Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 77458520

GI number: 77458520

Start: 2643436

End: 2644842

Strand: Direct

Name: gabP [H]

Synonym: Pfl01_2293

Alternate gene names: 77458520

Gene position: 2643436-2644842 (Clockwise)

Preceding gene: 77458519

Following gene: 77458525

Centisome position: 41.06

GC content: 60.13

Gene sequence:

>1407_bases
ATGAATAGCCTGAACTCGAAGGACTTGAACGGTCAGTTGGCGCAGGGTTTCAAACCGCGTCATGTCACCATGCTTTCCAT
TGCCGGCATCATCGGTGCGGGGCTGTTTGTCGGCTCCGGCCACGCCATTGCCGCCGCCGGCCCGGCCGTCTTGCTCGCTT
ATCTCTTCTCCGGTCTGCTGGTCGTGCTGGTCATGCGCATGCTCGGCGAAATGGCCGTGGCCCATCCGGACACGGGATCG
TTTTCCACCTATGCCGATCAGGCCATCGGCCGTTGGGCGGGGTTCACCATTGGCTGGTTGTATTGGTGGTTTTGGGTGCT
GGTGATTCCGATTGAAGCGCTGGCCGCCGGGCATGTCTTGAATCAGTGGTTTCCTCAGGTCGATGCGTGGTTGTTCGCGT
TGTTGTCGATCATTTTGCTGGTGGTGACCAACCTGTTCAGCGTGTCCAAGTACGGTGAGTTTGAGTTCTGGTTTGCGATG
GCCAAAGTGGTGGCGATCATCGGGTTCATCGGTCTGGGTTTTGCGGTGTTGATGGGCTGGATTCCGGGACGCGAGGCCAG
CGGTTTGAGCCGGTTGATGGAAGAGCACGGCGGGTTTGCACCCAATGGTTTGTCGGCGGTGGTCGGGGCTTTCATCACGA
TCATGTTCAGCTTCATCGGGACCGAAGCGGTGACCATCGCGGCCGCCGAATCGAGCAACCCGGCGCAGAACATCGCCAAG
GCGACGCGCTCGGTGATCTGGCGCATCGGCGTGTTTTATCTGCTGTCGATTTTCGTGGTGATTTCCGTGGTGCCCTGGAA
CGATCCACTGCTGGCGTCCGTCGGCTCATATCAGCGGGCTCTGGAGCTGATGAACATTCCCAACGCCAAATTTCTGGTCG
ATGTGGTCGTGCTGATCGCGGTGGCCAGTTGCATGAATTCCTCGATCTACATTTCCTCGCGGATGCTGTTCTCGCTGGGC
CGACGCGGCGATGCTCCGCAACCGCTGAAAGTGACCTCCGCGGCGGGCGTGCCGAGGGCGGCGGTGATTGCCAGCACCGT
GATCGGTGCCGGGGTGACGTTGTTCAGCTATTTCATGCCGGGCGGGCTGTTCCAGTTTTTGCTCGCCAGTTCCGGCGCGA
TTGCGTTGCTGGTGTATCTGGTGATCGCGATTTCGCAATTGCGCATGCGCCGGATGCTGCGTCGGCAGAACGTCGAGCTG
ACGTTTCGCATGTGGCTGTTTCCGTGGCTGACGTGGCTGGTGATCGCGTTCATCTGCGCCGCGCTGGCGGTGATGATGGT
GACGCCCGAGCATCGTCTGGAAGTGACGTCGACCATCGGCCTTGCGCTGACGATTTCCTTTATCGGACTGGTGACCACGC
GGCAGCATGGGCAGATGAGGGCGGTGGTTTCGGCGGGCAAGGCCTAG

Upstream 100 bases:

>100_bases
GAGGTGCGCCGCTCTGGAGCAGGGCAACAGGAAGAAATGATGATCGCCTGACAAGTCGTCAGTACGCCCAAACGTCGATC
ACCAGAGAACAACAAAAACA

Downstream 100 bases:

