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The map label for this gene is adhc1 [H]

Identifier: 77460341

GI number: 77460341

Start: 4661879

End: 4662931

Strand: Direct

Name: adhc1 [H]

Synonym: Pfl01_4120

Alternate gene names: 77460341

Gene position: 4661879-4662931 (Clockwise)

Preceding gene: 77460339

Following gene: 77460352

Centisome position: 72.41

GC content: 62.68

Gene sequence:

>1053_bases
ATGTACACCGCCATCGGCTATGCCGCTCAAACGGCCACCACCCCCCTCGCCCCGATGAAGTTCGAACGCCGCAGCCCACG
GGCCGACGACGTCGCCATCGAGATCCTGTACTGCGGCGTCTGCCACTCCGACATCCACCAGGCGCGCAACGAATGGGGCA
TCGCCGTTTACCCGTTGATGCCCGGCCACGAGATCGTCGGAAAAGTCACCGCCGTCGGTGCGAACGTCACCAAACACAAG
GTCGGCGACCTGGTCGGTGTCGGCTGCATGGTCGACTCTTGCCGCACCTGCGAAGCCTGCCAGTCGAACCTCGAGCAATA
CTGCCTCGAAGGCCCGACCATGACCTACGCCACTCCGGACCGGGTCGATGGCAGTAACACCATGGGCGGTTATTCGGACA
GCATCGTGGTCAGCGAACACTTCGTGGTGCGCATTCCCGAGAAGCTGGATCTGGCGGCTGCCGCGCCGATTCTCTGCGCC
GGCATCACCACCTACTCGCCACTCAAGCACTACGGCGTGAAGGCCGGCGACAAGGTCGGGATTCTCGGCATGGGCGGCCT
CGGCCACATGGGCATCAAGTTCGCCAAGGCCATGGGCGCCGAAGTGACGCTGTTCACCCGTTCGGCAAGCAAAGCCGAGG
AAGGTCGTCGACAGGGCGCCGATCACGTCATTGTCTCCACCGACGAAGAGCAGATGAAAGCCGCTGCCGGCCGTTTCGAC
TTCCTGCTGGACACCATTCCGGTGCAGCACGATCTGAACCCGTACCTCGACACCCTGCGCTTCGACGGCGTGCACATTCT
GGTGGGTCTGATCGAACCGATCGATCCGCCGGTCCACGCCGCGAAACTGGTGCTGGGTCGTCGCGTATTGGCCGGCTCGT
TGATCGGTGGCGTCGCCGAAACCCAGGAAGTCCTGGATTTCTGCGCCGAGCACAACATCAGCTGCGACATCGAAATGCTC
GACATCCGCCAGATCAACGAAGCCTACGCCCGCATGATCGCCGGCGATGTGAAGTACCGCTTCGTGATCGACATGGCGAC
TCTGAAGCTCTGA

Upstream 100 bases:

>100_bases
GAGGATTAGGCATGACACCCGGAGGAATCGCCATGGCCGGACGACCGGACGGCGCCCAGAATGCGCCGCCTCACCTGTCA
CTGCTTTTGCGAGGTTTCAC

Downstream 100 bases:

>100_bases
TTCCTCAGACCTTCAAGCCAAGCTCCGCCGAGAGCCGGGCCGTGACCCCTTTGATCAGGGGAATCAGCTCGGCCATTTTT
TCCAGCGGCATGTACGGCAC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MYTAIGYAAQTATTPLAPMKFERRSPRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGKVTAVGANVTKHK
VGDLVGVGCMVDSCRTCEACQSNLEQYCLEGPTMTYATPDRVDGSNTMGGYSDSIVVSEHFVVRIPEKLDLAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSASKAEEGRRQGADHVIVSTDEEQMKAAAGRFD
FLLDTIPVQHDLNPYLDTLRFDGVHILVGLIEPIDPPVHAAKLVLGRRVLAGSLIGGVAETQEVLDFCAEHNISCDIEML
DIRQINEAYARMIAGDVKYRFVIDMATLKL

Sequences:

