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The map label for this gene is degU [H]

Identifier: 77460178

GI number: 77460178

Start: 4484715

End: 4485374

Strand: Direct

Name: degU [H]

Synonym: Pfl01_3957

Alternate gene names: 77460178

Gene position: 4484715-4485374 (Clockwise)

Preceding gene: 77460177

Following gene: 77460180

Centisome position: 69.66

GC content: 60.0

Gene sequence:

>660_bases
TTGACTTGTAACTTACTTCTGGTGGATGACCACTCGCTGATCAGGGCCGGCGTGCGCGCCCTGGTGCTGGATATTCCCGG
TTATGCGGTCATCGGCGAGGCCAATGACGGCTCGCAGCTGCTCGAAATGGTCGAGCTGCTGTCTCCCGATATAGTGTTGC
TGGACATTTCCATGAAAGAAACCGGCGGTCTGGAAGCCCTGCAGCGACTCAGACGCGTACGCCCGCACGCCAAAGTGCTG
ATTCTGTCGATGCACACCGACCCCGCGCTGATCATGCAGGCGCTGGAGTCCGGCGCTCACGGCTACCTGCTCAAGGACAC
CACGGCCACCGAGCTCGAACATGCACTCGAAGCGCTGCGCAACAACGAGCGCTACTTGAGCCCAGCCATCGCCCATACCG
TGATCAACCAGGCGCTGACCCGTAACCTGAAGCAGCAACCGGAAGTCGCCGAGTCGCACAACCTGACAGCACGCCAACTG
GAAATCCTGCGCCTCATCGTGCGCGGCAAGTCCACGCGGGAAATCGCCAACGGCCTGGGCTTGAGCATCAAGACGGTCGA
AACCCACCGTTCGCAGATCATGAAACGCCTGCAGATCTACGATGTGGCGGGTCTGGTGCTGTTTGCCGTGCGCGAACAGA
TCATCAGTCTGGATGACTGA

Upstream 100 bases:

>100_bases
TGAGCGTGACCAGCGAGCCGGGCAAAGGCACTCAAATCGAAGCACTATTCCCCTGGGCGCCCCGTGCACTCGAGCGGGCC
AGTACGAATAAGGTTATGCG

Downstream 100 bases:

>100_bases
TCCGGTGTGTTGCGCTCAACAGCGGCGAATCCTTCGGCAGATGCACACGCAACGCCCCGGCGCGCGCCGCAAACCGCAAA
CTTTCGCCCTCCAGTGGCTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTCNLLLVDDHSLIRAGVRALVLDIPGYAVIGEANDGSQLLEMVELLSPDIVLLDISMKETGGLEALQRLRRVRPHAKVL
ILSMHTDPALIMQALESGAHGYLLKDTTATELEHALEALRNNERYLSPAIAHTVINQALTRNLKQQPEVAESHNLTARQL
EILRLIVRGKSTREIANGLGLSIKTVETHRSQIMKRLQIYDVAGLVLFAVREQIISLDD

Sequences:

>Translated_219_residues
MTCNLLLVDDHSLIRAGVRALVLDIPGYAVIGEANDGSQLLEMVELLSPDIVLLDISMKETGGLEALQRLRRVRPHAKVL
ILSMHTDPALIMQALESGAHGYLLKDTTATELEHALEALRNNERYLSPAIAHTVINQALTRNLKQQPEVAESHNLTARQL
EILRLIVRGKSTREIANGLGLSIKTVETHRSQIMKRLQIYDVAGLVLFAVREQIISLDD
>Mature_218_residues
TCNLLLVDDHSLIRAGVRALVLDIPGYAVIGEANDGSQLLEMVELLSPDIVLLDISMKETGGLEALQRLRRVRPHAKVLI
LSMHTDPALIMQALESGAHGYLLKDTTATELEHALEALRNNERYLSPAIAHTVINQALTRNLKQQPEVAESHNLTARQLE
ILRLIVRGKSTREIANGLGLSIKTVETHRSQIMKRLQIYDVAGLVLFAVREQIISLDD

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=210, Percent_Identity=35.7142857142857, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=33.6585365853659, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788712, Length=213, Percent_Identity=28.6384976525822, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790102, Length=195, Percent_Identity=32.3076923076923, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1787473, Length=193, Percent_Identity=35.7512953367876, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=23.7864077669903, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=26.5, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790566, Length=137, Percent_Identity=31.3868613138686, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24273; Mature: 24141

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCNLLLVDDHSLIRAGVRALVLDIPGYAVIGEANDGSQLLEMVELLSPDIVLLDISMKE
CCEEEEEECCHHHHHHHHHHEEEECCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCC
TGGLEALQRLRRVRPHAKVLILSMHTDPALIMQALESGAHGYLLKDTTATELEHALEALR
CCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
NNERYLSPAIAHTVINQALTRNLKQQPEVAESHNLTARQLEILRLIVRGKSTREIANGLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCC
LSIKTVETHRSQIMKRLQIYDVAGLVLFAVREQIISLDD
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TCNLLLVDDHSLIRAGVRALVLDIPGYAVIGEANDGSQLLEMVELLSPDIVLLDISMKE
CEEEEEECCHHHHHHHHHHEEEECCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCC
TGGLEALQRLRRVRPHAKVLILSMHTDPALIMQALESGAHGYLLKDTTATELEHALEALR
CCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
NNERYLSPAIAHTVINQALTRNLKQQPEVAESHNLTARQLEILRLIVRGKSTREIANGLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCC
LSIKTVETHRSQIMKRLQIYDVAGLVLFAVREQIISLDD
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]