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The map label for this gene is hisD [H]

Identifier: 77457098

GI number: 77457098

Start: 1016337

End: 1017662

Strand: Direct

Name: hisD [H]

Synonym: Pfl01_0871

Alternate gene names: 77457098

Gene position: 1016337-1017662 (Clockwise)

Preceding gene: 77457097

Following gene: 77457099

Centisome position: 15.79

GC content: 63.95

Gene sequence:

>1326_bases
ATGACCGCACCGACTGCAATTCGCCGACTCAACGCTGCTGACCCGGATTTCGCGCATCATCTGGATCATCTGCTGAGCTG
GGAAAGTGTGTCTGACGACTCGGTCAATCAGCGGGTGCTGGACATCATCAAGGCTGTGCGCGAGCGCGGTGACGCGGCGC
TGGTCGAGTTCACCCAGAAATTCGACGGCCTCGAAGTCGCCTCCATGGCAGACCTGATCCTGCCGCGCGAGCGTCTGGAA
CTGGCCCTGACCCGTATCACCGTGGCTCAACGCGAAGCGCTGGAAAAAGCCGCCGCCCGTGTGCGCAGCTATCACGAAAA
ACAGAAGCAGGACTCCTGGAGCTACACCGAAGCCGACGGCACCGTGCTGGGCCAGAAGGTCACGCCGCTGGATCGCGCCG
GTCTGTATGTGCCGGGCGGCAAGGCGTCGTACCCGTCGTCGGTGTTGATGAATGCGATTCCGGCCAAGGTCGCTGGCGTG
ACTGAAGTGGTCATGGTGGTGCCAACCCCGCGTGGCGAGGTCAACGAACTGGTGCTGGCGGCGGCGTGCATTGCCGGCGT
CGACCGGGTGTTCACCATCGGTGGCGCACAAGCCGTTGCTGCGTTGGCCTATGGCACCGAAAGCGTGCCGCAGGTGGACA
AGGTCGTCGGCCCGGGCAACATCTATGTCGCCACTGCCAAGCGTCACGTGTTCGGTCAGGTCGGCATCGACATGATTGCC
GGCCCGTCTGAAATCCTCGTGGTGTGCGACGGCCAGACCGATCCGGACTGGATCGCCATGGACCTGTTCTCCCAGGCCGA
ACACGACGAAGACGCCCAGGCGATTCTGGTCAGCCCGGACGCCGAGTTCCTCGACAAGGTCGCCGCGAGCATCGACAAGC
TGCTGCCGACCATGGATCGCGCAACCATCATCGAAACCTCGATCAACGGCCGTGGTGCCCTGATTCACGTGCGCGACATG
GCCCAGGCCATCGAAGTCGCCAACCGCATTGCCCCGGAACACCTTGAGCTGTCGGTCGCCGACCCTCAGGCCTGGCTGCC
GCAGATCCGCCACGCCGGCGCGATTTTCATGGGCCGCCACACCTCCGAGGCGCTGGGCGACTACTGCGCGGGTCCGAACC
ACGTGCTGCCGACCTCCGGCACTGCGCGTTTCTCTTCGCCGCTGGGCGTGTACGACTTCCAGAAACGCTCGTCGATCATC
TTCTGCTCCGAGGCCGGCGCTTCGGAGCTTGGCAAGACTGCATCGATTCTGGCCCGTGGCGAATCGCTGAGCGCCCACGC
GCGTAGCGCCGAATACCGCATCAAAGACGACGTGAAGGGGAACTGA

Upstream 100 bases:

>100_bases
CCCGTCTATCCGCCTCATAGCCAGAATCTCAGGTGCCCAAGCGGAAACGACTGCTAAGTTAGGGCGCCTGAGTTTTTGCC
ATTCCTATGAGGCTCTCGCT

Downstream 100 bases:

>100_bases
ACATGAGCAAATTCTGGAGCCCGTTCGTCAAGGATCTGGTGCCTTACGTGCCGGGCGAGCAGCCGAAGTTGACCCGTCTG
GTCAAACTCAATACCAACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLEVASMADLILPRERLE
LALTRITVAQREALEKAAARVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGV
TEVVMVVPTPRGEVNELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPQVDKVVGPGNIYVATAKRHVFGQVGIDMIA
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIDKLLPTMDRATIIETSINGRGALIHVRDM
AQAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSII
FCSEAGASELGKTASILARGESLSAHARSAEYRIKDDVKGN

Sequences:

>Translated_441_residues
MTAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLEVASMADLILPRERLE
LALTRITVAQREALEKAAARVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGV
TEVVMVVPTPRGEVNELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPQVDKVVGPGNIYVATAKRHVFGQVGIDMIA
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIDKLLPTMDRATIIETSINGRGALIHVRDM
AQAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSII
FCSEAGASELGKTASILARGESLSAHARSAEYRIKDDVKGN
>Mature_440_residues
TAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLEVASMADLILPRERLEL
ALTRITVAQREALEKAAARVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVT
EVVMVVPTPRGEVNELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPQVDKVVGPGNIYVATAKRHVFGQVGIDMIAG
PSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIDKLLPTMDRATIIETSINGRGALIHVRDMA
QAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIF
CSEAGASELGKTASILARGESLSAHARSAEYRIKDDVKGN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=39.3364928909953, Blast_Score=291, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=404, Percent_Identity=36.1386138613861, Blast_Score=247, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47306; Mature: 47175

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQK
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FDGLEVASMADLILPRERLELALTRITVAQREALEKAAARVRSYHEKQKQDSWSYTEADG
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
TVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEVNELVLA
CEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHH
AACIAGVDRVFTIGGAQAVAALAYGTESVPQVDKVVGPGNIYVATAKRHVFGQVGIDMIA
HHHHHCCHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHCCHHEEC
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIDKLLPTMDR
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCC
ATIIETSINGRGALIHVRDMAQAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRH
CEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECC
TSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIFCSEAGASELGKTASILARG
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCHHHHHHCC
ESLSAHARSAEYRIKDDVKGN
CCCHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
TAPTAIRRLNAADPDFAHHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQK
CCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
FDGLEVASMADLILPRERLELALTRITVAQREALEKAAARVRSYHEKQKQDSWSYTEADG
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
TVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEVNELVLA
CEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHH
AACIAGVDRVFTIGGAQAVAALAYGTESVPQVDKVVGPGNIYVATAKRHVFGQVGIDMIA
HHHHHCCHHEEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEECCHHHHHHCCHHEEC
GPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASIDKLLPTMDR
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCC
ATIIETSINGRGALIHVRDMAQAIEVANRIAPEHLELSVADPQAWLPQIRHAGAIFMGRH
CEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCEEEEECC
TSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIFCSEAGASELGKTASILARG
CHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCHHHHHHCC
ESLSAHARSAEYRIKDDVKGN
CCCHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA