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The map label for this gene is hexR [H]

Identifier: 77456950

GI number: 77456950

Start: 850141

End: 851001

Strand: Direct

Name: hexR [H]

Synonym: Pfl01_0722

Alternate gene names: 77456950

Gene position: 850141-851001 (Clockwise)

Preceding gene: 77456949

Following gene: 77456951

Centisome position: 13.2

GC content: 66.09

Gene sequence:

>861_bases
ATGGACATCCTTTATCAGATCCGCGCCCGTCAGGATTCCTTCAGCGCCGGTGAAGGACGCATCGCCCGTCTGATGCTCGA
CGACGTAGGATTTGCCGCCTCCGCCAGCCTCGAAGAGCTGGCGCAGCGGGCCGAAGTCAGCACCGCCACGCTGTCGCGCT
TTGCCCGCACCGTCGGTTGCCGCGACCTGCGCGATCTGCGCCTGCAACTGGCCCAGGCCAGCGGCGTCGGCAGCCGTTTC
CTCGACCCGGCGGGCACGCCCGAACAGTCGGCGTTTTACGGGCAGATCGTCGGCGATATCGAAACCACCCTGCGCCAGCA
TCTGTCGGCGTTCGACGAATCGCGCTTCGCCGATGCGGTGAAACTGCTGGGCCAGGCGCGGATGATCCACGCCTTCGGCA
TCGGCGGTTGCTCGACCCTGTGCAGCGATGAGTTGCAGGTGCGACTGGTACGCCTCGGCTACCCGATTGCGGTGTGCCAC
GACGCGGTGATGATGCGCGTCACCGCCGCCAGCCTCAGCGCCGAGCAGGTGGTGATCGTCTGTTCGCTGACCGGCATCAC
CCCGGAGTTGCTGGAGACCGTAGCGCTGGCGCGCAACTACGGCGCACGGATTCTCGCCATCACCCGCGCCGACTCGCCGC
TGGCGGAACTGGCCGACATCGTCCTGCCGCTGCAAGGCGCCGAGACCTCGTTCATCTACAAACCGACGGCGGCGCGCTAC
GGCATGCTGCTCGCCATCGACGTGCTGGCAACCGAGCTTGCGCTGGCCAATCCTGAAGACAATCAAGAACGTCTGCGGCG
GATCAAACTCGCCCTCGACGAATACCGTGGCGGCGACGATCACCTGCCGCTGGGAGACTGA

Upstream 100 bases:

>100_bases
GACGTTCAAGACCTGGACGGTGCTGGAAACCCTGATCTCGATTGTCGCTTTCGCCCTGACCGTCGGTCTTTCTTACCTGC
TGTAGTCGGAGTTATCCGCC

Downstream 100 bases:

>100_bases
CATGCTGTACGACACCCTGATTCGCAACGCCCTGGTCATCGACGGCAGCAACCGCCCCGGTTACGCCGCCGACGTGGCGA
TCCTCGGCGGCCGCATCGCG

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MDILYQIRARQDSFSAGEGRIARLMLDDVGFAASASLEELAQRAEVSTATLSRFARTVGCRDLRDLRLQLAQASGVGSRF
LDPAGTPEQSAFYGQIVGDIETTLRQHLSAFDESRFADAVKLLGQARMIHAFGIGGCSTLCSDELQVRLVRLGYPIAVCH
DAVMMRVTAASLSAEQVVIVCSLTGITPELLETVALARNYGARILAITRADSPLAELADIVLPLQGAETSFIYKPTAARY
GMLLAIDVLATELALANPEDNQERLRRIKLALDEYRGGDDHLPLGD

Sequences:

>Translated_286_residues
MDILYQIRARQDSFSAGEGRIARLMLDDVGFAASASLEELAQRAEVSTATLSRFARTVGCRDLRDLRLQLAQASGVGSRF
LDPAGTPEQSAFYGQIVGDIETTLRQHLSAFDESRFADAVKLLGQARMIHAFGIGGCSTLCSDELQVRLVRLGYPIAVCH
DAVMMRVTAASLSAEQVVIVCSLTGITPELLETVALARNYGARILAITRADSPLAELADIVLPLQGAETSFIYKPTAARY
GMLLAIDVLATELALANPEDNQERLRRIKLALDEYRGGDDHLPLGD
>Mature_286_residues
MDILYQIRARQDSFSAGEGRIARLMLDDVGFAASASLEELAQRAEVSTATLSRFARTVGCRDLRDLRLQLAQASGVGSRF
LDPAGTPEQSAFYGQIVGDIETTLRQHLSAFDESRFADAVKLLGQARMIHAFGIGGCSTLCSDELQVRLVRLGYPIAVCH
DAVMMRVTAASLSAEQVVIVCSLTGITPELLETVALARNYGARILAITRADSPLAELADIVLPLQGAETSFIYKPTAARY
GMLLAIDVLATELALANPEDNQERLRRIKLALDEYRGGDDHLPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=288, Percent_Identity=31.5972222222222, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082369, Length=280, Percent_Identity=24.2857142857143, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788767, Length=277, Percent_Identity=24.187725631769, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30968; Mature: 30968

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILYQIRARQDSFSAGEGRIARLMLDDVGFAASASLEELAQRAEVSTATLSRFARTVGC
CCCEEEECCCCCCCCCCCCCEEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
RDLRDLRLQLAQASGVGSRFLDPAGTPEQSAFYGQIVGDIETTLRQHLSAFDESRFADAV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLGQARMIHAFGIGGCSTLCSDELQVRLVRLGYPIAVCHDAVMMRVTAASLSAEQVVIV
HHHHHHHHHEEECCCCHHHHHCHHHHEEHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEE
CSLTGITPELLETVALARNYGARILAITRADSPLAELADIVLPLQGAETSFIYKPTAARY
EEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHH
GMLLAIDVLATELALANPEDNQERLRRIKLALDEYRGGDDHLPLGD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDILYQIRARQDSFSAGEGRIARLMLDDVGFAASASLEELAQRAEVSTATLSRFARTVGC
CCCEEEECCCCCCCCCCCCCEEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
RDLRDLRLQLAQASGVGSRFLDPAGTPEQSAFYGQIVGDIETTLRQHLSAFDESRFADAV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLGQARMIHAFGIGGCSTLCSDELQVRLVRLGYPIAVCHDAVMMRVTAASLSAEQVVIV
HHHHHHHHHEEECCCCHHHHHCHHHHEEHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEE
CSLTGITPELLETVALARNYGARILAITRADSPLAELADIVLPLQGAETSFIYKPTAARY
EEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCCHHHH
GMLLAIDVLATELALANPEDNQERLRRIKLALDEYRGGDDHLPLGD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]