Click here to switch to the map view.

The map label for this gene is mtnP [H]

Identifier: 77460090

GI number: 77460090

Start: 4375632

End: 4376369

Strand: Reverse

Name: mtnP [H]

Synonym: Pfl01_3869

Alternate gene names: 77460090

Gene position: 4376369-4375632 (Counterclockwise)

Preceding gene: 77460091

Following gene: 77460086

Centisome position: 67.97

GC content: 62.2

Gene sequence:

>738_bases
ATGACGGTTTACGCAATCATCGGCGGCACCGGCCTGACCCAGTTGGAAGGCCTGAGCATTCGTCAGTCGCTGGCGGTGGA
TACGCCCTATGGCGCGCCATCGGCCGAGGTTCAGATTGGTGAGTACGCCGGCAAGGAAGTGCTGTTCCTCGCTCGCCACG
GTCATCCGCATCGCTTTCCGCCGCACAAGGTCAACTACCGCGCCAACCTGTGGGCGTTGAAGCAGGCCGGAGCCGAATCG
ATCATTGCGGTCAACGCCGTGGGCGGGATTCATCCTGCAATGGGCACCGGACATTTCTGCGTGCCGCATCAGGTCGTGGA
CTACACCAGCGGTCGCGAGCACACCTATTTCGCCGATGACCTGGAACATGTCACACACATCGACTTCAGCTTTCCCTACA
GCGAACCGCTGCGTCAGCAATTGATTGCTGCGTTGGCCGCCGAAGGTTGCGAGTACAGCGATCAGGGCGTTTACGCCTGC
ACCCAAGGCCCGCGTCTGGAAACCGTGGCCGAGATCGTGCGCCTGGAGCGTGACGGTTGCGACATCGTCGGCATGACCGG
CATGCCGGAAGCGGCGCTGGCCCGCGAGCTGGATCTGAATTACGCCTGCCTGTCGTTGGTGGTGAACCCGGCGGCGGGCA
AGACCACTGAAGTGATCACCATGGCCGAGATCGAGCAGGCGCTGCATGACGGGATGGGCAAGGTGAAATCGACGTTGGCG
CGGGTGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
TCAGGCATTCGCCAACACCGAATACCGTCAGGATCCGCGCTGGCTGACCGCTGTCGGTGCGCTCAAAGACGCTCAACTGA
TCGATTAAGGATTTTTCGCT

Downstream 100 bases:

>100_bases
GTCTGGCTCCGCAATGACGTGACTGAACAAGCGCTGAGAATCTCAGCGCTTTTCAAACTTGTCCGGCAACGGCGCAAACA
GCGCCTCGATATCATCACTC

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTVYAIIGGTGLTQLEGLSIRQSLAVDTPYGAPSAEVQIGEYAGKEVLFLARHGHPHRFPPHKVNYRANLWALKQAGAES
IIAVNAVGGIHPAMGTGHFCVPHQVVDYTSGREHTYFADDLEHVTHIDFSFPYSEPLRQQLIAALAAEGCEYSDQGVYAC
TQGPRLETVAEIVRLERDGCDIVGMTGMPEAALARELDLNYACLSLVVNPAAGKTTEVITMAEIEQALHDGMGKVKSTLA
RVLKG

Sequences:

>Translated_245_residues
MTVYAIIGGTGLTQLEGLSIRQSLAVDTPYGAPSAEVQIGEYAGKEVLFLARHGHPHRFPPHKVNYRANLWALKQAGAES
IIAVNAVGGIHPAMGTGHFCVPHQVVDYTSGREHTYFADDLEHVTHIDFSFPYSEPLRQQLIAALAAEGCEYSDQGVYAC
TQGPRLETVAEIVRLERDGCDIVGMTGMPEAALARELDLNYACLSLVVNPAAGKTTEVITMAEIEQALHDGMGKVKSTLA
RVLKG
>Mature_244_residues
TVYAIIGGTGLTQLEGLSIRQSLAVDTPYGAPSAEVQIGEYAGKEVLFLARHGHPHRFPPHKVNYRANLWALKQAGAESI
IAVNAVGGIHPAMGTGHFCVPHQVVDYTSGREHTYFADDLEHVTHIDFSFPYSEPLRQQLIAALAAEGCEYSDQGVYACT
QGPRLETVAEIVRLERDGCDIVGMTGMPEAALARELDLNYACLSLVVNPAAGKTTEVITMAEIEQALHDGMGKVKSTLAR
VLKG

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=240, Percent_Identity=32.5, Blast_Score=134, Evalue=6e-32,
Organism=Escherichia coli, GI1788746, Length=213, Percent_Identity=24.8826291079812, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71980569, Length=242, Percent_Identity=38.8429752066116, Blast_Score=153, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323045, Length=216, Percent_Identity=33.7962962962963, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221459247, Length=207, Percent_Identity=35.7487922705314, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20130079, Length=238, Percent_Identity=31.9327731092437, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26399; Mature: 26268

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYAIIGGTGLTQLEGLSIRQSLAVDTPYGAPSAEVQIGEYAGKEVLFLARHGHPHRFP
CEEEEEECCCCCCHHCCCHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCC
PHKVNYRANLWALKQAGAESIIAVNAVGGIHPAMGTGHFCVPHQVVDYTSGREHTYFADD
CCCCCCEEHEEEHHHCCCCCEEEEECCCCCCCCCCCCCEECCHHHHHCCCCCCCCEEHHH
LEHVTHIDFSFPYSEPLRQQLIAALAAEGCEYSDQGVYACTQGPRLETVAEIVRLERDGC
HHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
DIVGMTGMPEAALARELDLNYACLSLVVNPAAGKTTEVITMAEIEQALHDGMGKVKSTLA
CEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RVLKG
HHHCC
>Mature Secondary Structure 
TVYAIIGGTGLTQLEGLSIRQSLAVDTPYGAPSAEVQIGEYAGKEVLFLARHGHPHRFP
EEEEEECCCCCCHHCCCHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCC
PHKVNYRANLWALKQAGAESIIAVNAVGGIHPAMGTGHFCVPHQVVDYTSGREHTYFADD
CCCCCCEEHEEEHHHCCCCCEEEEECCCCCCCCCCCCCEECCHHHHHCCCCCCCCEEHHH
LEHVTHIDFSFPYSEPLRQQLIAALAAEGCEYSDQGVYACTQGPRLETVAEIVRLERDGC
HHHHEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCC
DIVGMTGMPEAALARELDLNYACLSLVVNPAAGKTTEVITMAEIEQALHDGMGKVKSTLA
CEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RVLKG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]