>Translated_350_residues
MYTAIGYAAQTATTPLAPMKFERRSPRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGKVTAVGANVTKHK
VGDLVGVGCMVDSCRTCEACQSNLEQYCLEGPTMTYATPDRVDGSNTMGGYSDSIVVSEHFVVRIPEKLDLAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSASKAEEGRRQGADHVIVSTDEEQMKAAAGRFD
FLLDTIPVQHDLNPYLDTLRFDGVHILVGLIEPIDPPVHAAKLVLGRRVLAGSLIGGVAETQEVLDFCAEHNISCDIEML
DIRQINEAYARMIAGDVKYRFVIDMATLKL
>Mature_350_residues
MYTAIGYAAQTATTPLAPMKFERRSPRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLMPGHEIVGKVTAVGANVTKHK
VGDLVGVGCMVDSCRTCEACQSNLEQYCLEGPTMTYATPDRVDGSNTMGGYSDSIVVSEHFVVRIPEKLDLAAAAPILCA
GITTYSPLKHYGVKAGDKVGILGMGGLGHMGIKFAKAMGAEVTLFTRSASKAEEGRRQGADHVIVSTDEEQMKAAAGRFD
FLLDTIPVQHDLNPYLDTLRFDGVHILVGLIEPIDPPVHAAKLVLGRRVLAGSLIGGVAETQEVLDFCAEHNISCDIEML
DIRQINEAYARMIAGDVKYRFVIDMATLKL

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=25.4189944134078, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI34577061, Length=364, Percent_Identity=25.8241758241758, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=23.3983286908078, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4501929, Length=357, Percent_Identity=24.9299719887955, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI71743840, Length=235, Percent_Identity=27.2340425531915, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI262073058, Length=235, Percent_Identity=27.2340425531915, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786518, Length=342, Percent_Identity=54.3859649122807, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=34.7058823529412, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=29.4478527607362, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788073, Length=220, Percent_Identity=30, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787863, Length=212, Percent_Identity=28.3018867924528, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI226510992, Length=277, Percent_Identity=25.2707581227437, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=27.2455089820359, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=345, Percent_Identity=28.1159420289855, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=26.8221574344023, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=323, Percent_Identity=25.6965944272446, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=325, Percent_Identity=25.5384615384615, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=25.1908396946565, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319949, Length=325, Percent_Identity=40, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323980, Length=330, Percent_Identity=37.2727272727273, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=32.1212121212121, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=31.1572700296736, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=337, Percent_Identity=30.2670623145401, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319621, Length=336, Percent_Identity=30.6547619047619, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319258, Length=341, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=25.3405994550409, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=222, Percent_Identity=31.5315315315315, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=222, Percent_Identity=31.5315315315315, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=24.6537396121884, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37797; Mature: 37797

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTAIGYAAQTATTPLAPMKFERRSPRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLM
CCCEECCHHHCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECC
PGHEIVGKVTAVGANVTKHKVGDLVGVGCMVDSCRTCEACQSNLEQYCLEGPTMTYATPD
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCC
RVDGSNTMGGYSDSIVVSEHFVVRIPEKLDLAAAAPILCAGITTYSPLKHYGVKAGDKVG
CCCCCCCCCCCCCCEEEECCEEEECCCHHCHHHHCHHHHHCCCCCCHHHHCCCCCCCCEE
ILGMGGLGHMGIKFAKAMGAEVTLFTRSASKAEEGRRQGADHVIVSTDEEQMKAAAGRFD
EEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEECCHHHHHHHHCHHH
FLLDTIPVQHDLNPYLDTLRFDGVHILVGLIEPIDPPVHAAKLVLGRRVLAGSLIGGVAE
HHHHCCCCCCCCCHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
TQEVLDFCAEHNISCDIEMLDIRQINEAYARMIAGDVKYRFVIDMATLKL
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
>Mature Secondary Structure
MYTAIGYAAQTATTPLAPMKFERRSPRADDVAIEILYCGVCHSDIHQARNEWGIAVYPLM
CCCEECCHHHCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECC
PGHEIVGKVTAVGANVTKHKVGDLVGVGCMVDSCRTCEACQSNLEQYCLEGPTMTYATPD
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCC
RVDGSNTMGGYSDSIVVSEHFVVRIPEKLDLAAAAPILCAGITTYSPLKHYGVKAGDKVG
CCCCCCCCCCCCCCEEEECCEEEECCCHHCHHHHCHHHHHCCCCCCHHHHCCCCCCCCEE
ILGMGGLGHMGIKFAKAMGAEVTLFTRSASKAEEGRRQGADHVIVSTDEEQMKAAAGRFD
EEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEECCHHHHHHHHCHHH
FLLDTIPVQHDLNPYLDTLRFDGVHILVGLIEPIDPPVHAAKLVLGRRVLAGSLIGGVAE
HHHHCCCCCCCCCHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHH
TQEVLDFCAEHNISCDIEMLDIRQINEAYARMIAGDVKYRFVIDMATLKL
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]