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The map label for this gene is prpC [H]

Identifier: 77457992

GI number: 77457992

Start: 1960071

End: 1961198

Strand: Direct

Name: prpC [H]

Synonym: Pfl01_1765

Alternate gene names: 77457992

Gene position: 1960071-1961198 (Clockwise)

Preceding gene: 77457991

Following gene: 77457993

Centisome position: 30.44

GC content: 62.41

Gene sequence:

>1128_bases
ATGGCCGAAGCAAAAGTACTCAGTGGCGCCGGGCTCCGGGGCCAGGTCGCCGGGCAAACCGCACTGTCCACCGTGGGCCA
GGCCGGTGCCGGGCTGACCTATCGCGGCTACGACGTGCGCGAACTGGCAGCCGACGCACAATTTGAAGAGGTGGCGTACC
TGCTGCTCTACGGGGAGCTGCCGACCAAGGCGCAACTCGCCGACTATCAAGGCAAGCTGAGCAAGCTGCGCGACCTGCCG
CAAGCGCTGAAAGAAGTGCTGGAGCGCATCCCCGCCGACGCCCACCCGATGGACGTGATGCGCACCGGTTGCTCGTTCCT
TGGCAATATCGAGCCGGAGAAAGACTTCTCCGAGCAACGCGACAAGACCGACCGCCTGCTGGCCGCGTTTCCGGCGATCA
TGTGCTACTGGTATCGCTTCAGCCACGACGGCAAACGCATCAACTGCGTGAGCGACGAGCCGTCCATCGGCGGCCACTTC
CTGCACCTGCTGCACGACAAGAAGCCGAGCGAGCTGCACGTCAAAGTGATGAACGTGTCGCTGATCCTCTACGCCGAGCA
CGAATTCAACGCCTCGACCTTCACCGCTCGGGTGTGTGCTTCGACCTTGTCCGATCTGTATTCCTGCGTCACGGCGGCCA
TCGGCTCGCTGCGCGGCCCGCTGCATGGCGGCGCCAACGAAGCGGCGATGGAAATGATCGAGCGCTTCTCGTCGCCGGAA
GAGGCGGTCAAGGGCACCCTCGGCATGCTCGAACGCAAGGACAAGATCATGGGCTTCGGTCACGCGATCTATAAGGACAG
CGATCCGCGCAACGAGGTGATCAAGGGCTGGTCGAAAAAACTCGCCGACGAAGTGGGCGACAAGGTGTTGTTCGCGGTTT
CGGAAGCCATCGACAAGACCATGTGGGAGCAGAAGAAACTGTTCCCCAACGCCGACTTCTACCATGCCTCGGCGTATCAC
TTCATGGGCATCCCGACCAAGCTGTTCACCCCGATCTTCGTCTGCTCGCGCCTGACCGGCTGGGCAGCGCACGTGTTCGA
GCAGCGTGCCAACAACCGCATCATCCGTCCAAGCGCCGAGTACACCGGCGTCGAACAGCGCAAGTTCGTGCCCATCGAAC
AGCGCTGA

Upstream 100 bases:

>100_bases
ATCGATTACCACACCTTCGAGCAGAAGCTCGACGCGTTGTTTGCGGCGAAGAAGTAAGCCGCAACCGTACTCCCTAATAA
ATTCAAGATTGGAGACAACA

Downstream 100 bases:

>100_bases
CCGGGGAGGGCGCCGGCACAGGCGCCCCCTCTTTGAAACTACCGTGACCGAGTCCTGACCGATGAACACAGAATTTCGCA
AGAACCTGCCCGGCACGCCG

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAEAKVLSGAGLRGQVAGQTALSTVGQAGAGLTYRGYDVRELAADAQFEEVAYLLLYGELPTKAQLADYQGKLSKLRDLP
QALKEVLERIPADAHPMDVMRTGCSFLGNIEPEKDFSEQRDKTDRLLAAFPAIMCYWYRFSHDGKRINCVSDEPSIGGHF
LHLLHDKKPSELHVKVMNVSLILYAEHEFNASTFTARVCASTLSDLYSCVTAAIGSLRGPLHGGANEAAMEMIERFSSPE
EAVKGTLGMLERKDKIMGFGHAIYKDSDPRNEVIKGWSKKLADEVGDKVLFAVSEAIDKTMWEQKKLFPNADFYHASAYH
FMGIPTKLFTPIFVCSRLTGWAAHVFEQRANNRIIRPSAEYTGVEQRKFVPIEQR

Sequences:

>Translated_375_residues
MAEAKVLSGAGLRGQVAGQTALSTVGQAGAGLTYRGYDVRELAADAQFEEVAYLLLYGELPTKAQLADYQGKLSKLRDLP
QALKEVLERIPADAHPMDVMRTGCSFLGNIEPEKDFSEQRDKTDRLLAAFPAIMCYWYRFSHDGKRINCVSDEPSIGGHF
LHLLHDKKPSELHVKVMNVSLILYAEHEFNASTFTARVCASTLSDLYSCVTAAIGSLRGPLHGGANEAAMEMIERFSSPE
EAVKGTLGMLERKDKIMGFGHAIYKDSDPRNEVIKGWSKKLADEVGDKVLFAVSEAIDKTMWEQKKLFPNADFYHASAYH
FMGIPTKLFTPIFVCSRLTGWAAHVFEQRANNRIIRPSAEYTGVEQRKFVPIEQR
>Mature_374_residues
AEAKVLSGAGLRGQVAGQTALSTVGQAGAGLTYRGYDVRELAADAQFEEVAYLLLYGELPTKAQLADYQGKLSKLRDLPQ
ALKEVLERIPADAHPMDVMRTGCSFLGNIEPEKDFSEQRDKTDRLLAAFPAIMCYWYRFSHDGKRINCVSDEPSIGGHFL
HLLHDKKPSELHVKVMNVSLILYAEHEFNASTFTARVCASTLSDLYSCVTAAIGSLRGPLHGGANEAAMEMIERFSSPEE
AVKGTLGMLERKDKIMGFGHAIYKDSDPRNEVIKGWSKKLADEVGDKVLFAVSEAIDKTMWEQKKLFPNADFYHASAYHF
MGIPTKLFTPIFVCSRLTGWAAHVFEQRANNRIIRPSAEYTGVEQRKFVPIEQR

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=377, Percent_Identity=23.342175066313, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786527, Length=367, Percent_Identity=52.8610354223433, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786939, Length=382, Percent_Identity=32.7225130890052, Blast_Score=195, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17555174, Length=379, Percent_Identity=24.802110817942, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319850, Length=399, Percent_Identity=24.3107769423559, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=378, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325257, Length=338, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=24.802110817942, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=24.802110817942, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356863, Length=378, Percent_Identity=24.3386243386243, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41759; Mature: 41628

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAKVLSGAGLRGQVAGQTALSTVGQAGAGLTYRGYDVRELAADAQFEEVAYLLLYGEL
CCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHCCCHHHHEEEEEECCC
PTKAQLADYQGKLSKLRDLPQALKEVLERIPADAHPMDVMRTGCSFLGNIEPEKDFSEQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
DKTDRLLAAFPAIMCYWYRFSHDGKRINCVSDEPSIGGHFLHLLHDKKPSELHVKVMNVS
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEE
LILYAEHEFNASTFTARVCASTLSDLYSCVTAAIGSLRGPLHGGANEAAMEMIERFSSPE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHH
EAVKGTLGMLERKDKIMGFGHAIYKDSDPRNEVIKGWSKKLADEVGDKVLFAVSEAIDKT
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWEQKKLFPNADFYHASAYHFMGIPTKLFTPIFVCSRLTGWAAHVFEQRANNRIIRPSAE
HHHHHHCCCCCCCEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
YTGVEQRKFVPIEQR
HCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEAKVLSGAGLRGQVAGQTALSTVGQAGAGLTYRGYDVRELAADAQFEEVAYLLLYGEL
CCCCEECCCCCCCCCCHHHHHHHHHCCCCCCEECCCCHHHHHHCCCHHHHEEEEEECCC
PTKAQLADYQGKLSKLRDLPQALKEVLERIPADAHPMDVMRTGCSFLGNIEPEKDFSEQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
DKTDRLLAAFPAIMCYWYRFSHDGKRINCVSDEPSIGGHFLHLLHDKKPSELHVKVMNVS
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEEE
LILYAEHEFNASTFTARVCASTLSDLYSCVTAAIGSLRGPLHGGANEAAMEMIERFSSPE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHH
EAVKGTLGMLERKDKIMGFGHAIYKDSDPRNEVIKGWSKKLADEVGDKVLFAVSEAIDKT
HHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWEQKKLFPNADFYHASAYHFMGIPTKLFTPIFVCSRLTGWAAHVFEQRANNRIIRPSAE
HHHHHHCCCCCCCEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
YTGVEQRKFVPIEQR
HCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]