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The map label for this gene is cpxR [H]

Identifier: 77457710

GI number: 77457710

Start: 1663921

End: 1664598

Strand: Reverse

Name: cpxR [H]

Synonym: Pfl01_1483

Alternate gene names: 77457710

Gene position: 1664598-1663921 (Counterclockwise)

Preceding gene: 77457711

Following gene: 77457709

Centisome position: 25.85

GC content: 66.52

Gene sequence:

>678_bases
ATGAGCGAGCTGTTACTGATTGATGATGACCAGGAGTTGTGTGAACTCCTGAGTAGCTGGCTGAGCCAGGAAGGCTTTCA
GGTCCGGGCCTGCCACGATGGTCAGAGTGCCCGCAAGGCGCTGGCCGAAACCGCGCCGGCGGCCGTGGTGCTGGACGTGA
TGCTGCCCGACGGCAGCGGCCTGGAACTGCTCAAGCAACTGCGCAGCGATCACGCCGACCTGCCGGTGCTGATGCTCTCG
GCCCGGGGCGAGCCGCTGGACCGGATCCTCGGCCTGGAACTGGGCGCCGACGATTACCTGGCCAAACCCTGTGATCCGCG
CGAACTGACTGCCCGGCTGCGCGCCGTGCTGCGCCGCAGTCATCCGGCCGCCGTGTCGACCCAGCTCGAACTGGGCGACC
TGAGCTTCAGCCCCGTGCGCGGCGTGGTCAGCATCGACGAAAAGGAATTCACCCTCACCGTCTCCGAAAGCCGCCTGCTC
GAAGCCCTGCTCAAGCAACCGGGCGAGCCGCTGGACAAACAGGAACTGGCGCAGATCGCCCTCGGCCGCAAGCTGACCCT
GTACGACCGCAGCCTGGACATGCACGTCAGCAACCTGCGCAAAAAGATCGGCCCGCACCCCGACGGCCGCCCGCGCATCG
TCGCCCTGCGCAGCCGTGGCTACTACTACAGCCTCTGA

Upstream 100 bases:

>100_bases
TTCGTCACCGGGGCCGGGGTAGCGCTATTGGCGCTGCTCTGCGGTATCTTTGCCAGTGGAGCAAGCCGAAAACGTCGGCA
ATGGCTAAATTGAGTGAGTC

Downstream 100 bases:

>100_bases
TCGTCTGTCAGTTTTGTCAGGTCGGCGCGAAAACGTGTTTACCCAAGCTTTACACAGCGCTGACCGCCGCTGACCTTGAT
CTCCGTAATCTGTACTCATC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGQSARKALAETAPAAVVLDVMLPDGSGLELLKQLRSDHADLPVLMLS
ARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPAAVSTQLELGDLSFSPVRGVVSIDEKEFTLTVSESRLL
EALLKQPGEPLDKQELAQIALGRKLTLYDRSLDMHVSNLRKKIGPHPDGRPRIVALRSRGYYYSL

Sequences:

>Translated_225_residues
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGQSARKALAETAPAAVVLDVMLPDGSGLELLKQLRSDHADLPVLMLS
ARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPAAVSTQLELGDLSFSPVRGVVSIDEKEFTLTVSESRLL
EALLKQPGEPLDKQELAQIALGRKLTLYDRSLDMHVSNLRKKIGPHPDGRPRIVALRSRGYYYSL
>Mature_224_residues
SELLLIDDDQELCELLSSWLSQEGFQVRACHDGQSARKALAETAPAAVVLDVMLPDGSGLELLKQLRSDHADLPVLMLSA
RGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRSHPAAVSTQLELGDLSFSPVRGVVSIDEKEFTLTVSESRLLE
ALLKQPGEPLDKQELAQIALGRKLTLYDRSLDMHVSNLRKKIGPHPDGRPRIVALRSRGYYYSL

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=45.1754385964912, Blast_Score=180, Evalue=8e-47,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=37.5, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.5638766519824, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=39.0909090909091, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=33.6363636363636, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=32.579185520362, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=34.703196347032, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.3612334801762, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1789402, Length=201, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=29.3617021276596, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1787229, Length=207, Percent_Identity=28.5024154589372, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=30.8695652173913, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1788550, Length=162, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=133, Percent_Identity=29.3233082706767, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24901; Mature: 24770

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLLIDDDQELCELLSSWLSQEGFQVRACHDGQSARKALAETAPAAVVLDVMLPDGSG
CCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCC
LELLKQLRSDHADLPVLMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
HPAAVSTQLELGDLSFSPVRGVVSIDEKEFTLTVSESRLLEALLKQPGEPLDKQELAQIA
CCCCEEEEEEECCCCCCCCCCEEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRKKIGPHPDGRPRIVALRSRGYYYSL
HCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEECC
>Mature Secondary Structure 
SELLLIDDDQELCELLSSWLSQEGFQVRACHDGQSARKALAETAPAAVVLDVMLPDGSG
CCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCC
LELLKQLRSDHADLPVLMLSARGEPLDRILGLELGADDYLAKPCDPRELTARLRAVLRRS
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHC
HPAAVSTQLELGDLSFSPVRGVVSIDEKEFTLTVSESRLLEALLKQPGEPLDKQELAQIA
CCCCEEEEEEECCCCCCCCCCEEEECCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHH
LGRKLTLYDRSLDMHVSNLRKKIGPHPDGRPRIVALRSRGYYYSL
HCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]