>100_bases
GGTTTTTCTGGTGCTTGAACGGTGGGGCTATCCCCGGCATGGACGCAGGGGAGGTCCGATCACCGGGCTTCGGCTCGCAG
CCAACGTCTGACTTCGCCCT

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNSLNSKDLNGQLAQGFKPRHVTMLSIAGIIGAGLFVGSGHAIAAAGPAVLLAYLFSGLLVVLVMRMLGEMAVAHPDTGS
FSTYADQAIGRWAGFTIGWLYWWFWVLVIPIEALAAGHVLNQWFPQVDAWLFALLSIILLVVTNLFSVSKYGEFEFWFAM
AKVVAIIGFIGLGFAVLMGWIPGREASGLSRLMEEHGGFAPNGLSAVVGAFITIMFSFIGTEAVTIAAAESSNPAQNIAK
ATRSVIWRIGVFYLLSIFVVISVVPWNDPLLASVGSYQRALELMNIPNAKFLVDVVVLIAVASCMNSSIYISSRMLFSLG
RRGDAPQPLKVTSAAGVPRAAVIASTVIGAGVTLFSYFMPGGLFQFLLASSGAIALLVYLVIAISQLRMRRMLRRQNVEL
TFRMWLFPWLTWLVIAFICAALAVMMVTPEHRLEVTSTIGLALTISFIGLVTTRQHGQMRAVVSAGKA

Sequences:

>Translated_468_residues
MNSLNSKDLNGQLAQGFKPRHVTMLSIAGIIGAGLFVGSGHAIAAAGPAVLLAYLFSGLLVVLVMRMLGEMAVAHPDTGS
FSTYADQAIGRWAGFTIGWLYWWFWVLVIPIEALAAGHVLNQWFPQVDAWLFALLSIILLVVTNLFSVSKYGEFEFWFAM
AKVVAIIGFIGLGFAVLMGWIPGREASGLSRLMEEHGGFAPNGLSAVVGAFITIMFSFIGTEAVTIAAAESSNPAQNIAK
ATRSVIWRIGVFYLLSIFVVISVVPWNDPLLASVGSYQRALELMNIPNAKFLVDVVVLIAVASCMNSSIYISSRMLFSLG
RRGDAPQPLKVTSAAGVPRAAVIASTVIGAGVTLFSYFMPGGLFQFLLASSGAIALLVYLVIAISQLRMRRMLRRQNVEL
TFRMWLFPWLTWLVIAFICAALAVMMVTPEHRLEVTSTIGLALTISFIGLVTTRQHGQMRAVVSAGKA
>Mature_468_residues
MNSLNSKDLNGQLAQGFKPRHVTMLSIAGIIGAGLFVGSGHAIAAAGPAVLLAYLFSGLLVVLVMRMLGEMAVAHPDTGS
FSTYADQAIGRWAGFTIGWLYWWFWVLVIPIEALAAGHVLNQWFPQVDAWLFALLSIILLVVTNLFSVSKYGEFEFWFAM
AKVVAIIGFIGLGFAVLMGWIPGREASGLSRLMEEHGGFAPNGLSAVVGAFITIMFSFIGTEAVTIAAAESSNPAQNIAK
ATRSVIWRIGVFYLLSIFVVISVVPWNDPLLASVGSYQRALELMNIPNAKFLVDVVVLIAVASCMNSSIYISSRMLFSLG
RRGDAPQPLKVTSAAGVPRAAVIASTVIGAGVTLFSYFMPGGLFQFLLASSGAIALLVYLVIAISQLRMRRMLRRQNVEL
TFRMWLFPWLTWLVIAFICAALAVMMVTPEHRLEVTSTIGLALTISFIGLVTTRQHGQMRAVVSAGKA

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=59.6774193548387, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1786302, Length=432, Percent_Identity=35.8796296296296, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1786789, Length=422, Percent_Identity=38.3886255924171, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=37.5921375921376, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=34.8684210526316, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87081708, Length=411, Percent_Identity=35.7664233576642, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=31.6593886462882, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081915, Length=414, Percent_Identity=31.6425120772947, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1786602, Length=405, Percent_Identity=34.5679012345679, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87081869, Length=325, Percent_Identity=25.8461538461538, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=433, Percent_Identity=33.0254041570439, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=31.042654028436, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=434, Percent_Identity=33.1797235023041, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=402, Percent_Identity=30.8457711442786, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=433, Percent_Identity=32.3325635103926, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=414, Percent_Identity=30.6763285024155, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=471, Percent_Identity=28.8747346072187, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=30.5, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=441, Percent_Identity=28.5714285714286, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=405, Percent_Identity=29.3827160493827, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=410, Percent_Identity=28.5365853658537, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=410, Percent_Identity=29.2682926829268, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=427, Percent_Identity=28.3372365339578, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=424, Percent_Identity=29.0094339622642, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=26.448362720403, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324981, Length=398, Percent_Identity=27.6381909547739, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=423, Percent_Identity=24.5862884160757, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=411, Percent_Identity=24.330900243309, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24667468, Length=423, Percent_Identity=21.7494089834515, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50560; Mature: 50560

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]