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The map label for this gene is hisN [H]

Identifier: 77459181

GI number: 77459181

Start: 3395145

End: 3395924

Strand: Reverse

Name: hisN [H]

Synonym: Pfl01_2956

Alternate gene names: 77459181

Gene position: 3395924-3395145 (Counterclockwise)

Preceding gene: 77459182

Following gene: 77459180

Centisome position: 52.74

GC content: 50.51

Gene sequence:

>780_bases
ATGCATTTGATTAATCAGTATCAGCATTTCGCTGAGCGTTTAGCTGATCTCTCCGCTAAGGTTATTGAGCCATACTTTAG
AGTTAAGTTGGATGTAAAGCACAAAGGGGGGAGCGTCTACGATCCGGTAACGTTGGCTGATCGAAAAGCCGAGCAAGCAA
TGCGTGAACTGATTCAGGATCAATACCCCACACATGGAATTTTAGGTGAGGAGGAAGGCTCGCTGCTGGGTAGCAGTGAA
CTGACTTGGGTACTTGATCCTATCGATGGGACTCGATCGTTTATCACCGGGTTGCCACTGTGGGGCACGCTTATAGCCTT
AAACGATGGTCAGCGCCCCGTCCTTGGAGTGATGAATCAGCCATTTACTGGCGAGCGGTACGTTGGCACGCCTGAAGGCG
CTTGGCTCAATGGAAACAAGTTGAAAACACGTCAATGCCCGGAAATTTCCTCGGCCACGTTGATGTGCACGACATTGCAA
TTGTTCAACACGGCAGTTCGTCGAGACGCCTTTCAAGCGGTAGCGGATCAGGTGAAGTTGGTTCGTTTTGGCGGAGATTG
TTATGCGTACTGCATGCTCGCATCGGGACTCGTTGATGTGGTGATCGAAGCCAGTCTGCAGCCTTACGATATCCAAGCGT
TGATTCCAATAATAGAAGGCGCTGGTGGAGTGATTACCACTTGGGATGGCAGCTCAGCGCAGTATGGTGGAACGATCATC
GCTTGCGGAGACCGGTCACTGCATATGCAACTGATAGAAAGGCTGAAACACGCCACTTGA

Upstream 100 bases:

>100_bases
AAGCACGACGAAAAATACATGCCGCCGGAAGTGGCCAAGGCTCTGAAAGACAGCGGTCAGTCGGCACCCGCGCCCGGGAA
GGAGGGCTGATCTGTTGGAC

Downstream 100 bases:

>100_bases
CTGATGAGCTGTCGCTCACCGACCAGTGGTTTGATGTTGTTCTGGACCGATCGGTCCTTAACGATTAGAGTAGTTCTCCA
CACAGTCCAATCCGGCTTAC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MHLINQYQHFAERLADLSAKVIEPYFRVKLDVKHKGGSVYDPVTLADRKAEQAMRELIQDQYPTHGILGEEEGSLLGSSE
LTWVLDPIDGTRSFITGLPLWGTLIALNDGQRPVLGVMNQPFTGERYVGTPEGAWLNGNKLKTRQCPEISSATLMCTTLQ
LFNTAVRRDAFQAVADQVKLVRFGGDCYAYCMLASGLVDVVIEASLQPYDIQALIPIIEGAGGVITTWDGSSAQYGGTII
ACGDRSLHMQLIERLKHAT

Sequences:

>Translated_259_residues
MHLINQYQHFAERLADLSAKVIEPYFRVKLDVKHKGGSVYDPVTLADRKAEQAMRELIQDQYPTHGILGEEEGSLLGSSE
LTWVLDPIDGTRSFITGLPLWGTLIALNDGQRPVLGVMNQPFTGERYVGTPEGAWLNGNKLKTRQCPEISSATLMCTTLQ
LFNTAVRRDAFQAVADQVKLVRFGGDCYAYCMLASGLVDVVIEASLQPYDIQALIPIIEGAGGVITTWDGSSAQYGGTII
ACGDRSLHMQLIERLKHAT
>Mature_259_residues
MHLINQYQHFAERLADLSAKVIEPYFRVKLDVKHKGGSVYDPVTLADRKAEQAMRELIQDQYPTHGILGEEEGSLLGSSE
LTWVLDPIDGTRSFITGLPLWGTLIALNDGQRPVLGVMNQPFTGERYVGTPEGAWLNGNKLKTRQCPEISSATLMCTTLQ
LFNTAVRRDAFQAVADQVKLVRFGGDCYAYCMLASGLVDVVIEASLQPYDIQALIPIIEGAGGVITTWDGSSAQYGGTII
ACGDRSLHMQLIERLKHAT

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=262, Percent_Identity=25.5725190839695, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI221625487, Length=262, Percent_Identity=25.5725190839695, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI7657236, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI221625507, Length=142, Percent_Identity=31.6901408450704, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788882, Length=262, Percent_Identity=29.7709923664122, Blast_Score=88, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193202572, Length=221, Percent_Identity=28.5067873303167, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202570, Length=220, Percent_Identity=29.0909090909091, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=27.8606965174129, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321836, Length=117, Percent_Identity=32.4786324786325, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664918, Length=217, Percent_Identity=29.0322580645161, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357957, Length=236, Percent_Identity=29.2372881355932, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664922, Length=220, Percent_Identity=29.5454545454545, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664926, Length=236, Percent_Identity=26.271186440678, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357329, Length=195, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357303, Length=200, Percent_Identity=27, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28441; Mature: 28441

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLINQYQHFAERLADLSAKVIEPYFRVKLDVKHKGGSVYDPVTLADRKAEQAMRELIQD
CCHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHH
QYPTHGILGEEEGSLLGSSELTWVLDPIDGTRSFITGLPLWGTLIALNDGQRPVLGVMNQ
CCCCCCCCCCCCCCEECCCCCEEEECCCCCHHHHHHCCCCHHEEEEECCCCCCEECCCCC
PFTGERYVGTPEGAWLNGNKLKTRQCPEISSATLMCTTLQLFNTAVRRDAFQAVADQVKL
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VRFGGDCYAYCMLASGLVDVVIEASLQPYDIQALIPIIEGAGGVITTWDGSSAQYGGTII
EEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEHHCCCCCEEEECCCCCCCCCCEEE
ACGDRSLHMQLIERLKHAT
EECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHLINQYQHFAERLADLSAKVIEPYFRVKLDVKHKGGSVYDPVTLADRKAEQAMRELIQD
CCHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEEECCCCEECCHHHHHHHHHHHHHHHHHH
QYPTHGILGEEEGSLLGSSELTWVLDPIDGTRSFITGLPLWGTLIALNDGQRPVLGVMNQ
CCCCCCCCCCCCCCEECCCCCEEEECCCCCHHHHHHCCCCHHEEEEECCCCCCEECCCCC
PFTGERYVGTPEGAWLNGNKLKTRQCPEISSATLMCTTLQLFNTAVRRDAFQAVADQVKL
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE
VRFGGDCYAYCMLASGLVDVVIEASLQPYDIQALIPIIEGAGGVITTWDGSSAQYGGTII
EEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEHHCCCCCEEEECCCCCCCCCCEEE
ACGDRSLHMQLIERLKHAT
EECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]