Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 77459449

GI number: 77459449

Start: 3707857

End: 3709593

Strand: Direct

Name: ilvD [H]

Synonym: Pfl01_3227

Alternate gene names: 77459449

Gene position: 3707857-3709593 (Clockwise)

Preceding gene: 77459440

Following gene: 77459450

Centisome position: 57.59

GC content: 62.64

Gene sequence:

>1737_bases
ATGTCTGATAAGAAACCCACCCTGCGCTCCGCCCAATGGTTTGGCACGGCCGACAAGAACGGCTTCATGTACCGCAGCTG
GATGAAGAATCAGGGCATCGCCGACCATCAGTTCCACGGCAAGCCGATCATCGGCATCTGCAACACCTGGTCAGAACTGA
CCCCGTGCAACGCGCACTTCCGCCAGATCGCGGAACACGTCAAACGCGGGGTGATCGAGGCCGGTGGTTTTCCGGTTGAA
TTTCCTGTGTTCTCCAATGGCGAGTCGAACCTGCGCCCGACCGCCATGCTCACCCGCAATCTGGCGAGCATGGACGTCGA
GGAAGCGATTCGCGGCAACCCGATTGATGGCGTGGTGCTGCTGACCGGTTGCGACAAGACCACCCCGGCCCTGCTGATGG
GCGCAGCCAGTTGCGACGTGCCGGCGATCGTCGTCACTGGCGGGCCGATGCTCAACGGCAAGCACAAGGGTAAGGACATC
GGCTCCGGCACCGTGGTCTGGCAGCTCAGCGAACAGGTCAAGGCCGGCACCATCACGATTGACGATTTCCTCGCGGCCGA
GGGCGGCATGTCCCGTTCGGCCGGCACTTGCAACACCATGGGCACCGCGTCGACCATGGCCTGCATGGCCGAAGCACTGG
GCACTTCCCTGCCGCACAACGCGGCGATTCCGGCGGTGGATGCGCGACGTTATGTGTTGGCGCACATGTCCGGCATGCGT
GCGGTCGAGATGGTGCGTGAAGACTTGAAGCTGTCGAAGATCCTGACCAAGGAAGCCTTCGAAAATGCGATCCGGGTCAA
CGCAGCCATTGGCGGTTCGACCAACGCGGTGATCCACCTCAAAGCTATCGCCGGGCGCATTGGTGTCGAGCTGGATCTGG
ACGACTGGACGCGCATCGGTCGTGGCATGCCGACCATCGTCGACCTGCAACCGTCCGGGCGTTTCCTGATGGAAGAGTTC
TACTACGCGGGCGGCCTGCCGGCCGTGCTGCGGCGTCTTGGTGAAGCCAATCTGATTCCCAATCCGAACGCGCTGACCGT
CAACGGCAAATCCATCGGCGAGAACACCAAGGACGCACCGATCTATGGCGAGGACGAAGTGATCCGCACCCTCGACAACC
CGATCCGCGCTGACGGCGGGATCTGTGTGTTGCGCGGCAACCTGGCGCCGCTGGGCGCAGTGCTCAAACCGTCAGCCGCC
ACGCCGGAACTGATGCAGCACCGTGGCCGCGCCGTTGTGTTCGAGAACTTCGACATGTACAAGGCGCGGATCAACGACCC
GGAACTGGACGTCGATGCGAACTCGATTCTGGTGATGAAGAACTGCGGGCCGAAGGGTTATCCGGGCATGGCCGAAGTCG
GCAACATGGGCTTGCCGGCCAAGCTGCTGGCGCAGGGCGTGACCGACATGGTGCGCATCTCCGACGCGCGGATGAGCGGC
ACGGCTTACGGCACCGTTGTGTTGCACGTTGCCCCAGAAGCCGCAGCGGGCGGGCCTTTGGCGGCGGTGAAGGAAGGTGA
CTGGATCGAGCTGGACTGTGCCAGCGGGCGTCTGCATCTGGATATTCCGGACGCTGAACTGGCAGCGCGGATGGCGGATC
TGCAACCGCCGCAGCAGCTGTTGGTGGGAGGGTATCGTCAGTTGTATATCGACCATGTGCTGCAGGCGGATCAGGGTTGC
GATTTCGACTTCCTGGTAGGTTGCCGAGGGGCTGAAGTCCCGCGCCATTCCCACTAA

Upstream 100 bases:

>100_bases
TAGTAATACTAATTGCGCAACAACACTTCCAAAGCGGCGATTTTGCGCTTATGTTTAGCCAAAGCTCGCAAACAATAGTC
TTACAATAAGAGAATCGATC

Downstream 100 bases:

>100_bases
CACCGTCATCCCCTTGTGGGAGCCAGCCTGCTGGCGATGGCGATCTGTCAGTTGATATTCATATTGACTGATACACCGCT
ATCGCGAGCAGGCTCGCTCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFHGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKHKGKDI
GSGTVVWQLSEQVKAGTITIDDFLAAEGGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDARRYVLAHMSGMR
AVEMVREDLKLSKILTKEAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVELDLDDWTRIGRGMPTIVDLQPSGRFLMEEF
YYAGGLPAVLRRLGEANLIPNPNALTVNGKSIGENTKDAPIYGEDEVIRTLDNPIRADGGICVLRGNLAPLGAVLKPSAA
TPELMQHRGRAVVFENFDMYKARINDPELDVDANSILVMKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMSG
TAYGTVVLHVAPEAAAGGPLAAVKEGDWIELDCASGRLHLDIPDAELAARMADLQPPQQLLVGGYRQLYIDHVLQADQGC
DFDFLVGCRGAEVPRHSH

Sequences:

>Translated_578_residues
MSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFHGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGFPVE
FPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKHKGKDI
GSGTVVWQLSEQVKAGTITIDDFLAAEGGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDARRYVLAHMSGMR
AVEMVREDLKLSKILTKEAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVELDLDDWTRIGRGMPTIVDLQPSGRFLMEEF
YYAGGLPAVLRRLGEANLIPNPNALTVNGKSIGENTKDAPIYGEDEVIRTLDNPIRADGGICVLRGNLAPLGAVLKPSAA
TPELMQHRGRAVVFENFDMYKARINDPELDVDANSILVMKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMSG
TAYGTVVLHVAPEAAAGGPLAAVKEGDWIELDCASGRLHLDIPDAELAARMADLQPPQQLLVGGYRQLYIDHVLQADQGC
DFDFLVGCRGAEVPRHSH
>Mature_577_residues
SDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFHGKPIIGICNTWSELTPCNAHFRQIAEHVKRGVIEAGGFPVEF
PVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDGVVLLTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKHKGKDIG
SGTVVWQLSEQVKAGTITIDDFLAAEGGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDARRYVLAHMSGMRA
VEMVREDLKLSKILTKEAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVELDLDDWTRIGRGMPTIVDLQPSGRFLMEEFY
YAGGLPAVLRRLGEANLIPNPNALTVNGKSIGENTKDAPIYGEDEVIRTLDNPIRADGGICVLRGNLAPLGAVLKPSAAT
PELMQHRGRAVVFENFDMYKARINDPELDVDANSILVMKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVKEGDWIELDCASGRLHLDIPDAELAARMADLQPPQQLLVGGYRQLYIDHVLQADQGCD
FDFLVGCRGAEVPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=579, Percent_Identity=30.2245250431779, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI2367371, Length=487, Percent_Identity=31.6221765913758, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1788157, Length=532, Percent_Identity=28.0075187969925, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1786464, Length=451, Percent_Identity=32.8159645232816, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=543, Percent_Identity=31.6758747697974, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 61802; Mature: 61671

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFHGKPIIGICNTWSELTPCNAHF
CCCCCCCCCCCEECCCCCCCCCEEHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
RQIAEHVKRGVIEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDGVVL
HHHHHHHHHCHHHCCCCEEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEE
LTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKHKGKDIGSGTVVWQLSEQVKAGTITI
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCEEEE
DDFLAAEGGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDARRYVLAHMSGMR
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHH
AVEMVREDLKLSKILTKEAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVELDLDDWTRIG
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEECCCCCEEEECHHHHHHC
RGMPTIVDLQPSGRFLMEEFYYAGGLPAVLRRLGEANLIPNPNALTVNGKSIGENTKDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHCCCCCCCCC
IYGEDEVIRTLDNPIRADGGICVLRGNLAPLGAVLKPSAATPELMQHRGRAVVFENFDMY
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCEE
KARINDPELDVDANSILVMKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMSG
EEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
TAYGTVVLHVAPEAAAGGPLAAVKEGDWIELDCASGRLHLDIPDAELAARMADLQPPQQL
CEEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCCHHHHHHHHCCCCHHHH
LVGGYRQLYIDHVLQADQGCDFDFLVGCRGAEVPRHSH
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SDKKPTLRSAQWFGTADKNGFMYRSWMKNQGIADHQFHGKPIIGICNTWSELTPCNAHF
CCCCCCCCCCEECCCCCCCCCEEHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHH
RQIAEHVKRGVIEAGGFPVEFPVFSNGESNLRPTAMLTRNLASMDVEEAIRGNPIDGVVL
HHHHHHHHHCHHHCCCCEEECCEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCEEE
LTGCDKTTPALLMGAASCDVPAIVVTGGPMLNGKHKGKDIGSGTVVWQLSEQVKAGTITI
EECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCEEEE
DDFLAAEGGMSRSAGTCNTMGTASTMACMAEALGTSLPHNAAIPAVDARRYVLAHMSGMR
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHH
AVEMVREDLKLSKILTKEAFENAIRVNAAIGGSTNAVIHLKAIAGRIGVELDLDDWTRIG
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEEEECCCCCEEEECHHHHHHC
RGMPTIVDLQPSGRFLMEEFYYAGGLPAVLRRLGEANLIPNPNALTVNGKSIGENTKDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEECCHHCCCCCCCCC
IYGEDEVIRTLDNPIRADGGICVLRGNLAPLGAVLKPSAATPELMQHRGRAVVFENFDMY
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCEE
KARINDPELDVDANSILVMKNCGPKGYPGMAEVGNMGLPAKLLAQGVTDMVRISDARMSG
EEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
TAYGTVVLHVAPEAAAGGPLAAVKEGDWIELDCASGRLHLDIPDAELAARMADLQPPQQL
CEEEEEEEEECCCCCCCCCEEEECCCCEEEEEECCCEEEEECCCHHHHHHHHCCCCHHHH
LVGGYRQLYIDHVLQADQGCDFDFLVGCRGAEVPRHSH
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA