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The map label for this gene is atoB [H]

Identifier: 77458301

GI number: 77458301

Start: 2359412

End: 2360593

Strand: Reverse

Name: atoB [H]

Synonym: Pfl01_2074

Alternate gene names: 77458301

Gene position: 2360593-2359412 (Counterclockwise)

Preceding gene: 77458302

Following gene: 77458299

Centisome position: 36.66

GC content: 64.55

Gene sequence:

>1182_bases
ATGCAAGACGTCGTCATTGTTGCCGCCACGCGTACCGCGATCGGCAGTTTCCAGGGATCGCTGGCCAGCGTCTCCGCCGT
GGATCTGGGCGCAGCGGTCATCCGCCAGTTGCTTGAGCAGACCGGTCTGGACGGTGCTCAGGTCGATGAAGTGATCATGG
GCCAGGTGCTGACCGCCGGCGCCGGCCAGAACCCGGCGCGCCAATCGGCGATCAAGGCCGGCCTGCCCCACGCCGTGCCG
GCCATGACCCTGAACAAGGTCTGCGGCTCGGGCCTCAAGGCCCTGCACCTCGGTGCACAGGCGATCCGTTGCGGCGACGC
AGACGTAATCATCGCCGGCGGCCAGGAAAACATGAGCCTGGCCAACTACGTCATGCCGGGCGCACGCACCGGTCTGCGCA
TGGGGCACGCGCAAATCGTCGACACCATGATCAGCGACGGCCTGTGGGATGCGTTCAACGATTACCACATGGGTATCACC
GCCGAAAATCTGGTCGAGAAATACGAGATCAGCCGCGAGCAGCAAGACGCCTTCGCTGCCGCGTCGCAACAAAAAGCCGC
CGCAGCCATCGAGGCCGGTCGCTTTGTCGATGAAATCACCCCGATCCTGATCCCGCAGCGCAAAGGCGATCCGGTGGCGT
TCAAGGTCGACGAACAACCACGTGGCGATACCACCGCCGATTCCCTGGCCAAACTGCGTCCGGCCTTCAAGAAGGACGGC
AGCGTCACTGCCGGCAACGCTTCGTCACTGAACGACGGCGCGGCTGCGGTCATTCTGATGAGCGCCGAAAAAGCCAAAGC
CCTGGGCCTGCCGGTGCTGGCGAAGATCGCCGCTTATGCCAACGCCGGCGTCGACCCGGCGATCATGGGCATCGGCCCGG
TGTCCGCCACTCGCCGCTGCCTGGACAAGGCTGGCTGGAACATCGGCCAGCTGGATCTGATCGAAGCCAACGAAGCCTTC
GCCGCGCAATCGCTGGCGGTGGCCAAGGATCTGCAATGGGATCTGGACAAGGTTAACGTCAACGGCGGCGCCATCGCCCT
CGGTCACCCGATCGGTGCATCGGGCTGCCGTGTGCTGGTGACCCTGCTGCACGAAATGATCAAGCGTGATGCGAAAAAGG
GTCTGGCGACCCTGTGCATCGGCGGCGGTCAGGGCGTGGCCCTGGCGCTGGAACGCGCGTAA

Upstream 100 bases:

>100_bases
GCGTCAGCGTCGAGGAAATCGTCGCCAAAACCGCTGGTAAACTGATCGTCCCGGATCACGTACCGGAAATGCAGTTCGCT
GCCGAGTGAGGAATTCGAAT

Downstream 100 bases:

>100_bases
GGCCGCAGAGTTACAAAAGCGAGTTCACAGCGGACGGCGGATCCACGACATCCACTGCCCGTTGGCAACAAAACCCGGTA
CGACTCACGTCGCACCGGGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MQDVVIVAATRTAIGSFQGSLASVSAVDLGAAVIRQLLEQTGLDGAQVDEVIMGQVLTAGAGQNPARQSAIKAGLPHAVP
AMTLNKVCGSGLKALHLGAQAIRCGDADVIIAGGQENMSLANYVMPGARTGLRMGHAQIVDTMISDGLWDAFNDYHMGIT
AENLVEKYEISREQQDAFAAASQQKAAAAIEAGRFVDEITPILIPQRKGDPVAFKVDEQPRGDTTADSLAKLRPAFKKDG
SVTAGNASSLNDGAAAVILMSAEKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRCLDKAGWNIGQLDLIEANEAF
AAQSLAVAKDLQWDLDKVNVNGGAIALGHPIGASGCRVLVTLLHEMIKRDAKKGLATLCIGGGQGVALALERA

Sequences:

>Translated_393_residues
MQDVVIVAATRTAIGSFQGSLASVSAVDLGAAVIRQLLEQTGLDGAQVDEVIMGQVLTAGAGQNPARQSAIKAGLPHAVP
AMTLNKVCGSGLKALHLGAQAIRCGDADVIIAGGQENMSLANYVMPGARTGLRMGHAQIVDTMISDGLWDAFNDYHMGIT
AENLVEKYEISREQQDAFAAASQQKAAAAIEAGRFVDEITPILIPQRKGDPVAFKVDEQPRGDTTADSLAKLRPAFKKDG
SVTAGNASSLNDGAAAVILMSAEKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRCLDKAGWNIGQLDLIEANEAF
AAQSLAVAKDLQWDLDKVNVNGGAIALGHPIGASGCRVLVTLLHEMIKRDAKKGLATLCIGGGQGVALALERA
>Mature_393_residues
MQDVVIVAATRTAIGSFQGSLASVSAVDLGAAVIRQLLEQTGLDGAQVDEVIMGQVLTAGAGQNPARQSAIKAGLPHAVP
AMTLNKVCGSGLKALHLGAQAIRCGDADVIIAGGQENMSLANYVMPGARTGLRMGHAQIVDTMISDGLWDAFNDYHMGIT
AENLVEKYEISREQQDAFAAASQQKAAAAIEAGRFVDEITPILIPQRKGDPVAFKVDEQPRGDTTADSLAKLRPAFKKDG
SVTAGNASSLNDGAAAVILMSAEKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRCLDKAGWNIGQLDLIEANEAF
AAQSLAVAKDLQWDLDKVNVNGGAIALGHPIGASGCRVLVTLLHEMIKRDAKKGLATLCIGGGQGVALALERA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=49.3606138107417, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=43.9393939393939, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=43.6548223350254, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=42.7848101265823, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=31.4553990610329, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=66.5816326530612, Blast_Score=546, Evalue=1e-157,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=59.5419847328244, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=45.3865336658354, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.25, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=33.4894613583138, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=44.6153846153846, Blast_Score=331, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=39.7932816537468, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.1679389312977, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=32.0843091334895, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.8066157760814, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=45.2020202020202, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.8521303258145, Blast_Score=249, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.3775510204082, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.7570332480818, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=44.6428571428571, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI17137578, Length=434, Percent_Identity=31.7972350230415, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40544; Mature: 40544

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDVVIVAATRTAIGSFQGSLASVSAVDLGAAVIRQLLEQTGLDGAQVDEVIMGQVLTAG
CCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
AGQNPARQSAIKAGLPHAVPAMTLNKVCGSGLKALHLGAQAIRCGDADVIIAGGQENMSL
CCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCHHHEEECCCCEEEECCCCCCCH
ANYVMPGARTGLRMGHAQIVDTMISDGLWDAFNDYHMGITAENLVEKYEISREQQDAFAA
HHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHH
ASQQKAAAAIEAGRFVDEITPILIPQRKGDPVAFKVDEQPRGDTTADSLAKLRPAFKKDG
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC
SVTAGNASSLNDGAAAVILMSAEKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRC
CEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
LDKAGWNIGQLDLIEANEAFAAQSLAVAKDLQWDLDKVNVNGGAIALGHPIGASGCRVLV
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHH
TLLHEMIKRDAKKGLATLCIGGGQGVALALERA
HHHHHHHHHHHHCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MQDVVIVAATRTAIGSFQGSLASVSAVDLGAAVIRQLLEQTGLDGAQVDEVIMGQVLTAG
CCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
AGQNPARQSAIKAGLPHAVPAMTLNKVCGSGLKALHLGAQAIRCGDADVIIAGGQENMSL
CCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCHHHEEECCCCEEEECCCCCCCH
ANYVMPGARTGLRMGHAQIVDTMISDGLWDAFNDYHMGITAENLVEKYEISREQQDAFAA
HHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHH
ASQQKAAAAIEAGRFVDEITPILIPQRKGDPVAFKVDEQPRGDTTADSLAKLRPAFKKDG
HHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC
SVTAGNASSLNDGAAAVILMSAEKAKALGLPVLAKIAAYANAGVDPAIMGIGPVSATRRC
CEECCCCCCCCCCCEEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
LDKAGWNIGQLDLIEANEAFAAQSLAVAKDLQWDLDKVNVNGGAIALGHPIGASGCRVLV
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHHHH
TLLHEMIKRDAKKGLATLCIGGGQGVALALERA
HHHHHHHHHHHHCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]