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The map label for this gene is copA [H]

Identifier: 77458043

GI number: 77458043

Start: 2027475

End: 2029925

Strand: Reverse

Name: copA [H]

Synonym: Pfl01_1816

Alternate gene names: 77458043

Gene position: 2029925-2027475 (Counterclockwise)

Preceding gene: 77458044

Following gene: 77458042

Centisome position: 31.53

GC content: 67.16

Gene sequence:

>2451_bases
ATGACCACCCCGATCCCCTGCTACCACTGCGCCCTGCCCGTCCCGTCCGGCAGCCGCTTCACCGCCGTCGTGCTCGGGGA
GTCCCGCGAGTTCTGCTGCCCCGGCTGTCAGGCCGTGGCCGAAGCCATCGTCGCCGGTGGTCTGGAAAGCTATTACCAGC
ATCGCAGCGAAGCCTCGGCCAACCCCGAAGCGCTGCCGGTGCAACTGGTCGATGAGCTTGAGCTGTACGACCGCGCCGAT
GTGCAGCAACCGTTTGTGCGCCACGAAGGTGAACTGGCCGAAACCACGTTGCTGATGGAAGGCATCAGTTGCGCCGCCTG
CGGCTGGCTGATCGAGAAACACCTGCGCACCCTGCCCGCCGTGGCCGAGGCGCGGCTGAACCTGTCCAATCATCGCCTGC
ATGTGCGCTGGGCTGACGCTCAGCTGCCACTGAGCCAGATCCTCGGCGAACTGCGCCACATCGGCTACGCCGCGCACCCG
TATCAGGCCGACCGCGCGAGCGAACAACTGGCCAGCGAAAACCGTCTCGCCCTGCGCCAACTCGGGGTCGCCGGGCTGCT
GTGGTTTCAGGCGATGATGGCGACCATGGCGACCTGGCCGGAATTCAACATCGACCTCAGCCCGGAGTTGCACACCATCC
TGCGCTGGGTCGCGCTGTTCCTCACCACGCCGATCGTGTTCTACAGCTGCGCGCCGTTTTTCAAAGGGGCCATGCGCGAC
TTGCGCACCCGTCATCTGACCATGGATGTCTCGGTGTCGCTGGCGATCGGCGCAGCGTATGTCGCCGGAATCTGGACCTC
TATTACCGGGGTTGGCGAGCTGTATTTCGATGCGGTGGGCATGTTCGCGCTGTTCCTGCTCGCCGGCCGCTACCTCGAAC
GCCGCGCCCGCGAGCGCACCGCTGCCGCCACCGCGCAACTGGTCAATCTGCTGCCCGCCTCGTGCCTGCGCCTCGACGAC
GCCGGCCAGAGCGAGCGGATCCTGCTCAGCGAACTGCGCCTCGGTGACCGGGTACTGGTGCAGCCCGGTTCGGTGCTGCC
GGCGGACGGCAAGATCCTTGATGGCCAGTCGAGCATCGACGAATCGGTGCTGACCGGCGAATACCTGCCGCAACCGCGTG
CCAAGGGCGATGCCGTCACCGCTGGCACGCTGAACGTGGAAGGTGCGCTGACCGTCGAGGTGCAGGCGCTGGGTCAGGAC
ACGCGACTCTCGGCGATCGTCCGCCTGCTGGATCGCGCCCAGGCGGAAAAACCACGGCTGGCGGAAATCGCCGACCGCGC
CGCGCAATGGTTCCTGTTGCTGTCGTTGATCGCGGCGGCCGCCATCGGCTTACTGTGGTGGGAACTGGATTCGTCACGGG
CCTTCTGGATCGTCCTCGCCATGCTGGTGGCGACCTGCCCGTGCGCGCTGTCGCTGGCGACACCGACCGCCCTCACCGCC
GCCACCGGCACCCTGCACAAACTCGGCCTGCTGCTGACCCGCGGCCATGTGCTGGAAGGCCTGAACCAGATCGACACGGT
GATTTTCGACAAGACCGGCACCCTCACCGAGGGGCGTCTGGTATTGCGCTCGATCCGCCCGCTCGGCGCCCTCGACAACG
ATCATTGCCTGAGCCTCGCCGCCGCCCTGGAAAACCGTTCCGAACACCCGATTGCCCGCGCCTTCGGCCGCGCGCCGCTG
GCTGCCGAAGATGTCCACAGCACGCCGGGCCTGGGGCTTGAAGGGTTGGTTGGCGAACAACGCTTGCGCATCGGCCAGGC
GGATTTTGTCTGTGATCTCAGCGGCGCGCCGGTGCCATCGATGCCGAACGAGCCGGGTCAATGGCTGCTGCTCGGTAACC
GTCAGGGGCCGCTGGCCTGGTTCGCCCTCGACGACCGTCTGCGCGACGACGCCCCGGCCCTGCTCGCGGCGTGCAAGGCG
CGCGGCTGGCGCACGCTGCTGCTGTCGGGCGACAGTTCGCCAATGGTCGCCAGTGTCGCCGCCGAACTGGGCATCGACGA
GGCCCGTGGCGGCTTGCGTCCGGACGACAAGTTGCAAGTGCTGCAACAACTGCACAGGAACGGCCGCAAGGTGTTGATGC
TCGGCGACGGGGTCAACGACGTGCCGGTACTGGCCGCTGCGGACATCAGCGTGGCCATGGGTTCGGCCACCGATCTGGCA
AAAACCAGTGCCGACGCGGTGTTGCTGTCCAACCGTCTCGACGCCTTGGTACAAGCCTTCACGCTGGCCCGCCGCACTCG
CCGGGTGATCATCGAGAACCTGTTGTGGGCCGCGCTGTACAATGGCCTCATGTTGCCGTTCGCCGCCCTCGGCTGGATCA
CTCCGGTGTGGGCCGCCGTCGGCATGTCGATCAGTTCGCTGACCGTGGTGCTCAACGCCCTGCGCCTGACTCGCCTGCCG
AGCGCGCCGGCCGTCAGCGCCACGTCAGAAACCCGCCCGCTGCCGGCCTGA

Upstream 100 bases:

>100_bases
TTCCGGCTCACATCAATCGGCCCCCTCTCCCTCTGGGAGAGGGCTGGGGTGAGGGCAAGCGGACCACTCGATTCCAAGGG
TTTATCCCCTCGACAATGCC

Downstream 100 bases:

>100_bases
ACCGCGCGGGCATGGAGTACAGATGCCAGCTCTCTACGTGATGATTCCGGCCGCGCTGCTGATCGTGGCCATCGCCGTCT
ACATCTTCTTCTGGGCGGTG

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MTTPIPCYHCALPVPSGSRFTAVVLGESREFCCPGCQAVAEAIVAGGLESYYQHRSEASANPEALPVQLVDELELYDRAD
VQQPFVRHEGELAETTLLMEGISCAACGWLIEKHLRTLPAVAEARLNLSNHRLHVRWADAQLPLSQILGELRHIGYAAHP
YQADRASEQLASENRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPELHTILRWVALFLTTPIVFYSCAPFFKGAMRD
LRTRHLTMDVSVSLAIGAAYVAGIWTSITGVGELYFDAVGMFALFLLAGRYLERRARERTAAATAQLVNLLPASCLRLDD
AGQSERILLSELRLGDRVLVQPGSVLPADGKILDGQSSIDESVLTGEYLPQPRAKGDAVTAGTLNVEGALTVEVQALGQD
TRLSAIVRLLDRAQAEKPRLAEIADRAAQWFLLLSLIAAAAIGLLWWELDSSRAFWIVLAMLVATCPCALSLATPTALTA
ATGTLHKLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLVLRSIRPLGALDNDHCLSLAAALENRSEHPIARAFGRAPL
AAEDVHSTPGLGLEGLVGEQRLRIGQADFVCDLSGAPVPSMPNEPGQWLLLGNRQGPLAWFALDDRLRDDAPALLAACKA
RGWRTLLLSGDSSPMVASVAAELGIDEARGGLRPDDKLQVLQQLHRNGRKVLMLGDGVNDVPVLAAADISVAMGSATDLA
KTSADAVLLSNRLDALVQAFTLARRTRRVIIENLLWAALYNGLMLPFAALGWITPVWAAVGMSISSLTVVLNALRLTRLP
SAPAVSATSETRPLPA

Sequences:

>Translated_816_residues
MTTPIPCYHCALPVPSGSRFTAVVLGESREFCCPGCQAVAEAIVAGGLESYYQHRSEASANPEALPVQLVDELELYDRAD
VQQPFVRHEGELAETTLLMEGISCAACGWLIEKHLRTLPAVAEARLNLSNHRLHVRWADAQLPLSQILGELRHIGYAAHP
YQADRASEQLASENRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPELHTILRWVALFLTTPIVFYSCAPFFKGAMRD
LRTRHLTMDVSVSLAIGAAYVAGIWTSITGVGELYFDAVGMFALFLLAGRYLERRARERTAAATAQLVNLLPASCLRLDD
AGQSERILLSELRLGDRVLVQPGSVLPADGKILDGQSSIDESVLTGEYLPQPRAKGDAVTAGTLNVEGALTVEVQALGQD
TRLSAIVRLLDRAQAEKPRLAEIADRAAQWFLLLSLIAAAAIGLLWWELDSSRAFWIVLAMLVATCPCALSLATPTALTA
ATGTLHKLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLVLRSIRPLGALDNDHCLSLAAALENRSEHPIARAFGRAPL
AAEDVHSTPGLGLEGLVGEQRLRIGQADFVCDLSGAPVPSMPNEPGQWLLLGNRQGPLAWFALDDRLRDDAPALLAACKA
RGWRTLLLSGDSSPMVASVAAELGIDEARGGLRPDDKLQVLQQLHRNGRKVLMLGDGVNDVPVLAAADISVAMGSATDLA
KTSADAVLLSNRLDALVQAFTLARRTRRVIIENLLWAALYNGLMLPFAALGWITPVWAAVGMSISSLTVVLNALRLTRLP
SAPAVSATSETRPLPA
>Mature_815_residues
TTPIPCYHCALPVPSGSRFTAVVLGESREFCCPGCQAVAEAIVAGGLESYYQHRSEASANPEALPVQLVDELELYDRADV
QQPFVRHEGELAETTLLMEGISCAACGWLIEKHLRTLPAVAEARLNLSNHRLHVRWADAQLPLSQILGELRHIGYAAHPY
QADRASEQLASENRLALRQLGVAGLLWFQAMMATMATWPEFNIDLSPELHTILRWVALFLTTPIVFYSCAPFFKGAMRDL
RTRHLTMDVSVSLAIGAAYVAGIWTSITGVGELYFDAVGMFALFLLAGRYLERRARERTAAATAQLVNLLPASCLRLDDA
GQSERILLSELRLGDRVLVQPGSVLPADGKILDGQSSIDESVLTGEYLPQPRAKGDAVTAGTLNVEGALTVEVQALGQDT
RLSAIVRLLDRAQAEKPRLAEIADRAAQWFLLLSLIAAAAIGLLWWELDSSRAFWIVLAMLVATCPCALSLATPTALTAA
TGTLHKLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLVLRSIRPLGALDNDHCLSLAAALENRSEHPIARAFGRAPLA
AEDVHSTPGLGLEGLVGEQRLRIGQADFVCDLSGAPVPSMPNEPGQWLLLGNRQGPLAWFALDDRLRDDAPALLAACKAR
GWRTLLLSGDSSPMVASVAAELGIDEARGGLRPDDKLQVLQQLHRNGRKVLMLGDGVNDVPVLAAADISVAMGSATDLAK
TSADAVLLSNRLDALVQAFTLARRTRRVIIENLLWAALYNGLMLPFAALGWITPVWAAVGMSISSLTVVLNALRLTRLPS
APAVSATSETRPLPA

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=820, Percent_Identity=26.8292682926829, Blast_Score=287, Evalue=3e-77,
Organism=Homo sapiens, GI55743071, Length=833, Percent_Identity=27.8511404561825, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI55743073, Length=617, Percent_Identity=28.2009724473258, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1786691, Length=742, Percent_Identity=30.8625336927224, Blast_Score=308, Evalue=9e-85,
Organism=Escherichia coli, GI1789879, Length=727, Percent_Identity=31.636863823934, Blast_Score=261, Evalue=2e-70,
Organism=Escherichia coli, GI1786914, Length=456, Percent_Identity=27.8508771929825, Blast_Score=129, Evalue=1e-30,
Organism=Escherichia coli, GI2367363, Length=149, Percent_Identity=32.8859060402685, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=567, Percent_Identity=25.7495590828924, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320475, Length=723, Percent_Identity=27.939142461964, Blast_Score=258, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319772, Length=652, Percent_Identity=27.4539877300614, Blast_Score=227, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6321430, Length=503, Percent_Identity=24.0556660039761, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6325221, Length=503, Percent_Identity=24.0556660039761, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321271, Length=356, Percent_Identity=25.8426966292135, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221329854, Length=561, Percent_Identity=29.2335115864528, Blast_Score=203, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 87920; Mature: 87788

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPIPCYHCALPVPSGSRFTAVVLGESREFCCPGCQAVAEAIVAGGLESYYQHRSEASA
CCCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCC
NPEALPVQLVDELELYDRADVQQPFVRHEGELAETTLLMEGISCAACGWLIEKHLRTLPA
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VAEARLNLSNHRLHVRWADAQLPLSQILGELRHIGYAAHPYQADRASEQLASENRLALRQ
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHH
LGVAGLLWFQAMMATMATWPEFNIDLSPELHTILRWVALFLTTPIVFYSCAPFFKGAMRD
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTRHLTMDVSVSLAIGAAYVAGIWTSITGVGELYFDAVGMFALFLLAGRYLERRARERT
HHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAATAQLVNLLPASCLRLDDAGQSERILLSELRLGDRVLVQPGSVLPADGKILDGQSSID
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCEECCCHHHH
ESVLTGEYLPQPRAKGDAVTAGTLNVEGALTVEVQALGQDTRLSAIVRLLDRAQAEKPRL
HHHHCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHH
AEIADRAAQWFLLLSLIAAAAIGLLWWELDSSRAFWIVLAMLVATCPCALSLATPTALTA
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCEECCCCHHHHH
ATGTLHKLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLVLRSIRPLGALDNDHCLSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
AALENRSEHPIARAFGRAPLAAEDVHSTPGLGLEGLVGEQRLRIGQADFVCDLSGAPVPS
HHHHCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCC
MPNEPGQWLLLGNRQGPLAWFALDDRLRDDAPALLAACKARGWRTLLLSGDSSPMVASVA
CCCCCCCEEEEECCCCCEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
AELGIDEARGGLRPDDKLQVLQQLHRNGRKVLMLGDGVNDVPVLAAADISVAMGSATDLA
HHHCCHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHHCCCCCHHHH
KTSADAVLLSNRLDALVQAFTLARRTRRVIIENLLWAALYNGLMLPFAALGWITPVWAAV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMSISSLTVVLNALRLTRLPSAPAVSATSETRPLPA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPIPCYHCALPVPSGSRFTAVVLGESREFCCPGCQAVAEAIVAGGLESYYQHRSEASA
CCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCC
NPEALPVQLVDELELYDRADVQQPFVRHEGELAETTLLMEGISCAACGWLIEKHLRTLPA
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VAEARLNLSNHRLHVRWADAQLPLSQILGELRHIGYAAHPYQADRASEQLASENRLALRQ
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHH
LGVAGLLWFQAMMATMATWPEFNIDLSPELHTILRWVALFLTTPIVFYSCAPFFKGAMRD
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTRHLTMDVSVSLAIGAAYVAGIWTSITGVGELYFDAVGMFALFLLAGRYLERRARERT
HHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAATAQLVNLLPASCLRLDDAGQSERILLSELRLGDRVLVQPGSVLPADGKILDGQSSID
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCEECCCHHHH
ESVLTGEYLPQPRAKGDAVTAGTLNVEGALTVEVQALGQDTRLSAIVRLLDRAQAEKPRL
HHHHCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHH
AEIADRAAQWFLLLSLIAAAAIGLLWWELDSSRAFWIVLAMLVATCPCALSLATPTALTA
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCEECCCCHHHHH
ATGTLHKLGLLLTRGHVLEGLNQIDTVIFDKTGTLTEGRLVLRSIRPLGALDNDHCLSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
AALENRSEHPIARAFGRAPLAAEDVHSTPGLGLEGLVGEQRLRIGQADFVCDLSGAPVPS
HHHHCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCC
MPNEPGQWLLLGNRQGPLAWFALDDRLRDDAPALLAACKARGWRTLLLSGDSSPMVASVA
CCCCCCCEEEEECCCCCEEEEEECCHHCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
AELGIDEARGGLRPDDKLQVLQQLHRNGRKVLMLGDGVNDVPVLAAADISVAMGSATDLA
HHHCCHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCHHHCCCCCHHHH
KTSADAVLLSNRLDALVQAFTLARRTRRVIIENLLWAALYNGLMLPFAALGWITPVWAAV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMSISSLTVVLNALRLTRLPSAPAVSATSETRPLPA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA