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The map label for this gene is qor [C]

Identifier: 77458701

GI number: 77458701

Start: 2831219

End: 2832217

Strand: Reverse

Name: qor [C]

Synonym: Pfl01_2476

Alternate gene names: 77458701

Gene position: 2832217-2831219 (Counterclockwise)

Preceding gene: 77458702

Following gene: 77458699

Centisome position: 43.99

GC content: 59.36

Gene sequence:

>999_bases
ATGAAAGCATTTCTGATTGATGGCTATGGCAAGAACCCCGGACGCATTGGCGAAGCGCCCGCCCCCGCAGTCGGTGCCCA
CGACGTCTTGATCGAGGTCCATGCGAGCAGTGTCAACGTGCTGGATTCGAAGATCAGCAAAGGCGAGTTCAAGCTGATCC
TGCCCTACGCCTTTCCGTTGATATTGGGCAATGACCTGGCGGGTGTCGTGGTTGAAGTCGGCCCGCAGGTGACACGCTTC
AAACCGGGAGACGAGGTATACGCTCGCCCGCCCGAAGCGCGGATCGGGACGTTCGCCCAATTGATCGCTGTGAACGAAAA
CGCGGTCGCCCTGAAACCTGCCAATACCGACATGGCACAAGCCGCATCCCTGCCTTTGGTTGCACTGACCGCCTGGCAAG
TACTGGTTGAAACCGCCCGGCTGCAAAAGGGCCAGAAAGTGCTGATTCACGCGGGTTCCGGCGGCGTCGGCACAGTTGCG
ATTCAGCTTGCCAAACACCTCGGTGCGTTTGTCGCCACAACCACCAGTACCGCCAATGTCGAATGGGTCAAGGCGCTGGG
GGCCGATCTGGTGATCGACTACACACAGCAGGACTTCGCAAGTGTCCTGCATGACTACGACGTGGTGCTGAACAGCCTCG
GCGCCGACGTGCTGGAGAAGTCACTCAAGGTCCTGAAGCCCGGCGGCCAACTCATTTCCATCTCGGGCCCACCCACTGTG
CAGTTCGCGAGGGAGCATGGATTGTCCTGGCCATTGCAGCAAGTCATGCGCCTGCTGAGCCTTGGCATTCGTCGCAAAGC
GCGCAAGCAGGATGTCAGCTACGCGTTCGTGTTCATGCGGGCCAATGGCGCTCAACTGCAACACATCACCGCGCTCGTGG
AGGACGGGATCATCAAACCCGTGGTCGATCGCTCCTTCCTCTTTGAATCAACGGCCGAGGCATTGAAGTACGTTGAGCGG
GGACGCGCCAAGGGCAAGGTCGTTGTTGCGCTCAAATGA

Upstream 100 bases:

>100_bases
GTGGCCAAGGCGCAGGCGTTTCTCGATGCTTGATCACGTCACGCAGCAACACCGCAACCCACCGACTACCCTCCGTACAA
CCAGCAAGAGCCGCACCACG

Downstream 100 bases:

>100_bases
CCACGCCGCCTACTCATGAATCGACCGTAGACACTGCACAGCTTTTACTGCTGGAGCGGCCCTCAGCCGAATTGATTTCG
CCAGAGGAGCAGGAACAGCA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKAFLIDGYGKNPGRIGEAPAPAVGAHDVLIEVHASSVNVLDSKISKGEFKLILPYAFPLILGNDLAGVVVEVGPQVTRF
KPGDEVYARPPEARIGTFAQLIAVNENAVALKPANTDMAQAASLPLVALTAWQVLVETARLQKGQKVLIHAGSGGVGTVA
IQLAKHLGAFVATTTSTANVEWVKALGADLVIDYTQQDFASVLHDYDVVLNSLGADVLEKSLKVLKPGGQLISISGPPTV
QFAREHGLSWPLQQVMRLLSLGIRRKARKQDVSYAFVFMRANGAQLQHITALVEDGIIKPVVDRSFLFESTAEALKYVER
GRAKGKVVVALK

Sequences:

