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The map label for this gene is fabF [H]

Identifier: 77456653

GI number: 77456653

Start: 483910

End: 485106

Strand: Reverse

Name: fabF [H]

Synonym: Pfl01_0425

Alternate gene names: 77456653

Gene position: 485106-483910 (Counterclockwise)

Preceding gene: 77456654

Following gene: 77456652

Centisome position: 7.53

GC content: 65.16

Gene sequence:

>1197_bases
ATGACCGCCTACCTCAATGCCCTCGGCGTGATCTGTGCCCTGGGGCGCGACAAGCAAACCGTGGCACGCAACCTGTTTGC
CGGCGACTGCTCCGGCATGCGCCGCGAGTCCGGCTGGGTGCCGGAGCGCGAACTGCCGGTGGCCGCCGTACACGGCGATC
TGGCGCCGATTCCCGAGGCGCTGGCCGACCAGCGCAGCCGCAACAATCAACTGTTGCTGGAAGCCGCGTTGCAGATTCGC
GATGACATCGAGCAGGCGATCCAGACGTACGGCCGCGATCGCATCGGCGTGGTGCTCGGCACCAGCACTTCCGGTATCGA
CGAAGCCAGCCGTGGCCTGGCGCACTACATTCGTGACCAGCAGTTCCCGGCCGATTACGACTACCGGCAACAGGAACTCG
GCGCCCCGGCGAATTTCCTCGCCGACTGGCTGCAACTGAGCGGCCCGACCTATGTGATTTCCACCGCCTGCACCTCCAGC
GCACGCGCCTTGATGAGCGCCCGGCGCCTGCTCGATCTGGGCCTGTGCGACGCGGTGCTGTGTGGCGGTGTCGACAGCCT
GTGCAAACTGACCCTCAACGGTTTCAGTGCGCTGGAAGCGGTGTCGGACGAGCGCTGCAATCCGTTTTCCGCCAACCGCA
ACGGCATCAACATCGGCGAAGCGGCGGTGCTGTTCGTGATGAGCAAAGAACGCGGCGCAGGGCCGGGCATCGCCTTGCTC
GGCGCTGGCGCCAGCTCCGACGCGCACCATATTTCCGCACCTGAGCCAACCGGCCGCGGCGCGCTGCAAGCGATGCAAAA
AGCCCTCGATCAAGCCCACCTGCAAGCCGACGACATCAGCTACCTGAACCTGCACGGCACCGCGACCCAGCACAACGACG
CCATGGAAAGCCTGGCCGTTGACGCGCTGTTTGCCGACGGCGTGCCGTGTTCCTCGACCAAACCGATGACCGGTCATACC
CTCGGTGCCGCCGGTGCACTGGAAGCAGCCTTCTGCTGGTTGAGCCTGAGTGCCGACAACCCCGACCACGCCTTGCCACC
GCACATCTGGGACGGCCAGGCCGATCCCGACCTGCCAGCGCTGAAGTGGGTGACCGCAAGCGAACGCCTGGCGTCCATTG
CACCTCGCTACCTGATGAGCAACTCGTTTGCCTTCGGTGGCAATAACGTCAGCCTGATTATCGGAGACGCCCCATGA

Upstream 100 bases:

>100_bases
CGGCGCGCTGGGACATCCGTTACACCCAACCCTTGAGTTTCGAATTGAACCTGCCACAAGGCCCGCACTATCGCGTAACG
CCACTCGGTGAACCGACGTC

Downstream 100 bases:

>100_bases
CCCACTGGCCGCTCGCCGAATTGCTGCCCCACGCTGGCGACATGATCCTGATCGACCGGATCCTGAGCTTTGACGACGAA
CAGATCCACACCACGCTCAC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTAYLNALGVICALGRDKQTVARNLFAGDCSGMRRESGWVPERELPVAAVHGDLAPIPEALADQRSRNNQLLLEAALQIR
DDIEQAIQTYGRDRIGVVLGTSTSGIDEASRGLAHYIRDQQFPADYDYRQQELGAPANFLADWLQLSGPTYVISTACTSS
ARALMSARRLLDLGLCDAVLCGGVDSLCKLTLNGFSALEAVSDERCNPFSANRNGINIGEAAVLFVMSKERGAGPGIALL
GAGASSDAHHISAPEPTGRGALQAMQKALDQAHLQADDISYLNLHGTATQHNDAMESLAVDALFADGVPCSSTKPMTGHT
LGAAGALEAAFCWLSLSADNPDHALPPHIWDGQADPDLPALKWVTASERLASIAPRYLMSNSFAFGGNNVSLIIGDAP

Sequences:

>Translated_398_residues
MTAYLNALGVICALGRDKQTVARNLFAGDCSGMRRESGWVPERELPVAAVHGDLAPIPEALADQRSRNNQLLLEAALQIR
DDIEQAIQTYGRDRIGVVLGTSTSGIDEASRGLAHYIRDQQFPADYDYRQQELGAPANFLADWLQLSGPTYVISTACTSS
ARALMSARRLLDLGLCDAVLCGGVDSLCKLTLNGFSALEAVSDERCNPFSANRNGINIGEAAVLFVMSKERGAGPGIALL
GAGASSDAHHISAPEPTGRGALQAMQKALDQAHLQADDISYLNLHGTATQHNDAMESLAVDALFADGVPCSSTKPMTGHT
LGAAGALEAAFCWLSLSADNPDHALPPHIWDGQADPDLPALKWVTASERLASIAPRYLMSNSFAFGGNNVSLIIGDAP
>Mature_397_residues
TAYLNALGVICALGRDKQTVARNLFAGDCSGMRRESGWVPERELPVAAVHGDLAPIPEALADQRSRNNQLLLEAALQIRD
DIEQAIQTYGRDRIGVVLGTSTSGIDEASRGLAHYIRDQQFPADYDYRQQELGAPANFLADWLQLSGPTYVISTACTSSA
RALMSARRLLDLGLCDAVLCGGVDSLCKLTLNGFSALEAVSDERCNPFSANRNGINIGEAAVLFVMSKERGAGPGIALLG
AGASSDAHHISAPEPTGRGALQAMQKALDQAHLQADDISYLNLHGTATQHNDAMESLAVDALFADGVPCSSTKPMTGHTL
GAAGALEAAFCWLSLSADNPDHALPPHIWDGQADPDLPALKWVTASERLASIAPRYLMSNSFAFGGNNVSLIIGDAP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=265, Percent_Identity=39.622641509434, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI223972627, Length=155, Percent_Identity=41.9354838709677, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI41872631, Length=310, Percent_Identity=28.3870967741935, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787337, Length=274, Percent_Identity=38.3211678832117, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788663, Length=427, Percent_Identity=29.03981264637, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71983541, Length=273, Percent_Identity=30.7692307692308, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=30.7984790874525, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI212642053, Length=276, Percent_Identity=26.8115942028986, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=192, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=435, Percent_Identity=26.4367816091954, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24644341, Length=265, Percent_Identity=35.4716981132075, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI221330659, Length=315, Percent_Identity=24.1269841269841, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19920632, Length=315, Percent_Identity=24.1269841269841, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42092; Mature: 41961

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYLNALGVICALGRDKQTVARNLFAGDCSGMRRESGWVPERELPVAAVHGDLAPIPEA
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHH
LADQRSRNNQLLLEAALQIRDDIEQAIQTYGRDRIGVVLGTSTSGIDEASRGLAHYIRDQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
QFPADYDYRQQELGAPANFLADWLQLSGPTYVISTACTSSARALMSARRLLDLGLCDAVL
CCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
CGGVDSLCKLTLNGFSALEAVSDERCNPFSANRNGINIGEAAVLFVMSKERGAGPGIALL
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
GAGASSDAHHISAPEPTGRGALQAMQKALDQAHLQADDISYLNLHGTATQHNDAMESLAV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHH
DALFADGVPCSSTKPMTGHTLGAAGALEAAFCWLSLSADNPDHALPPHIWDGQADPDLPA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LKWVTASERLASIAPRYLMSNSFAFGGNNVSLIIGDAP
EEEEHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCC
>Mature Secondary Structure 
TAYLNALGVICALGRDKQTVARNLFAGDCSGMRRESGWVPERELPVAAVHGDLAPIPEA
CHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHH
LADQRSRNNQLLLEAALQIRDDIEQAIQTYGRDRIGVVLGTSTSGIDEASRGLAHYIRDQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
QFPADYDYRQQELGAPANFLADWLQLSGPTYVISTACTSSARALMSARRLLDLGLCDAVL
CCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
CGGVDSLCKLTLNGFSALEAVSDERCNPFSANRNGINIGEAAVLFVMSKERGAGPGIALL
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEE
GAGASSDAHHISAPEPTGRGALQAMQKALDQAHLQADDISYLNLHGTATQHNDAMESLAV
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHH
DALFADGVPCSSTKPMTGHTLGAAGALEAAFCWLSLSADNPDHALPPHIWDGQADPDLPA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
LKWVTASERLASIAPRYLMSNSFAFGGNNVSLIIGDAP
EEEEHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]