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The map label for this gene is tyrR [H]

Identifier: 77457727

GI number: 77457727

Start: 1678399

End: 1679961

Strand: Direct

Name: tyrR [H]

Synonym: Pfl01_1500

Alternate gene names: 77457727

Gene position: 1678399-1679961 (Clockwise)

Preceding gene: 77457721

Following gene: 77457728

Centisome position: 26.07

GC content: 64.11

Gene sequence:

>1563_bases
ATGCGTATCAAAGTCCACTGCCAGAACCGCATCGGCATCCTGCGCGACATTCTCAATCTGCTGGTGGAGTACGGGATCAA
CGTCGCCCGTGGCGAGGTGGGCGGTGAGCATGGCAACGCGATCTACCTGCATTGCCCGAACCTGATCAACATTCAGTTCC
AGGCGTTGCGACCCAAGTTCGAGGCGATTGCCGGGGTGTTCGGCGTCAAGCGGGTAGGGTTGATGCCCAGCGAGCGGCGG
CACATGGAGTTGAATGCGCTGCTCGGCGCGCTGGAGTTTCCGGTGCTGTCGATCGACATGGGCGGCTCCATCGTTGCCGC
CAACCGTGCGGCAGCGCAGTTGCTCGGAGTACGGGTGGACGAGGTGCCGGGGATTCCGTTGTCGCGTTACGCCGAAGATT
TCGATCTGCCGGAACTGGTGCGCGCCAACAAATCGCGAATCAACGGCATGCGGGTCAAGGTCAAGGGCGACATCTTTCTG
GCCGACATCGCGCCGCTGCAATCGGAACACGACGACAGCGAGGCCATGGCTGGCGCAGTGCTGACGCTGCACCGCGCAGA
CCGGGTCGGCGAGCGCATCTATAACGTGCGCAAACAAGAGCTGCGTGGCTTCGATAGCATCTTCCAGAGCTCCAAGGTGA
TGGCAGCGGTGGTGCGCGAGGCCCGGCGCATGGCGCCGCTGGATGCGCCGTTGTTGATTGAGGGCGAAACCGGCACCGGC
AAGGAATTGCTGGCGCGGGCCTGCCACCTGGCGAGCCCGCGTGGTCAGTCGCCGCTGATGGCGCTCAACTGCGCGGGGCT
GCCGGAGTCGATGGCCGAGACCGAACTGTTCGGCTACGGCCCCGGTGCCTTTGAGGGCGCGCGGGCCGAAGGCAAGCTCG
GGCTGCTGGAGCTGACGGCGGGCGGCACGCTGTTCCTCGATGGTGTCGGCGAAATGAGCCCGCGCTTGCAGGTGAAACTG
CTGCGATTCCTGCAGGACGGCTGCTTCCGCCGTGTGGGCAGTGATGAAGAGGTTTACCTCGATGTGCGGGTGATCTGCGC
AACCCAGGTCGACCTGTCGGAGCTGTGCGCGCGCGGCGAATTTCGCCAGGATCTGTATCACCGCTTGAACGTGCTGTCGC
TGCACATCCCGCCACTGCGCGAATGCCTCGACGGTTTGACGCCGCTGGTGGAGCACTTTCTCGATCAGGCCAGTCGACAG
ATCGGCTGCCCGCTGCCGAAACTGGCGCCGGCGGCGATGGACCGGCTCAGTCACTACCATTGGCCGGGCAATGTGCGGCA
ACTGGAGAACGTGCTGTTCCAGGCGGTTTCGCTGTGCGACGGCGGCACGGTCAAGGCCGAGCACATTCGCCTGCCGGATT
ACGGCGTGCGTCAGCCGCTTGGCGATTTCTCCCTCGAAGGCGGGCTGGACGAGATTGTTGGGCGCTTCGAGAAGGCGGTG
CTGGAGCGCTTGTATTCCGAGCATCCGAGCAGCCGGCAACTGGGCAAGCGGCTCGGGGTTTCCCATACGACCATCGCCAA
CAAGTTGCGTGAGTACGAAGTCGGCAAGGACGCGTCGGAGTGA

Upstream 100 bases:

>100_bases
GAAAAGGCCGATGGCTGTCACATAATCTTGACGACTATCTTGCGCGCTGCGCAGAAAATTCCGGCGTCAGACCGCCTCTT
CACCTGTTTCGGGCCTTTAT

Downstream 100 bases:

>100_bases
TCACGGCCGGATCGGGTGTTTGCCGCCAAGCGGCATGACACCGCCGGTTTTTCGTCTTCGATACATTTCCCTCCTCTCGG
CAAAATCCCTCAAGTCCTTT

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MRIKVHCQNRIGILRDILNLLVEYGINVARGEVGGEHGNAIYLHCPNLINIQFQALRPKFEAIAGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGSIVAANRAAAQLLGVRVDEVPGIPLSRYAEDFDLPELVRANKSRINGMRVKVKGDIFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYNVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTAGGTLFLDGVGEMSPRLQVKL
LRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGEFRQDLYHRLNVLSLHIPPLRECLDGLTPLVEHFLDQASRQ
IGCPLPKLAPAAMDRLSHYHWPGNVRQLENVLFQAVSLCDGGTVKAEHIRLPDYGVRQPLGDFSLEGGLDEIVGRFEKAV
LERLYSEHPSSRQLGKRLGVSHTTIANKLREYEVGKDASE

Sequences:

>Translated_520_residues
MRIKVHCQNRIGILRDILNLLVEYGINVARGEVGGEHGNAIYLHCPNLINIQFQALRPKFEAIAGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGSIVAANRAAAQLLGVRVDEVPGIPLSRYAEDFDLPELVRANKSRINGMRVKVKGDIFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYNVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTAGGTLFLDGVGEMSPRLQVKL
LRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGEFRQDLYHRLNVLSLHIPPLRECLDGLTPLVEHFLDQASRQ
IGCPLPKLAPAAMDRLSHYHWPGNVRQLENVLFQAVSLCDGGTVKAEHIRLPDYGVRQPLGDFSLEGGLDEIVGRFEKAV
LERLYSEHPSSRQLGKRLGVSHTTIANKLREYEVGKDASE
>Mature_520_residues
MRIKVHCQNRIGILRDILNLLVEYGINVARGEVGGEHGNAIYLHCPNLINIQFQALRPKFEAIAGVFGVKRVGLMPSERR
HMELNALLGALEFPVLSIDMGGSIVAANRAAAQLLGVRVDEVPGIPLSRYAEDFDLPELVRANKSRINGMRVKVKGDIFL
ADIAPLQSEHDDSEAMAGAVLTLHRADRVGERIYNVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
KELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTAGGTLFLDGVGEMSPRLQVKL
LRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGEFRQDLYHRLNVLSLHIPPLRECLDGLTPLVEHFLDQASRQ
IGCPLPKLAPAAMDRLSHYHWPGNVRQLENVLFQAVSLCDGGTVKAEHIRLPDYGVRQPLGDFSLEGGLDEIVGRFEKAV
LERLYSEHPSSRQLGKRLGVSHTTIANKLREYEVGKDASE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=523, Percent_Identity=45.697896749522, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788550, Length=314, Percent_Identity=39.171974522293, Blast_Score=215, Evalue=6e-57,
Organism=Escherichia coli, GI1789233, Length=313, Percent_Identity=36.4217252396166, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1790437, Length=301, Percent_Identity=39.8671096345515, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1788905, Length=243, Percent_Identity=45.679012345679, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=36.8263473053892, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87082152, Length=267, Percent_Identity=44.1947565543071, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1790299, Length=225, Percent_Identity=45.7777777777778, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87082117, Length=243, Percent_Identity=41.5637860082305, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1786524, Length=217, Percent_Identity=45.1612903225806, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI87081872, Length=233, Percent_Identity=40.7725321888412, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1789828, Length=357, Percent_Identity=29.9719887955182, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI87081858, Length=469, Percent_Identity=25.5863539445629, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57211; Mature: 57211

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKVHCQNRIGILRDILNLLVEYGINVARGEVGGEHGNAIYLHCPNLINIQFQALRPKF
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCEEEEEHHHHCCHH
EAIAGVFGVKRVGLMPSERRHMELNALLGALEFPVLSIDMGGSIVAANRAAAQLLGVRVD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHCCCHH
EVPGIPLSRYAEDFDLPELVRANKSRINGMRVKVKGDIFLADIAPLQSEHDDSEAMAGAV
CCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCEEEEECCCCCCCCCCHHHHHHHH
LTLHRADRVGERIYNVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
KELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTA
HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC
GGTLFLDGVGEMSPRLQVKLLRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHCCH
FRQDLYHRLNVLSLHIPPLRECLDGLTPLVEHFLDQASRQIGCPLPKLAPAAMDRLSHYH
HHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
WPGNVRQLENVLFQAVSLCDGGTVKAEHIRLPDYGVRQPLGDFSLEGGLDEIVGRFEKAV
CCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LERLYSEHPSSRQLGKRLGVSHTTIANKLREYEVGKDASE
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIKVHCQNRIGILRDILNLLVEYGINVARGEVGGEHGNAIYLHCPNLINIQFQALRPKF
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCEEEEEHHHHCCHH
EAIAGVFGVKRVGLMPSERRHMELNALLGALEFPVLSIDMGGSIVAANRAAAQLLGVRVD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCEEECHHHHHHHHCCCHH
EVPGIPLSRYAEDFDLPELVRANKSRINGMRVKVKGDIFLADIAPLQSEHDDSEAMAGAV
CCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCEEEEECCCCCCCCCCHHHHHHHH
LTLHRADRVGERIYNVRKQELRGFDSIFQSSKVMAAVVREARRMAPLDAPLLIEGETGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
KELLARACHLASPRGQSPLMALNCAGLPESMAETELFGYGPGAFEGARAEGKLGLLELTA
HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC
GGTLFLDGVGEMSPRLQVKLLRFLQDGCFRRVGSDEEVYLDVRVICATQVDLSELCARGE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHCCH
FRQDLYHRLNVLSLHIPPLRECLDGLTPLVEHFLDQASRQIGCPLPKLAPAAMDRLSHYH
HHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
WPGNVRQLENVLFQAVSLCDGGTVKAEHIRLPDYGVRQPLGDFSLEGGLDEIVGRFEKAV
CCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LERLYSEHPSSRQLGKRLGVSHTTIANKLREYEVGKDASE
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]