>Translated_332_residues
MKAFLIDGYGKNPGRIGEAPAPAVGAHDVLIEVHASSVNVLDSKISKGEFKLILPYAFPLILGNDLAGVVVEVGPQVTRF
KPGDEVYARPPEARIGTFAQLIAVNENAVALKPANTDMAQAASLPLVALTAWQVLVETARLQKGQKVLIHAGSGGVGTVA
IQLAKHLGAFVATTTSTANVEWVKALGADLVIDYTQQDFASVLHDYDVVLNSLGADVLEKSLKVLKPGGQLISISGPPTV
QFAREHGLSWPLQQVMRLLSLGIRRKARKQDVSYAFVFMRANGAQLQHITALVEDGIIKPVVDRSFLFESTAEALKYVER
GRAKGKVVVALK
>Mature_332_residues
MKAFLIDGYGKNPGRIGEAPAPAVGAHDVLIEVHASSVNVLDSKISKGEFKLILPYAFPLILGNDLAGVVVEVGPQVTRF
KPGDEVYARPPEARIGTFAQLIAVNENAVALKPANTDMAQAASLPLVALTAWQVLVETARLQKGQKVLIHAGSGGVGTVA
IQLAKHLGAFVATTTSTANVEWVKALGADLVIDYTQQDFASVLHDYDVVLNSLGADVLEKSLKVLKPGGQLISISGPPTV
QFAREHGLSWPLQQVMRLLSLGIRRKARKQDVSYAFVFMRANGAQLQHITALVEDGIIKPVVDRSFLFESTAEALKYVER
GRAKGKVVVALK

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=353, Percent_Identity=35.1274787535411, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI194239674, Length=315, Percent_Identity=28.2539682539683, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI13236495, Length=315, Percent_Identity=28.2539682539683, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI22538446, Length=333, Percent_Identity=29.7297297297297, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI22538444, Length=333, Percent_Identity=29.7297297297297, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI18379349, Length=313, Percent_Identity=27.7955271565495, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI194239676, Length=153, Percent_Identity=34.640522875817, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI24308257, Length=344, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI41872631, Length=242, Percent_Identity=28.9256198347107, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI67078404, Length=252, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28557745, Length=333, Percent_Identity=27.3273273273273, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI67078406, Length=219, Percent_Identity=29.2237442922374, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI90669511, Length=157, Percent_Identity=30.5732484076433, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790485, Length=216, Percent_Identity=32.4074074074074, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=353, Percent_Identity=30.3116147308782, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17507255, Length=332, Percent_Identity=26.2048192771084, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=230, Percent_Identity=29.5652173913043, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24581341, Length=333, Percent_Identity=28.2282282282282, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24581339, Length=333, Percent_Identity=28.2282282282282, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35527; Mature: 35527

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFLIDGYGKNPGRIGEAPAPAVGAHDVLIEVHASSVNVLDSKISKGEFKLILPYAFPL
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEEECHHHHH
ILGNDLAGVVVEVGPQVTRFKPGDEVYARPPEARIGTFAQLIAVNENAVALKPANTDMAQ
HCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHEEEEEECCCEEEEECCCCCHHH
AASLPLVALTAWQVLVETARLQKGQKVLIHAGSGGVGTVAIQLAKHLGAFVATTTSTANV
HHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCH
EWVKALGADLVIDYTQQDFASVLHDYDVVLNSLGADVLEKSLKVLKPGGQLISISGPPTV
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEECCCCCC
QFAREHGLSWPLQQVMRLLSLGIRRKARKQDVSYAFVFMRANGAQLQHITALVEDGIIKP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCH
VVDRSFLFESTAEALKYVERGRAKGKVVVALK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MKAFLIDGYGKNPGRIGEAPAPAVGAHDVLIEVHASSVNVLDSKISKGEFKLILPYAFPL
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCEEEEECHHHHH
ILGNDLAGVVVEVGPQVTRFKPGDEVYARPPEARIGTFAQLIAVNENAVALKPANTDMAQ
HCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHHHHHEEEEEECCCEEEEECCCCCHHH
AASLPLVALTAWQVLVETARLQKGQKVLIHAGSGGVGTVAIQLAKHLGAFVATTTSTANV
HHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCH
EWVKALGADLVIDYTQQDFASVLHDYDVVLNSLGADVLEKSLKVLKPGGQLISISGPPTV
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEECCCCCC
QFAREHGLSWPLQQVMRLLSLGIRRKARKQDVSYAFVFMRANGAQLQHITALVEDGIIKP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCCH
VVDRSFLFESTAEALKYVERGRAKGKVVVALK
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA