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The map label for this gene is aphA [H]

Identifier: 77460116

GI number: 77460116

Start: 4405620

End: 4406645

Strand: Reverse

Name: aphA [H]

Synonym: Pfl01_3895

Alternate gene names: 77460116

Gene position: 4406645-4405620 (Counterclockwise)

Preceding gene: 77460117

Following gene: 77460113

Centisome position: 68.44

GC content: 63.55

Gene sequence:

>1026_bases
ATGCGCAGTTTTTTCCACCCCGAACAATTGCTCCACCATCCACGCAGCTATTACTCGCGCGGGCAGATGCGTACGCCGCA
GGAAGTTCCCGAGCGTGCGCAACGTCTGGTGCAGGCCGCCCACGGTCTGGGCTTCAGTGTCGAGCAACCCGCCGATGCCG
GTCTCGCGCCGTTGCTGGCGGTGCATGGCGCGCCGTATCTGACCTTTCTTCAGGAAGCGCACGCACGCTGGAAGGAAATC
CCCGAAGACTGGGGCGATGAAGTGATGTCGAACATTTTCGTCCGCGAGCCCAACGCTTTGCGCGGCATTCTCGCCCAAGC
GGCGCGCTATCTGGCGGACGGCAGTTGCCCGGTCGGCGAGCAGACCTGGCGCTCGGCCTACTGGTCGGCGCAAAGCGCAG
TGGCCGGGGCGCAGGCGTTGATTGATGGCGAGCCGGCAGCCTACGCCCTGTGCCGTCCGCCGGGGCATCATGCCCGGGCC
GAAGCGGCGGGCGGTTTCTGCTACGTGAACAACGCAGCGGTGGCGGCGCAGGTGCTGCGCGACAAGTTTGAAAAAGTCGC
GGTACTCGACACCGACATGCACCACGGCCAGGGCATTCAGGAGATTTTCTACGACCGCGATGACGTGCTCTACGTCTCGG
TGCATGGCGATCCGACCAACTTCTATCCGGGCGTCGCCGGGTTCGCCGACGAACGTGGCAGCGGCGCGGGGGAGGGCTTC
AACCTCAACCTGCCGATGGCCCATGGTTCAAGCGAAGCGGATTTCCTTGGGCAACTGGAAGTCGCTTTGGCTGCCGTGCG
CGAGTTCGGCGCTGAGGTGCTGGTGCTGTCGTTGGGCTTCGATATCTATGAGCTGGACCCGCAAAGCAAGGTCGCTGTGA
CCCGCGAAGGTTTTGCAGCACTGGGCGAGCGGATCCGCAGCCTGGACCTGCCATGCCTGATCGTGCAGGAGGGCGGCTAT
CACCTGGAAAGTCTCGAAGACAACGCACGGGCGTTTTTCGTGAATGCTGAGGTGTGGCAGATCTGA

Upstream 100 bases:

>100_bases
AGCCGAAGACGTGTTGCCCGAAGACGTGAAGCAGGGCACCGATGTATTGCTCAACGCCGTGCTGGCCCGCGCCGGTCGAA
TCGAACAGGAAGCCTGAACC

Downstream 100 bases:

>100_bases
AATTGATGTGATCCGACAGGTCGCCATCGCTGACAAGTCAGCTCCCACAGGGGTTTGTGCAGTTGCAGTTTTTTGTGATC
GACACAAAAACTGTGGGAGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRSFFHPEQLLHHPRSYYSRGQMRTPQEVPERAQRLVQAAHGLGFSVEQPADAGLAPLLAVHGAPYLTFLQEAHARWKEI
PEDWGDEVMSNIFVREPNALRGILAQAARYLADGSCPVGEQTWRSAYWSAQSAVAGAQALIDGEPAAYALCRPPGHHARA
EAAGGFCYVNNAAVAAQVLRDKFEKVAVLDTDMHHGQGIQEIFYDRDDVLYVSVHGDPTNFYPGVAGFADERGSGAGEGF
NLNLPMAHGSSEADFLGQLEVALAAVREFGAEVLVLSLGFDIYELDPQSKVAVTREGFAALGERIRSLDLPCLIVQEGGY
HLESLEDNARAFFVNAEVWQI

Sequences:

>Translated_341_residues
MRSFFHPEQLLHHPRSYYSRGQMRTPQEVPERAQRLVQAAHGLGFSVEQPADAGLAPLLAVHGAPYLTFLQEAHARWKEI
PEDWGDEVMSNIFVREPNALRGILAQAARYLADGSCPVGEQTWRSAYWSAQSAVAGAQALIDGEPAAYALCRPPGHHARA
EAAGGFCYVNNAAVAAQVLRDKFEKVAVLDTDMHHGQGIQEIFYDRDDVLYVSVHGDPTNFYPGVAGFADERGSGAGEGF
NLNLPMAHGSSEADFLGQLEVALAAVREFGAEVLVLSLGFDIYELDPQSKVAVTREGFAALGERIRSLDLPCLIVQEGGY
HLESLEDNARAFFVNAEVWQI
>Mature_341_residues
MRSFFHPEQLLHHPRSYYSRGQMRTPQEVPERAQRLVQAAHGLGFSVEQPADAGLAPLLAVHGAPYLTFLQEAHARWKEI
PEDWGDEVMSNIFVREPNALRGILAQAARYLADGSCPVGEQTWRSAYWSAQSAVAGAQALIDGEPAAYALCRPPGHHARA
EAAGGFCYVNNAAVAAQVLRDKFEKVAVLDTDMHHGQGIQEIFYDRDDVLYVSVHGDPTNFYPGVAGFADERGSGAGEGF
NLNLPMAHGSSEADFLGQLEVALAAVREFGAEVLVLSLGFDIYELDPQSKVAVTREGFAALGERIRSLDLPCLIVQEGGY
HLESLEDNARAFFVNAEVWQI

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=200, Percent_Identity=36, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI17158039, Length=200, Percent_Identity=36, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI30795202, Length=200, Percent_Identity=36, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI20070354, Length=188, Percent_Identity=41.4893617021277, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13128864, Length=317, Percent_Identity=31.8611987381703, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148539870, Length=219, Percent_Identity=34.2465753424658, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI169234807, Length=195, Percent_Identity=35.3846153846154, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI153085395, Length=148, Percent_Identity=41.2162162162162, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI8923769, Length=208, Percent_Identity=32.2115384615385, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI13128860, Length=311, Percent_Identity=25.4019292604502, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=35.8974358974359, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=35.8974358974359, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI262073088, Length=177, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI226529806, Length=187, Percent_Identity=39.0374331550802, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI13128862, Length=281, Percent_Identity=25.2669039145907, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI293336691, Length=295, Percent_Identity=24.7457627118644, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262073092, Length=140, Percent_Identity=32.8571428571429, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193206283, Length=197, Percent_Identity=40.6091370558376, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=197, Percent_Identity=40.6091370558376, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540334, Length=206, Percent_Identity=40.2912621359223, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17508561, Length=311, Percent_Identity=25.7234726688103, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17561978, Length=310, Percent_Identity=26.1290322580645, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193209491, Length=307, Percent_Identity=28.6644951140065, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=322, Percent_Identity=27.3291925465839, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=213, Percent_Identity=29.5774647887324, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25154020, Length=222, Percent_Identity=29.2792792792793, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=222, Percent_Identity=27.9279279279279, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=222, Percent_Identity=35.5855855855856, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=252, Percent_Identity=26.1904761904762, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321244, Length=206, Percent_Identity=25.2427184466019, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=98, Percent_Identity=33.6734693877551, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325141, Length=232, Percent_Identity=26.2931034482759, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642144, Length=247, Percent_Identity=35.2226720647773, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360899, Length=247, Percent_Identity=35.2226720647773, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642146, Length=247, Percent_Identity=35.2226720647773, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360799, Length=202, Percent_Identity=34.1584158415842, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641720, Length=202, Percent_Identity=34.1584158415842, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642142, Length=247, Percent_Identity=35.2226720647773, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360801, Length=202, Percent_Identity=34.1584158415842, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24657891, Length=313, Percent_Identity=25.2396166134185, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24644244, Length=314, Percent_Identity=23.8853503184713, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37290; Mature: 37290

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSFFHPEQLLHHPRSYYSRGQMRTPQEVPERAQRLVQAAHGLGFSVEQPADAGLAPLLA
CCCCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
VHGAPYLTFLQEAHARWKEIPEDWGDEVMSNIFVREPNALRGILAQAARYLADGSCPVGE
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCH
QTWRSAYWSAQSAVAGAQALIDGEPAAYALCRPPGHHARAEAAGGFCYVNNAAVAAQVLR
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCCEEEECCHHHHHHHHH
DKFEKVAVLDTDMHHGQGIQEIFYDRDDVLYVSVHGDPTNFYPGVAGFADERGSGAGEGF
HHHHHEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NLNLPMAHGSSEADFLGQLEVALAAVREFGAEVLVLSLGFDIYELDPQSKVAVTREGFAA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEEEHHHHHHH
LGERIRSLDLPCLIVQEGGYHLESLEDNARAFFVNAEVWQI
HHHHHHHCCCCEEEEECCCCEECCCCCCCEEEEEECCEECC
>Mature Secondary Structure
MRSFFHPEQLLHHPRSYYSRGQMRTPQEVPERAQRLVQAAHGLGFSVEQPADAGLAPLLA
CCCCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
VHGAPYLTFLQEAHARWKEIPEDWGDEVMSNIFVREPNALRGILAQAARYLADGSCPVGE
HCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCH
QTWRSAYWSAQSAVAGAQALIDGEPAAYALCRPPGHHARAEAAGGFCYVNNAAVAAQVLR
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCCEEEECCHHHHHHHHH
DKFEKVAVLDTDMHHGQGIQEIFYDRDDVLYVSVHGDPTNFYPGVAGFADERGSGAGEGF
HHHHHEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NLNLPMAHGSSEADFLGQLEVALAAVREFGAEVLVLSLGFDIYELDPQSKVAVTREGFAA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCEEEHHHHHHH
LGERIRSLDLPCLIVQEGGYHLESLEDNARAFFVNAEVWQI
HHHHHHHCCCCEEEEECCCCEECCCCCCCEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]