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The map label for this gene is dht [H]

Identifier: 77459663

GI number: 77459663

Start: 3924919

End: 3926358

Strand: Direct

Name: dht [H]

Synonym: Pfl01_3441

Alternate gene names: 77459663

Gene position: 3924919-3926358 (Clockwise)

Preceding gene: 77459657

Following gene: 77459664

Centisome position: 60.96

GC content: 62.64

Gene sequence:

>1440_bases
ATGTCTCTGTTGATCCGTGGCGCCACCATTGTTACCCATGATGAAAGTTACCGCGCCGATGTCTATTGCGCTGACGGCGT
GATCAAAGCCATTGGTGAAAACCTGGATATTCCCGCCGGCGCCGAAGTGCTCGACGGCAGCGGACAATACCTGATGCCCG
GCGGCATCGATCCGCACACCCACATGCAACTCCCGTTCATGGGCACCGTGGCCAGCGAAGACTTCTACAGCGGCACCGCC
GCAGGCCTGGCCGGAGGCACCACTTCGATCATCGATTTCGTGATTCCCAATCCGCAGCAGTCACTGCTCGAAGCGTTTCA
CCAGTGGCGTGGCTGGGCGGAAAAATCCGCGTCCGACTACGGCTTCCACGTCGCGATTACCTGGTGGAGTGAGCAGGTGC
GTGAGGAAATGGCCGAGCTGGTCAGCCATCACGGGATCAACAGCTTCAAGCATTTCATGGCTTACAAGAACGCGATCATG
GCCGCCGACGACACGCTGGTGGCGAGCTTCGAGCGCTGCCTGGAACTCGGCGCGGTGCCGACCGTGCACGCAGAAAACGG
CGAGCTGGTCTATCACCTGCAACGCAAGTTGATGGCCCAGGGCATCACCGGGCCGGAAGCGCATCCGCTGTCGCGGCCCT
CGCAGGTCGAAGGCGAAGCCGCGAGCCGGGCAATCCGGATCGCTGAAACCATCGGCACGCCGCTGTACCTGGTGCACGTC
TCGACCAAGGAAGCCCTCGACGAAATCACCTATGCCCGCAGCAAGGGCCAACCGGTTTACGGCGAAGTGCTGGCCGGGCA
TCTGCTGCTGGACGACAGTGTCTATCAGCATCCGGACTGGCAGACCGCCGCCGGTTATGTGATGAGCCCGCCGTTCCGTC
CGCGCGGGCATCAGGATGCGCTGTGGCATGGTTTGCAGAGCGGCAATCTGCACACCACCGCCACCGACCATTGCTGCTTC
TGCGCCGAGCAGAAAGCCGCCGGCCGCGACGACTTCAGCAAGATCCCCAACGGCACTGCCGGCATCGAAGACCGCATGGC
GGTGTTGTGGGATGAAGGGGTGAATTCGGGGCGATTGTCGATGCAGGACTTCGTCGCCCTCACCTCCACCAACACTGCAA
AGATCTTCAACCTCTACCCGCGCAAGGGCGCGATCCGCGTCGGCGCCGATGCCGACCTGGTGCTGTGGGACCCGCAAGGC
ACCCGCACCATCTCCGCCAAGACCCACCATCAGCAGGTGGACTTCAACATCTTCGAAGGCAAGACCGTGACCGGTGTGCC
GAGCCATACCGTCAGCCAGGGCCGGGTGGTCTGGGCCGACGGTGACCTGCGCGCCGAGCGTGGGGCGGGCCGGTATATCG
AACGGCCGGCGTATCCGGCGGTGTTTGATTTGCTGAGCAAGCGGGCTGAGCAACATAAGCCTACTGCTGTGAAACGCTGA

Upstream 100 bases:

>100_bases
CGTCTATTCCTGACAGCGCTGACAAGATTACGCATTTGGCGCTGCAGACAATAAAACACTAGAACCGACACAAGTCGGTC
ATGCCTGCGAGGAACTCGGA

Downstream 100 bases:

