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The map label for this gene is tibA [H]

Identifier: 77459122

GI number: 77459122

Start: 3338552

End: 3340795

Strand: Reverse

Name: tibA [H]

Synonym: Pfl01_2897

Alternate gene names: 77459122

Gene position: 3340795-3338552 (Counterclockwise)

Preceding gene: 77459123

Following gene: 77459117

Centisome position: 51.89

GC content: 54.46

Gene sequence:

>2244_bases
ATGCAAAGAAAAATATCGAATGTACGTCTACGCGATATCCGTTGGGGGCTAGTGCTTTCATCGTTTCTAGCTCCGTTTTC
GCAAATCGCCATCGGAGGAAATCTGATCGGAGGGACTACAACGATTACTGGAGGCACTCCCGAGGACTGGACGCTCAGTT
CCAATGCAACCTTGAATGTCAATGGTGCTGACACCTTGTTTATCAACACGGATGCTTCAGTCCTCAATGTCAATTCGGGT
AATACTCAACAAATTGCTGCCCGCAATGGTTCACAAGTCAATCTGAGCGGCGCGAACGTTTCAGGTGCAAGTGGTTTGGC
AGCGGTGACACTTGTCAACAGCGATGGCAGCATCAAAAACAGCACGATCAATGGTAATCGTGTCGGGCTTCAGGTTGTGC
GTGACGCAAGTACCCTGACCGGATCGACTGCCACCGTAAGCGGCAAAAGCGTTATAACCGGCGTGACGGGCGGCGCATTG
GTTAGCGCGTTCAGTCGTCTGGATATTGTCGACTCAACCCTTCAGGCAACGGGTGCCAGCAGTTATGGGGTGCGCCTGGC
GAGCGGTCAGGCAACGGCAACGGACAGCACAATCATAGGAGGACAAAACGGCGTAATCATTGGTCTGGACGGTAACTCCG
TTCAGCCTGCGACACTGACCCTTACCAAGACAACCGTTGAAGGCGTAACGGGCTCCGCCATTCTGGTCGACTTCGCCAAC
GCTGGATCGTCCAGAGCGACCATCACTCTGGACAATGCGAATCTGTTGGCAGGCAACGGCACGATACTGGATGTACGGGG
CGGTGCAACGGCCTCGATGACGGTGAATAACAGTACCTTGAATGGCAATGTCATCAATGAAGCTGGCAGCACGGCTGAAT
TGGTATTGCAAAACAACTCGGCGCTGACCGGGCGTTTGGAAAACGTTTCTCATGCAACCATCAACGACACATCTCGTTGG
GTTCTGGTGGGCGATGGCCAGATTGAAAACCTTACTTTGAACGGTGGCACCGTGCGCTTCGGCGCTGACAATGCTTTTTA
TCAATTAAACGTCGGGCAACTGGCGGGAACTGGCCATTTCGAGTTGGGCACTGACTTCGCCACGGGTCAGACAGACTTGC
TGAATGTGACGGGGACAGCGACGGGGCGCCATGAGCTCGCAATCAGCAGTTCCGGTGTCGATCCGGCGGCCGGTCAACCG
ATCCGGGTGGTGCAGACTGCCGGGGGCGATGCAGAGTTCTTCATAAATCATCCTGTCGACCTTGGCACCTACTCATACGG
TCTGGAAAAAAACGGCAATGACTGGGTTCTTGATCCCACAACCAAAACGGTCAGCCCTGGAACGCGTTCGGTGTTGGCGC
TATTTAAAACTGCGCCAACCGTGTGGTATGGCGAACTTGCCTCACTGCATTCGCGCATGGGCGAGTTGCGTTTCAACGGT
GGGCAAGGTGGTGCGTGGGGGCGTACCTATGGCAATAAATACAATGTCGCCGATGCCTCAGGTGTCGGCTACCAGCAAAC
CCAGCAGGGTTTTACGTTAGGCGCTGATACTCCACTGCCATTTGGAGACCGACAATGGCTGATCGGCGTGATGGCAGGGC
ACAGCAAGTCGGATCTGAACCTGGATGGCGGCACTTCCGGCACGGTTACAAGCAATTATCTGGGAACCTACCTCACCTGG
ATTGACCCGCTCAGCGGTTATTACGTTGATGCTGTACTCAAGGTGAACCGCTTTCGCAACGACGCAAAAGTCGGCTTGAG
TGACGGTGGCAGGGCCAAGGGCGATTACGACAACACGGGATTGGGTGGTTCAGTCGAGCTGGGGCGGCGCATCAAACTGG
AAGATGGTGTTTTCATTGAGCCCTACACCAAGTGGTCCGGCGTGGTCATTGAGGGCAAGCATTTTTCCCTGGATAACGAC
ATGCAAGCCGATGGCGACCGTACTCGATCACTCCTGGGCGAGGCCGGCATGACCGTGGGACGCACATTTGCGCTCGAACG
CGATTTGAAAGTTCAACCCTACGCCCGTGTCGCGATGGCGCACGAGTTCGCGAAAAACAATGAGGTCAAGGTCAACAACA
ATGAATTCAACAATGATTTGTCGGGGAGTCGAGGTGAACTGGCCGTTGGCGTGGCAATTGCCATGACCGACCGCCTGCAG
GTGCACTTTGATGCGGACTACAGCAACGGGAAAAATATAGAGCGGCCAATAGGCTTGAACATCGGTGCCCGTTATAACTT
CTAG

Upstream 100 bases:

>100_bases
GATTAATCCTACATAAATCTACGCTACTTCAAGCTAGCTTAGCGACCCTCGTTTTCATGGCCCTTTCCCCGTGGCTCGTT
TTAAATAACAGGTGTTCACT

Downstream 100 bases:

>100_bases
ATAACGCTGTAATAAGAGATCAATAAAAAAGGAAGCCAATGCTTCCTTTTTTATTGCGTGCCAATATTCATGCGTCTCAA
GCAACCTTCAAATTCTTTTT

Product: outer membrane autotransporter barrel protein

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MQRKISNVRLRDIRWGLVLSSFLAPFSQIAIGGNLIGGTTTITGGTPEDWTLSSNATLNVNGADTLFINTDASVLNVNSG
NTQQIAARNGSQVNLSGANVSGASGLAAVTLVNSDGSIKNSTINGNRVGLQVVRDASTLTGSTATVSGKSVITGVTGGAL
VSAFSRLDIVDSTLQATGASSYGVRLASGQATATDSTIIGGQNGVIIGLDGNSVQPATLTLTKTTVEGVTGSAILVDFAN
AGSSRATITLDNANLLAGNGTILDVRGGATASMTVNNSTLNGNVINEAGSTAELVLQNNSALTGRLENVSHATINDTSRW
VLVGDGQIENLTLNGGTVRFGADNAFYQLNVGQLAGTGHFELGTDFATGQTDLLNVTGTATGRHELAISSSGVDPAAGQP
IRVVQTAGGDAEFFINHPVDLGTYSYGLEKNGNDWVLDPTTKTVSPGTRSVLALFKTAPTVWYGELASLHSRMGELRFNG
GQGGAWGRTYGNKYNVADASGVGYQQTQQGFTLGADTPLPFGDRQWLIGVMAGHSKSDLNLDGGTSGTVTSNYLGTYLTW
IDPLSGYYVDAVLKVNRFRNDAKVGLSDGGRAKGDYDNTGLGGSVELGRRIKLEDGVFIEPYTKWSGVVIEGKHFSLDND
MQADGDRTRSLLGEAGMTVGRTFALERDLKVQPYARVAMAHEFAKNNEVKVNNNEFNNDLSGSRGELAVGVAIAMTDRLQ
VHFDADYSNGKNIERPIGLNIGARYNF

Sequences:

>Translated_747_residues
MQRKISNVRLRDIRWGLVLSSFLAPFSQIAIGGNLIGGTTTITGGTPEDWTLSSNATLNVNGADTLFINTDASVLNVNSG
NTQQIAARNGSQVNLSGANVSGASGLAAVTLVNSDGSIKNSTINGNRVGLQVVRDASTLTGSTATVSGKSVITGVTGGAL
VSAFSRLDIVDSTLQATGASSYGVRLASGQATATDSTIIGGQNGVIIGLDGNSVQPATLTLTKTTVEGVTGSAILVDFAN
AGSSRATITLDNANLLAGNGTILDVRGGATASMTVNNSTLNGNVINEAGSTAELVLQNNSALTGRLENVSHATINDTSRW
VLVGDGQIENLTLNGGTVRFGADNAFYQLNVGQLAGTGHFELGTDFATGQTDLLNVTGTATGRHELAISSSGVDPAAGQP
IRVVQTAGGDAEFFINHPVDLGTYSYGLEKNGNDWVLDPTTKTVSPGTRSVLALFKTAPTVWYGELASLHSRMGELRFNG
GQGGAWGRTYGNKYNVADASGVGYQQTQQGFTLGADTPLPFGDRQWLIGVMAGHSKSDLNLDGGTSGTVTSNYLGTYLTW
IDPLSGYYVDAVLKVNRFRNDAKVGLSDGGRAKGDYDNTGLGGSVELGRRIKLEDGVFIEPYTKWSGVVIEGKHFSLDND
MQADGDRTRSLLGEAGMTVGRTFALERDLKVQPYARVAMAHEFAKNNEVKVNNNEFNNDLSGSRGELAVGVAIAMTDRLQ
VHFDADYSNGKNIERPIGLNIGARYNF
>Mature_747_residues
MQRKISNVRLRDIRWGLVLSSFLAPFSQIAIGGNLIGGTTTITGGTPEDWTLSSNATLNVNGADTLFINTDASVLNVNSG
NTQQIAARNGSQVNLSGANVSGASGLAAVTLVNSDGSIKNSTINGNRVGLQVVRDASTLTGSTATVSGKSVITGVTGGAL
VSAFSRLDIVDSTLQATGASSYGVRLASGQATATDSTIIGGQNGVIIGLDGNSVQPATLTLTKTTVEGVTGSAILVDFAN
AGSSRATITLDNANLLAGNGTILDVRGGATASMTVNNSTLNGNVINEAGSTAELVLQNNSALTGRLENVSHATINDTSRW
VLVGDGQIENLTLNGGTVRFGADNAFYQLNVGQLAGTGHFELGTDFATGQTDLLNVTGTATGRHELAISSSGVDPAAGQP
IRVVQTAGGDAEFFINHPVDLGTYSYGLEKNGNDWVLDPTTKTVSPGTRSVLALFKTAPTVWYGELASLHSRMGELRFNG
GQGGAWGRTYGNKYNVADASGVGYQQTQQGFTLGADTPLPFGDRQWLIGVMAGHSKSDLNLDGGTSGTVTSNYLGTYLTW
IDPLSGYYVDAVLKVNRFRNDAKVGLSDGGRAKGDYDNTGLGGSVELGRRIKLEDGVFIEPYTKWSGVVIEGKHFSLDND
MQADGDRTRSLLGEAGMTVGRTFALERDLKVQPYARVAMAHEFAKNNEVKVNNNEFNNDLSGSRGELAVGVAIAMTDRLQ
VHFDADYSNGKNIERPIGLNIGARYNF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=474, Percent_Identity=30.5907172995781, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787452, Length=521, Percent_Identity=25.5278310940499, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 78034; Mature: 78034

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKISNVRLRDIRWGLVLSSFLAPFSQIAIGGNLIGGTTTITGGTPEDWTLSSNATLNV
CCCCCCCCEEEEEHHHHHHHHHHCCHHHEEECCEEECCEEEECCCCCCCEEECCCCEEEE
NGADTLFINTDASVLNVNSGNTQQIAARNGSQVNLSGANVSGASGLAAVTLVNSDGSIKN
CCCEEEEEECCCEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCEEE
STINGNRVGLQVVRDASTLTGSTATVSGKSVITGVTGGALVSAFSRLDIVDSTLQATGAS
CCCCCCEEEEEEEECCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
SYGVRLASGQATATDSTIIGGQNGVIIGLDGNSVQPATLTLTKTTVEGVTGSAILVDFAN
CCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCEEEEEEEC
AGSSRATITLDNANLLAGNGTILDVRGGATASMTVNNSTLNGNVINEAGSTAELVLQNNS
CCCCEEEEEECCCEEEECCCEEEEECCCCEEEEEECCCCCCCCEECCCCCEEEEEEECCC
ALTGRLENVSHATINDTSRWVLVGDGQIENLTLNGGTVRFGADNAFYQLNVGQLAGTGHF
EEEEEECCCEEEEECCCCCEEEEECCEEEEEEECCCEEEECCCCEEEEEECHHCCCCCCE
ELGTDFATGQTDLLNVTGTATGRHELAISSSGVDPAAGQPIRVVQTAGGDAEFFINHPVD
EECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCC
LGTYSYGLEKNGNDWVLDPTTKTVSPGTRSVLALFKTAPTVWYGELASLHSRMGELRFNG
CCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHCCEEEEC
GQGGAWGRTYGNKYNVADASGVGYQQTQQGFTLGADTPLPFGDRQWLIGVMAGHSKSDLN
CCCCCCCCCCCCEECCCCCCCCCCHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCC
LDGGTSGTVTSNYLGTYLTWIDPLSGYYVDAVLKVNRFRNDAKVGLSDGGRAKGDYDNTG
CCCCCCCCEEHHHHHHHEEECCCCCCEEEEEEEEEHHCCCCCEEECCCCCCCCCCCCCCC
LGGSVELGRRIKLEDGVFIEPYTKWSGVVIEGKHFSLDNDMQADGDRTRSLLGEAGMTVG
CCCEEECCCEEEECCCEEEECCCCCCCEEEECCEECCCCCCCCCCHHHHHHHHHCCCCCC
RTFALERDLKVQPYARVAMAHEFAKNNEVKVNNNEFNNDLSGSRGELAVGVAIAMTDRLQ
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEE
VHFDADYSNGKNIERPIGLNIGARYNF
EEEECCCCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MQRKISNVRLRDIRWGLVLSSFLAPFSQIAIGGNLIGGTTTITGGTPEDWTLSSNATLNV
CCCCCCCCEEEEEHHHHHHHHHHCCHHHEEECCEEECCEEEECCCCCCCEEECCCCEEEE
NGADTLFINTDASVLNVNSGNTQQIAARNGSQVNLSGANVSGASGLAAVTLVNSDGSIKN
CCCEEEEEECCCEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCEEE
STINGNRVGLQVVRDASTLTGSTATVSGKSVITGVTGGALVSAFSRLDIVDSTLQATGAS
CCCCCCEEEEEEEECCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
SYGVRLASGQATATDSTIIGGQNGVIIGLDGNSVQPATLTLTKTTVEGVTGSAILVDFAN
CCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCEEEEEEEC
AGSSRATITLDNANLLAGNGTILDVRGGATASMTVNNSTLNGNVINEAGSTAELVLQNNS
CCCCEEEEEECCCEEEECCCEEEEECCCCEEEEEECCCCCCCCEECCCCCEEEEEEECCC
ALTGRLENVSHATINDTSRWVLVGDGQIENLTLNGGTVRFGADNAFYQLNVGQLAGTGHF
EEEEEECCCEEEEECCCCCEEEEECCEEEEEEECCCEEEECCCCEEEEEECHHCCCCCCE
ELGTDFATGQTDLLNVTGTATGRHELAISSSGVDPAAGQPIRVVQTAGGDAEFFINHPVD
EECCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCC
LGTYSYGLEKNGNDWVLDPTTKTVSPGTRSVLALFKTAPTVWYGELASLHSRMGELRFNG
CCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHCCEEEEC
GQGGAWGRTYGNKYNVADASGVGYQQTQQGFTLGADTPLPFGDRQWLIGVMAGHSKSDLN
CCCCCCCCCCCCEECCCCCCCCCCHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCC
LDGGTSGTVTSNYLGTYLTWIDPLSGYYVDAVLKVNRFRNDAKVGLSDGGRAKGDYDNTG
CCCCCCCCEEHHHHHHHEEECCCCCCEEEEEEEEEHHCCCCCEEECCCCCCCCCCCCCCC
LGGSVELGRRIKLEDGVFIEPYTKWSGVVIEGKHFSLDNDMQADGDRTRSLLGEAGMTVG
CCCEEECCCEEEECCCEEEECCCCCCCEEEECCEECCCCCCCCCCHHHHHHHHHCCCCCC
RTFALERDLKVQPYARVAMAHEFAKNNEVKVNNNEFNNDLSGSRGELAVGVAIAMTDRLQ
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEE
VHFDADYSNGKNIERPIGLNIGARYNF
EEEECCCCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]