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The map label for this gene is rmlA2 [H]

Identifier: 77456930

GI number: 77456930

Start: 830225

End: 831148

Strand: Direct

Name: rmlA2 [H]

Synonym: Pfl01_0702

Alternate gene names: 77456930

Gene position: 830225-831148 (Clockwise)

Preceding gene: 77456929

Following gene: 77456932

Centisome position: 12.89

GC content: 60.39

Gene sequence:

>924_bases
ATGGCCAAGTACAAAGGAATTCTGCTGGCGGGCGGCGCCGGTTCGCGTCTGCACCCGATCACCCTGGGCGTCTCGAAACA
GTCGCTGCCGGTGTATGACAAACCGATGATCTATTACCCGCTGTCGGTGCTGATGCTGGCGGAAATCCGCGAGATCCTGA
TCATCTCCACCCCGGAAGATCTGCCGGGTTTCCAGCGCATGCTCGGCGACGGCAGTCAGTTGGGCCTGAGCTTGAGTTAC
GCGGTGCAACCGAGTCCGGACGGCCTCGCTCAGGCGTTCATCATCGGTCGTGAATTCGTCGGTGAAGACAACGTCTGCCT
AGTGCTCGGTGACAACATTTTCTACGGCGCCGGCTTCGGTGAAACCCTGCTGCAAGCGGCGGCGCGTGATGAAGGCGCGA
CAGTGTTCGGCTATTACGTGGCCGATCCCGAGCGCTTTGGCGTGGTGGAATTCGATGCTGCCGGCAAGGCCTTGAGCATC
TGCGAAAAACCGAGCGATCCAAAGTCCAACTACGCCGTCACCGGCCTGTATTTCTACGACAACGAAGTGCTGCAGATTGC
CGCCGACATCAAGCCGTCGCCGCGCGGCGAGCTGGAGATCACCGACGTCAACAACGTCTACCTGCAACGCGGCAAATTGA
ATGTGTCGGTGATGGGCCGTGGCATGGCCTGGCTCGACACCGGCACCCACGACGCGTTGATGGAAGCGGGCAATTTCGTC
CAGGCCATCGAGAAACGCCAGGGCCTGAAAATCGCCTGCCTCGAAGAGATCGCCTACCACAAGGGCTGGATCGACGACGC
GCAATTGCTGGTGCATGCGGGCAGCATGAGCAAGACCGGTTACGGTCAGTACCTGGCGCGTTTGATCCACGATGATGTGG
TGGTGGCGATGGATGCGCAGCGCCCGTTGAAAGGCGCTGCCTGA

Upstream 100 bases:

>100_bases
CGGTGCCTACGCGCTGGAGCGCCTCGGCGAGCAAAGCGACAAAGCCCTTGTGGCCTGAACGTTCAGTCATTCAAATCTCA
CTGCTTGAAAGGAAAAAAGC

Downstream 100 bases:

>100_bases
TCAAGTGTGGGAGCGAGCCTGCTCGCTCCCACAGGGTCAGTGGCCGGTCACGCTGTCGAGTTCGGCAGCTTTGACCGTAG
CGCGTGGATCGGCCGACGGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MAKYKGILLAGGAGSRLHPITLGVSKQSLPVYDKPMIYYPLSVLMLAEIREILIISTPEDLPGFQRMLGDGSQLGLSLSY
AVQPSPDGLAQAFIIGREFVGEDNVCLVLGDNIFYGAGFGETLLQAAARDEGATVFGYYVADPERFGVVEFDAAGKALSI
CEKPSDPKSNYAVTGLYFYDNEVLQIAADIKPSPRGELEITDVNNVYLQRGKLNVSVMGRGMAWLDTGTHDALMEAGNFV
QAIEKRQGLKIACLEEIAYHKGWIDDAQLLVHAGSMSKTGYGQYLARLIHDDVVVAMDAQRPLKGAA

Sequences:

>Translated_307_residues
MAKYKGILLAGGAGSRLHPITLGVSKQSLPVYDKPMIYYPLSVLMLAEIREILIISTPEDLPGFQRMLGDGSQLGLSLSY
AVQPSPDGLAQAFIIGREFVGEDNVCLVLGDNIFYGAGFGETLLQAAARDEGATVFGYYVADPERFGVVEFDAAGKALSI
CEKPSDPKSNYAVTGLYFYDNEVLQIAADIKPSPRGELEITDVNNVYLQRGKLNVSVMGRGMAWLDTGTHDALMEAGNFV
QAIEKRQGLKIACLEEIAYHKGWIDDAQLLVHAGSMSKTGYGQYLARLIHDDVVVAMDAQRPLKGAA
>Mature_306_residues
AKYKGILLAGGAGSRLHPITLGVSKQSLPVYDKPMIYYPLSVLMLAEIREILIISTPEDLPGFQRMLGDGSQLGLSLSYA
VQPSPDGLAQAFIIGREFVGEDNVCLVLGDNIFYGAGFGETLLQAAARDEGATVFGYYVADPERFGVVEFDAAGKALSIC
EKPSDPKSNYAVTGLYFYDNEVLQIAADIKPSPRGELEITDVNNVYLQRGKLNVSVMGRGMAWLDTGTHDALMEAGNFVQ
AIEKRQGLKIACLEEIAYHKGWIDDAQLLVHAGSMSKTGYGQYLARLIHDDVVVAMDAQRPLKGAA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=67.8321678321678, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788351, Length=291, Percent_Identity=64.2611683848797, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=181, Percent_Identity=25.414364640884, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=255, Percent_Identity=25.0980392156863, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355443, Length=190, Percent_Identity=23.1578947368421, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644084, Length=190, Percent_Identity=23.1578947368421, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33228; Mature: 33097

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYKGILLAGGAGSRLHPITLGVSKQSLPVYDKPMIYYPLSVLMLAEIREILIISTPED
CCCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCEEEEEECCCC
LPGFQRMLGDGSQLGLSLSYAVQPSPDGLAQAFIIGREFVGEDNVCLVLGDNIFYGAGFG
CCHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEHHHHCCCCCEEEEECCCEEEECCHH
ETLLQAAARDEGATVFGYYVADPERFGVVEFDAAGKALSICEKPSDPKSNYAVTGLYFYD
HHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCCCEEHHHCCCCCCCCCEEEEEEEEEC
NEVLQIAADIKPSPRGELEITDVNNVYLQRGKLNVSVMGRGMAWLDTGTHDALMEAGNFV
CCEEEEEECCCCCCCCCEEEEECCCEEEECCEEEEEEEECCEEEEECCCHHHHHHCCHHH
QAIEKRQGLKIACLEEIAYHKGWIDDAQLLVHAGSMSKTGYGQYLARLIHDDVVVAMDAQ
HHHHHHCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECC
RPLKGAA
CCCCCCC
>Mature Secondary Structure 
AKYKGILLAGGAGSRLHPITLGVSKQSLPVYDKPMIYYPLSVLMLAEIREILIISTPED
CCCCCEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHCEEEEEECCCC
LPGFQRMLGDGSQLGLSLSYAVQPSPDGLAQAFIIGREFVGEDNVCLVLGDNIFYGAGFG
CCHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEHHHHCCCCCEEEEECCCEEEECCHH
ETLLQAAARDEGATVFGYYVADPERFGVVEFDAAGKALSICEKPSDPKSNYAVTGLYFYD
HHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCCCEEHHHCCCCCCCCCEEEEEEEEEC
NEVLQIAADIKPSPRGELEITDVNNVYLQRGKLNVSVMGRGMAWLDTGTHDALMEAGNFV
CCEEEEEECCCCCCCCCEEEEECCCEEEECCEEEEEEEECCEEEEECCCHHHHHHCCHHH
QAIEKRQGLKIACLEEIAYHKGWIDDAQLLVHAGSMSKTGYGQYLARLIHDDVVVAMDAQ
HHHHHHCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECC
RPLKGAA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]