding gene: 77460385

Following gene: 77460382

Centisome position: 72.99

GC content: 57.78

Gene sequence:

>990_bases
ATGACCGACGAATGGAAAGCACCGGCCAAGGCAACTGCCGACGACGGTGATGCGAAAAGCTGGAAGCTCCTGGAAAAGAC
CCTGCTGGCCGGCGTGCAGGAGCAACGTCGTTCGCGGCGCTGGGGCATCTTCTTCAAGCTGTTGACCTTTATTTATCTGT
TTGTTGCGTTGATTCTGTTTACGCCGTTGATGGATATGGAGAAAAGCGCCACGCGCAGTGGCAACTACACCGCATTGATC
GACGTTACCGGCATGATCGCTGATAAAGAACCTGCCAGTGCCGACAATATCGTAGGTAGTCTGCGCGCGGCGTTCGAGGA
CAAGAAGGTCAAGGGCGTAATCCTGCGCATCAATAGTCCGGGCGGCAGTCCGGTGCAGTCGGGTTACGTGTATGACGAGA
TCAAGCGTCTGCGCGGCCTGCACCCCGACACCAAGCTGTACGCGGTGATTTCCGACCTGGGCGCTTCCGGTGCCTATTAC
ATTGCCAGTGCGGCGGATCAGATCTATGCCGACAAGGCCAGTCTGGTGGGTTCCATTGGTGTGACGGCAGCCGGTTACGG
CTTTGTCGGCACCATGGAGAAGCTTGGTGTCGAGCGCCGCACTTACACTTCCGGCGAGCACAAGGCTTTCCTCGATCCGT
TCCAGCCGCAGAAGCCGGAAGAGACGGCGTTCTGGCAAAGTGTGCTGGATACCACGCACAAGCAGTTCATCAACAGCGTC
AAGCAGGGGCGTGGCGATCGACTGAAGGACAAGGAGCATCCGGAGCTGTTCTCCGGGCTGGTCTGGTCGGGTGAGCAAGC
GTTACCGCTGGGCTTGATCGATGGCTTGGGCAATGCGAGTTCGGTGGCGCGTGATGTGATTGGCGAAAAAGAGCTGGTGG
ACTTCACCGTTCAGGAATCGCCGTTCGACCGCTTCTCGAAGAAGCTCGGAGCAAGCGTTGCCGAAAAACTGGCAATGTGG
ATGGGTTTCAACGGCCCGTCGTTACGCTGA

Upstream 100 bases:

>100_bases
GCTGCAACAGTTCGAGCCGCGACTGTCGATCGACCATTTTTCCGAATTGCATGCCTGGCTGGGGCAGCAGGCTTAATACG
TTTTTGCTGGGGTGGATGGC

Downstream 100 bases:

>100_bases
TCGAATGCTGCAAGAAAAACCGGCCTGAGGGCCGGTTTTTTGTGGGTCAGGGAATCTGTACGCCTTCCGCCAGCAGCATG
TCGATCAGGCGAATCAGTGG

Product: peptidase S49, SppA

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTDEWKAPAKATADDGDAKSWKLLEKTLLAGVQEQRRSRRWGIFFKLLTFIYLFVALILFTPLMDMEKSATRSGNYTALI
DVTGMIADKEPASADNIVGSLRAAFEDKKVKGVILRINSPGGSPVQSGYVYDEIKRLRGLHPDTKLYAVISDLGASGAYY
IASAADQIYADKASLVGSIGVTAAGYGFVGTMEKLGVERRTYTSGEHKAFLDPFQPQKPEETAFWQSVLDTTHKQFINSV
KQGRGDRLKDKEHPELFSGLVWSGEQALPLGLIDGLGNASSVARDVIGEKELVDFTVQESPFDRFSKKLGASVAEKLAMW
MGFNGPSLR

Sequences:

>Translated_329_residues
MTDEWKAPAKATADDGDAKSWKLLEKTLLAGVQEQRRSRRWGIFFKLLTFIYLFVALILFTPLMDMEKSATRSGNYTALI
DVTGMIADKEPASADNIVGSLRAAFEDKKVKGVILRINSPGGSPVQSGYVYDEIKRLRGLHPDTKLYAVISDLGASGAYY
IASAADQIYADKASLVGSIGVTAAGYGFVGTMEKLGVERRTYTSGEHKAFLDPFQPQKPEETAFWQSVLDTTHKQFINSV
KQGRGDRLKDKEHPELFSGLVWSGEQALPLGLIDGLGNASSVARDVIGEKELVDFTVQESPFDRFSKKLGASVAEKLAMW
MGFNGPSLR
>Mature_328_residues
TDEWKAPAKATADDGDAKSWKLLEKTLLAGVQEQRRSRRWGIFFKLLTFIYLFVALILFTPLMDMEKSATRSGNYTALID
VTGMIADKEPASADNIVGSLRAAFEDKKVKGVILRINSPGGSPVQSGYVYDEIKRLRGLHPDTKLYAVISDLGASGAYYI
ASAADQIYADKASLVGSIGVTAAGYGFVGTMEKLGVERRTYTSGEHKAFLDPFQPQKPEETAFWQSVLDTTHKQFINSVK
QGRGDRLKDKEHPELFSGLVWSGEQALPLGLIDGLGNASSVARDVIGEKELVDFTVQESPFDRFSKKLGASVAEKLAMWM
GFNGPSLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788064, Length=218, Percent_Identity=27.0642201834862, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 36086; Mature: 35955

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEWKAPAKATADDGDAKSWKLLEKTLLAGVQEQRRSRRWGIFFKLLTFIYLFVALILF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLMDMEKSATRSGNYTALIDVTGMIADKEPASADNIVGSLRAAFEDKKVKGVILRINSP
HHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECC
GGSPVQSGYVYDEIKRLRGLHPDTKLYAVISDLGASGAYYIASAADQIYADKASLVGSIG
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCC
VTAAGYGFVGTMEKLGVERRTYTSGEHKAFLDPFQPQKPEETAFWQSVLDTTHKQFINSV
CHHCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KQGRGDRLKDKEHPELFSGLVWSGEQALPLGLIDGLGNASSVARDVIGEKELVDFTVQES
HHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHCCHHHHEEECCCC
PFDRFSKKLGASVAEKLAMWMGFNGPSLR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDEWKAPAKATADDGDAKSWKLLEKTLLAGVQEQRRSRRWGIFFKLLTFIYLFVALILF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLMDMEKSATRSGNYTALIDVTGMIADKEPASADNIVGSLRAAFEDKKVKGVILRINSP
HHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECC
GGSPVQSGYVYDEIKRLRGLHPDTKLYAVISDLGASGAYYIASAADQIYADKASLVGSIG
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCC
VTAAGYGFVGTMEKLGVERRTYTSGEHKAFLDPFQPQKPEETAFWQSVLDTTHKQFINSV
CHHCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KQGRGDRLKDKEHPELFSGLVWSGEQALPLGLIDGLGNASSVARDVIGEKELVDFTVQES
HHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHCCHHHHEEECCCC
PFDRFSKKLGASVAEKLAMWMGFNGPSLR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA