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The map label for this gene is mdtL [H]

Identifier: 77457539

GI number: 77457539

Start: 1486766

End: 1487932

Strand: Reverse

Name: mdtL [H]

Synonym: Pfl01_1312

Alternate gene names: 77457539

Gene position: 1487932-1486766 (Counterclockwise)

Preceding gene: 77457544

Following gene: 77457537

Centisome position: 23.11

GC content: 62.9

Gene sequence:

>1167_bases
ATGAACCCCAGCCTCATTCTGCTCATCACCTGTTCCACCGTGTTCCTCGCCCAGTTGGGCATGAGCATTTACCTGCCGGC
GCTGCCACAGATCGCCAAGCATTTACAGGTCGATGCAACACAGGTGGCCTGGGGCTTGTCGCTGTACCTGATCGGCATGG
CGCTGCCGATGCTGCTGTGGGGCAGTCTGGCGCAGCGCATCGGCCGCAAACCGGTGCTGCTCGCGGCGCTGGGGATTTAT
GGGCTGGCGAACCTGGCGTTGCCGCTGGGTGCGACGCTGGAATCGTTCCTGTTGCTGCGACTGCTTCAGGGGATCGGCGC
CAGCGGCATTTCGGTGATGGCGCGGGTGCTGATTCGAGACAGCTTTCGGGGGGATCTGCTGGCGAAGGCGTTGTCGTGGA
TTTCGATTTCGTTCGTTGTCGCGCTCGGGATCGGGCAATACGCCGGTTCGCTCATTCAGGTGACGCTGGGCTGGCAGGCG
ATCTTTTATCTGCTGGGCGCGGTCAGCCTGTTGATGGCCGCGATAGTCTCGCGCCTGAGTTTCCCGAAACTCGTCGAAGC
GCCCACAACCGCTTCGCCCTGGGAGGTCTATCGAACGATCCTGATCCATCGGGCGTTTCTGCTGCCGGCGCTTGCGGGCG
GTCTGGGTTATGGCGTGATCATCGCGTTCAACAGCGCTGCGCCGTTGATTCTGCAAGGCCCGTTCAACTGGTCGGCGACC
GCATATGGGTTGCTGGGCTGGCCGATCAGCGCCGCATATTTCCTGGGGGCGCTGGCGGTCAATCGCTTTGTGCTGCGTAC
CGGTCAGCACCGGCTGATGACACTGGGGGTCAGCCTGGTGATGGCCGGCACTGGCGTGATGCTGGCCGGCAGTCTGTTGG
CCAGCTCGATGGCCTGGCTGCTCTGGCTGCCTTACTGCGTCGCCGTGTTCGGCCAGTCGCTGAACTATCCGATCAGCCTG
TCACGGGCCAACGATGGTGCGCCGATTGCCGGCGCTTACGCGATGGCCCTGAGCGGTTTCATCCACCAATTGATGGCTGC
ACTGATCGGCGCGGTGGCCAGCCTGCTCGCCAGTCCGCAGGCATGGCCGCTATCGATGCTGTGCTGCGTTCTGGCATTTG
GCGCGGTGCTCTGCACGAGGTTAACGCCCGATCATCAGCCCGCTTAA

Upstream 100 bases:

>100_bases
CACACAGCACTACCGGACGTAGCCGATGCTGGCCTGACGTATCATTCGCCTGGTTTTTTGCTGACCGACAGTGAACATCT
CTGCCCCCCACGGACGACTC

Downstream 100 bases:

>100_bases
AACGCGCTGCGGAAAATCTCCTCGATCTGCCGCTGATCCGCCACTCGCGGATTGGTGAAGCCGCAGGCGTCTTTCAGGGC
GTTGGCGGCGAGCACCGGGA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNPSLILLITCSTVFLAQLGMSIYLPALPQIAKHLQVDATQVAWGLSLYLIGMALPMLLWGSLAQRIGRKPVLLAALGIY
GLANLALPLGATLESFLLLRLLQGIGASGISVMARVLIRDSFRGDLLAKALSWISISFVVALGIGQYAGSLIQVTLGWQA
IFYLLGAVSLLMAAIVSRLSFPKLVEAPTTASPWEVYRTILIHRAFLLPALAGGLGYGVIIAFNSAAPLILQGPFNWSAT
AYGLLGWPISAAYFLGALAVNRFVLRTGQHRLMTLGVSLVMAGTGVMLAGSLLASSMAWLLWLPYCVAVFGQSLNYPISL
SRANDGAPIAGAYAMALSGFIHQLMAALIGAVASLLASPQAWPLSMLCCVLAFGAVLCTRLTPDHQPA

Sequences:

>Translated_388_residues
MNPSLILLITCSTVFLAQLGMSIYLPALPQIAKHLQVDATQVAWGLSLYLIGMALPMLLWGSLAQRIGRKPVLLAALGIY
GLANLALPLGATLESFLLLRLLQGIGASGISVMARVLIRDSFRGDLLAKALSWISISFVVALGIGQYAGSLIQVTLGWQA
IFYLLGAVSLLMAAIVSRLSFPKLVEAPTTASPWEVYRTILIHRAFLLPALAGGLGYGVIIAFNSAAPLILQGPFNWSAT
AYGLLGWPISAAYFLGALAVNRFVLRTGQHRLMTLGVSLVMAGTGVMLAGSLLASSMAWLLWLPYCVAVFGQSLNYPISL
SRANDGAPIAGAYAMALSGFIHQLMAALIGAVASLLASPQAWPLSMLCCVLAFGAVLCTRLTPDHQPA
>Mature_388_residues
MNPSLILLITCSTVFLAQLGMSIYLPALPQIAKHLQVDATQVAWGLSLYLIGMALPMLLWGSLAQRIGRKPVLLAALGIY
GLANLALPLGATLESFLLLRLLQGIGASGISVMARVLIRDSFRGDLLAKALSWISISFVVALGIGQYAGSLIQVTLGWQA
IFYLLGAVSLLMAAIVSRLSFPKLVEAPTTASPWEVYRTILIHRAFLLPALAGGLGYGVIIAFNSAAPLILQGPFNWSAT
AYGLLGWPISAAYFLGALAVNRFVLRTGQHRLMTLGVSLVMAGTGVMLAGSLLASSMAWLLWLPYCVAVFGQSLNYPISL
SRANDGAPIAGAYAMALSGFIHQLMAALIGAVASLLASPQAWPLSMLCCVLAFGAVLCTRLTPDHQPA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=243, Percent_Identity=29.2181069958848, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788509, Length=355, Percent_Identity=25.9154929577465, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994889, Length=322, Percent_Identity=26.7080745341615, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790794, Length=310, Percent_Identity=26.7741935483871, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082312, Length=385, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787065, Length=299, Percent_Identity=25.752508361204, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081738, Length=156, Percent_Identity=32.6923076923077, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=153, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=159, Percent_Identity=32.7044025157233, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40976; Mature: 40976

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSLILLITCSTVFLAQLGMSIYLPALPQIAKHLQVDATQVAWGLSLYLIGMALPMLLW
CCCCEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GSLAQRIGRKPVLLAALGIYGLANLALPLGATLESFLLLRLLQGIGASGISVMARVLIRD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SFRGDLLAKALSWISISFVVALGIGQYAGSLIQVTLGWQAIFYLLGAVSLLMAAIVSRLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
FPKLVEAPTTASPWEVYRTILIHRAFLLPALAGGLGYGVIIAFNSAAPLILQGPFNWSAT
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCH
AYGLLGWPISAAYFLGALAVNRFVLRTGQHRLMTLGVSLVMAGTGVMLAGSLLASSMAWL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LWLPYCVAVFGQSLNYPISLSRANDGAPIAGAYAMALSGFIHQLMAALIGAVASLLASPQ
HHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWPLSMLCCVLAFGAVLCTRLTPDHQPA
CCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNPSLILLITCSTVFLAQLGMSIYLPALPQIAKHLQVDATQVAWGLSLYLIGMALPMLLW
CCCCEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GSLAQRIGRKPVLLAALGIYGLANLALPLGATLESFLLLRLLQGIGASGISVMARVLIRD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SFRGDLLAKALSWISISFVVALGIGQYAGSLIQVTLGWQAIFYLLGAVSLLMAAIVSRLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
FPKLVEAPTTASPWEVYRTILIHRAFLLPALAGGLGYGVIIAFNSAAPLILQGPFNWSAT
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCH
AYGLLGWPISAAYFLGALAVNRFVLRTGQHRLMTLGVSLVMAGTGVMLAGSLLASSMAWL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LWLPYCVAVFGQSLNYPISLSRANDGAPIAGAYAMALSGFIHQLMAALIGAVASLLASPQ
HHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWPLSMLCCVLAFGAVLCTRLTPDHQPA
CCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA