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The map label for this gene is msrA [H]

Identifier: 77458523

GI number: 77458523

Start: 2647275

End: 2647781

Strand: Reverse

Name: msrA [H]

Synonym: Pfl01_2296

Alternate gene names: 77458523

Gene position: 2647781-2647275 (Counterclockwise)

Preceding gene: 77458524

Following gene: 77458522

Centisome position: 41.12

GC content: 59.57

Gene sequence:

>507_bases
ATGACCACTCAAACCGAAACTGCGATTCTCGCCGGCGGCTGCTTCTGGGGCATGCAGGATCTGTTGCGCCGCTACCCCGG
CGTGCTGCAGACGCGGGTCGGTTACACCGGTGGCGATGTGCCGAACGCCACTTACCGTAACCATGGCAATCACGCCGAGG
CCATCGAAATCGTCTTCGACCCTGCTGTGATCAGCTATCGGCAGATCCTTGAGTTTTTCTTTCAGATCCACGACCCGAGC
ACACCCAACCGTCAGGGCAACGACCTCGGTCCGAGCTATCGTTCGGCGATCTATTACCTGAACGAGCAGCAACGCGATAT
CGCTGAAGACACTGCGGCTGATGTCGATGCATCGGGCCTGTGGCCAGGCCGGGTGGTTACCGAAATCGAACCGGCAGGGC
CGTTCTGGGAAGCGGAGCCGGAGCATCAGGATTACCTCGAGCGCATTCCGAATGGCTACACCTGCCACTTCATTCGCCCG
AACTGGAAGCTGCCGAAACGCGGTTGA

Upstream 100 bases:

>100_bases
CCCGCGCTTCACGATTTATTTACCGGCTCAACCTTGGAATCAGCCCACACTCCCTCATATCAAGGAACATCTGCGACCCA
TTCGAGAGGAAGGACATGCC

Downstream 100 bases:

>100_bases
AGGTCCAGCGGGGCTCGGTGCTGTAAGCCGTTCATCTATTGCTGCAGCGACACCTGACTGCTTGTATCCTTGCGCACGAT
GAGGACGAACGGCTGCCGTT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTTQTETAILAGGCFWGMQDLLRRYPGVLQTRVGYTGGDVPNATYRNHGNHAEAIEIVFDPAVISYRQILEFFFQIHDPS
TPNRQGNDLGPSYRSAIYYLNEQQRDIAEDTAADVDASGLWPGRVVTEIEPAGPFWEAEPEHQDYLERIPNGYTCHFIRP
NWKLPKRG

Sequences:

>Translated_168_residues
MTTQTETAILAGGCFWGMQDLLRRYPGVLQTRVGYTGGDVPNATYRNHGNHAEAIEIVFDPAVISYRQILEFFFQIHDPS
TPNRQGNDLGPSYRSAIYYLNEQQRDIAEDTAADVDASGLWPGRVVTEIEPAGPFWEAEPEHQDYLERIPNGYTCHFIRP
NWKLPKRG
>Mature_167_residues
TTQTETAILAGGCFWGMQDLLRRYPGVLQTRVGYTGGDVPNATYRNHGNHAEAIEIVFDPAVISYRQILEFFFQIHDPST
PNRQGNDLGPSYRSAIYYLNEQQRDIAEDTAADVDASGLWPGRVVTEIEPAGPFWEAEPEHQDYLERIPNGYTCHFIRPN
WKLPKRG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=36.9426751592357, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=36.9426751592357, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=47.3684210526316, Blast_Score=129, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=39.1608391608392, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=35.3658536585366, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.8794326241135, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45553131, Length=135, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=35.6643356643357, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19072; Mature: 18941

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTETAILAGGCFWGMQDLLRRYPGVLQTRVGYTGGDVPNATYRNHGNHAEAIEIVFD
CCCCCCCEEEECHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PAVISYRQILEFFFQIHDPSTPNRQGNDLGPSYRSAIYYLNEQQRDIAEDTAADVDASGL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEECCHHHHHHHHHHCCCCCCCC
WPGRVVTEIEPAGPFWEAEPEHQDYLERIPNGYTCHFIRPNWKLPKRG
CCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TTQTETAILAGGCFWGMQDLLRRYPGVLQTRVGYTGGDVPNATYRNHGNHAEAIEIVFD
CCCCCCEEEECHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PAVISYRQILEFFFQIHDPSTPNRQGNDLGPSYRSAIYYLNEQQRDIAEDTAADVDASGL
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEEECCHHHHHHHHHHCCCCCCCC
WPGRVVTEIEPAGPFWEAEPEHQDYLERIPNGYTCHFIRPNWKLPKRG
CCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11344133 [H]