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The map label for this gene is hisG [H]

Identifier: 77457097

GI number: 77457097

Start: 1015576

End: 1016211

Strand: Direct

Name: hisG [H]

Synonym: Pfl01_0870

Alternate gene names: 77457097

Gene position: 1015576-1016211 (Clockwise)

Preceding gene: 77457096

Following gene: 77457098

Centisome position: 15.77

GC content: 62.26

Gene sequence:

>636_bases
ATGTTGACCATCGCACTGTCCAAGGGCCGCATCCTTGACGACACCCTGCCGCTTCTCGCCGAAGCGGGCATCGTGCCGAC
CGAGAATCCGGACAAGAGCCGCAAGCTGATCATCCCCACGACCCAGGAAGACGTTCGCCTGTTGATCGTGCGGGCCACCG
ACGTGCCGACCTATGTCGAGCATGGCGCGGCCGACCTCGGCGTTGCCGGTAAAGATGTGCTGATGGAATACACCGGCCAG
GGCCTGTACGAGCCGCTGGACCTGCAGATTGCCCAGTGCAAGCTGATGACCGCCGGCAAGGTCGGCGCGGTCGAGCCCAA
GGGCCGCCTGCGCGTCGCCACCAAATTCGTCAATGTCGCCAAGCGTTATTACGCCGAGCAGGGCCGTCAGGTCGACATCA
TCAAGCTGTACGGCTCGATGGAGCTGGCACCGCTGATCGGTCTGGCCGACAAGATCATCGACGTGGTCGACACCGGTAAC
ACCCTGCGTGCCAACGGCCTGGAACCCCAGGAACTGATCGCCACGATCAGCTCGCGTCTGGTGGTCAATAAAGCTTCGAT
GAAAATGCAACACGCCCGAATCCAGGCGTTGATCGACACCCTGCGCAAGGCAGTGGAGTCTCGACACCGCGGCTGA

Upstream 100 bases:

>100_bases
CCGTTGAATTCGTTTTGATCGGGGGTGGCAACGCCCTCGAAGTATGTCCGGCGCCGATTGCGACCGGACATGAGTACCTT
GATAAGGACTGACGTTTCCC

Downstream 100 bases:

>100_bases
TGTACCTGCGCGACGTTAAGTCGCGCCCGTCTATCCGCCTCATAGCCAGAATCTCAGGTGCCCAAGCGGAAACGACTGCT
AAGTTAGGGCGCCTGAGTTT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQEDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAQCKLMTAGKVGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRG

Sequences:

>Translated_211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQEDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAQCKLMTAGKVGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRG
>Mature_211_residues
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQEDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQ
GLYEPLDLQIAQCKLMTAGKVGAVEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGN
TLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=214, Percent_Identity=35.0467289719626, Blast_Score=87, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=211, Percent_Identity=29.8578199052133, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23038; Mature: 23038

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQEDVRLLIVRATDVPTYVE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHH
HGAADLGVAGKDVLMEYTGQGLYEPLDLQIAQCKLMTAGKVGAVEPKGRLRVATKFVNVA
CCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGNTLRANGLEPQELIATISSRL
HHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
VVNKASMKMQHARIQALIDTLRKAVESRHRG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQEDVRLLIVRATDVPTYVE
CEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHH
HGAADLGVAGKDVLMEYTGQGLYEPLDLQIAQCKLMTAGKVGAVEPKGRLRVATKFVNVA
CCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
KRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGNTLRANGLEPQELIATISSRL
HHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHH
VVNKASMKMQHARIQALIDTLRKAVESRHRG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA