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The map label for this gene is rsbRA [H]

Identifier: 77459355

GI number: 77459355

Start: 3596345

End: 3597196

Strand: Direct

Name: rsbRA [H]

Synonym: Pfl01_3133

Alternate gene names: 77459355

Gene position: 3596345-3597196 (Clockwise)

Preceding gene: 77459354

Following gene: 77459356

Centisome position: 55.86

GC content: 59.15

Gene sequence:

>852_bases
ATGGCAGCACTGCAGAACAGCACACTCGATGCGATTAAAAACAATCAGGTTCAACTGCTGGGCGAATGGATCAAGGGACT
GCAAGACAGCGGCGCCAGCCGCAACCTCAAAGAACATGATTTACAACAACAGACCCGCGAATTCCTGCAACTGGTGGTCA
GCGGCCTGGAAAACGACAGCGGCACCAACATCACCGCGCCGGGCTGGGAAGGCATGCGCCAGTTCCTCGAAAAACTCTCC
CACAGCCGCGCCCAGCTCGGTCAGGATTCCCAGCAGACCGCCAGCTTCATTTTCTCGCTCAAGGGCCCGCTGTTCGCCCT
GCTGCAAAACCATTATCAGGACCAGCCTGCCCTGCTCGCCGAACAGCTTTGGGAAATCTCCGAACTGTTCGATGCATTCG
GCCTGTACACCATTCGCACGTTCCAGAAATCCCGTGAAGCGGTGATCAAGCGCCAGCAGGAAGAACTGCTGGAGTTGTCG
ACCCCGGTGGTCAAACTGTGGGATGGCGTGCTCGCCCTGCCGATGATCGGCACCCTCGATTCACAACGCACCCAAGTGGT
GATGGAATCGCTGCTGCAACGCATCGTCGACACCGGCTCGGAAATCGCCATCATCGACATCACTGGCGTGCCAACCGTCG
ACACACTGGTCGCCCAACACCTGCTCAAGACCGTGACCGCGATCCGTCTGATGGGCGCCGACTGCATCATCAGCGGCGTG
CGTCCGCAGATTGCCCAGACCATCGTCCATCTGGGCCTGGATCTGCAGGGTGTGGTCACCAAAGCCAATCTGGCCGACGC
ACTGAAGCTGGCCCTGACCCGTCTGGGCATCACCCTCACCAAGACGGTCTGA

Upstream 100 bases:

>100_bases
TCGCGGGAACGAACAACTATTTCGAACGGCCAGGGTCATTCACTTCGCGCCGGTCATTTTCCGAAGAACCGGCCCCAATT
CGCAATGGAGCAACAGGCAC

Downstream 100 bases:

>100_bases
ACAATGGAACGTATCCCGATTCTTCAGATGGGTGACTTCCTGCTGGTGACCATCCAGGTCGACATGCATGACCAACTCGC
CCTCACCCTGCAAGACGACC

Product: anti-sigma-factor antagonist (STAS)

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAALQNSTLDAIKNNQVQLLGEWIKGLQDSGASRNLKEHDLQQQTREFLQLVVSGLENDSGTNITAPGWEGMRQFLEKLS
HSRAQLGQDSQQTASFIFSLKGPLFALLQNHYQDQPALLAEQLWEISELFDAFGLYTIRTFQKSREAVIKRQQEELLELS
TPVVKLWDGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADCIISGV
RPQIAQTIVHLGLDLQGVVTKANLADALKLALTRLGITLTKTV

Sequences:

>Translated_283_residues
MAALQNSTLDAIKNNQVQLLGEWIKGLQDSGASRNLKEHDLQQQTREFLQLVVSGLENDSGTNITAPGWEGMRQFLEKLS
HSRAQLGQDSQQTASFIFSLKGPLFALLQNHYQDQPALLAEQLWEISELFDAFGLYTIRTFQKSREAVIKRQQEELLELS
TPVVKLWDGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADCIISGV
RPQIAQTIVHLGLDLQGVVTKANLADALKLALTRLGITLTKTV
>Mature_282_residues
AALQNSTLDAIKNNQVQLLGEWIKGLQDSGASRNLKEHDLQQQTREFLQLVVSGLENDSGTNITAPGWEGMRQFLEKLSH
SRAQLGQDSQQTASFIFSLKGPLFALLQNHYQDQPALLAEQLWEISELFDAFGLYTIRTFQKSREAVIKRQQEELLELST
PVVKLWDGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADCIISGVR
PQIAQTIVHLGLDLQGVVTKANLADALKLALTRLGITLTKTV

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 31204; Mature: 31073

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALQNSTLDAIKNNQVQLLGEWIKGLQDSGASRNLKEHDLQQQTREFLQLVVSGLENDS
CCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTNITAPGWEGMRQFLEKLSHSRAQLGQDSQQTASFIFSLKGPLFALLQNHYQDQPALLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EQLWEISELFDAFGLYTIRTFQKSREAVIKRQQEELLELSTPVVKLWDGVLALPMIGTLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
SQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADCIISGV
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPQIAQTIVHLGLDLQGVVTKANLADALKLALTRLGITLTKTV
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
AALQNSTLDAIKNNQVQLLGEWIKGLQDSGASRNLKEHDLQQQTREFLQLVVSGLENDS
CCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTNITAPGWEGMRQFLEKLSHSRAQLGQDSQQTASFIFSLKGPLFALLQNHYQDQPALLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EQLWEISELFDAFGLYTIRTFQKSREAVIKRQQEELLELSTPVVKLWDGVLALPMIGTLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
SQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADCIISGV
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPQIAQTIVHLGLDLQGVVTKANLADALKLALTRLGITLTKTV
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]