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The map label for this gene is bioA [C]

Identifier: 77456913

GI number: 77456913

Start: 799475

End: 800824

Strand: Direct

Name: bioA [C]

Synonym: Pfl01_0685

Alternate gene names: 77456913

Gene position: 799475-800824 (Clockwise)

Preceding gene: 77456906

Following gene: 77456914

Centisome position: 12.42

GC content: 62.07

Gene sequence:

>1350_bases
ATGAACATGCCTGAAAACGCGCCGTCGCCACTGGCCAGCCAACTGAAGCTGGACGCGCACTGGATGCCGTACACCGCCAA
CCGCAACTTCCAGCGCGACCCGCGTCTGATCGTCGGTGCCGAAGGCAGCTGGCTGATCGACGACAAGGGCCGCAAGGTGT
ACGACTCGCTGTCCGGTCTGTGGACCTGCGGCGCCGGGCATACCCGCAAGGAAATCCAGGAAGCGGTGGCCAAACAGTTG
GGCACCCTCGATTACTCGCCGGGCTTCCAGTACGGCCACCCGCTGTCGTTCCAGCTGGCGGAGAAAATCACCGACCTGAC
GCCGGGCAACCTGAATCACGTGTTCTTCACCGACTCCGGTTCCGAGTGCGCCGATACCGCGGTGAAAATGGTCCGTGCTT
ACTGGCGCCTGAAAGGCCAGTCGACCAAGACCAAGATGATCGGCCGCGCCCGTGGCTATCACGGTGTGAACATCGCCGGC
ACCAGCCTTGGCGGCGTCAACGGCAACCGCAAGCTGTTCGGTCAGGCGATGATGGATGTCGATCACCTGCCGCACACTTT
GCTGGCGAGCAATGCTTTCTCCCGTGGCATGCCGGAGCAGGGTGGTATCGCCCTGGCCGATGAGCTGCTGAAGCTGATCG
AACTGCACGATGCGTCGAACATCGCAGCGGTGTTCGTTGAGCCTATGGCGGGTTCCGCTGGCGTGCTGGTTCCACCACAG
GGCTACCTCAAGCGTCTGCGTGAAATCTGCGATCAACACAACATCCTGCTGGTGTTCGACGAAGTGATCACCGGCTTCGG
CCGTACCGGCACCATGTTCGGCGCCACCACCTTCGGCGTGACCCCGGACCTGATGTGCATCGCCAAGCAAGTCACCAACG
GCGCGATCCCTATGGGCGCGGTGATTGCCAGCTCCGAGATCTACCAGACCTTCATGAACCAGCCGACCCCGGAATACGCC
GTTGAATTCCCGCACGGCTACACCTACTCGGCACACCCGGTGGCTTGCGCCGCGGGCCTGGCGGCACTCGACCTGCTGCA
AAAGGAAAACCTGGTGCAGAGCGTGGCCGAAGTCGCACCGCATTTCGAAAATGCCCTGCATGGTCTGAAAGGCGCGAAGA
ACGTCATCGACATTCGTAACTTCGGCCTGGCCGGTGCGATCCAGATTGCGGGCCGTGACGGCGACGCCATCGTGCGTCCG
TTCGAAGCCGGTATGGCGTTGTGGAAAGCCGGGTTCTACGTGCGCTTCGGTGGCGACACCCTGCAGTTCGGCCCAACCTT
CAACAGCAAGCCGCAGGACCTTGATCGTCTGTTCGACGCGGTCGGCGAAGTGCTGAACAAGCTCGACTGA

Upstream 100 bases:

>100_bases
TTAGAAGAGTTGAATTTCACCGACTTTATCCCCGTGGCAATTTAGCTGCAACAACGCTTTCTATCGCTCCGAAGCTTATT
GCCCTGCGAGGTTTTGCCCG

Downstream 100 bases:

>100_bases
TTTTCCTTCTATATAGATAAGCCAATGGCAGGCGCCCCTTGCGGGCGTCTGCGCACAAGAATTCAGGAGTTCCCCGATGA
GCGTTATCCCGCATTTGATC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNMPENAPSPLASQLKLDAHWMPYTANRNFQRDPRLIVGAEGSWLIDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQL
GTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECADTAVKMVRAYWRLKGQSTKTKMIGRARGYHGVNIAG
TSLGGVNGNRKLFGQAMMDVDHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQ
GYLKRLREICDQHNILLVFDEVITGFGRTGTMFGATTFGVTPDLMCIAKQVTNGAIPMGAVIASSEIYQTFMNQPTPEYA
VEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAPHFENALHGLKGAKNVIDIRNFGLAGAIQIAGRDGDAIVRP
FEAGMALWKAGFYVRFGGDTLQFGPTFNSKPQDLDRLFDAVGEVLNKLD

Sequences:

>Translated_449_residues
MNMPENAPSPLASQLKLDAHWMPYTANRNFQRDPRLIVGAEGSWLIDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQL
GTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECADTAVKMVRAYWRLKGQSTKTKMIGRARGYHGVNIAG
TSLGGVNGNRKLFGQAMMDVDHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQ
GYLKRLREICDQHNILLVFDEVITGFGRTGTMFGATTFGVTPDLMCIAKQVTNGAIPMGAVIASSEIYQTFMNQPTPEYA
VEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAPHFENALHGLKGAKNVIDIRNFGLAGAIQIAGRDGDAIVRP
FEAGMALWKAGFYVRFGGDTLQFGPTFNSKPQDLDRLFDAVGEVLNKLD
>Mature_449_residues
MNMPENAPSPLASQLKLDAHWMPYTANRNFQRDPRLIVGAEGSWLIDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQL
GTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECADTAVKMVRAYWRLKGQSTKTKMIGRARGYHGVNIAG
TSLGGVNGNRKLFGQAMMDVDHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQ
GYLKRLREICDQHNILLVFDEVITGFGRTGTMFGATTFGVTPDLMCIAKQVTNGAIPMGAVIASSEIYQTFMNQPTPEYA
VEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAPHFENALHGLKGAKNVIDIRNFGLAGAIQIAGRDGDAIVRP
FEAGMALWKAGFYVRFGGDTLQFGPTFNSKPQDLDRLFDAVGEVLNKLD

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=423, Percent_Identity=29.0780141843972, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13994255, Length=379, Percent_Identity=29.5514511873351, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI284507298, Length=334, Percent_Identity=29.3413173652695, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI37574042, Length=367, Percent_Identity=27.7929155313352, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226442705, Length=367, Percent_Identity=27.5204359673025, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI24119277, Length=386, Percent_Identity=26.4248704663212, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI226442709, Length=331, Percent_Identity=28.0966767371601, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1786991, Length=431, Percent_Identity=29.6983758700696, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI145693181, Length=307, Percent_Identity=33.2247557003257, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=30.2158273381295, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1788044, Length=421, Percent_Identity=29.2161520190024, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1789016, Length=389, Percent_Identity=28.5347043701799, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1787560, Length=397, Percent_Identity=28.7153652392947, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=350, Percent_Identity=25.4285714285714, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=28.2850779510022, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=417, Percent_Identity=26.1390887290168, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=379, Percent_Identity=27.7044854881267, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=224, Percent_Identity=31.25, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=378, Percent_Identity=27.5132275132275, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=24.8936170212766, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=23.0769230769231, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161085790, Length=379, Percent_Identity=28.4960422163588, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574759, Length=379, Percent_Identity=28.4960422163588, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21357415, Length=401, Percent_Identity=26.9326683291771, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21356575, Length=367, Percent_Identity=27.5204359673025, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48614; Mature: 48614

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMPENAPSPLASQLKLDAHWMPYTANRNFQRDPRLIVGAEGSWLIDDKGRKVYDSLSGL
CCCCCCCCCCHHHHHEECCCCCCEECCCCCCCCCCEEEECCCCEEEECCCCHHHHHHCCC
WTCGAGHTRKEIQEAVAKQLGTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSG
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
SECADTAVKMVRAYWRLKGQSTKTKMIGRARGYHGVNIAGTSLGGVNGNRKLFGQAMMDV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
DHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQ
HHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCH
GYLKRLREICDQHNILLVFDEVITGFGRTGTMFGATTFGVTPDLMCIAKQVTNGAIPMGA
HHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCCHHH
VIASSEIYQTFMNQPTPEYAVEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAP
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFENALHGLKGAKNVIDIRNFGLAGAIQIAGRDGDAIVRPFEAGMALWKAGFYVRFGGDT
HHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCEECHHHHHHHHHHCCCEEEECCCE
LQFGPTFNSKPQDLDRLFDAVGEVLNKLD
EEECCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMPENAPSPLASQLKLDAHWMPYTANRNFQRDPRLIVGAEGSWLIDDKGRKVYDSLSGL
CCCCCCCCCCHHHHHEECCCCCCEECCCCCCCCCCEEEECCCCEEEECCCCHHHHHHCCC
WTCGAGHTRKEIQEAVAKQLGTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSG
EECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCC
SECADTAVKMVRAYWRLKGQSTKTKMIGRARGYHGVNIAGTSLGGVNGNRKLFGQAMMDV
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
DHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQ
HHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCH
GYLKRLREICDQHNILLVFDEVITGFGRTGTMFGATTFGVTPDLMCIAKQVTNGAIPMGA
HHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCCCHHH
VIASSEIYQTFMNQPTPEYAVEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAP
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFENALHGLKGAKNVIDIRNFGLAGAIQIAGRDGDAIVRPFEAGMALWKAGFYVRFGGDT
HHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCEECHHHHHHHHHHCCCEEEECCCE
LQFGPTFNSKPQDLDRLFDAVGEVLNKLD
EEECCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]