>100_bases
AAGCGGCCTTCGGCCTCATCGCGGGCAAGCCCGCTCCCACAGGTTTTATGCGCGCCGTAGATCCCTGTGGGAGCTGGCTT
GCCAGCGATGAGGCCAGTTC

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSLLIRGATIVTHDESYRADVYCADGVIKAIGENLDIPAGAEVLDGSGQYLMPGGIDPHTHMQLPFMGTVASEDFYSGTA
AGLAGGTTSIIDFVIPNPQQSLLEAFHQWRGWAEKSASDYGFHVAITWWSEQVREEMAELVSHHGINSFKHFMAYKNAIM
AADDTLVASFERCLELGAVPTVHAENGELVYHLQRKLMAQGITGPEAHPLSRPSQVEGEAASRAIRIAETIGTPLYLVHV
STKEALDEITYARSKGQPVYGEVLAGHLLLDDSVYQHPDWQTAAGYVMSPPFRPRGHQDALWHGLQSGNLHTTATDHCCF
CAEQKAAGRDDFSKIPNGTAGIEDRMAVLWDEGVNSGRLSMQDFVALTSTNTAKIFNLYPRKGAIRVGADADLVLWDPQG
TRTISAKTHHQQVDFNIFEGKTVTGVPSHTVSQGRVVWADGDLRAERGAGRYIERPAYPAVFDLLSKRAEQHKPTAVKR

Sequences:

>Translated_479_residues
MSLLIRGATIVTHDESYRADVYCADGVIKAIGENLDIPAGAEVLDGSGQYLMPGGIDPHTHMQLPFMGTVASEDFYSGTA
AGLAGGTTSIIDFVIPNPQQSLLEAFHQWRGWAEKSASDYGFHVAITWWSEQVREEMAELVSHHGINSFKHFMAYKNAIM
AADDTLVASFERCLELGAVPTVHAENGELVYHLQRKLMAQGITGPEAHPLSRPSQVEGEAASRAIRIAETIGTPLYLVHV
STKEALDEITYARSKGQPVYGEVLAGHLLLDDSVYQHPDWQTAAGYVMSPPFRPRGHQDALWHGLQSGNLHTTATDHCCF
CAEQKAAGRDDFSKIPNGTAGIEDRMAVLWDEGVNSGRLSMQDFVALTSTNTAKIFNLYPRKGAIRVGADADLVLWDPQG
TRTISAKTHHQQVDFNIFEGKTVTGVPSHTVSQGRVVWADGDLRAERGAGRYIERPAYPAVFDLLSKRAEQHKPTAVKR
>Mature_478_residues
SLLIRGATIVTHDESYRADVYCADGVIKAIGENLDIPAGAEVLDGSGQYLMPGGIDPHTHMQLPFMGTVASEDFYSGTAA
GLAGGTTSIIDFVIPNPQQSLLEAFHQWRGWAEKSASDYGFHVAITWWSEQVREEMAELVSHHGINSFKHFMAYKNAIMA
ADDTLVASFERCLELGAVPTVHAENGELVYHLQRKLMAQGITGPEAHPLSRPSQVEGEAASRAIRIAETIGTPLYLVHVS
TKEALDEITYARSKGQPVYGEVLAGHLLLDDSVYQHPDWQTAAGYVMSPPFRPRGHQDALWHGLQSGNLHTTATDHCCFC
AEQKAAGRDDFSKIPNGTAGIEDRMAVLWDEGVNSGRLSMQDFVALTSTNTAKIFNLYPRKGAIRVGADADLVLWDPQGT
RTISAKTHHQQVDFNIFEGKTVTGVPSHTVSQGRVVWADGDLRAERGAGRYIERPAYPAVFDLLSKRAEQHKPTAVKR

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=484, Percent_Identity=52.6859504132231, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI4503377, Length=468, Percent_Identity=47.6495726495726, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI4503379, Length=476, Percent_Identity=45.7983193277311, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=47.9302832244009, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=47.9302832244009, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI190194363, Length=468, Percent_Identity=47.4358974358974, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI19923821, Length=482, Percent_Identity=43.5684647302905, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI18105007, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082175, Length=469, Percent_Identity=35.8208955223881, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1786722, Length=450, Percent_Identity=27.5555555555556, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539558, Length=484, Percent_Identity=48.7603305785124, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71989490, Length=483, Percent_Identity=45.5486542443064, Blast_Score=443, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI86575075, Length=469, Percent_Identity=34.1151385927505, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI193204318, Length=446, Percent_Identity=24.4394618834081, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=410, Percent_Identity=25.3658536585366, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221377917, Length=483, Percent_Identity=48.6542443064182, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137462, Length=481, Percent_Identity=47.4012474012474, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24644287, Length=297, Percent_Identity=49.4949494949495, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24644289, Length=232, Percent_Identity=51.7241379310345, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24642586, Length=409, Percent_Identity=27.3838630806846, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859883, Length=417, Percent_Identity=25.8992805755396, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52400; Mature: 52269

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLIRGATIVTHDESYRADVYCADGVIKAIGENLDIPAGAEVLDGSGQYLMPGGIDPHT
CCEEEECCEEEECCCCCCEEEEECCHHHHHHCCCCCCCCCCCEECCCCCEEECCCCCCCC
HMQLPFMGTVASEDFYSGTAAGLAGGTTSIIDFVIPNPQQSLLEAFHQWRGWAEKSASDY
EEECCEEEEECCCCCCCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCCCC
GFHVAITWWSEQVREEMAELVSHHGINSFKHFMAYKNAIMAADDTLVASFERCLELGAVP
CEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCC
TVHAENGELVYHLQRKLMAQGITGPEAHPLSRPSQVEGEAASRAIRIAETIGTPLYLVHV
EEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
STKEALDEITYARSKGQPVYGEVLAGHLLLDDSVYQHPDWQTAAGYVMSPPFRPRGHQDA
CHHHHHHHHHHHHCCCCCCHHHHHHCEEEECCCHHCCCCCCCCCCCEECCCCCCCCCHHH
LWHGLQSGNLHTTATDHCCFCAEQKAAGRDDFSKIPNGTAGIEDRMAVLWDEGVNSGRLS
HHHCCCCCCEEECCCCCEEEECCHHCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
MQDFVALTSTNTAKIFNLYPRKGAIRVGADADLVLWDPQGTRTISAKTHHQQVDFNIFEG
HHHEEEEECCCCEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEECCCCCEECEEEECC
KTVTGVPSHTVSQGRVVWADGDLRAERGAGRYIERPAYPAVFDLLSKRAEQHKPTAVKR
CEEECCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLLIRGATIVTHDESYRADVYCADGVIKAIGENLDIPAGAEVLDGSGQYLMPGGIDPHT
CEEEECCEEEECCCCCCEEEEECCHHHHHHCCCCCCCCCCCEECCCCCEEECCCCCCCC
HMQLPFMGTVASEDFYSGTAAGLAGGTTSIIDFVIPNPQQSLLEAFHQWRGWAEKSASDY
EEECCEEEEECCCCCCCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHCCCCCC
GFHVAITWWSEQVREEMAELVSHHGINSFKHFMAYKNAIMAADDTLVASFERCLELGAVP
CEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCC
TVHAENGELVYHLQRKLMAQGITGPEAHPLSRPSQVEGEAASRAIRIAETIGTPLYLVHV
EEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEE
STKEALDEITYARSKGQPVYGEVLAGHLLLDDSVYQHPDWQTAAGYVMSPPFRPRGHQDA
CHHHHHHHHHHHHCCCCCCHHHHHHCEEEECCCHHCCCCCCCCCCCEECCCCCCCCCHHH
LWHGLQSGNLHTTATDHCCFCAEQKAAGRDDFSKIPNGTAGIEDRMAVLWDEGVNSGRLS
HHHCCCCCCEEECCCCCEEEECCHHCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
MQDFVALTSTNTAKIFNLYPRKGAIRVGADADLVLWDPQGTRTISAKTHHQQVDFNIFEG
HHHEEEEECCCCEEEEEECCCCCCEEECCCCCEEEECCCCCEEEEECCCCCEECEEEECC
KTVTGVPSHTVSQGRVVWADGDLRAERGAGRYIERPAYPAVFDLLSKRAEQHKPTAVKR
CEEECCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]