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The map label for this gene is betA [H]

Identifier: 77458590

GI number: 77458590

Start: 2721510

End: 2723039

Strand: Direct

Name: betA [H]

Synonym: Pfl01_2363

Alternate gene names: 77458590

Gene position: 2721510-2723039 (Clockwise)

Preceding gene: 77458589

Following gene: 77458591

Centisome position: 42.27

GC content: 64.97

Gene sequence:

>1530_bases
ATGAACGATACCCTTGTTAATTCTGCCCAGCGTGCCCCGGTCGATGTGATCGTGGTGGGCGGCGGTTCCGCCGGCGCGGT
ACTGGCCCGTCGCTTGAGTGAAAACGTCCGGCGCCAGGTGCTGTTGCTGGAGGCGGGTCAGAGTTTTGCCCCGGGCAAGT
ACCCCGAAATCGTCGCCAGTAGCGATGTGGTCGGTGCCAATGGCAATCGCCAGTTCGAGTGGGGTTACACCTCCCGGCCG
GGCTATGTCGAACACCCGATCGGCGCGTTGCGCGGCAAAGTGCTGGGCGGCAGTTCGGCCATCAACGGCGCGGTGGCGAT
TCGCGCCCGAGCCACGGACTTCCAGCGCTGGAATCTGCCGGGCTGGAGCTTTGAGGACTTGCTGCCCTCGTTCAAAAAAC
TGGAAAACCACAGCGGCGGAGCCAGCGCATTGCATGGCCACGACGGGCCGCTGCCGGTGCGTCAGCTCGGCAGCGCCGAC
GTCACACCAATGCAGAAAGCCTTCATCTACGCCACGGTCGCCAACGGTTACCGGATGATCGACGACTTCGACGGCGCGAA
TGCCAACGGCGTCGGCCCGTACCCGATGAACATCGTCGACGGCGTGCGGGTCAACACCGGCATGGCTTACCTCACGGACG
AGGTGCGCGCCCGCGACAATTTGCAGATTCGCGCCGACAGCCTGGTGGACAAGGTGCTGTTCGACGGCAAACGTGCGGTG
GGTGTGCAACTGGCGAATGGCGAGCAATTACGCGCCAACGAAGTGATTCTTTCGGCGGGCAGTTACGGCAGCGCGGCGAT
CCTGTTGCGCTCCGGTATCGGCCCTGGCGACGATCTGCGCGCACTGGACATTGAGCCGGTCGCCGAATTGCCGGTCGGGC
AGAACCTGGCGGATCACCCGTTCTATTACAATGCCTACGCCGCCAAACCCGACCTGATCGGTCGCCAGTCGCCGGCCATA
GGCGCCAAGCTCTGGACCCACAGCCGCAGCGCCGAGCACGGCGATCTGGATATTCACATCACCGCGACCCACCTGTTCCC
CCATGACCAGAGCCCGACCCAGGTGGGCTTCGTGCTCGCGGTGGCGCTGACCCGGCCGCTGTCCCGAGGCAAGGTTACGC
TGGCCAGCCGCGATCCGTCGGTGGCGCCGAATATCGATCTGAATTTTCTCGCCGAGCCCATGGACCGCCAGCGCCTGCTG
GACGGTATTCGTCTGGCACGGCGGATCGGTGCGACCGCGCCGCTCAAGGGTTTGATTCACTCGGAGCTGAATCCGGGGCA
GGGCAACGACTCCGACGACGCCTTGCTGGCCAGCGTCAAAGCCACGCTCGACACCTATCACCACCCGACCTCGACCGCGC
CGATGGGCCGGCCGGGCGATGCCATGGCCGTGGTCGACCTCGAAGCCCGAGTAATCGGCGTGCAGGGCCTGCGGGTGGTC
GACGCTTCCATCTTCCCGGACGTGCCGTCCGTTGCCACCAACCTCACCGTGATCGCCACCGCCGAAAAAATCGCCGGTCT
CTACGCCTGA

Upstream 100 bases:

>100_bases
CGAAACCGCGATTCGTTTTTCCCCGGCTTATGAGCCCTCGAACCCTTCAATAAGCTCTTCCTCAACAGGCGCGCTTTGAC
GCCTGACAGGGAAGAAACCG

Downstream 100 bases:

>100_bases
ATCCAAGGAAGCTTTCGCCATGAACAACACCAAGGTTTTGAACTGGATCGACGGCCTGTGGCTGGATTCCGGTGACTACA
AAGACTCCATCGACCCAGCG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNDTLVNSAQRAPVDVIVVGGGSAGAVLARRLSENVRRQVLLLEAGQSFAPGKYPEIVASSDVVGANGNRQFEWGYTSRP
GYVEHPIGALRGKVLGGSSAINGAVAIRARATDFQRWNLPGWSFEDLLPSFKKLENHSGGASALHGHDGPLPVRQLGSAD
VTPMQKAFIYATVANGYRMIDDFDGANANGVGPYPMNIVDGVRVNTGMAYLTDEVRARDNLQIRADSLVDKVLFDGKRAV
GVQLANGEQLRANEVILSAGSYGSAAILLRSGIGPGDDLRALDIEPVAELPVGQNLADHPFYYNAYAAKPDLIGRQSPAI
GAKLWTHSRSAEHGDLDIHITATHLFPHDQSPTQVGFVLAVALTRPLSRGKVTLASRDPSVAPNIDLNFLAEPMDRQRLL
DGIRLARRIGATAPLKGLIHSELNPGQGNDSDDALLASVKATLDTYHHPTSTAPMGRPGDAMAVVDLEARVIGVQGLRVV
DASIFPDVPSVATNLTVIATAEKIAGLYA

Sequences:

>Translated_509_residues
MNDTLVNSAQRAPVDVIVVGGGSAGAVLARRLSENVRRQVLLLEAGQSFAPGKYPEIVASSDVVGANGNRQFEWGYTSRP
GYVEHPIGALRGKVLGGSSAINGAVAIRARATDFQRWNLPGWSFEDLLPSFKKLENHSGGASALHGHDGPLPVRQLGSAD
VTPMQKAFIYATVANGYRMIDDFDGANANGVGPYPMNIVDGVRVNTGMAYLTDEVRARDNLQIRADSLVDKVLFDGKRAV
GVQLANGEQLRANEVILSAGSYGSAAILLRSGIGPGDDLRALDIEPVAELPVGQNLADHPFYYNAYAAKPDLIGRQSPAI
GAKLWTHSRSAEHGDLDIHITATHLFPHDQSPTQVGFVLAVALTRPLSRGKVTLASRDPSVAPNIDLNFLAEPMDRQRLL
DGIRLARRIGATAPLKGLIHSELNPGQGNDSDDALLASVKATLDTYHHPTSTAPMGRPGDAMAVVDLEARVIGVQGLRVV
DASIFPDVPSVATNLTVIATAEKIAGLYA
>Mature_509_residues
MNDTLVNSAQRAPVDVIVVGGGSAGAVLARRLSENVRRQVLLLEAGQSFAPGKYPEIVASSDVVGANGNRQFEWGYTSRP
GYVEHPIGALRGKVLGGSSAINGAVAIRARATDFQRWNLPGWSFEDLLPSFKKLENHSGGASALHGHDGPLPVRQLGSAD
VTPMQKAFIYATVANGYRMIDDFDGANANGVGPYPMNIVDGVRVNTGMAYLTDEVRARDNLQIRADSLVDKVLFDGKRAV
GVQLANGEQLRANEVILSAGSYGSAAILLRSGIGPGDDLRALDIEPVAELPVGQNLADHPFYYNAYAAKPDLIGRQSPAI
GAKLWTHSRSAEHGDLDIHITATHLFPHDQSPTQVGFVLAVALTRPLSRGKVTLASRDPSVAPNIDLNFLAEPMDRQRLL
DGIRLARRIGATAPLKGLIHSELNPGQGNDSDDALLASVKATLDTYHHPTSTAPMGRPGDAMAVVDLEARVIGVQGLRVV
DASIFPDVPSVATNLTVIATAEKIAGLYA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=537, Percent_Identity=37.243947858473, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1786503, Length=534, Percent_Identity=36.7041198501873, Blast_Score=264, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17532301, Length=546, Percent_Identity=30.7692307692308, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24650267, Length=580, Percent_Identity=32.0689655172414, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24642039, Length=563, Percent_Identity=32.1492007104796, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24642037, Length=568, Percent_Identity=30.6338028169014, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642048, Length=566, Percent_Identity=31.8021201413428, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17137792, Length=557, Percent_Identity=31.4183123877917, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24642042, Length=569, Percent_Identity=31.2829525483304, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=29.7723292469352, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24642051, Length=564, Percent_Identity=28.1914893617021, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642057, Length=576, Percent_Identity=28.8194444444444, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI45549471, Length=308, Percent_Identity=34.7402597402597, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI18859995, Length=305, Percent_Identity=37.0491803278689, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551458, Length=308, Percent_Identity=34.7402597402597, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642035, Length=307, Percent_Identity=35.5048859934853, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642055, Length=309, Percent_Identity=36.2459546925566, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24642059, Length=308, Percent_Identity=35.0649350649351, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 54018; Mature: 54018

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00623 GMC_OXRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTLVNSAQRAPVDVIVVGGGSAGAVLARRLSENVRRQVLLLEAGQSFAPGKYPEIVAS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEC
SDVVGANGNRQFEWGYTSRPGYVEHPIGALRGKVLGGSSAINGAVAIRARATDFQRWNLP
CCEECCCCCEEEECCCCCCCCCCCCCHHHHHCEEECCCCCCCCEEEEEEECCCCEECCCC
GWSFEDLLPSFKKLENHSGGASALHGHDGPLPVRQLGSADVTPMQKAFIYATVANGYRMI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHEEEEEEECCCEEEE
DDFDGANANGVGPYPMNIVDGVRVNTGMAYLTDEVRARDNLQIRADSLVDKVLFDGKRAV
ECCCCCCCCCCCCCCCHHCCCEEECCCCEEEEHHHHCCCCCEEEHHHHHHHHHHCCCCEE
GVQLANGEQLRANEVILSAGSYGSAAILLRSGIGPGDDLRALDIEPVAELPVGQNLADHP
EEEECCCCCEECCEEEEECCCCCCEEEEEECCCCCCCCCEEECCCCHHCCCCCCCCCCCC
FYYNAYAAKPDLIGRQSPAIGAKLWTHSRSAEHGDLDIHITATHLFPHDQSPTQVGFVLA
EEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHH
VALTRPLSRGKVTLASRDPSVAPNIDLNFLAEPMDRQRLLDGIRLARRIGATAPLKGLIH
HHHHCCCCCCEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
SELNPGQGNDSDDALLASVKATLDTYHHPTSTAPMGRPGDAMAVVDLEARVIGVQGLRVV
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEEECCEEEE
DASIFPDVPSVATNLTVIATAEKIAGLYA
EHHHCCCCCHHHCCEEEEEEHHHHHHCCC
>Mature Secondary Structure
MNDTLVNSAQRAPVDVIVVGGGSAGAVLARRLSENVRRQVLLLEAGQSFAPGKYPEIVAS
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEC
SDVVGANGNRQFEWGYTSRPGYVEHPIGALRGKVLGGSSAINGAVAIRARATDFQRWNLP
CCEECCCCCEEEECCCCCCCCCCCCCHHHHHCEEECCCCCCCCEEEEEEECCCCEECCCC
GWSFEDLLPSFKKLENHSGGASALHGHDGPLPVRQLGSADVTPMQKAFIYATVANGYRMI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHEEEEEEECCCEEEE
DDFDGANANGVGPYPMNIVDGVRVNTGMAYLTDEVRARDNLQIRADSLVDKVLFDGKRAV
ECCCCCCCCCCCCCCCHHCCCEEECCCCEEEEHHHHCCCCCEEEHHHHHHHHHHCCCCEE
GVQLANGEQLRANEVILSAGSYGSAAILLRSGIGPGDDLRALDIEPVAELPVGQNLADHP
EEEECCCCCEECCEEEEECCCCCCEEEEEECCCCCCCCCEEECCCCHHCCCCCCCCCCCC
FYYNAYAAKPDLIGRQSPAIGAKLWTHSRSAEHGDLDIHITATHLFPHDQSPTQVGFVLA
EEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHH
VALTRPLSRGKVTLASRDPSVAPNIDLNFLAEPMDRQRLLDGIRLARRIGATAPLKGLIH
HHHHCCCCCCEEEEECCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
SELNPGQGNDSDDALLASVKATLDTYHHPTSTAPMGRPGDAMAVVDLEARVIGVQGLRVV
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEEECCEEEE
DASIFPDVPSVATNLTVIATAEKIAGLYA
EHHHCCCCCHHHCCEEEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA