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The map label for this gene is mntH1 [H]

Identifier: 77458298

GI number: 77458298

Start: 2356350

End: 2357687

Strand: Direct

Name: mntH1 [H]

Synonym: Pfl01_2071

Alternate gene names: 77458298

Gene position: 2356350-2357687 (Clockwise)

Preceding gene: 77458297

Following gene: 77458300

Centisome position: 36.6

GC content: 62.71

Gene sequence:

>1338_bases
TTGTTTCTGGATGTGTTCGTGAAATTCAGTTTGCCCAAAATCGCCACTGCGCCGTTCTGCCCGCCGGAAGTGGCCGGCAG
TGTCCCGGTCGATCCCAACGCCTCGTTCTTCAAACGCGTGCTGCGCTTTGCCGGCCCCGGTTTGCTGGTGTCGATCGGCT
ACATGGATCCGGGCAACTGGGCCACTGCCATCGAGGCCGGTTCGCGCTTCGGTTACAGCCTGTTGTTCGTGGTATTGCTG
GCCAGCCTGGCGGGCATGGTTGTGCAATGCCTGTGCTCGCGGCTGGGCATCGCCACCGGGCGCGATCTGGCGCAGCTGTC
CCGCGAACGCTACAGCACCCCGACGGCGCGGCTGCAATGGGTGCTGGCGGAAATCTCGATCATCGCCACCGACCTTGCGG
AAGTGCTCGGCTGCGCGCTGGCGTTTCACCTGTTACTGGGTTGTTCGCTGACGTTCGGCATCGCCCTGACCGCATTCGAT
ACGTTGCTGGTGCTGGCCCTGCAAAACCGCGGTTTCCGCCGGCTGGAGGCGATCATGCTGGTGCTGGTGGGCACCATCGG
CGCGTGCTTCTTTGTCGAGTTGCTGCTGATCAAACCGTACTGGCCGGATGTCGCTCAAGGCTTCACACCGTCGCTGTCGG
CGATCAGCGATGCTGCGCCGTTGTACCTGGCTATCGGCATCCTCGGTGCCACGGTGATGCCACACAACCTGTACCTGCAC
ACCTCGATCGTGCAGACGCGGCTGATCGGCAAGGATCTGGCCAGCAAGCAGGATGCGGTGAAACTGGCGCGCATCGACAC
CATCGGTTCGCTGGCGCTGGCGTTGCTGGTCAACGCGGCGATCCTGATACTCGCGGCGGCCGCTTTTCATCAGTCCGGGC
ACACCGACGTGGTCGACATCCAGGACGCCTATCACTTGCTCGATCCACTGGTGGGCGGCGCGCTGGCCAGTGTGCTGTTC
GGCGTGGCGCTGCTGGCGTCGGGGCAGAGCTCAACCTTCACCGGCACCATCGCCGGGCAAGTGATCATGGAAGGCTATCT
GAATCTGCGGATTCCCTGCTGGCAACGACGCCTGATCACCCGTGGGCTGGCGCTGATCCCGGCATTCATCGGCGTGTGGC
TGATGGGCGACGGCGCGGTGGGCAAGTTGCTGGTGCTGAGCCAGGTGGTGTTGAGCCTGCAATTGCCGTTTGCGCTGTAT
CCGCTGATTCGCATGACCAACGACAAACAACTGATGGGGCCGTTTGTGAATCGGTTACCGACGCAGGTGCTGGCGTGGGG
ATTGTTTGTGCTGATCAGCGGGGCGAATGCCTGGTTGATTCTGCAGCTGGCGGCCTAG

Upstream 100 bases:

>100_bases
CCCGAGCTGCGCCAGCAATTGCTGGGCGACGCCAAACCTTGAGTCCATCACATCGGCGCTTGGGCACGCCGACTGAAACG
TCTAAGCTGCGCCTTTCGAC

Downstream 100 bases:

>100_bases
CGGCCAAACGCTTCGACCACAAAATCAATGAACACTCGGGTCTTGGCCGGCAGCAAGGTTCGGCTCGGGTAGTACAACGA
TATTGCGCCGGCATCGCATT

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFLDVFVKFSLPKIATAPFCPPEVAGSVPVDPNASFFKRVLRFAGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVLL
ASLAGMVVQCLCSRLGIATGRDLAQLSRERYSTPTARLQWVLAEISIIATDLAEVLGCALAFHLLLGCSLTFGIALTAFD
TLLVLALQNRGFRRLEAIMLVLVGTIGACFFVELLLIKPYWPDVAQGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLH
TSIVQTRLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILILAAAAFHQSGHTDVVDIQDAYHLLDPLVGGALASVLF
GVALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLITRGLALIPAFIGVWLMGDGAVGKLLVLSQVVLSLQLPFALY
PLIRMTNDKQLMGPFVNRLPTQVLAWGLFVLISGANAWLILQLAA

Sequences:

>Translated_445_residues
MFLDVFVKFSLPKIATAPFCPPEVAGSVPVDPNASFFKRVLRFAGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVLL
ASLAGMVVQCLCSRLGIATGRDLAQLSRERYSTPTARLQWVLAEISIIATDLAEVLGCALAFHLLLGCSLTFGIALTAFD
TLLVLALQNRGFRRLEAIMLVLVGTIGACFFVELLLIKPYWPDVAQGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLH
TSIVQTRLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILILAAAAFHQSGHTDVVDIQDAYHLLDPLVGGALASVLF
GVALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLITRGLALIPAFIGVWLMGDGAVGKLLVLSQVVLSLQLPFALY
PLIRMTNDKQLMGPFVNRLPTQVLAWGLFVLISGANAWLILQLAA
>Mature_445_residues
MFLDVFVKFSLPKIATAPFCPPEVAGSVPVDPNASFFKRVLRFAGPGLLVSIGYMDPGNWATAIEAGSRFGYSLLFVVLL
ASLAGMVVQCLCSRLGIATGRDLAQLSRERYSTPTARLQWVLAEISIIATDLAEVLGCALAFHLLLGCSLTFGIALTAFD
TLLVLALQNRGFRRLEAIMLVLVGTIGACFFVELLLIKPYWPDVAQGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLH
TSIVQTRLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILILAAAAFHQSGHTDVVDIQDAYHLLDPLVGGALASVLF
GVALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLITRGLALIPAFIGVWLMGDGAVGKLLVLSQVVLSLQLPFALY
PLIRMTNDKQLMGPFVNRLPTQVLAWGLFVLISGANAWLILQLAA

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=455, Percent_Identity=31.4285714285714, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI295293167, Length=442, Percent_Identity=32.3529411764706, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI295293178, Length=442, Percent_Identity=32.3529411764706, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI295293175, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI295293173, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI10835169, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI295293171, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI295293169, Length=442, Percent_Identity=32.3529411764706, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI1788736, Length=418, Percent_Identity=43.5406698564593, Blast_Score=291, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI193210616, Length=443, Percent_Identity=31.3769751693002, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17569473, Length=397, Percent_Identity=31.4861460957179, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71999499, Length=428, Percent_Identity=30.3738317757009, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71993856, Length=223, Percent_Identity=35.4260089686099, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324450, Length=427, Percent_Identity=37.4707259953162, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6323062, Length=395, Percent_Identity=38.4810126582278, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6321841, Length=413, Percent_Identity=38.498789346247, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24648607, Length=463, Percent_Identity=32.6133909287257, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI281362176, Length=463, Percent_Identity=32.6133909287257, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24648609, Length=463, Percent_Identity=32.6133909287257, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI45553443, Length=441, Percent_Identity=33.5600907029478, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47555; Mature: 47555

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDVFVKFSLPKIATAPFCPPEVAGSVPVDPNASFFKRVLRFAGPGLLVSIGYMDPGNW
CEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCC
ATAIEAGSRFGYSLLFVVLLASLAGMVVQCLCSRLGIATGRDLAQLSRERYSTPTARLQW
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
VLAEISIIATDLAEVLGCALAFHLLLGCSLTFGIALTAFDTLLVLALQNRGFRRLEAIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLVGTIGACFFVELLLIKPYWPDVAQGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLH
HHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
TSIVQTRLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILILAAAAFHQSGHTDVVDI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEH
QDAYHLLDPLVGGALASVLFGVALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHH
RGLALIPAFIGVWLMGDGAVGKLLVLSQVVLSLQLPFALYPLIRMTNDKQLMGPFVNRLP
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
TQVLAWGLFVLISGANAWLILQLAA
HHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MFLDVFVKFSLPKIATAPFCPPEVAGSVPVDPNASFFKRVLRFAGPGLLVSIGYMDPGNW
CEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCC
ATAIEAGSRFGYSLLFVVLLASLAGMVVQCLCSRLGIATGRDLAQLSRERYSTPTARLQW
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
VLAEISIIATDLAEVLGCALAFHLLLGCSLTFGIALTAFDTLLVLALQNRGFRRLEAIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VLVGTIGACFFVELLLIKPYWPDVAQGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLH
HHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
TSIVQTRLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILILAAAAFHQSGHTDVVDI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEH
QDAYHLLDPLVGGALASVLFGVALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLIT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHH
RGLALIPAFIGVWLMGDGAVGKLLVLSQVVLSLQLPFALYPLIRMTNDKQLMGPFVNRLP
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
TQVLAWGLFVLISGANAWLILQLAA
HHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10844693; 10984043 [H]