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The map label for this gene is glmS [H]

Identifier: 77457232

GI number: 77457232

Start: 1171228

End: 1172238

Strand: Reverse

Name: glmS [H]

Synonym: Pfl01_1005

Alternate gene names: 77457232

Gene position: 1172238-1171228 (Counterclockwise)

Preceding gene: 77457233

Following gene: 77457231

Centisome position: 18.21

GC content: 66.47

Gene sequence:

>1011_bases
ATGCTTGAGGAGGCGCTGTCCTCGTTCGAGGCCGTGCAAGCCCAACTGCAACAGCTCGACCCGCCAATGATCGAGATCGC
CGGACGCCTGCGCCGTCAGCCACCGCAAGTGGCGATGACCGTTGCCCGTGGCAGCTCCGACCATGCCGCGAGTTACTTCG
CCTACCTGACCATGCAGCAACTCGGCGTACCGGTGGCGTCGTTGCCGATGTCAGTGGTGACCATGCAACAGGCGCCGTTG
AAGGTCAGCGGTCAGGTCGCGTTCGCCTTCTCGCAGTCGGGCCAAAGCCCGGATCTGGTCAACAGCCTGCGCCTGCTGCG
CAAGCGCGGCGCCCTGAGCGTGTCGATGGTCAACGCCGCCGATTCGCCGCTGGAAGCCGCCTGTGAATTCAGCCTGCCGT
TGCTGGCCGGCACCGAAAGCAGCGTCGCCGCGACCAAGAGTTTCATCGCCACCCTCAGCGCCAGCGCCCGTCTGATCGCG
CACTGGAAAGAGGACGCCGAATTGCTGGAGGCGCACAACGCCCTGCCCGAAGGCCTGCGCGAAGCTGCGCAACAGGACTG
GAGCCCGGCCATCGACGCCCTGCGCGATTGCGAGCGGTTGATGGTGATCGGCCGTGGCGCCGGTTTTGCCATCGCCCAGG
AAGCCGCGCTGAAATTCAAGGAAACCTCGGCGATCCAGGCCGAAGCCTTCAGCAGCGCCGAAGTCCGTCACGGCCCGATG
GCCCTGATCGACGAACACTACCCATTGCTGGTGTTCGCCCCGCGCGGCGCCGAACAGGCCGGTCTGCTGAGCCTGGCAGC
CGAGATGCGTCAGCGCGGTGCCCGCGTGTTGCTGGCTGCGCCGGATGACGTGAGCGAACGCGACCTGACCCTCAGCCGTG
CCGAACACCCGGCCCTCGATCCGATCCTGGCGATCCAGAGTTTCTACGTGATGGCGGCCGGCCTGGCCGTGGCCCGTGGC
ATGGACCCGGATCAGCCGCGACACCTGAGCAAAGTCACCCGTACGCACTGA

Upstream 100 bases:

>100_bases
GGGCGCCTTGCACCTGGCGCCTGGGCCGACTGCGTGCGGCTGGATCGCTCACTCACACTGACCGCCGTCATGGTCGAAGG
AGAAGACATTGACTTCAAAA

Downstream 100 bases:

>100_bases
GTCCGAACCGAACGTTTTCCTGATGAGACCGAGCCATGCACAACAACAATAAAGAGCTGACTTTAAGCGCCCCGCTCAGC
GGCCCGGTGCTCACGCTCGC

Product: sugar isomerase (SIS)

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLEEALSSFEAVQAQLQQLDPPMIEIAGRLRRQPPQVAMTVARGSSDHAASYFAYLTMQQLGVPVASLPMSVVTMQQAPL
KVSGQVAFAFSQSGQSPDLVNSLRLLRKRGALSVSMVNAADSPLEAACEFSLPLLAGTESSVAATKSFIATLSASARLIA
HWKEDAELLEAHNALPEGLREAAQQDWSPAIDALRDCERLMVIGRGAGFAIAQEAALKFKETSAIQAEAFSSAEVRHGPM
ALIDEHYPLLVFAPRGAEQAGLLSLAAEMRQRGARVLLAAPDDVSERDLTLSRAEHPALDPILAIQSFYVMAAGLAVARG
MDPDQPRHLSKVTRTH

Sequences:

>Translated_336_residues
MLEEALSSFEAVQAQLQQLDPPMIEIAGRLRRQPPQVAMTVARGSSDHAASYFAYLTMQQLGVPVASLPMSVVTMQQAPL
KVSGQVAFAFSQSGQSPDLVNSLRLLRKRGALSVSMVNAADSPLEAACEFSLPLLAGTESSVAATKSFIATLSASARLIA
HWKEDAELLEAHNALPEGLREAAQQDWSPAIDALRDCERLMVIGRGAGFAIAQEAALKFKETSAIQAEAFSSAEVRHGPM
ALIDEHYPLLVFAPRGAEQAGLLSLAAEMRQRGARVLLAAPDDVSERDLTLSRAEHPALDPILAIQSFYVMAAGLAVARG
MDPDQPRHLSKVTRTH
>Mature_336_residues
MLEEALSSFEAVQAQLQQLDPPMIEIAGRLRRQPPQVAMTVARGSSDHAASYFAYLTMQQLGVPVASLPMSVVTMQQAPL
KVSGQVAFAFSQSGQSPDLVNSLRLLRKRGALSVSMVNAADSPLEAACEFSLPLLAGTESSVAATKSFIATLSASARLIA
HWKEDAELLEAHNALPEGLREAAQQDWSPAIDALRDCERLMVIGRGAGFAIAQEAALKFKETSAIQAEAFSSAEVRHGPM
ALIDEHYPLLVFAPRGAEQAGLLSLAAEMRQRGARVLLAAPDDVSERDLTLSRAEHPALDPILAIQSFYVMAAGLAVARG
MDPDQPRHLSKVTRTH

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=342, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI205277386, Length=339, Percent_Identity=26.2536873156342, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790167, Length=262, Percent_Identity=33.206106870229, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17532899, Length=318, Percent_Identity=27.3584905660377, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17532897, Length=318, Percent_Identity=27.3584905660377, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17539970, Length=318, Percent_Identity=27.3584905660377, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322745, Length=358, Percent_Identity=25.6983240223464, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323731, Length=267, Percent_Identity=24.3445692883895, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357745, Length=355, Percent_Identity=25.9154929577465, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 36027; Mature: 36027

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEEALSSFEAVQAQLQQLDPPMIEIAGRLRRQPPQVAMTVARGSSDHAASYFAYLTMQQ
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHHH
LGVPVASLPMSVVTMQQAPLKVSGQVAFAFSQSGQSPDLVNSLRLLRKRGALSVSMVNAA
HCCCHHHCCHHHHHHCCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
DSPLEAACEFSLPLLAGTESSVAATKSFIATLSASARLIAHWKEDAELLEAHNALPEGLR
CCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EAAQQDWSPAIDALRDCERLMVIGRGAGFAIAQEAALKFKETSAIQAEAFSSAEVRHGPM
HHHHCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ALIDEHYPLLVFAPRGAEQAGLLSLAAEMRQRGARVLLAAPDDVSERDLTLSRAEHPALD
CEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCC
PILAIQSFYVMAAGLAVARGMDPDQPRHLSKVTRTH
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MLEEALSSFEAVQAQLQQLDPPMIEIAGRLRRQPPQVAMTVARGSSDHAASYFAYLTMQQ
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHHH
LGVPVASLPMSVVTMQQAPLKVSGQVAFAFSQSGQSPDLVNSLRLLRKRGALSVSMVNAA
HCCCHHHCCHHHHHHCCCCCEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCC
DSPLEAACEFSLPLLAGTESSVAATKSFIATLSASARLIAHWKEDAELLEAHNALPEGLR
CCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EAAQQDWSPAIDALRDCERLMVIGRGAGFAIAQEAALKFKETSAIQAEAFSSAEVRHGPM
HHHHCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ALIDEHYPLLVFAPRGAEQAGLLSLAAEMRQRGARVLLAAPDDVSERDLTLSRAEHPALD
CEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCC
PILAIQSFYVMAAGLAVARGMDPDQPRHLSKVTRTH
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]