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The map label for this gene is csdA [H]

Identifier: 77457319

GI number: 77457319

Start: 1263565

End: 1264857

Strand: Reverse

Name: csdA [H]

Synonym: Pfl01_1092

Alternate gene names: 77457319

Gene position: 1264857-1263565 (Counterclockwise)

Preceding gene: 77457320

Following gene: 77457318

Centisome position: 19.65

GC content: 63.81

Gene sequence:

>1293_bases
ATGGCGTTCGACCGATCGTCATCGCGGGCAAGCCCGCTCCCACAGGGTTCGGCGTTAACCCGCCCATCTTCACCAGGGCT
TGAAACCGTGATGATTCCCTCCCCCTGGCGCGCCGATTTCCCGGCCATCGCCGCCCTGCAACGGCAAGACCAGACTTACC
TGGACAACGCCGCCACCACGCAAAAACCCCAGGCCTTGCTCGACGCGCTGGCGCATTACTACGCCAACGGCGCAGCCAAC
GTGCATCGTGCCCAGCACTTGCCCGGCGCCCATGCCACGCAGGCGTTCGAGGACAGCCGCCTGAAGGTTGCCCAGTGGCT
GAATGCCGGTGACAGCGGGCAGATCATCTTTACCCACGGCGCCACCAGCGCGCTGAATCTCCTGGCTTACGGCCTGGAAC
ATCTTCTCCATCCGGGCGATGAAATTGTCATCAGCGCCCTGGAGCATCACGCCAACCTGCTGCCTTGGCAGCAACTGGCA
CAACGTCGCGAACTCAAACTGGTGATCCTGCCGCTGGACGATGACGGCGTGATCGACCTCGCCGCCGCCGTTCACCTGAT
CGGCCCGCGCACTCGCTTGCTGGCGGTCAGTCAGTTGTCCAACGTGCTTGGTGCCTGGCAACCGTTGCCGGCATTGTTGG
CGATGGCCAAAGCACACAACGCGCTGACCGTGGTCGATGGCGCTCAAGGCGTGGTCCACGGCCGGCATGACGTGCAGGCG
CTGGGTTGCGACTTTTACGTGTTTTCCAGCCACAAGCTGTACGGCCCCGATGGCCTCGGCGTGCTGTTCGGGTGCAACGC
AGCGCTTGAGCAACTGCGCCCGTGGCAATTTGGTGGCGAGATGGTGCTGGAAGCCAATTATCACGACGCTCGTTTTCGTC
CGGCGCCACTGGGCTTCGAGGCCGGAACGCCACCGATTGCCAGCGTGATCGGCCTGGGTGCGACCCTCGACTACCTGGCC
GGTCTGGATCAGGACGCCGTGTCCGCCCACGAAGCCGCGCTGCACGATTACCTTTTGCGAGGCCTCGCCGCCCGCAATGG
CATCCGTCTGCTGGGCAAGCCGCAACTGGCGCTGGCCAGTTTTGTCGTCGAAGGCGTGCACAACGCCGATCTGGCGCATT
TGCTGACCGAGCAAGGCATCGCCGTGCGTGCCGGGCATCACTGCGCGATGCCGTTGCTCAAGCGCTTTGAACTGGCCGGG
GCCATCCGCGTGTCGCTGGCGCTGTACAACGATTCCGAGGATCTGGAGCGGTTCTTTGAGGCGCTGGATCAGGCGTTGGA
GTTGTTGCGATGA

Upstream 100 bases:

>100_bases
TGGAATGCAAAACCCACAAATCGGCGATCGAACTGAACGAAGCACTGCACGCTCACAACTAAGCGCCAGAAGCTCACCTG
AGGGAGCCAGCCTGTTTGCG

Downstream 100 bases:

>100_bases
GCCTGCCGGTAGAAGCCGCCGAGGCGCTGCAAACGTTTCAGAACGCTGCCGGTTGGGAACAACGGGCGCGGCTGTTGATG
CAGTTCGGTGATCGCCTGCC

Product: aromatic amino acid beta-eliminating lyase/threonine aldolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MAFDRSSSRASPLPQGSALTRPSSPGLETVMIPSPWRADFPAIAALQRQDQTYLDNAATTQKPQALLDALAHYYANGAAN
VHRAQHLPGAHATQAFEDSRLKVAQWLNAGDSGQIIFTHGATSALNLLAYGLEHLLHPGDEIVISALEHHANLLPWQQLA
QRRELKLVILPLDDDGVIDLAAAVHLIGPRTRLLAVSQLSNVLGAWQPLPALLAMAKAHNALTVVDGAQGVVHGRHDVQA
LGCDFYVFSSHKLYGPDGLGVLFGCNAALEQLRPWQFGGEMVLEANYHDARFRPAPLGFEAGTPPIASVIGLGATLDYLA
GLDQDAVSAHEAALHDYLLRGLAARNGIRLLGKPQLALASFVVEGVHNADLAHLLTEQGIAVRAGHHCAMPLLKRFELAG
AIRVSLALYNDSEDLERFFEALDQALELLR

Sequences:

>Translated_430_residues
MAFDRSSSRASPLPQGSALTRPSSPGLETVMIPSPWRADFPAIAALQRQDQTYLDNAATTQKPQALLDALAHYYANGAAN
VHRAQHLPGAHATQAFEDSRLKVAQWLNAGDSGQIIFTHGATSALNLLAYGLEHLLHPGDEIVISALEHHANLLPWQQLA
QRRELKLVILPLDDDGVIDLAAAVHLIGPRTRLLAVSQLSNVLGAWQPLPALLAMAKAHNALTVVDGAQGVVHGRHDVQA
LGCDFYVFSSHKLYGPDGLGVLFGCNAALEQLRPWQFGGEMVLEANYHDARFRPAPLGFEAGTPPIASVIGLGATLDYLA
GLDQDAVSAHEAALHDYLLRGLAARNGIRLLGKPQLALASFVVEGVHNADLAHLLTEQGIAVRAGHHCAMPLLKRFELAG
AIRVSLALYNDSEDLERFFEALDQALELLR
>Mature_429_residues
AFDRSSSRASPLPQGSALTRPSSPGLETVMIPSPWRADFPAIAALQRQDQTYLDNAATTQKPQALLDALAHYYANGAANV
HRAQHLPGAHATQAFEDSRLKVAQWLNAGDSGQIIFTHGATSALNLLAYGLEHLLHPGDEIVISALEHHANLLPWQQLAQ
RRELKLVILPLDDDGVIDLAAAVHLIGPRTRLLAVSQLSNVLGAWQPLPALLAMAKAHNALTVVDGAQGVVHGRHDVQAL
GCDFYVFSSHKLYGPDGLGVLFGCNAALEQLRPWQFGGEMVLEANYHDARFRPAPLGFEAGTPPIASVIGLGATLDYLAG
LDQDAVSAHEAALHDYLLRGLAARNGIRLLGKPQLALASFVVEGVHNADLAHLLTEQGIAVRAGHHCAMPLLKRFELAGA
IRVSLALYNDSEDLERFFEALDQALELLR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=265, Percent_Identity=28.3018867924528, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI156713448, Length=340, Percent_Identity=25.8823529411765, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=43.424317617866, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1787970, Length=398, Percent_Identity=40.4522613065327, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994898, Length=410, Percent_Identity=26.5853658536585, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=345, Percent_Identity=26.3768115942029, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=420, Percent_Identity=24.5238095238095, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=26.9521410579345, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI20129463, Length=262, Percent_Identity=30.1526717557252, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46274; Mature: 46143

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDRSSSRASPLPQGSALTRPSSPGLETVMIPSPWRADFPAIAALQRQDQTYLDNAATT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCHHHHCCCCCC
QKPQALLDALAHYYANGAANVHRAQHLPGAHATQAFEDSRLKVAQWLNAGDSGQIIFTHG
CCHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
ATSALNLLAYGLEHLLHPGDEIVISALEHHANLLPWQQLAQRRELKLVILPLDDDGVIDL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCHHHH
AAAVHLIGPRTRLLAVSQLSNVLGAWQPLPALLAMAKAHNALTVVDGAQGVVHGRHDVQA
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHE
LGCDFYVFSSHKLYGPDGLGVLFGCNAALEQLRPWQFGGEMVLEANYHDARFRPAPLGFE
ECCEEEEEECCEEECCCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
AGTPPIASVIGLGATLDYLAGLDQDAVSAHEAALHDYLLRGLAARNGIRLLGKPQLALAS
CCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
FVVEGVHNADLAHLLTEQGIAVRAGHHCAMPLLKRFELAGAIRVSLALYNDSEDLERFFE
HHHHCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCEEEEEEEEECCHHHHHHHHH
ALDQALELLR
HHHHHHHHHC
>Mature Secondary Structure 
AFDRSSSRASPLPQGSALTRPSSPGLETVMIPSPWRADFPAIAALQRQDQTYLDNAATT
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCHHHHCCCCCC
QKPQALLDALAHYYANGAANVHRAQHLPGAHATQAFEDSRLKVAQWLNAGDSGQIIFTHG
CCHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
ATSALNLLAYGLEHLLHPGDEIVISALEHHANLLPWQQLAQRRELKLVILPLDDDGVIDL
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCCHHHH
AAAVHLIGPRTRLLAVSQLSNVLGAWQPLPALLAMAKAHNALTVVDGAQGVVHGRHDVQA
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHE
LGCDFYVFSSHKLYGPDGLGVLFGCNAALEQLRPWQFGGEMVLEANYHDARFRPAPLGFE
ECCEEEEEECCEEECCCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
AGTPPIASVIGLGATLDYLAGLDQDAVSAHEAALHDYLLRGLAARNGIRLLGKPQLALAS
CCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
FVVEGVHNADLAHLLTEQGIAVRAGHHCAMPLLKRFELAGAIRVSLALYNDSEDLERFFE
HHHHCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCEEEEEEEEECCHHHHHHHHH
ALDQALELLR
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]