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The map label for this gene is proA [H]

Identifier: 77459594

GI number: 77459594

Start: 3846685

End: 3848187

Strand: Reverse

Name: proA [H]

Synonym: Pfl01_3372

Alternate gene names: 77459594

Gene position: 3848187-3846685 (Counterclockwise)

Preceding gene: 77459595

Following gene: 77459590

Centisome position: 59.77

GC content: 66.07

Gene sequence:

>1503_bases
ATGTCTCTCGCGCTCGAACGTCTCGTCGCTGGCACGCCTATCCCTTTCGCCGGTAACCGCGTCACCGTGGTCAGCCCCGA
ACTGGCCGAGCGTTTCCGACCCGGCGACCACCTGTTGGTGGAGCAGGTGAGCGGCGAGCTGTTGCTGATTCCGGTGGTGG
ATCAGCAGGCCGCATCGGTGGCGATCGAGCGTGCAGCGGCGGCGTTTACGGCGTTGTCCGCTGTGCCGGATGAGGCCATC
AGCCGCTTCTTCGATCTGTTTGCCCAACGTCTGGAAAACCCGGACGCCTGGGCACTGATCGAAACCGCCAACCTCGCCGA
CATCGAACGGGCCAAGGCGCGCGGTCGCTCCACCACCCGGTTGCTCGCCGACGAGCGGATGCGCCGCGACATGATCGCCG
GTCTGCGTGCCTGGCGTGATGCGCCGGCCACCCGCGGCAAGGTGATCAGCAGCGTCGATCACGACGGCTGGAAGGTCGAG
CAGGTGGTGTCGCCGCTGGGCATCGTCGCGTTCGTGTTCGAAGGCCGGCCTAACGTCTTTGCCGACGCTGCTGGTGTACT
GCGCACCGGCAACACCGCCGTACTGCGCATTGGCAGCGATGCGCTGGGCACCGCGCAAGCCATCGTCACTCACGCCCTGA
ACCCGGCGCTGGCCGATGCCGGACTGCCGGCGGGAGCGGTGTCGCTGGTGGAGAGCGTCAACCACGCCGCCGGTTGGGCG
ATGTTCGCCGACCGGCGTCTGTCGCTGGCGGTGGCCCGTGGTTCGGGGCGTGCGGTCAGCCAGTTGGGCAGCATCGCCCA
GCAGGCCGGCACCGCCGTCAGCCTGCACGGCACCGGTGGCGCGTGGCTGATTGCTGATCGCGATGCCGACGCCAAACGCT
TCGCCGCGGTGGTACGCAACTCGCTGGACCGCAAAGTCTGCAACACCTTGAACGTCTGCCTGATCCAGCGCGACCGTGCC
GCCGAGCTGGTGCCGCTGTTCCTCGACGCCTTGCAGCAGGCCGGCACCGCGCGCGGTCAGGGCTGCAAATTGCACATCGT
CGAAGGCAGCGAAAGCTACCTGCCGGGCGAATGGCAGAACGCGACGGTCGAGGTCTATCGCGCCGGGGGTTACCAGACCG
AAGCATTGGCCGAGCCGCTGCCGGAAGCGCAACTGGGCCGCGAGTGGGAATGGGAAGAAACCCCGGAAACCAGCCTGATG
ATCGTCGACGATCTGGATCAGGCCATCGCGCTGTTCAATCGCTACAGCCCGCAATTCACGGTGTCGTTGATCAGCGAAGA
TCCAGCGGTTCAGGAATGTTTCTACAGCGCGGTCAACGCGCCGTTCGTGGGCAACGGGATTACCCGTTGGGTCGATGGCC
AGTACGCGCTGAACAAGCCGGAGCTGGGGCTTTCGAACTGGGAAAGCGGCCGGTTGTTTGCCCGCAGCGCGATCCTCTCG
GGGGACGGCGTGTTCACCGTCCGCAGCCGTATGACGCAAATCGATCTGGGCGTAAAACGCTGA

Upstream 100 bases:

>100_bases
CAGTTCGCGGATTGGCTGGTCGGTGTTCTGAGCCCGTGTTGCTTTGAGGGAGGCCAACCTATACATTTTCCGGCCGCCCT
CAATATGGTGAATCCGCTCC

Downstream 100 bases:

>100_bases
ACAGAACAACGCCGCGCCCGTCGCAATGACGGGCGCGGCGTTGTGTTTTCAAGCCGCATCGACTGTCTGACCGTACACCG
CGCACGTCGACGGTTGCTCG

Product: glutamate-5-semialdehyde dehydrogenase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSLALERLVAGTPIPFAGNRVTVVSPELAERFRPGDHLLVEQVSGELLLIPVVDQQAASVAIERAAAAFTALSAVPDEAI
SRFFDLFAQRLENPDAWALIETANLADIERAKARGRSTTRLLADERMRRDMIAGLRAWRDAPATRGKVISSVDHDGWKVE
QVVSPLGIVAFVFEGRPNVFADAAGVLRTGNTAVLRIGSDALGTAQAIVTHALNPALADAGLPAGAVSLVESVNHAAGWA
MFADRRLSLAVARGSGRAVSQLGSIAQQAGTAVSLHGTGGAWLIADRDADAKRFAAVVRNSLDRKVCNTLNVCLIQRDRA
AELVPLFLDALQQAGTARGQGCKLHIVEGSESYLPGEWQNATVEVYRAGGYQTEALAEPLPEAQLGREWEWEETPETSLM
IVDDLDQAIALFNRYSPQFTVSLISEDPAVQECFYSAVNAPFVGNGITRWVDGQYALNKPELGLSNWESGRLFARSAILS
GDGVFTVRSRMTQIDLGVKR

Sequences:

>Translated_500_residues
MSLALERLVAGTPIPFAGNRVTVVSPELAERFRPGDHLLVEQVSGELLLIPVVDQQAASVAIERAAAAFTALSAVPDEAI
SRFFDLFAQRLENPDAWALIETANLADIERAKARGRSTTRLLADERMRRDMIAGLRAWRDAPATRGKVISSVDHDGWKVE
QVVSPLGIVAFVFEGRPNVFADAAGVLRTGNTAVLRIGSDALGTAQAIVTHALNPALADAGLPAGAVSLVESVNHAAGWA
MFADRRLSLAVARGSGRAVSQLGSIAQQAGTAVSLHGTGGAWLIADRDADAKRFAAVVRNSLDRKVCNTLNVCLIQRDRA
AELVPLFLDALQQAGTARGQGCKLHIVEGSESYLPGEWQNATVEVYRAGGYQTEALAEPLPEAQLGREWEWEETPETSLM
IVDDLDQAIALFNRYSPQFTVSLISEDPAVQECFYSAVNAPFVGNGITRWVDGQYALNKPELGLSNWESGRLFARSAILS
GDGVFTVRSRMTQIDLGVKR
>Mature_499_residues
SLALERLVAGTPIPFAGNRVTVVSPELAERFRPGDHLLVEQVSGELLLIPVVDQQAASVAIERAAAAFTALSAVPDEAIS
RFFDLFAQRLENPDAWALIETANLADIERAKARGRSTTRLLADERMRRDMIAGLRAWRDAPATRGKVISSVDHDGWKVEQ
VVSPLGIVAFVFEGRPNVFADAAGVLRTGNTAVLRIGSDALGTAQAIVTHALNPALADAGLPAGAVSLVESVNHAAGWAM
FADRRLSLAVARGSGRAVSQLGSIAQQAGTAVSLHGTGGAWLIADRDADAKRFAAVVRNSLDRKVCNTLNVCLIQRDRAA
ELVPLFLDALQQAGTARGQGCKLHIVEGSESYLPGEWQNATVEVYRAGGYQTEALAEPLPEAQLGREWEWEETPETSLMI
VDDLDQAIALFNRYSPQFTVSLISEDPAVQECFYSAVNAPFVGNGITRWVDGQYALNKPELGLSNWESGRLFARSAILSG
DGVFTVRSRMTQIDLGVKR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786438, Length=387, Percent_Identity=27.1317829457364, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17569969, Length=405, Percent_Identity=28.1481481481481, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17569967, Length=405, Percent_Identity=28.1481481481481, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324899, Length=409, Percent_Identity=25.9168704156479, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357643, Length=422, Percent_Identity=24.8815165876777, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 53774; Mature: 53643

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLALERLVAGTPIPFAGNRVTVVSPELAERFRPGDHLLVEQVSGELLLIPVVDQQAASV
CCHHHHHHHCCCCCCCCCCEEEEECHHHHHHCCCCCHHHHEECCCCEEEEEECCCHHHHH
AIERAAAAFTALSAVPDEAISRFFDLFAQRLENPDAWALIETANLADIERAKARGRSTTR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHH
LLADERMRRDMIAGLRAWRDAPATRGKVISSVDHDGWKVEQVVSPLGIVAFVFEGRPNVF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHCCCCEEEEEECCCCCCH
ADAAGVLRTGNTAVLRIGSDALGTAQAIVTHALNPALADAGLPAGAVSLVESVNHAAGWA
HHCCCCEECCCEEEEEECCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
MFADRRLSLAVARGSGRAVSQLGSIAQQAGTAVSLHGTGGAWLIADRDADAKRFAAVVRN
HHHCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHH
SLDRKVCNTLNVCLIQRDRAAELVPLFLDALQQAGTARGQGCKLHIVEGSESYLPGEWQN
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
ATVEVYRAGGYQTEALAEPLPEAQLGREWEWEETPETSLMIVDDLDQAIALFNRYSPQFT
CEEEEEECCCCCHHHHHCCCCHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCEE
VSLISEDPAVQECFYSAVNAPFVGNGITRWVDGQYALNKPELGLSNWESGRLFARSAILS
EEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCEECCCCCCCCCCCCCCCEEEEHEEEC
GDGVFTVRSRMTQIDLGVKR
CCCEEHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SLALERLVAGTPIPFAGNRVTVVSPELAERFRPGDHLLVEQVSGELLLIPVVDQQAASV
CHHHHHHHCCCCCCCCCCEEEEECHHHHHHCCCCCHHHHEECCCCEEEEEECCCHHHHH
AIERAAAAFTALSAVPDEAISRFFDLFAQRLENPDAWALIETANLADIERAKARGRSTTR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHH
LLADERMRRDMIAGLRAWRDAPATRGKVISSVDHDGWKVEQVVSPLGIVAFVFEGRPNVF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEHHHHHCCCCEEEEEECCCCCCH
ADAAGVLRTGNTAVLRIGSDALGTAQAIVTHALNPALADAGLPAGAVSLVESVNHAAGWA
HHCCCCEECCCEEEEEECCCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
MFADRRLSLAVARGSGRAVSQLGSIAQQAGTAVSLHGTGGAWLIADRDADAKRFAAVVRN
HHHCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHH
SLDRKVCNTLNVCLIQRDRAAELVPLFLDALQQAGTARGQGCKLHIVEGSESYLPGEWQN
HHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
ATVEVYRAGGYQTEALAEPLPEAQLGREWEWEETPETSLMIVDDLDQAIALFNRYSPQFT
CEEEEEECCCCCHHHHHCCCCHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCEE
VSLISEDPAVQECFYSAVNAPFVGNGITRWVDGQYALNKPELGLSNWESGRLFARSAILS
EEEECCCHHHHHHHHHHHCCCCCCCCCCEEECCCEECCCCCCCCCCCCCCCEEEEHEEEC
GDGVFTVRSRMTQIDLGVKR
CCCEEHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA