Click here to switch to the map view.

The map label for this gene is dapL [H]

Identifier: 77457325

GI number: 77457325

Start: 1269916

End: 1271115

Strand: Reverse

Name: dapL [H]

Synonym: Pfl01_1098

Alternate gene names: 77457325

Gene position: 1271115-1269916 (Counterclockwise)

Preceding gene: 77457326

Following gene: 77457324

Centisome position: 19.74

GC content: 63.83

Gene sequence:

>1200_bases
ATGAACAACGCTCTGTCCCAGCTTCAGCCCTACCCGTTCGAAAAGCTCCGCGCCCTGCTCGGCAGCGTCACGCCAAACCC
GGACAAGCGCCCGATCGCGCTGTCCATTGGCGAACCGAAGCATCGCTCGCCAAGCTTTGTCGCCGAGGCGCTGGCGAACA
ATCTGGAGCAGATGTCGGTGTACCCGACCACCCTCGGCATTCCGGCCCTGCGCGAAGCCATCGCGGCTTGGTGCGAACGT
CGTTTCAACGTGCCGAGCGGCTGGATCGACCCGGCGCGCAACGTGCTGCCGGTCAACGGCACCCGTGAAGCGCTGTTCGC
TTTCACCCAGACCGTGGTCAATCGTGGCGACGACGCGCTGGTGGTCAGCCCGAATCCGTTCTATCAGATCTACGAAGGCG
CGGCGTTTCTCGCCGGCGCCAAGCCGCACTACCTGCCATGCCTGGACGAGAACGGCTTCAACCCGGACTTCGACGCGGTA
TCGCCTGACATCTGGAAGCGCTGCCAGATCCTGTTCCTGTGCTCGCCGGGCAACCCGACCGGCGCACTGATTCCGGTCGA
CGTGCTGAAAAAGCTCATTGCCCTGGCCGACGAATACGACTTCGTGATCGCCGCCGACGAGTGCTACAGCGAGCTGTACT
TCGACGAACAGACCCCGCCGCCGGGCCTGCTCAGCGCCTGCGCCGATCTGGGTCGCAAGGACTTCAAGCGTTGCGTGGTG
TTCCACAGCCTGTCCAAGCGCTCGAACCTGCCGGGCCTGCGCTCCGGTTTTGTCGCCGGCGATGCCGACATCCTCAAGGG
CTTCCTGCTGTACCGCACCTACCACGGCTGCGCGATGCCGGTTCAAACCCAACTGGCCAGCGTCGCCGCATGGAATGACG
AAGTGCATGTTCGCGCCAACCGTGCGCTGTACCGCGAAAAATTCGATGCCGTGCTGGCGATCCTCAGCCCGGTGATGGAT
GTGCAGCGTCCGGATGGCAGCTTCTACCTGTGGCCGAATGTGCAAGGTGACGATGCCGCGTTCTGCCGGGATCTGTTTGC
TGAAGAGCACGTGACTGTGGTGCCGGGTTCGTATCTGTCGCGGGACGTCGATGGCGTCAATCCGGGCGCCGGGCGCGTGC
GCATGGCGCTGGTAGCCCCCTTGGCGGAGTGCGTGGAAGCGGCCGAGCGCATTCGCGATTTCGTCTTGCGCCATAAGTAA

Upstream 100 bases:

>100_bases
GAACAGCTGAGCGTCAATCAGGAACCCGATATCAAACTGTCGCGCATCAGCATTTGATTGCGCGCCCGGATTCAACCGCT
TTGCACGAGATCCCGCACCG

Downstream 100 bases:

>100_bases
TCGCTCACGCCCGTGCCGGGCAATCCGGCACGGGCGATCAAACATGACGTAACACTTCCCCCGCTTTTTGTACCCCACCT
TTACGCTGGCCCGACGTTAG

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNNALSQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALANNLEQMSVYPTTLGIPALREAIAAWCER
RFNVPSGWIDPARNVLPVNGTREALFAFTQTVVNRGDDALVVSPNPFYQIYEGAAFLAGAKPHYLPCLDENGFNPDFDAV
SPDIWKRCQILFLCSPGNPTGALIPVDVLKKLIALADEYDFVIAADECYSELYFDEQTPPPGLLSACADLGRKDFKRCVV
FHSLSKRSNLPGLRSGFVAGDADILKGFLLYRTYHGCAMPVQTQLASVAAWNDEVHVRANRALYREKFDAVLAILSPVMD
VQRPDGSFYLWPNVQGDDAAFCRDLFAEEHVTVVPGSYLSRDVDGVNPGAGRVRMALVAPLAECVEAAERIRDFVLRHK

Sequences:

>Translated_399_residues
MNNALSQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALANNLEQMSVYPTTLGIPALREAIAAWCER
RFNVPSGWIDPARNVLPVNGTREALFAFTQTVVNRGDDALVVSPNPFYQIYEGAAFLAGAKPHYLPCLDENGFNPDFDAV
SPDIWKRCQILFLCSPGNPTGALIPVDVLKKLIALADEYDFVIAADECYSELYFDEQTPPPGLLSACADLGRKDFKRCVV
FHSLSKRSNLPGLRSGFVAGDADILKGFLLYRTYHGCAMPVQTQLASVAAWNDEVHVRANRALYREKFDAVLAILSPVMD
VQRPDGSFYLWPNVQGDDAAFCRDLFAEEHVTVVPGSYLSRDVDGVNPGAGRVRMALVAPLAECVEAAERIRDFVLRHK
>Mature_399_residues
MNNALSQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALANNLEQMSVYPTTLGIPALREAIAAWCER
RFNVPSGWIDPARNVLPVNGTREALFAFTQTVVNRGDDALVVSPNPFYQIYEGAAFLAGAKPHYLPCLDENGFNPDFDAV
SPDIWKRCQILFLCSPGNPTGALIPVDVLKKLIALADEYDFVIAADECYSELYFDEQTPPPGLLSACADLGRKDFKRCVV
FHSLSKRSNLPGLRSGFVAGDADILKGFLLYRTYHGCAMPVQTQLASVAAWNDEVHVRANRALYREKFDAVLAILSPVMD
VQRPDGSFYLWPNVQGDDAAFCRDLFAEEHVTVVPGSYLSRDVDGVNPGAGRVRMALVAPLAECVEAAERIRDFVLRHK

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507369, Length=419, Percent_Identity=23.3890214797136, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI95147551, Length=328, Percent_Identity=24.6951219512195, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI169881279, Length=328, Percent_Identity=24.6951219512195, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI56713256, Length=284, Percent_Identity=23.2394366197183, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=284, Percent_Identity=23.2394366197183, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788722, Length=400, Percent_Identity=27.5, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788627, Length=355, Percent_Identity=24.2253521126761, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786816, Length=404, Percent_Identity=25.990099009901, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790797, Length=408, Percent_Identity=25, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788332, Length=197, Percent_Identity=28.4263959390863, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17567663, Length=400, Percent_Identity=26.75, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994472, Length=438, Percent_Identity=23.0593607305936, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=438, Percent_Identity=23.0593607305936, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859735, Length=421, Percent_Identity=25.1781472684086, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28573069, Length=276, Percent_Identity=21.7391304347826, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24646114, Length=276, Percent_Identity=21.7391304347826, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573067, Length=276, Percent_Identity=21.7391304347826, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573065, Length=276, Percent_Identity=21.7391304347826, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44013; Mature: 44013

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNALSQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALANNLEQMSV
CCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCHHHHEE
YPTTLGIPALREAIAAWCERRFNVPSGWIDPARNVLPVNGTREALFAFTQTVVNRGDDAL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCEE
VVSPNPFYQIYEGAAFLAGAKPHYLPCLDENGFNPDFDAVSPDIWKRCQILFLCSPGNPT
EECCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEEECCCCCC
GALIPVDVLKKLIALADEYDFVIAADECYSELYFDEQTPPPGLLSACADLGRKDFKRCVV
CCEEHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHH
FHSLSKRSNLPGLRSGFVAGDADILKGFLLYRTYHGCAMPVQTQLASVAAWNDEVHVRAN
HHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEHH
RALYREKFDAVLAILSPVMDVQRPDGSFYLWPNVQGDDAAFCRDLFAEEHVTVVPGSYLS
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCEEECCCHHHH
RDVDGVNPGAGRVRMALVAPLAECVEAAERIRDFVLRHK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNALSQLQPYPFEKLRALLGSVTPNPDKRPIALSIGEPKHRSPSFVAEALANNLEQMSV
CCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCHHHHEE
YPTTLGIPALREAIAAWCERRFNVPSGWIDPARNVLPVNGTREALFAFTQTVVNRGDDAL
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCEE
VVSPNPFYQIYEGAAFLAGAKPHYLPCLDENGFNPDFDAVSPDIWKRCQILFLCSPGNPT
EECCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEEECCCCCC
GALIPVDVLKKLIALADEYDFVIAADECYSELYFDEQTPPPGLLSACADLGRKDFKRCVV
CCEEHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHH
FHSLSKRSNLPGLRSGFVAGDADILKGFLLYRTYHGCAMPVQTQLASVAAWNDEVHVRAN
HHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEHH
RALYREKFDAVLAILSPVMDVQRPDGSFYLWPNVQGDDAAFCRDLFAEEHVTVVPGSYLS
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCEEECCCHHHH
RDVDGVNPGAGRVRMALVAPLAECVEAAERIRDFVLRHK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA